array:23 [ "pii" => "S0213005X10700045" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(10)70004-5" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70004" "copyright" => "Elsevier España S.L.. Todos los derechos reservados" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2010;28 Supl 1:19-28" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5335 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 3516 "PDF" => 1809 ] ] "itemSiguiente" => array:18 [ "pii" => "S0213005X10700057" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(10)70005-7" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70005" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2010;28 Supl 1:29-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 11160 "formatos" => array:3 [ "EPUB" => 15 "HTML" => 7277 "PDF" => 3868 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Infección por <span class="elsevierStyleItalic">Coxiella burnetii</span> (fiebre Q)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "29" "paginaFinal" => "32" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Infection by Coxiella burnetii (fever Q)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Teresa Fraile Fariñas, Carlos Muñoz Collado" "autores" => array:2 [ 0 => array:2 [ "nombre" => "María Teresa Fraile" "apellidos" => "Fariñas" ] 1 => array:2 [ "nombre" => "Carlos Muñoz" "apellidos" => "Collado" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X10700057?idApp=UINPBA00004N" "url" => "/0213005X/00000028000000S1/v1_201305090227/S0213005X10700057/v1_201305090227/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0213005X10700033" "issn" => "0213005X" "doi" => "10.1016/S0213-005X(10)70003-3" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70003" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Enferm Infecc Microbiol Clin. 2010;28 Supl 1:12-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6962 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3688 "PDF" => 3263 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Betalactamasas de espectro extendido en enterobacterias distintas de <span class="elsevierStyleItalic">Escherichia coli</span> y <span class="elsevierStyleItalic">Klebsiella</span>" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "18" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Extended-spectrum beta-lactamases in enterobacteria other than <span class="elsevierStyleItalic">Escherichia coli</span> and <span class="elsevierStyleItalic">Klebsiella</span>" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristina Seral García, María Pardos de la Gándara, Francisco Javier Castillo García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cristina Seral" "apellidos" => "García" ] 1 => array:2 [ "nombre" => "María Pardos" "apellidos" => "de la Gándara" ] 2 => array:2 [ "nombre" => "Francisco Javier Castillo" "apellidos" => "García" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X10700033?idApp=UINPBA00004N" "url" => "/0213005X/00000028000000S1/v1_201305090227/S0213005X10700033/v1_201305090227/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Carbapenemasas en especies del género <span class="elsevierStyleItalic">Pseudomonas</span>" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "19" "paginaFinal" => "28" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carlos Juan Nicolau, Antonio Oliver" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Carlos Juan" "apellidos" => "Nicolau" "email" => array:1 [ 0 => "carlos.juan@ssib.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Oliver" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Microbiología, Hospital Son Dureta, Palma de Mallorca; Área de Microbiología, Universitat de les Illes Balears (UIB), Institut Universitari d’ Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Carbapenemases in <span class="elsevierStyleItalic">Pseudomonas</span> spp" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec138269" "palabras" => array:3 [ 0 => "Género <span class="elsevierStyleItalic">Pseudomonas</span>" 1 => "Carbapenemasas" 2 => "Metalo-β-lactamasas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec138268" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Pseudomonas</span> spp" 1 => "Carbapenemases" 2 => "Metallo-β-lactamases" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> es uno de los patógenos nosocomiales más relevantes, así como una de las principales causas de infección respiratoria crónica en pacientes con enfermedades de base, como la fibrosis quística o la enfermedad pulmonar obstructiva crónica. Su elevado nivel de resistencia intrínseca a los antibióticos, unido a su extraordinaria capacidad para desarrollar resistencias adicionales por mutaciones cromosómicas, hacen de este patógeno uno de los más difíciles de tratar. Aún es más preocupante, si cabe, la creciente detección en este microorganismo de múltiples determinantes de resistencia, frecuentemente localizados en integrones, adquiridos por transferencia horizontal a través de plásmidos o transposones. Entre estos mecanismos destacan las carbapenemasas, por el abanico de antibióticos afectados (pues en conjunto hidrolizan a prácticamente todos los betalactámicos), variedad y capacidad de dispersión. En el presente trabajo se revisa la epidemiología, el impacto y la detección de las carbapenemasas descritas hasta la fecha en el género <span class="elsevierStyleItalic">Pseudomonas</span>, que pertenecen principalmente a la clase B (metalo-β-lactamasas [MBL]: IMP, VIM, SPM, GIM, AIM o DIM]), pero también, en menor medida, a las clases A (GES y KPC) y D (OXA). La presencia de estas carbapenemasas transferibles no sólo es importante en <span class="elsevierStyleItalic">P. aeruginosa</span>, sino también en otras especies clínicamente menos relevantes dentro del género, pero que pueden actuar como reservorio y vector de dispersión de estos determinantes de resistencia. La frecuencia creciente de cepas clínicas portadoras de carbapenemasas apremia a la puesta a punto de estrategias que faciliten su detección y reduzcan la expansión de estas cepas multirresistentes y de los mecanismos transferibles implicados.