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array:25 [ "pii" => "S0213485310700049" "issn" => "02134853" "doi" => "10.1016/S0213-4853(10)70004-9" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "70004" "copyright" => "Sociedad Española de Neurología" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2010;25:163-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6328 "formatos" => array:3 [ "EPUB" => 74 "HTML" => 5025 "PDF" => 1229 ] ] "itemSiguiente" => array:19 [ "pii" => "S0213485310700050" "issn" => "02134853" "doi" => "10.1016/S0213-4853(10)70005-0" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "70005" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2010;25:168-73" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 10627 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 9669 "PDF" => 914 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>" "titulo" => "Gliomatosis cerebral: estudio de 22 pacientes" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "168" "paginaFinal" => "173" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Gliomatosis cerebri: review of 22 patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1228 "Ancho" => 998 "Tamanyo" => 174279 ] ] "descripcion" => array:1 [ "es" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Resonancia magnética con secuencias FLAIR y T1 tras administración de contraste (gadolinio intravenoso) en la que observamos diferente grado de captación de las lesiones. 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"apellidos" => "Dalmau" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485310700050?idApp=UINPBA00004N" "url" => "/02134853/0000002500000003/v1_201305151020/S0213485310700050/v1_201305151020/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0213485310700037" "issn" => "02134853" "doi" => "10.1016/S0213-4853(10)70003-7" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "70003" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2010;25:156-62" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7694 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 6723 "PDF" => 928 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>" "titulo" => "Diseño de una vía clínica para la atención a los pacientes con esclerosis múltiple" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "156" "paginaFinal" => "162" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical pathways for the care of multiple sclerosis patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1478 "Ancho" => 2067 "Tamanyo" => 819724 ] ] "descripcion" => array:1 [ "es" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Documento de información al paciente con esclerosis múltiple.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Oreja-Guevara, A. Miralles, J. García-Caballero, S. Noval, L. Gabaldón, M.D. Esteban-Vasallo, M.J. García-Matres, C. Bayón-Pérez, A. Royo, A. González, A. Hernanz, M.R. López-Pajares, J.L. Morante, E. Díez-Tejedor" "autores" => array:14 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Oreja-Guevara" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Miralles" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "García-Caballero" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Noval" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Gabaldón" ] 5 => array:2 [ "nombre" => "M.D." "apellidos" => "Esteban-Vasallo" ] 6 => array:2 [ "nombre" => "M.J." "apellidos" => "García-Matres" ] 7 => array:2 [ "nombre" => "C." "apellidos" => "Bayón-Pérez" ] 8 => array:2 [ "nombre" => "A." "apellidos" => "Royo" ] 9 => array:2 [ "nombre" => "A." "apellidos" => "González" ] 10 => array:2 [ "nombre" => "A." "apellidos" => "Hernanz" ] 11 => array:2 [ "nombre" => "M.R." "apellidos" => "López-Pajares" ] 12 => array:2 [ "nombre" => "J.L." "apellidos" => "Morante" ] 13 => array:2 [ "nombre" => "E." "apellidos" => "Díez-Tejedor" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485310700037?idApp=UINPBA00004N" "url" => "/02134853/0000002500000003/v1_201305151020/S0213485310700037/v1_201305151020/es/main.assets" ] "es" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>" "titulo" => "Validación de un cuestionario diagnóstico para migraña adaptado para encuesta telefónica asistida por ordenador" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "163" "paginaFinal" => "167" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Porta-Etessam, A. López-Gil, J. Matías-Guiu, C. Fernández" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Porta-Etessam" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "López-Gil" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:4 [ "nombre" => "J." "apellidos" => "Matías-Guiu" "email" => array:1 [ 0 => "inc.hcsc@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:1 [ "colaborador" => "en representación del Comité Científico del Programa PALM" ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neurología, Hospital Clínico San Carlos, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento Médico, Merck Sharp & Dohme de España, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Validation of a diagnostic questionnaire for migraine adapted for a computer assisted telephone interviewing" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Introducción</span><p id="p0010" class="elsevierStylePara elsevierViewall">La migraña es una enfermedad incapacitante con un elevado impacto médico, social y económico<a class="elsevierStyleCrossRefs" href="#bb0005"><span class="elsevierStyleSup">1,2</span></a>. Aunque su prevalencia en Europa se ha estimado entre el 9,6 y el 24,6%<a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a>, la variabilidad en dicha tasa puede depender de factores metodológicos y diferencias en los diseños y por ello es imprescindible que los estudios estén basados en clasificaciones internacionales<a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a> y especialmente en los criterios