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array:22 [ "pii" => "S0025775300713649" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71364-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71364" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:561-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3722 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3651 "PDF" => 65 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300713650" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71365-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71365" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:566-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3124 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3008 "PDF" => 110 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Patrón de déficit neuropsicológico en la demencia tipo Alzheimer y en la demencia vascular" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "566" "paginaFinal" => "570" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Neuropsychological pattern of cognitive impairment in Alzheimer type dementia and vascular dementia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Teodor Marcos, Manuel Salamero, Pilar de Azpiazu, Joaquim Pujol, Teresa Boget, Josep M. Peri, M. Luisa Lázaro" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Teodor" "apellidos" => "Marcos" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Salamero" ] 2 => array:2 [ "nombre" => "Pilar" "apellidos" => "de Azpiazu" ] 3 => array:2 [ "nombre" => "Joaquim" "apellidos" => "Pujol" ] 4 => array:2 [ "nombre" => "Teresa" "apellidos" => "Boget" ] 5 => array:2 [ "nombre" => "Josep M." "apellidos" => "Peri" ] 6 => array:2 [ "nombre" => "M. Luisa" "apellidos" => "Lázaro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300713650?idApp=UINPBA00004N" "url" => "/00257753/0000011400000015/v1_201307291406/S0025775300713650/v1_201307291406/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Prevalencia y factores asociados a la presencia de esteatosis hepática en varones adultos aparentemente sanos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "561" "paginaFinal" => "565" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Albert Parés, Ricard Tresserras, Isabel Núñez, Matilde Cerralbo, Pere Plana, Francisco-Javier Pujol, Josep Massip, Llorenç Caballería, Concepció Bru, Joan Caballería, Josep Vidal, Lluis Salleras, y Joan Rodés" "autores" => array:13 [ 0 => array:4 [ "nombre" => "Albert" "apellidos" => "Parés" "email" => array:1 [ 0 => "pares@medicina.ub.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ricard" "apellidos" => "Tresserras" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] 2 => array:3 [ "nombre" => "Isabel" "apellidos" => "Núñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Matilde" "apellidos" => "Cerralbo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Pere" "apellidos" => "Plana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "Francisco-Javier" "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "Josep" "apellidos" => "Massip" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] 7 => array:3 [ "nombre" => "Llorenç" "apellidos" => "Caballería" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 8 => array:3 [ "nombre" => "Concepció" "apellidos" => "Bru" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "Joan" "apellidos" => "Caballería" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 10 => array:3 [ "nombre" => "Josep" "apellidos" => "Vidal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 11 => array:3 [ "nombre" => "Lluis" "apellidos" => "Salleras" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] 12 => array:3 [ "nombre" => "y Joan" "apellidos" => "Rodés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Unidades de Alcohología y Hepatología y Universidad de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centre de Diagnòstic per la Imatge. Hospital Clínic. Universidad de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Direcció General de Salut Pública. Departament de Sanitat i Seguretat Social. Generalitat de Catalunya" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicios Médicos de Empresa de Aigües de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Benckiser España, S.A" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "El Corte Inglés y Telefónica" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Telefónica" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "hUnidad de Bioestadística. Departamento de Salud Pública y Legislación Sanitaria. Universidad de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. A. Parés. Unidad de Hepatología. Hospital Clínic. Villarroel, 170. 08036 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevalence and associated factors for fatty liver in apparent healthy adult men" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-26" "fechaAceptado" => "1999-10-25" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220638" "palabras" => array:6 [ 0 => "Alcoholismo" 1 => "Diabetes" 2 => "Obesidad" 3 => "Dislipemia" 4 => "Ecografía hepática" 5 => "Esteatosis hepática" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El consumo de alcohol es uno de los factores que se asocian a esteatosis hepática, perola contribución de este consumo así como de otros factores no está suficientemente aclarada,particularmente en la población aparentemente sana. Por este motivo el objetivo de este estudio fueevaluar la prevalencia y factores asociados a la presencia de esteatosis hepática diagnosticadamediante ecografía.</p> <span class="elsevierStyleSectionTitle">Sujetos Y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 1.801 trabajadores varones aparentemente sanos (límites de edad: 18-60 años)se les efectuó una exploración física completa y analítica que incluyó el antígeno de superficie delvirus de la hepatitis B (HBsAg) y los anticuerpos frente al virus de la hepatitis C (anti-VHC). Todos lossujetos fueron interrogados sobre el consumo de alcohol y se les practicó una ecografía abdominal,estableciéndose el diagnóstico de esteatosis hepática según criterios ecográficos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Un total de 88 sujetos tenían HBsAg, anticuerpos anti-VHC o una exploración ecográficainsuficiente, por lo que fueron excluidos del estudio. De los 1.713 casos restantes, 236 teníanesteatosis (13,8%; 12,2–15,4). El análisis mediante regresión logística determinó la edad (OR: 1,04;IC del 95%: 1,03–1,05), la ingesta diaria de alcohol (superior a 40 g) (2,19; 1,81–2,65), los valoresde gamma-glutamiltransferasa superiores a 40 U/l (3,51; 2,95–4,18), el índice de masa corporalsuperior a 30 (3,87; 3,2–4,66) y la glucemia superior a 120 mg/dl (2,69; 1,85–3,90) como losfactores asociados a esteatosis hepática. La esteatosis hepática también se diagnosticó en el 8,8% delos pacientes sin obesidad, hiperglucemia o hipercolesterolemia. Cuando se excluyeron los pacientescon obesidad, hiperglucemia, o hipercolesterolemia, el análisis de regresión confirmó la edad, elconsumo de alcohol y el aumento de gamma-glutamiltransferasa como factores independientesasociados a la presencia de esteatosis.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La edad, el consumo de alcohol, la obesidad y el aumento de los valores de glucemia,colesterol y gamma-glutamiltransferasa son los principales factores asociados a la presencia deesteatosis hepática en la población adulta del sexo masculino, aparentemente sana.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Alcohol intake in one of the factors associated with fatty liver, although its contributionas well as other fators have not been completely established. Therefore the aim of this study was toassess the prevalence and associated factors for fatty liver diagnosed by ultrasonography.</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">1,801 presumably healthy male workers (age range 18-60 years). A completephysical and laboratory investigations, including HBsAg and anti-HCV antibodies, a detailed interviewon alcohol intake, and an abdominal ultrasound examination were performed in all cases. Diagnosis offatty liver was based on defined ultrasonographic criteria.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Eighty eight cases were excluded because of the HBsAg or anti-HCV positivity or incompleteultrasonography. Among the remaining 1,713 cases, 236 (13.8%; 12.2–15.4) had fatty liver. Logisticregression analysis disclosed age (RR: 1.04; CI 95%; 1.03–1.05), ethanol intake > 40 g/d (2.19;1.81–2.65), gamma-glutamyl-transferase > 40 U/l (3.51; 2.95–4.18), body mass index > 30 (3.87;3.22–4.66) and glycemia > 120 mg/dl (2.69; 1.85–3.90) as the risk factors for fatty liver. Fatty liverwas present in 8.8% of cases who did not have obesity, diabetes or hypercholesterolemia. When thesubjects with obesity, hyperglycemia or hypercholesterolemia were excluded, regression analysisconfirmed age, ethanol intake and gamma-glutamyl-transferase as independent factors associatedwith fatty liver.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Age, alcohol intake, obesity, and increased serum levels of glucose, cholesterol andgammaglutamyl transferase are the main factors associated with fatty liver in presumably healthyadult men.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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