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> is one of the most relevant nosocomial pathogens, as well as one of the main causes of chronic respiratory infections in patients with underlying diseases such as cystic fibrosis or chronic obstructive pulmonary disease. The high intrinsic antibiotic resistance of this pathogen, together with its extraordinary capacity for acquiring additional resistances through chromosomal mutations, determines a major threat for antimicrobial therapy in hospitals worldwide. Even more concerning is the increasing detection of multiple antimicrobial resistance determinants in this microorganism, frequently located on integrons, acquired by horizontal transfer through plasmids and/or transposons. Among these mechanisms, the carbapenemases are particularly relevant, due to the wide spectrum of antibiotics affected. This work reviews the epidemiology, impact, and detection of the carbapenemases described so far in the <span class="elsevierStyleItalic">Pseudomonas</span> spp.<span class="elsevierStyleItalic">,</span> that mainly include class B enzymes (metallo-β-lactamases [MBL]: IMP, VIM, SPM, GIM, AIM, or DIM), but also, to a lower extent, class A (GES y KPC) and D (OXA) beta-lactamases. The presence of transferable carbapenemases is not only important in <span class="elsevierStyleItalic">P. aeruginosa</span>, but also in other less clinically-relevant species of the genus, since they can act as reservoires and dispersion vectors of these resistance determinants. The growing prevalence of carbapenemase-producing clinical isolates calls for the implementation of multidisciplinary strategies to optimize the detection and minimize the dissemination of these multidrug resistant strains and the involved transferable genetic elements.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:89 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudomonas aeruginosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Pollack" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Principles and practice of infectious diseases" "paginaInicial" => "1980" "paginaFinal" => "2003" "edicion" => "5.ª ed." "serieFecha" => "2000" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidrug-resistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>: risk factors and clinical impact" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Aloush" 1 => "S. Navon-Venezia" 2 => "Y. Seigman-Igra" 3 => "S. Cabili" 4 => "Y. Carmeli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.50.1.43-48.2006" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2006" "volumen" => "50" "paginaInicial" => "43" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16377665" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hospital-acquired pneumonia: risk factors, microbiology, and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.P. Lynch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "119" "numero" => "Suppl 2" "paginaInicial" => "S373" "paginaFinal" => "S384" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nosocomial infections in adult intensive-care units" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.L. Vincent" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(03)13644-6" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2003" "volumen" => "361" "paginaInicial" => "2068" "paginaFinal" => "2077" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12814731" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aerobic, anaerobic and fungal burn wound infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.A. Mousa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hosp Infect" "fecha" => "1997" "volumen" => "37" "paginaInicial" => "317" "paginaFinal" => "323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9457609" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microbiology of airway disease in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.H. Gilligan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "1991" "volumen" => "4" "paginaInicial" => "35" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1900735" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> infection in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Martinez-Solano" 1 => "M.D. Macia" 2 => "A. Fajardo" 3 => "A. Oliver" 4 => "J.L. Martinez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/593186" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2008" "volumen" => "47" "paginaInicial" => "1526" "paginaFinal" => "1533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18990062" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> clinical strains" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Juan" 1 => "M.D. Macia" 2 => "O. Gutierrez" 3 => "C. Vidal" 4 => "J.L. Perez" 5 => "A. Oliver" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.11.4733-4738.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "4733" "paginaFinal" => "4738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16251318" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta-lactam resistance response triggered by inactivation of a non-essential penicillin-binding protein" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Moya" 1 => "A. Dötsch" 2 => "C. Juan" 3 => "J. Blazquez" 4 => "L. Zamorano" 5 => "S. Haussler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.ppat.1000353" "Revista" => array:5 [ "tituloSerie" => "PLoS Pathog" "fecha" => "2009" "volumen" => "5" "paginaInicial" => "e1000353" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19325877" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple mechanisms of antimicrobial resistance in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>: our worst nightmare?