de la IHS<a class="elsevierStyleCrossRef" href="#bb0025"><span class="elsevierStyleSup">5</span></a> para el diagnóstico de migraña. Entre los diferentes diseños, es motivo de discusión las diversas formas de obtener la información para establecer la definición de migraña en los estudios poblacionales<a class="elsevierStyleCrossRef" href="#bb0030"><span class="elsevierStyleSup">6</span></a>; se compara la entrevista clínica, realizada por médicos o por enfermeras<a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a>, con el uso de cuestionarios<a class="elsevierStyleCrossRef" href="#bb0040"><span class="elsevierStyleSup">8</span></a>. Muchos autores consideran que los cuestionarios diagnósticos son el mejor método en los estudios de campo, y se han utilizado ampliamente en la epidemiología de la migraña<a class="elsevierStyleCrossRefs" href="#bb0045"><span class="elsevierStyleSup">9–30</span></a>. Recientemente, el cuestionario ID-migraine<a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a>, sobre el que se han realizado versiones en diferentes idiomas<a class="elsevierStyleCrossRefs" href="#bb0160"><span class="elsevierStyleSup">32–37</span></a> ha sido utilizado para conocer la prevalencia de la migraña en Estados Unidos<a class="elsevierStyleCrossRef" href="#bb0190"><span class="elsevierStyleSup">38</span></a>. Sin embargo, para su uso todos los cuestionarios requieren su validación en la comparación con la entrevista clínica estructurada por un especialista, que continúa siendo el método estándar de diagnóstico de la migraña. En este artículo se presenta la validación de un cuestionario para diagnóstico de migraña administrado con un método telefónico asistido por ordenador.</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Sujetos y métodos</span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Sujetos</span><p id="p0015" class="elsevierStylePara elsevierViewall">Para la realización del estudio PALM, sobre prevalencia de la migraña en España, se ha diseñado el cuestionario para el diagnóstico de la migraña, que tenía por base los criterios de la ICDH-II (2004) siguiendo las adaptaciones descritas por Lipton et al<a class="elsevierStyleCrossRef" href="#bb0190"><span class="elsevierStyleSup">38</span></a>, preparado para ser administrado vía telefónica con apoyo de ordenador (CATI).</p><p id="p0020" class="elsevierStylePara elsevierViewall">Para validar el uso del cuestionario se determinó en una muestra de 50 sujetos seleccionados aleatoriamente entre los participantes en el estudio poblacional que habían respondido al cuestionario telefónicamente. De las 50 personas seleccionadas, 24 sujetos cumplían los criterios diagnósticos para migraña estricta según entrevista telefónica CATI y 26, no. Posteriormente, un neurólogo que no tenía conocimiento previo del diagnóstico de la encuesta telefónica evaluó a todos los sujetos. El neurólogo realizó una evaluación clínica completa de forma ciega para el diagnóstico, que incluía historia clínica y examen físico; el diagnóstico del dolor de cabeza se estableció según los criterios ICHD-II (<a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a>).</p><elsevierMultimedia ident="t0005"></elsevierMultimedia></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Análisis de datos</span><p id="p0025" class="elsevierStylePara elsevierViewall">Para la estimación del cálculo muestral, se utilizaron los datos procedentes de Lipton et al<a class="elsevierStyleCrossRef" href="#bb0190"><span class="elsevierStyleSup">38</span></a>, para un nivel de confianza del 95,5% y un error muestral del 15%, se calculó un tamaño muestral de 22 sujetos por grupo, tanto para el criterio positivo de migraña como para el criterio negativo. Los índices de validez de criterio del cuestionario de migraña, en comparación con el diagnóstico mediante entrevista clínica con el neurólogo, se estimaron de forma independiente. Los cocientes de probabilidades se calcularon siguiendo el método de Taylor. En todos los casos se calculó el IC del 95%. El paquete estadístico utilizado fue STATA versión 9.0.</p></span></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Resultados</span><p id="p0030" class="elsevierStylePara elsevierViewall">De los 50 sujetos seleccionados, 39 eran mujeres y 11, varones, con una media de edad de 42 años. En 24 de los sujetos participantes, resultó en un diagnóstico de migraña estricta. En los 26 restantes, no se pudo establecer un diagnóstico de migraña (13 participantes) o se los clasificó con migraña probable (13 sujetos), al no cumplir uno de los criterios ICHD-II. De los 24 pacientes diagnosticados de migraña estricta con la entrevista CATI, en tan sólo 2 (8%) de ellos el neurólogo determinó que no padecían migraña. Sin embargo, de entre los pacientes en que el cuestionario diagnóstico no concluyó que padecieran migraña no hubo ninguno en que el especialista estableciera dicho diagnóstico. El análisis estadístico reveló una sensibilidad del 81,5% (IC del 95%, 66,8%-96,1%) y una especificidad del 91,3% (IC del 95%, 79,8%-100%). El valor predictivo positivo fue del 91,7% y el negativo, del 80,8% (<a class="elsevierStyleCrossRef" href="#t0010">tabla 2</a>).</p><elsevierMultimedia ident="t0010"></elsevierMultimedia></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Discusión</span><p id="p0035" class="elsevierStylePara elsevierViewall">La entrevista clínica estructurada con un neurólogo se considera el método estándar de diagnóstico de la migraña; sin embargo, esta metodología requiere un gran esfuerzo logístico ya que hay que coordinar las visitas a un neurólogo de todos los sujetos participantes en el estudio y esto dificulta la posibilidad de analizar a grandes poblaciones. Otras opciones para recabar información de muestras grandes de población son los cuestionarios autoadministrados. Otra fórmula es la administración de encuestas mediante el teléfono, como nuestro cuestionario. El teléfono se ha utilizado como medio de entrevista clínica para el diagnóstico de cefalea crónica<a class="elsevierStyleCrossRef" href="#bb0195"><span class="elsevierStyleSup">39</span></a>, y como cuestionario en la cefalea postraumática<a class="elsevierStyleCrossRef" href="#bb0200"><span class="elsevierStyleSup">40</span></a>.