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Unidad de Litiasis. Hospital Clínico de la Universidad de Chile. José Joaquín Aguirre. Chile" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. Enrique Ossandón Salas Servicio de Urología. Unidad de Litiasis. Hospital Clínico de la Universidad de Chile" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Metabolic study results of 54 patients with high risk of recurrent urolitiasis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-01" "fechaAceptado" => "2009-01-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88942" "palabras" => array:3 [ 0 => "Urolitiasis" 1 => "Enfermedad metabólica" 2 => "Estudio metabólico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88941" "palabras" => array:3 [ 0 => "Lithiasis" 1 => "Metabolic disease" 2 => "Metabolic study" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La urolitiasis es considerada actualmente una enfermedad metabólica con tendencia a la recurrencia. El objetivo de este trabajo es evaluar la prevalencia de alteraciones metabólicas en pacientes de alto riesgo y su impacto según sexo y edad.</p> <span class="elsevierStyleSectionTitle">Materiales y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Es un estudio descriptivo de 54 pacientes (37 hombres y 17 mujeres), portadores de patología litiásica con alto riesgo de recurrencia. El estudio metabólico consistió en: calcemia, uricemia, fosfemia, PTH sérica, calciuria/ 24 h, uricosuria/24 h, fosfaturia/24h, oxalaturia/24 h, citraturia/24 h y creatininuria/24 h. Los valores obtenidos fueron ajustados de acuerdo a la creatininuria y peso. Para el análisis estadístico se utilizó t-student ( STATA 7.0). Se consideró significativo p<0,05.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En el 64,8% (35/54) se observó alguna alteración metabólica; el 27,7 % (15/54) presentó 2 o más alteraciones metabólicas. Las alteraciones más frecuentes fueron la Hipercalciuria (15/54) 27,7%, Hipocitraturia (15/54) 27,7%., Hiperuricemia (8/54) 14,8%. Hiperoxalaturia (8/54) 14,8%., Hiperuricosuria (7/54) 12,9%. No se observó diferencias significativas de edad o sexo entre los grupos con y sin alteración metabólica.</p> <span class="elsevierStyleSectionTitle">Conclusiones:</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La mayoría de los pacientes con patología litiásica recurrente o de alto riesgo presentan una o más alteraciones metabólicas, predominando la hipercalciuria y la hipocitraturia. En este estudio no hubo diferencias entre ambos sexos en la mayoría de las alteraciones metabólicas, ni tampoco en su distribución etaria. Estos resultados demuestran la necesidad de realizar estudios metabólicos en pacientes de alto riesgo, dado que existen herramientas terapéuticas que permiten un manejo médico de las alteraciones metabólicas y de esta forma reducir la recurrencia de litiasis.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Urolithiasis is a metabolic disorder with a tendency to relapse. The aim of this study was to assess the prevalence of metabolic abnormalities in patients at high risk and the impact of sex and age.</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Descriptive study of 54 patients (37 men and 17 women),with lithiasic pathology at high risk of recurrence. The metabolic study included the measurement of calcemia, uricemia, fosfemia, parathormone, calciuria/24 h, uricosuria/24 h, fosfaturia/24 h, oxalaturia/24 h, citraturia/24 h and creatinine/24 h. The values obtained were corrected according to weight and creatinine. The test used for statistical analysis was t-student (STATA 7.0). It was considered significant p<0.05.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In 64,8% (35/54) of the cases a metabolic abnormality was observed and in 27,7% (15/54) there was 2 or more alterations present. The metabolic disorders most frequently observed were hypercalciuria (15/54) 27,7%, hypocitraturia (15/54) 27,7%., hyperuricemia (8/54) 14,8%. and hyperoxaluria (8/54) 14,8%. There was no significant difference in age or sex between the groups with and without metabolic abnormality.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Most patients with recurrent lithiasic pathology or at high-risk display one or more metabolic disorders, being hypercalciuria and hypocitraturia the most frecuently encountered. In this study, there was no difference between sexes in most of the metabolic disorders, nor in its age distribution. These results demonstrate the need for metabolic studies in high-risk patients, since there are tools that allow therapeutic medical management of metabolic disorders and thus reduce the recurrence of lithiasis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Studies on the prevalence and epidemiology of urinary stone disease in men in Leeds" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.G. Robertson" 1 => "M. Peacock" 2 => "M. Baker" 3 => "D.H. Marshall" 4 => "B. Pearlman" 5 => "R. 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Resultados del estudio metabólico en 54 pacientes con urolitiasis de alto riesgo de recurrencia
Metabolic study results of 54 patients with high risk of recurrent urolitiasis
Enrique Ossandón Salas1
, Oscar Storme Cabrera, Rodrigo Ledesma, Fernando Marchant González, Cristian Palma Ceppi, Pedro Recabal Guiraldes
Autor para correspondencia
enriqueossandon@mi.cl
Correspondencia autor: Dr. Enrique Ossandón Salas Servicio de Urología. Unidad de Litiasis. Hospital Clínico de la Universidad de Chile
Correspondencia autor: Dr. Enrique Ossandón Salas Servicio de Urología. Unidad de Litiasis. Hospital Clínico de la Universidad de Chile
Servicio de Urología. Unidad de Litiasis. Hospital Clínico de la Universidad de Chile. José Joaquín Aguirre. Chile
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Este artículo está disponible en español
Resultados del estudio metabólico en 54 pacientes con urolitiasis de alto riesgo de recurrencia
Enrique Ossandón Salas, Oscar Storme Cabrera, Rodrigo Ledesma, Fernando Marchant González, Cristian Palma Ceppi, Pedro Recabal Guiraldes
10.1016/S0210-4806(09)74170-1Actas Urol Esp. 2009;33:429-32