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.M. Livermore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/338782" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2002" "volumen" => "34" "paginaInicial" => "634" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11823954" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>: resistance and therapeutics options in the turn of the new millennium" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Mesaros" 1 => "P. Nordmann" 2 => "P. Plesiat" 3 => "M. Roussel-Delvallez" 4 => "J. van Eldere" 5 => "Y. Glupczynski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-0691.2007.01681.x" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "560" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17266725" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypermutation is a key factor in development of multiple-antimicrobial resistance in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> strains causing chronic lung infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.D. Macia" 1 => "D. Blanquer" 2 => "B. Togores" 3 => "J. Sauleda" 4 => "J.L. Perez" 5 => "A. Oliver" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.8.3382-3386.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "3382" "paginaFinal" => "3386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16048951" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High frequency of hypermutable <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in cystic fibrosis lung infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Oliver" 1 => "R. Cantón" 2 => "P. Campo" 3 => "F. Baquero" 4 => "J. Blazquez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "2000" "volumen" => "288" "paginaInicial" => "1251" "paginaFinal" => "1254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10818002" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung infection with alginate-producing, mucoid <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.S. Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "APMIS" "fecha" => "1992" "numero" => "Suppl 28" "paginaInicial" => "S1" "paginaFinal" => "S79" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salvage of long-term central venous catheters during an outbreak of <span class="elsevierStyleItalic">Pseudomonas putida</span> and <span class="elsevierStyleItalic">Stenotrophomonas maltophilia</span> infections associated with contaminated heparin catheter-lock solution" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.B. Souza Dias" 1 => "A.B. Habert" 2 => "V. Borrasca" 3 => "V. Stempliuk" 4 => "A. Ciolli" 5 => "M.R. Araujo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/526440" "Revista" => array:6 [ "tituloSerie" => "Infect Control Hosp Epidemiol" "fecha" => "2008" "volumen" => "29" "paginaInicial" => "125" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18179367" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> and <span class="elsevierStyleItalic">Pseudomonas putida</span> outbreak associated with contaminated water outlets in an oncohaematology paediatric unit" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Aumeran" 1 => "C. Paillard" 2 => "F. Robin" 3 => "J. Kanold" 4 => "O. Baud" 5 => "R. Bonnet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhin.2006.08.009" "Revista" => array:6 [ "tituloSerie" => "J Hosp Infect" "fecha" => "2007" "volumen" => "65" "paginaInicial" => "47" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17141370" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Juan C, Zamorano L, Mena A, Albertí S, Perez JL, Oliver A. Metallo-β-lactamase (MBL)-producing <span class="elsevierStyleItalic">Pseudomonas putida</span> as a reservoir of multidrug-resistance elements that are efficiently amplified by transference to successful <span class="elsevierStyleItalic">P. aeruginosa</span> clones. J Antimicrob Chemother. 2009 (En prensa)." ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular epidemiology and mechanisms of carbapenem resistance in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> isolates from Spanish hospitals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Gutiérrez" 1 => "C. Juan" 2 => "E. Cercenado" 3 => "F. Navarro" 4 => "E. Bouza" 5 => "P. Coll" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00810-07" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2007" "volumen" => "51" "paginaInicial" => "4329" "paginaFinal" => "4335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17938181" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibacterial-resistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>: clinical impact and complex regulation of chromosomally encoded resistance mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.D. Lister" 1 => "D.J. Wolter" 2 => "N.D. Hanson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CMR.00040-09" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "582" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19822890" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Doripenem versus <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Mushtaq" 1 => "Y. Ge" 2 => "D.M. Livermore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.48.8.3086-3092.2004" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2004" "volumen" => "48" "paginaInicial" => "3086" "paginaFinal" => "3092" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15273124" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interplay of efflux system, <span class="elsevierStyleItalic">ampC</span>, and <span class="elsevierStyleItalic">oprD</span> expression in carbapenem resistance of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> clinical isolates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Quale" 1 => "S. Bratu" 2 => "J. Gupta" 3 => "D. Landman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.50.5.1633-1641.2006" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2006" "volumen" => "50" "paginaInicial" => "1633" "paginaFinal" => "1641" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16641429" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The structure of beta-lactamases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.P. Ambler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Philos Trans R Soc Lond B Biol Sci" "fecha" => "1980" "volumen" => "289" "paginaInicial" => "321" "paginaFinal" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6109327" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metallo-beta-lactamases: the quiet before the storm?