</p><p id="p0040" class="elsevierStylePara elsevierViewall">También se han diseñado cuestionarios telefónicos para diferenciar los tipos de migraña<a class="elsevierStyleCrossRef" href="#bb0205"><span class="elsevierStyleSup">41</span></a>, así como para el diagnóstico de migraña<a class="elsevierStyleCrossRefs" href="#bb0210"><span class="elsevierStyleSup">42–44</span></a>. También existen variaciones en la formula de administración del cuestionario telefónico, y en nuestro diseño se ha realizado mediante un modelo por asistencia computarizada (CATI)<a class="elsevierStyleCrossRef" href="#bb0225"><span class="elsevierStyleSup">45</span></a>. Nuestros resultados han mostrado unos valores de sensibilidad (81,5%) y especificidad (91,3%) semejantes a los de cuestionarios autoadministrados<a class="elsevierStyleCrossRefs" href="#bb0170"><span class="elsevierStyleSup">34,38</span></a>. Los índices de validez de criterio de este estudio se han calculado únicamente para el diagnóstico de la migraña estricta. Dado que es importante disponer de instrumentos diagnósticos fiables y reproducibles para los estudios epidemiológicos, el diseño de este cuestionario y su validez nos permiten disponer de una herramienta adecuada para obtener datos de prevalencia válidos en nuestro estudio epidemiológico.</p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Comité Científico del Programa PALM</span><p id="p0045" class="elsevierStylePara elsevierViewall">Jorge Matías-Guiu (Sociedad Española de Neurología, SEN) —coordinador del programa—; Valentín Mateos Marcos (Grupo de Estudio de Cefaleas de la SEN), Samuel Díaz Insa (Grupo de Estudio de Cefaleas de la SEN), Jesús Porta Etessam (Grupo de Estudio de Cefaleas de la SEN), Jaume Morera Guitart (Grupo de Estudio de Cefaleas de la SEN), Julio Pascual Gómez (Grupo de Estudio de Cefaleas de la SEN), Enrique Arrieta Antón (Grupo de Trabajo de Neurología, Sociedad Española de Medicina Rural y Generalista SEMERGEN), Adolfo Ramada Soriano (Grupo de Trabajo de Neurología, SEMERGEN), Salvador Tranche Iparraguirre (Grupo de Trabajo de Cefalea, Sociedad Española de Medicina Familiar y Comunitaria, semFYC), Vicente Baos Vicente (Grupo de Utilización de Fármacos, semFYC), Francisco Javier Sánchez Lores (Asociación de Especialistas en Medicina del Trabajo), Albert Jorge Jovell Fernández (Foro Español de Pacientes), Cristina Fernández Pérez (Hospital Clínico San Carlos de Madrid), Arturo López-Gil (Área de Neuropsiquiatría, Departamento Médico de Merck Sharp & Dohme de España).</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres168577" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 1 => array:2 [ "identificador" => "xpalclavsec156839" "titulo" => "Palabras clave" ] 2 => array:2 [ "identificador" => "xres168576" "titulo" => array:5 [ 0 => "Abstract" 1 => "Introduction" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 3 => array:2 [ "identificador" => "xpalclavsec156838" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introducción" ] 5 => array:3 [ "identificador" => "s0010" "titulo" => "Sujetos y métodos" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "s0015" "titulo" => "Sujetos" ] 1 => array:2 [ "identificador" => "s0020" "titulo" => "Análisis de datos" ] ] ] 6 => array:2 [ "identificador" => "s0025" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "s0030" "titulo" => "Discusión" ] 8 => array:2 [ "identificador" => "s0035" "titulo" => "Comité Científico del Programa PALM" ] 9 => array:1 [ "titulo" => "Bibliografía" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-03-03" "fechaAceptado" => "2010-03-08" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156839" "palabras" => array:5 [ 0 => "Migraña" 1 => "Diagnóstico" 2 => "Encuesta telefónica" 3 => "Sensibilidad" 4 => "Especificidad" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec156838" "palabras" => array:5 [ 0 => "Migraine" 1 => "Diagnosis" 2 => "Telephone survey" 3 => "Sensitivity" 4 => "Specificity" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0010">Introducción</span><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">La utilización de cuestionarios es la fórmula de obtención de la información sobre los casos y las variables a analizar en los estudios poblacionales de migraña.</p> <span class="elsevierStyleSectionTitle" id="st0015">Métodos</span><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado la validación del cuestionario dentro del estudio PALM, basado en los criterios de IHS-II y administrado telefónicamente según un muestreo asistido por ordenador (CATI). Se ha validado mediante el estudio de 50 sujetos elegidos aleatoriamente y analizados de forma ciega por un neurólogo experto en migraña.</p> <span class="elsevierStyleSectionTitle" id="st0020">Resultados</span><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">De los 24 pacientes diagnosticados de migraña estricta con la entrevista CATI, en tan sólo 2 (8%) de ellos el neurólogo determinó que no tenían migraña. Sin embargo, de entre los pacientes en que el cuestionario diagnóstico no concluyó que padecieran migraña no hubo ninguno en que el especialista estableciera dicho diagnóstico. El análisis reveló una sensibilidad del 81,5% (intervalo de confianza [IC] del 95%, 66,8%-96,1%) y una especificidad del 91,3% (IC del 95%, 79,8%-100%). El valor predictivo positivo fue del 91,7% y el negativo del 80,8%.</p> <span class="elsevierStyleSectionTitle" id="st0025">Conclusiones</span><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">El cuestionario PALM, administrado telefónicamente con apoyo de ordenador, es un instrumento válido para su uso en la determinación de la prevalencia de migraña en estudios poblacionales.