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array:23 [ "pii" => "S0210480607737622" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73762-2" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73762" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:989-1001" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1686 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 654 "PDF" => 1024 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480607737634" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73763-4" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73763" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:1002-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1132 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 727 "PDF" => 397 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Carcinoma urotelial de vejiga estadio T1: subestadiaje, patrones morfológicos de invasión y su significado pronóstico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1002" "paginaFinal" => "1008" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Bladder urothelial carcinoma stage t1: substaging, invasion morphological patterns and its prognosis significance" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Trias, A. Orsola, I. Español, N. Vidal, C.X. Raventós, S. Bucar" "autores" => array:6 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Trias" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Orsola" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Español" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Vidal" ] 4 => array:2 [ "nombre" => "C.X." "apellidos" => "Raventós" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Bucar" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737634?idApp=UINPBA00004N" "url" => "/02104806/0000003100000009/v1_201304251851/S0210480607737634/v1_201304251851/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480607737610" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73761-0" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73761" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:978-88" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1455 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 818 "PDF" => 628 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Clasificación de la OMS 2004 para los tumores vesicales: resumen y comentarios" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "978" "paginaFinal" => "988" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The 2004 who classification of bladder tumors: a summary and commentary" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Álvarez Kindelán, J.P. Campos Hernández, A. López Beltrán, M.J. Requena Tapia" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Álvarez Kindelán" ] 1 => array:2 [ "nombre" => "J.P." "apellidos" => "Campos Hernández" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "López Beltrán" ] 3 => array:2 [ "nombre" => "M.J." "apellidos" => "Requena Tapia" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737610?idApp=UINPBA00004N" "url" => "/02104806/0000003100000009/v1_201304251851/S0210480607737610/v1_201304251851/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Variantes histológicas del carcinoma urotelial con implicaciones diagnósticas, pronósticas y terapéuticas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "989" "paginaFinal" => "1001" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "MªL Picazo, R.Mª Regojo, P. González-Peramato" "autores" => array:3 [ 0 => array:4 [ "nombre" => "MªL" "apellidos" => "Picazo" "email" => array:1 [ 0 => "mlpicazol.hulp@salud.madrid.org" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R.Mª" "apellidos" => "Regojo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "González-Peramato" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica. Hospital Universitario La Paz. Madrid." "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Anatomía, Histología y Neurociencias. Facultad de Medicina. Universidad Autónoma de Madrid." "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Universitario de Guadalajara." "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Departamento de Especialidades Médicas Universidad de Alcalá." "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1." "correspondencia" => "Correspondencia autora: Dra. MªL. Picazo Departamento de Anatomía Patológica Hospital Universitario La Paz Castellana, 261 - 28046 Madrid. Tel.: 917 277 049" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Histological variants of urothelial carcinoma with diagnostic, prognostic and therapeutical implications" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88409" "palabras" => array:3 [ 0 => "Carcinoma de vejiga" 1 => "Carcinoma urotelial" 2 => "Tumores vesicales" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88410" "palabras" => array:3 [ 0 => "Bladder carcinoma" 1 => "Urothelial carcinoma" 2 => "Carcinoma transitional cell" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La mayoría de los carcinomas uroteliales (CU) tienen un patrón de crecimiento histológico de tipo papilar o de tipo sólido; sin embargo, en algunos casos existen variedades histológicas que difieren significativamente de estos patrones habituales En este artículo se han seleccionado aquellas variantes de CU que por su dificultad diagnóstica e implicaciones pronósticas o terapéuticas tienen que ser perfectamente identificadas y conocidas por los patólogos y los urólogos. Las variantes que hemos considerado de mayor interés tanto clínico como patológico han sido: CU variedad en nidos y/o tubular, CU variedad microquística, CU variedad micropapilar, CU con intenso estroma linfoide, tipo linfoepitelioma, CU variedad plasmocitoide y CU sarcomatoide. De cada uno de estos patrones se ha realizado una revisión de la literatura valorando los criterios diagnósticos, el comportamiento clínico y las posibilidades terapéuticas actuales. Además, sugerimos que estas variedades de CU deben ser reflejadas explícitamente en el informe del diagnóstico anatomopatológico, debido a sus implicaciones clínicas.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Most of urothelial carcinomas (UC) have a pattern of histological growth of papillary or solid type; nevertheless, in some cases there are histological types that significantly differ from these habitual patterns In this paper we have selected those UC variants that by its diagnosis difficulty and therapeutical or prognosis implications have to be perfectly identified and known by pathologists and urologist. The variants that we have considered of greater clinical and pathological interest have been: tubular and/or nested UC, microcystic UC, micropapillary UC, lymphoepithelioma like UC, plasmacytoid UC and sarcomatoid UC. A revision of the literature has been made of each one of these patterns evaluating the criteria diagnoses, clinical behavior and the present therapeutic options. In addition, we suggest that these UC variants must be explicitly reflected in the pathology report, due to its clinical implications.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:64 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma of the urinary bladder: a review of its diverse morphology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.N. Eble" 1 => "R.H. 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Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Sem Diagn Pathol" "fecha" => "1997" "volumen" => "14" "numero" => "2" "paginaInicial" => "98" "paginaFinal" => "108" "itemHostRev" => array:3 [ "pii" => "S0090825812002259" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An unusual variant of urothelial carcinoma: the “nested variant of urothelial carcinoma” report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Badoual" 1 => "A.M. Bergemer-Fouquet" 2 => "L. Renjard" 3 => "T. Lefrancq" 4 => "B. Lesourd" 5 => "H Belhiba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Pathol" "fecha" => "1999" "volumen" => "19" "numero" => "2" "paginaInicial" => "119" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10349476" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nested variant of the transitional cell bladder carcinoma: a case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.H. Ozdemir" 1 => "O.G. Ozdemir" 2 => "A. Sertcelik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int Urol Nephrol" "fecha" => "2000" "volumen" => "32" "numero" => "2" "paginaInicial" => "257" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11229644" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nested variant of transitional cell carcinoma: a rare neoplasm with poor prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Holmang" 1 => "S.L. Johansson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Scand J Urol Nephrol" "fecha" => "2001" "volumen" => "35" "numero" => "2" "paginaInicial" => "102" "paginaFinal" => "105" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11411650" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A nested variant of transitional cell carcinoma of the urinary bladder: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Tatsura" 1 => "K. Ogawa" 2 => "T. Sakata" 3 => "T. Okamura" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jap J Clin Oncol" "fecha" => "2001" "volumen" => "31" "numero" => "6" "paginaInicial" => "287" "paginaFinal" => "289" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nested variant of urothelial carcinoma: a rare but important bladder neoplasm with aggressive behavior. Three case reports and a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Liedberg" 1 => "G. Chebil" 2 => "T. Davidsson" 3 => "V. Gadaleanu" 4 => "M. Grabe" 5 => "W. Mansson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Oncol" "fecha" => "2003" "volumen" => "21" "numero" => "1" "paginaInicial" => "7" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684120" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nested variant of urothelial carcinoma: clinicopathology of 2 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.Q. Xiao" 1 => "S.J. Savage" 2 => "M.E. Gribetz" 3 => "D.E. Burstein" 4 => "L.K. Miller" 5 => "P.D. 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