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.R. Walsh" 1 => "M.A. Toleman" 2 => "L. Poirel" 3 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CMR.18.2.306-325.2005" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "306" "paginaFinal" => "325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15831827" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carbapenemases: the versatile beta-lactamases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Queenan" 1 => "K. Bush" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CMR.00001-07" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "2007" "volumen" => "20" "paginaInicial" => "440" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17630334" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carbapenemases: molecular diversity and clinical consequences" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Poirel" 1 => "J.D. Pitout" 2 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2217/17460913.2.5.501" "Revista" => array:6 [ "tituloSerie" => "Future Microbiol" "fecha" => "2007" "volumen" => "2" "paginaInicial" => "501" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17927473" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extended-spectrum cephalosporinases in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Rodriguez-Martinez" 1 => "L. Poirel" 2 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.01410-08" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2009" "volumen" => "53" "paginaInicial" => "1766" "paginaFinal" => "1771" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19258272" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Rodriguez-Martinez JM, Poirel L, Nordmann P. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009 Sep 8 [Epub ahead of print]." ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidrug-resistant Gram-negative infections: What are the treatment options?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Giamarellou" 1 => "G. Poulakou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/11315690-000000000-00000" "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "2009" "volumen" => "69" "paginaInicial" => "1879" "paginaFinal" => "1901" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19747006" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.C. Gales" 1 => "R.N. Jones" 2 => "H.S. Sader" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-0691.2005.01351.x" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2006" "volumen" => "12" "paginaInicial" => "315" "paginaFinal" => "321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16524407" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>: a survey of resistance in 136 hospitals in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Bouza" 1 => "F. Garcia-Garrote" 2 => "E. Cercenado" 3 => "M. Marin" 4 => "M.S. Diaz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1999" "volumen" => "43" "paginaInicial" => "981" "paginaFinal" => "982" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution of the antimicrobial resistance of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in Spain: second national study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Sanchez-Romero" 1 => "E. Cercenado" 2 => "O. Cuevas" 3 => "N. Garcia-Escribano" 4 => "J. Garcia-Martinez" 5 => "E. Bouza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Quimioter" "fecha" => "2003" "volumen" => "20" "paginaInicial" => "222" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17893760" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of carbapenem-resistance on <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> (PA) bloodstream infections outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Suarez" 1 => "C. Peña" 2 => "A. Campo" 3 => "J. Murillas" 4 => "B. Almirante" 5 => "V. Pomar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "49th Interscience Conference on Antimicrobial Agents and Chemotherapy" "conferencia" => "San Francisco" "serieFecha" => "2009" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.M. Rossolini" 1 => "F. Luzzaro" 2 => "R. Migliavacca" 3 => "C. Mugnaioli" 4 => "B. Pini" 5 => "F. de Luca" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00707-08" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2008" "volumen" => "52" "paginaInicial" => "4023" "paginaFinal" => "4029" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18809945" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metallo-beta-lactamaseproducing <span class="elsevierStyleItalic">Pseudomonas</span> spp. in Korea: high prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Lee" 1 => "A.J. Park" 2 => "M.Y. Kim" 3 => "H.J. Lee" 4 => "J.H. Cho" 5 => "J.O. Kang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3349/ymj.2009.50.3.335" "Revista" => array:6 [ "tituloSerie" => "Yonsei Med J" "fecha" => "2009" "volumen" => "50" "paginaInicial" => "335" "paginaFinal" => "339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19568593" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emerging metallo-betalactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance program" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.R. Fritsche" 1 => "H.S. Sader" 2 => "M.A. Toleman" 3 => "T.R. Walsh" 4 => "R.N. Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/430790" "Revista" => array:7 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2005" "volumen" => "41" "numero" => "Suppl 4" "paginaInicial" => "S276" "paginaFinal" => "S278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16032565" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A functional classification scheme for beta-lactamases and its correlation with molecular structure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Bush" 1 => "G.A. Jacoby" 2 => "A.A. Medeiros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1995" "volumen" => "39" "paginaInicial" => "211" "paginaFinal" => "233" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Class A carbapenemases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Walther-Rasmussen" 1 => "N. Høiby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dkm226" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2007" "volumen" => "60" "paginaInicial" => "470" "paginaFinal" => "482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17595289" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenemresistant strain of <span class="elsevierStyleItalic">Klebsiella pneumoniae</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Yigit" 1 => "A.M. Queenan" 2 => "G.J. Anderson" 3 => "A. Domenech-Sanchez" 4 => "J.W. Biddle" 5 => "C.D. Steward" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.45.4.1151-1161.2001" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2001" "volumen" => "45" "paginaInicial" => "1151" "paginaFinal" => "1161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11257029" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First identification of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> isolates producing a KPC-type carbapenemhydrolyzing beta-lactamase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.V. Villegas" 1 => "K. Lolans" 2 => "A. Correa" 3 => "J.N. Kattan" 4 => "J.A. Lopez" 5 => "J.P. Quinn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.01405-06" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2007" "volumen" => "51" "paginaInicial" => "1553" "paginaFinal" => "1555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17261621" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.J. Wolter" 1 => "P.M. Kurpiel" 2 => "N. Woodford" 3 => "M.F. Palepou" 4 => "R.V. Goering" 5 => "N.D. Hanson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00734-08" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2009" "volumen" => "53" "paginaInicial" => "557" "paginaFinal" => "562" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19015357" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from <span class="elsevierStyleItalic">Klebsiella pneumoniae</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Poirel" 1 => "I. Le Thomas" 2 => "T. Naas" 3 => "A. Karim" 4 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2000" "volumen" => "44" "paginaInicial" => "622" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10681329" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an <span class="elsevierStyleItalic">Enterobacter cloacae</span> clinical strain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Giakkoupi" 1 => "L.S. Tzouvelekis" 2 => "A. Tsakris" 3 => "V. Loukova" 4 => "D. Sofianou" 5 => "E. Tzelepi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2000" "volumen" => "44" "paginaInicial" => "2247" "paginaFinal" => "2253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10952563" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nomenclature of GES-type extended-spectrum beta-lactamases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.H. Lee" 1 => "S.H. Jeong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.5.2148-2150.2005" "Revista" => array:5 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "2148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15855553" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta-lactamase nomenclature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.A. Jacoby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.50.4.1123-1129.2006" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2006" "volumen" => "50" "paginaInicial" => "1123" "paginaFinal" => "1129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16569819" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GES-2, a class A beta-lactamase from <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> with increased hydrolysis of imipenem" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Poirel" 1 => "G.F. Weldhagen" 2 => "T. Naas" 3 => "C. de Champs" 4 => "M.G. Dove" 5 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2001" "volumen" => "45" "paginaInicial" => "2598" "paginaFinal" => "2603" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> isolate producing the GES-5 extended-spectrum beta-lactamase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Wang" 1 => "P. Cai" 2 => "D. Chang" 3 => "Z. Mi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dkl116" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2006" "volumen" => "57" "paginaInicial" => "1261" "paginaFinal" => "1262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16617065" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in South Africa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.J. Labuschagne" 1 => "G.F. Weldhagen" 2 => "M.M. Ehlers" 3 => "M.G. Dove" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijantimicag.2008.01.020" "Revista" => array:6 [ "tituloSerie" => "Int J Antimicrob Agents" "fecha" => "2008" "volumen" => "31" "paginaInicial" => "527" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18436436" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nosocomial spread of colistin-only-sensitive sequence type 235 <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Viedma" 1 => "C. Juan" 2 => "J. Acosta" 3 => "L. Zamorano" 4 => "J.R. Otero" 5 => "F. Sanz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00900-09" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2009" "volumen" => "53" "paginaInicial" => "4930" "paginaFinal" => "4933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19738007" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Integron-encoded GES-type extended-spectrum beta-lactamase with increased activity toward aztreonam in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Poirel" 1 => "L. Brinas" 2 => "N. Fortineau" 3 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.8.3593-3597.