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array:23 [ "pii" => "S0210480608739603" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73960-3" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73960" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:916-25" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1306 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 810 "PDF" => 489 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480608739615" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73961-5" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73961" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:926-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1074 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 647 "PDF" => 420 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Manifestaciones urológicas de los accidentes vásculo-medulares" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "926" "paginaFinal" => "930" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Urological Findings in Spinal Cord Ischemia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Luján Marco, G. García Fadrique, M. Ramírez Backhaus, S. Arlandis Guzmán, E. Martínez Agulló, J.F. Jiménez Cruz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Luján Marco" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "García Fadrique" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Ramírez Backhaus" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Arlandis Guzmán" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Agulló" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739615?idApp=UINPBA00004N" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739615/v1_201304251914/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480608739597" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73959-7" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73959" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:908-15" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1328 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 883 "PDF" => 438 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Derivaciones urinarias laparoscópicas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "908" "paginaFinal" => "915" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Laparoscopic Urinary Diversions" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Alonso y Gregorio, M. Álvarez Maestro, P.M. Cabrera Castillo, A. Tabernero Gómez, R. Cansino Alcaide, J. Cisneros Ledo, J.J. De la Peña Barthel" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Alonso y Gregorio" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Álvarez Maestro" ] 2 => array:2 [ "nombre" => "P.M." "apellidos" => "Cabrera Castillo" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Tabernero Gómez" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Cansino Alcaide" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Cisneros Ledo" ] 6 => array:2 [ "nombre" => "J.J." "apellidos" => "De la Peña Barthel" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739597?idApp=UINPBA00004N" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739597/v1_201304251914/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Evaluación económica del tratamiento médico de la hiperplasia benigna de próstata (HBP) en España en atención especializada. Aplicación al costeefectividad de dos fármacos habitualmente utilizados en su tratamiento" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "916" "paginaFinal" => "925" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Carballido, J.L. Ruiz-Cerdá, M. Unda, V. Baena, P. Campoy, J. Manasanch, J. Slof" "autores" => array:7 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Carballido" "email" => array:1 [ 0 => "EricJohn.Slof@uab.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.L." "apellidos" => "Ruiz-Cerdá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Unda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "V." "apellidos" => "Baena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "P." "apellidos" => "Campoy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Manasanch" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "J." "apellidos" => "Slof" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Servicio de Urología Hosp. Univ. Puerta de Hierro, Madrid" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología Hosp. Univ. La Fe, Valencia" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urología Hosp. de Basurto, Bilbao" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Urología Hosp. Univ. Carlos Haya, Málaga" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Urología Hosp. Univ. Virgen del Rocío, Sevilla" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Pierre Fabre Ibérica S.A., Barcelona" "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Departamento de Economía de la Empresa. Univ. Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. John Slof Departamento de Economía de la Empresa. Universidad Autónoma de Barcelona. Campus de la UAB 08193 Bellaterra (Barcelona). Tel.: 935 814 399; Fax.: 935 812 555" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Economic Evaluation Of Medical Treatment Of Benign Prostatic Hyperplasia (Bph) In The Specialised Care Setting In Spain. Application To The Cost-Effectiveness Of Two Drugs Frequently Used In Its Treatment" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-31" "fechaAceptado" => "2008-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88724" "palabras" => array:6 [ 0 => "Análisis coste-efectividad" 1 => "Hiperplasia benigna de próstata" 2 => "Tratamiento médico" 3 => "Gestión de recursos" 4 => "Serenoa repens" 5 => "Tamsulosina" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88723" "palabras" => array:6 [ 0 => "Benign prostatic hyperplasia" 1 => "Cost effectiveness analysis" 2 => "Drug therapy" 3 => "Healthcare resources" 4 => "Serenoa repens" 5 => "Tamsulosin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Llevar a cabo un estudio farmacoeconómico para conocer el coste medio del diagnóstico y seguimiento de la HBP en España en el ámbito de la atención especializada desde la perspectiva del sistema público de salud, considerando dos fármacos frecuentemente utilizados en el entorno sanitario español, un alfabloqueante (tamsulosina) y el extracto lipidoesterólico de Serenoa repens (Permixón®).</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se determinaron los costes sanitarios directos del diagnóstico y tratamiento de la HBP para cada presentación clínica según el valor del International Prostate Symptom Score (IPSS): leve, moderada y grave. Los datos sobre el consumo y los costes unitarios de los recursos sanitarios se recogieron mediante una encuesta semi-estructurada a expertos clínicos. La eficacia clínica del tratamiento médico fue obtenida del estudio clínico PERMAL, en el que se observó equivalencia terapéutica entre ambos fármacos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El coste medio anual de pruebas diagnósticas y visitas médicas de la HBP sintomática según fuese leve, moderada o grave fueron, respectivamente, 124, 207 y 286 para pacientes tratados en atención especializada. El coste medio anual del tratamiento médico, incluyendo la atención de los efectos adversos fue de 211 para Permixón® y 346 para tamsulosina.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El coste de la atención médica de la HBP es proporcional a la intensidad de la sintomatología. El tratamiento farmacológico constituye una parte significativa del coste de la enfermedad. En base al modelo utilizado, el tratamiento con Permixón® es sensiblemente más coste-efectivo que el tratamiento con tamsulosina, representando un ahorro medio de 135 por paciente y año.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To develop a pharmacoeconomic study in order to know the average cost of BPH diagnosis and follow-up in Spain in the Urology Department setting from the perspective of the public health system, considering two frequently used drugs in the Spanish Healthcare environment, an alpha-blocker (tamsulosin) and the lipido-sterolic extract of Serenoa repens (Permixon®).</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Direct healthcare costs of BPH diagnosis and treatment were determined for each clinical stage according to the International Prostate Symptom Score (IPSS): mild, moderate and severe. Data on the usage and unit costs of healthcare resources were obtained from a semi-structured interview with clinical experts. The clinical efficacy of the medical treatments was obtained from the PERMAL clinical study, where therapeutic equivalence between the two studied drugs was observed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">For patients treated in the Urology Department setting, the average annual cost of diagnostic tests and medical visits related to mild, moderate or severe BPH symptoms were, respectively, 124, 207, and 286. The average annual cost of the drugs, including adverse effects treatment, was 211 for Permixon® and 346 for tamsulosin.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Costs of medical care of BPH increases with symptom intensity. Pharmacological treatment makes up a significant part of the disease’s cost. According to the model used, treatment with Permixon® is considerably more cost-effective than with tamsulosin, offering average yearly savings of 135 per patient.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and natural history of benign prostatic hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.A. 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