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array:23 [ "pii" => "S0210480608739184" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73918-4" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73918" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:705-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1264 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 760 "PDF" => 494 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480608739196" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73919-6" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73919" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:713-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1001 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 609 "PDF" => 387 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Eficacia clínica de la biopsia prostática. Experiencia en nuestro centro 1990-2002" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "713" "paginaFinal" => "716" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical efficacy of prostatic biopsy. Experience in our center from 1990 to 2002" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Escudero bregante, P. López cubillana, E. Cao avellaneda, A.I. López lópez, A. Maluff torres, P.A. López gonzález, A. Prieto gonzález, M. Rigabert montiel, J.I. Tornero ruíz, G.A. Gómez gómez, M. Pérez albacete" "autores" => array:11 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Escudero bregante" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "López cubillana" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Cao avellaneda" ] 3 => array:2 [ "nombre" => "A.I." "apellidos" => "López lópez" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Maluff torres" ] 5 => array:2 [ "nombre" => "P.A." "apellidos" => "López gonzález" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Prieto gonzález" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "Rigabert montiel" ] 8 => array:2 [ "nombre" => "J.I." "apellidos" => "Tornero ruíz" ] 9 => array:2 [ "nombre" => "G.A." "apellidos" => "Gómez gómez" ] 10 => array:2 [ "nombre" => "M." "apellidos" => "Pérez albacete" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739196?idApp=UINPBA00004N" "url" => "/02104806/0000003200000007/v1_201304251911/S0210480608739196/v1_201304251911/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480608739172" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73917-2" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73917" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:696-704" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1138 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 717 "PDF" => 413 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Cistectomía radical como tratamiento del cáncer vesical infiltrante en el paciente de edad avanzada" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "696" "paginaFinal" => "704" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Radical cystectomy as a muscle-invasive bladder cancer treatment in elderly patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. March Villalba, J.M. Martinez Jabaloyas, F. Pastor Hernandez, F.J. Gunthner Stefan, R. Rodriguez Navarro, P. Chuan Nuez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "March Villalba" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Martinez Jabaloyas" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Pastor Hernandez" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Gunthner Stefan" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Rodriguez Navarro" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Chuan Nuez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739172?idApp=UINPBA00004N" "url" => "/02104806/0000003200000007/v1_201304251911/S0210480608739172/v1_201304251911/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Prevalencia de disfunción eyaculatoria secundaria al tratamiento con alfa-bloqueantes en pacientes con hiperplasia benigna de próstata" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "705" "paginaFinal" => "712" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martín-Morales, G. Meyer, E. Ramírez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martín-Morales" "email" => array:1 [ 0 => "amartinmorales@terra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Meyer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Ramírez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital Carlos Haya" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sanofi-Aventis SA" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Infociencia SL" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. A. Martín Morales Servicio de Urología, Unidad de Andrología. Hospital Carlos Haya. Plaza Hospital Civil, s/n – 29009 Málaga Tel.: 951 290 362" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevalence of ejaculatory dysfunction secondary to alpha-blocker therapy in patients with benign prostatic hyperplasia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-12-01" "fechaAceptado" => "2008-04-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88668" "palabras" => array:7 [ 0 => "Hiperplasia benigna de próstata" 1 => "Alfuzosina" 2 => "Alfa-bloqueantes" 3 => "Disfunción eréctil" 4 => "Enfermedad urológica" 5 => "Síntomas prostáticos" 6 => "Tracto urinario inferior" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88667" "palabras" => array:6 [ 0 => "Adrenergic alpha-Antagonists" 1 => "Ejaculation" 2 => "Prostatic Hyperplasia" 3 => "Sexual Dysfunction" 4 => "Physiological" 5 => "Urologic Diseases" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La hiperplasia benigna de próstata (HBP) se acompaña de síntomas del tracto urinario inferior (STUI) que pueden causar alteraciones eyaculatorias, aunque éstas podrían ser además consecuencia del tratamiento con alfa-bloqueantes</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de disfunción eyaculatoria en pacientes con HBP tratados con alfa-bloqueantes. Secundariamente, evaluar el efecto del tipo de fármaco y la relación de las alteraciones eyaculatorias con factores pronósticos y la gravedad de la HBP</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio epidemiológico, transversal, no controlado y abierto en 1.177 pacientes ≥40 años diagnosticados de HBP/STUI con más de 6 meses de evolución, tratados con el mismo alfa-bloqueante durante como mínimo los últimos 3 meses. El grado de disfunción eyaculatoria se determinó mediante el dominio sobre eyaculación del Male Sexual Health Questionnaire (MSHQ). Los resultados se estratificaron según la edad y gravedad de la HBP, establecida mediante el International Prostate Symptoms Score (IPSS)</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se ha estimado una prevalencia de disfunción eyaculatoria del 82,6% en pacientes con HBP/STUI en tratamiento con alfa-bloqueantes. Aunque generalmente leve, un amplio porcentaje de quienes la sufren la consideran un problema. La edad avanzada es el factor más influyente en la gravedad tanto de las alteraciones eyaculatorias como de los síntomas prostáticos. Entre ambos parámetros se ha establecido una sólida correlación. Finalmente, entre los alfa-bloqueantes evaluados, la alfuzosina se ha asociado a una mejor función sexual</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Más del 80% de pacientes con HBP sufren alteraciones eyaculatorias, estrechamente relacionadas con la severidad de los síntomas prostáticos y la edad del individuo. Al establecer tratamiento con alfa-bloqueantes, deberíamos tener en cuenta que la alfuzosina es el que menos impacto tiene sobre la función eyaculatoria</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Benign prostatic hyperplasia (BPH) is characterized by lower urinary tract symptoms (LUTS) that may cause ejaculatory disorders, although they could be also a consequence of alpha-blocker treatment</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of ejaculatory dysfunction in patients with HBP undergoing alpha-blocker therapy. Secondary objectives were to evaluate the effect of different drugs on normal ejaculation and the relationship of dysfunction degree to prognostic factors and BPH severity</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Epidemiologic, transversal, uncontrolled and open-label study in 1.177 patients older than 40, who had been diagnosed of BPH/LUTS with more than 6 months of evolution and treated with the same alpha-blocker for at least the last 3 months. Severity of ejaculatory dysfunction was determined by the domain on ejaculation of the Male Sexual Health Questionnaire (MSHQ). Results were stratified by age and BPH severity, determined by the International Prostate Symptoms Score (IPSS)</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The prevalence of ejaculatory dysfunction has been estimated to be 82.6% in patients with BPH/LUTS treated with alpha-blockers. Although usually mild, the dysfunction is considered as bothersome by a high percentage of those who suffer it. Advanced age is the most influential factor in the severity of both ejaculatory abnormalities and prostate symptoms. Moreover, a solid correlation between these two parameters has been established. Finally, among the analyzed alpha-blockers, alfuzosin has been associated with the best sexual function</p> <span class="elsevierStyleSectionTitle">Conclussions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">More than 80% of patients with BPH suffer ejaculatory abnormalities, which are closely related to the severity of prostate symptoms and increased age. When initiating alpha-blocker treatment, we should consider that alfuzosin is the one with less negative impact on ejaculatory function</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hiperplasia prostática benigna y medicina basada en la evidencia. 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Fernández-Hernando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "20163" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2000" "volumen" => "37" "numero" => "4" "paginaInicial" => "421" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10765072" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sustained-release Alfuzosin and trial without catheter after acute urinary retention: a prospective, placebo-controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.A. McNeill" 1 => "P.D. Daruwala" 2 => "I.D. Mitchell" 3 => "M.G. Shearer" 4 => "T.B. Hargreave" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "BJU Int" "fecha" => "1999" "volumen" => "84" "numero" => "6" "paginaInicial" => "622" "paginaFinal" => "627" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10510105" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postvoid residual urine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: pooled analysis of eleven controlled studies with Alfuzosin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.A. McNeill" 1 => "T.B. Hargreave" 2 => "C. Geffriaud-Ricouard" 3 => "J.P. Santoni" 4 => "C.G. 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