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "3593" "paginaFinal" => "3597" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16048994" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Yong D, Bell JM, Ritchie B, Pratt R, Toleman MA, Walsh TR, et al. A novel subgroup Metallo-β-lactamases (MBL) AIM-1 emerges in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> (PSA) from Australia. En: Abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2007. Abstract C1-593, p. 75. American Society for Microbiology. Washington, DC, USA." ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Poirel L, Rodríguez-Martínez J, Al Naiemi N, Debets-Ossenkopp Y, Nordmann P, et al. Characterization of blaDIM-1, a novel integron-located metallo-beta-lactamase gene from a <span class="elsevierStyleItalic">Pseudomonas stutzeri</span> clinical isolate in Netherlands. En: Oral sessions of the 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, 2009. Session 0309, p. 61. European Society of Clinical Microbiology and Infectious Diseases. Basel, Switzerland." ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a <span class="elsevierStyleItalic">Citrobacter freundii</span> clinical isolate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Sekiguchi" 1 => "K. Morita" 2 => "T. Kitao" 3 => "N. Watanabe" 4 => "M. Okazaki" 5 => "T. Miyoshi-Akiyama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.01337-07" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2008" "volumen" => "52" "paginaInicial" => "4194" "paginaFinal" => "4197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18765691" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of <span class="elsevierStyleItalic">Serratia marcescens</span> that shows imipenem resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Osano" 1 => "Y. Arakawa" 2 => "R. Wacharotayankun" 3 => "M. Ohta" 4 => "T. Horii" 5 => "H. Ito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1994" "volumen" => "38" "paginaInicial" => "71" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8141584" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IMP-12, a new plasmid-encoded metallo-beta-lactamase from a <span class="elsevierStyleItalic">Pseudomonas putida</span> clinical isolate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Docquier" 1 => "M.L. Riccio" 2 => "C. Mugnaioli" 3 => "F. Luzzaro" 4 => "A. Endimiani" 5 => "A. Toniolo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2003" "volumen" => "47" "paginaInicial" => "1522" "paginaFinal" => "1528" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12709317" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of bla(IMP-22) in <span class="elsevierStyleItalic">Pseudomonas</span> spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Pellegrini" 1 => "P.S. Mercuri" 2 => "G. Celenza" 3 => "M. Galleni" 4 => "B. Segatore" 5 => "E. Sacchetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dkp061" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2009" "volumen" => "63" "paginaInicial" => "901" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19270313" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PCR detection of metallo-beta-lactamase gene (blaIMP) in gram-negative rods resistant to broad-spectrum beta-lactams" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Senda" 1 => "Y. Arakawa" 2 => "S. Ichiyama" 3 => "K. Nakashima" 4 => "H. Ito" 5 => "S. Ohsuka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "1996" "volumen" => "34" "paginaInicial" => "2909" "paginaFinal" => "2913" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8940421" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Shibata" 1 => "Y. Doi" 2 => "K. Yamane" 3 => "T. Yagi" 4 => "H. Kurokawa" 5 => "K. Shibayama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2003" "volumen" => "41" "paginaInicial" => "5407" "paginaFinal" => "5413" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cloning and characterization of <span class="elsevierStyleItalic">bla</span>VIM, a new integron-borne metallo-beta-lactamase gene from a <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> clinical isolate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Lauretti" 1 => "M.L. Riccio" 2 => "A. Mazzariol" 3 => "G. Cornaglia" 4 => "A. Amicosante" 5 => "R. Fontana" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "1999" "volumen" => "43" "paginaInicial" => "1584" "paginaFinal" => "1590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10390207" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First isolation of blaVIM-2 in an environmental isolate of <span class="elsevierStyleItalic">Pseudomonas pseudoalcaligenes</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Quinteira" 1 => "H. Ferreira" 2 => "L. Peixe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.5.2140-2141.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "2140" "paginaFinal" => "2141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15855549" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "VIM-12, a novel plasmid-mediated metallo-beta-lactamase from <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> that resembles a VIM-1/VIM-2 hybrid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Pournaras" 1 => "A. Ikonomidis" 2 => "L.S. Tzouvelekis" 3 => "D. Tokatlidou" 4 => "N. Spanakis" 5 => "A.N. Maniatis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.12.5153-5156.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "5153" "paginaFinal" => "5156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16304191" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "On functional and structural heterogeneity of VIM-type metallo-beta-lactamases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Docquier" 1 => "J. Lamotte-Brasseur" 2 => "M. Galleni" 3 => "G. Amicosante" 4 => "J.M. Frère" 5 => "G.M. Rossolini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2003" "volumen" => "51" "paginaInicial" => "257" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12562689" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outbreak of carbapenem-resistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> producing SPM-1 metallo-(beta)-lactamase in a teaching hospital in southern Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.P. Zavascki" 1 => "P.B. Gaspareto" 2 => "A.F. Martins" 3 => "A.L. Gonçalves" 4 => "A.L. Barth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dki390" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2005" "volumen" => "56" "paginaInicial" => "1148" "paginaFinal" => "1151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16239284" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dissemination of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> producing SPM-1-like and IMP-1-like metallo-beta-lactamases in hospitals from southern Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.F. Martins" 1 => "A.P. Zavascki" 2 => "P.B. Gaspareto" 3 => "A.L. Barth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s15010-007-6289-3" "Revista" => array:6 [ "tituloSerie" => "Infection" "fecha" => "2007" "volumen" => "35" "paginaInicial" => "457" "paginaFinal" => "460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18034208" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First report of the metallo-β-lactamase, SPM-1, in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. El Salabi" 1 => "M.A. Toleman" 2 => "J. Weeks" 3 => "T. Bruderer" 4 => "R. Frei" 5 => "T.R. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2009" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallobeta- lactamase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Castanheira" 1 => "M.A. Toleman" 2 => "R.N. Jones" 3 => "F.J. Schmidt" 4 => "T.R. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.48.12.4654-4661.2004" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2004" "volumen" => "48" "paginaInicial" => "4654" "paginaFinal" => "4661" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15561840" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel acquired metallobeta-lactamase gene, bla(SIM-1), in a class 1 integron from <span class="elsevierStyleItalic">Acinetobacter baumannii</span> clinical isolates from Korea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Lee" 1 => "J.H. Yum" 2 => "D. Yong" 3 => "H.M. Lee" 4 => "H.D. Kim" 5 => "J.D. Docquier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.49.11.4485-4491.2005" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2005" "volumen" => "49" "paginaInicial" => "4485" "paginaFinal" => "4491" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16251286" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "OXA-type carbapenemases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Walther-Rasmussen" 1 => "N. Høiby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dki482" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother" "fecha" => "2006" "volumen" => "57" "paginaInicial" => "373" "paginaFinal" => "383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16446375" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extended-spectrum beta-lactamases: a clinical update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.L. Paterson" 1 => "R.A. Bonomo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CMR.18.4.657-686.2005" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "657" "paginaFinal" => "686" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16223952" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "OXA-type beta-lactamases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Naas" 1 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Pharm Des" "fecha" => "1999" "volumen" => "5" "paginaInicial" => "865" "paginaFinal" => "879" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10539993" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ARI 1: beta-lactamasemediated imipenem resistance in <span class="elsevierStyleItalic">Acinetobacter baumannii</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Paton" 1 => "R.S. Miles" 2 => "J. Hood" 3 => "S.G. Amyes" 4 => "R.S. Miles" 5 => "S.G. Amyes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Antimicrob Agents" "fecha" => "1993" "volumen" => "2" "paginaInicial" => "81" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18611526" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First detection of the OXA-40 carbapenemase in <span class="elsevierStyleItalic">P. aeruginosa</span> isolates, located on a plasmid also found in <span class="elsevierStyleItalic">A. baumannii</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Sevillano" 1 => "L. Gallego" 2 => "J.M. Garcia-Lobo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pathol Biol (Paris)" "fecha" => "2009" "volumen" => "57" "paginaInicial" => "493" "paginaFinal" => "495" ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical characterization of the naturally occurring oxacillinase OXA-50 of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Girlich" 1 => "T. Naas" 2 => "P. Nordmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.48.6.2043-2048.2004" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2004" "volumen" => "48" "paginaInicial" => "2043" "paginaFinal" => "2048" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15155197" "web" => "Medline" ] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of <span class="elsevierStyleItalic">poxB</span>, a chromosomal-encoded <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> oxacillinase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.F. Kong" 1 => "S.R. Jayawardena" 2 => "A. del Puerto" 3 => "L. Wiehlmann" 4 => "U. Laabs" 5 => "B. Tümmler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gene.2005.05.027" "Revista" => array:6 [ "tituloSerie" => "Gene" "fecha" => "2005" "volumen" => "358" "paginaInicial" => "82" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of <span class="elsevierStyleItalic">Pseudomonas</span> and <span class="elsevierStyleItalic">Acinetobacter</span> species" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "88" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of <span class="elsevierStyleItalic">Pseudomonas</span> spp. and <span class="elsevierStyleItalic">Acinetobacter</span> spp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2003" "volumen" => "41" "paginaInicial" => "4623" "paginaFinal" => "4629" ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of two methods to detect carbapenemase & metallo-beta-lactamase production in clinical isolates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Indian J Med Res" "fecha" => "2005" "volumen" => "121" "paginaInicial" => "780" "paginaFinal" => "783" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simple screening tests for detection of carbapenemases in clinical isolates of non-fermentative Gram-negative bacteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Indian J Med Res" "fecha" => "2009" "volumen" => "129" "paginaInicial" => "707" "paginaFinal" => "712" ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of <span class="elsevierStyleItalic">Pseudomonas</span> spp. and <span class="elsevierStyleItalic">Acinetobacter</span> spp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2002" "volumen" => "40" "paginaInicial" => "3798" "paginaFinal" => "3801" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2002" "volumen" => "40" "paginaInicial" => "755" "paginaFinal" => "759" ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the double-disk, combined disk, and Etest methods for detecting metallo-beta-lactamases in gram-negative bacilli" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.diagmicrobio.2004.01.002" "Revista" => array:6 [ "tituloSerie" => "Diagn Microbiol Infect Dis" "fecha" => "2004" "volumen" => "49" "paginaInicial" => "5" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Appropriate Müller-Hinton agar is crucial for the performance of metallo-lactamase Etest" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "19th European Congress of Clinical Microbiology and Infectious Diseases" "conferencia" => "Helsinki" "serieFecha" => "2009" ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First isolation of a carbapenem-hydrolyzing beta-lactamase in <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "932" "paginaFinal" => "933" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nosocomial spread of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> producing the metallo-beta-lactamase VIM-2 in a Spanish hospital: clinical and epidemiological implications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-0691.2007.01784.x" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "1026" "paginaFinal" => "1029" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> clinical isolate in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00465-08" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2008" "volumen" => "52" "paginaInicial" => "3589" "paginaFinal" => "3596" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outbreak of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> infections with PER-1 extended-spectrum betalactamase in Warsaw, Poland: further evidence for an international clonal complex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "2829" "paginaFinal" => "2834" ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endemic carbapenem resistance associated with OXA-40 carbapenemase among <span class="elsevierStyleItalic">Acinetobacter baumannii</span> isolates from a hospital in northern Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2002" "volumen" => "40" "paginaInicial" => "4741" "paginaFinal" => "4743" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isolation of multi-resistant carbapenemase-producing <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> (VIM-2) and extended-spectrum beta-lactamase-producing <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> (SHV-2) in a perianal ulcer in a patient with hematological disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Enferm Infecc Microbiol Clin" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "574" "paginaFinal" => "575" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular characterization of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> isolates in Cantabria, Spain, producing VIM-2 metallo-beta-lactamase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Enferm Infecc Microbiol Clin" "fecha" => "2009" ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic respiratory infections by mucoid carbapenemase-producing <span class="elsevierStyleItalic">Pseudomonas aeru</span>ginosa strains, a new potential public health problem" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/AAC.00076-08" "Revista" => array:6 [ "tituloSerie" => "Antimicrob Agents Chemother" "fecha" => "2008" "volumen" => "52" "paginaInicial" => "2285" "paginaFinal" => "2286" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/0213005X/00000028000000S1/v1_201305090227/S0213005X10700045/v1_201305090227/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/0213005X/00000028000000S1/v1_201305090227/S0213005X10700045/v1_201305090227/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X10700045?idApp=UINPBA00004N" ]
Información de la revista
Compartir
Descargar PDF
Más opciones de artículo
Carbapenemasas en especies del género Pseudomonas
Carbapenemases in Pseudomonas spp
Carlos Juan Nicolau
, Antonio Oliver
Autor para correspondencia
Servicio de Microbiología, Hospital Son Dureta, Palma de Mallorca; Área de Microbiología, Universitat de les Illes Balears (UIB), Institut Universitari d’ Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, España
Artículo
Este artículo está disponible en español
Carbapenemasas en especies del género Pseudomonas
Carlos Juan Nicolau, Antonio Oliver
10.1016/S0213-005X(10)70004-5Enferm Infecc Microbiol Clin. 2010;28 Supl 1:19-28