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0035">Introduction</span><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">The use of questionnaires is a tool for obtaining information on cases and the variables to analyse in migraine study populations.</p> <span class="elsevierStyleSectionTitle" id="st0040">Methods</span><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">We have validated the questionnaire within the PALM study, based on IHS-II criteria and administered by telephone using computer assisted sampling (CATI). The questionnaire has been validated using 50 randomly selected subjects, who had been assessed blind by a neurologist expert in migraine.</p> <span class="elsevierStyleSectionTitle" id="st0045">Results</span><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Of the 24 patients diagnosed with strict migraine with the CATI interview, only in 2 (8%) of them did the neurologist determine that they did not suffer from migraine. Furthermore, of the patients in whom the diagnostic questionnaire concluded that they did not suffer from migraine, the specialist did not establish that diagnosis in any of them either. The analysis showed a sensitivity of 81.5% (95% CI, 66.8%-96.1%) and a specificity of 91.3% (95% CI, 79.8%-100%). The positive predictive value was 91.7% and the negative was 80.8%.</p> <span class="elsevierStyleSectionTitle" id="st0050">Conclusions</span><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">The PALM questionnaire administered by telephone with computer support is a valid tool for use in determining the prevalence of migraine in study populations.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "t0005" "etiqueta" => "Tabla 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sujetos con migraña (n = 24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sujetos sin migraña (n = 26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total (n = 50) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mujeres \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (44%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (34%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 (78%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Varones \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (22%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Edad \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34,3 ± 10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50,7 ± 17,5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42,82 ± 16,5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Número de episodios</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> < 5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (12%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (36%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> 5 a 30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (16%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (34%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> > 30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (22%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (38%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duración</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Menos de 4<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> 4-12<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (14%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (28%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> 12-24<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (24%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> 24-48<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> 48-72<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (14%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (16%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Más de 72<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (18%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Localización del dolor</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Unilateral \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (28%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (38%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (66%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Bilateral \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (20%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (14%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (34%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulsátil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Sí \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (36%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (30%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (66%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (12%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (22%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (34%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Se agrava con el ejercicio</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> Sí \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (46%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (28%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (74%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (26%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab264212.png" ] ] ] ] "descripcion" => array:1 [ "es" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Características demográficas y del dolor de cabeza de los sujetos participantes en el estudio</p>" ] ] 1 => array:7 [ "identificador" => "t0010" "etiqueta" => "Tabla 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IC del 95% \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sensibilidad \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81,5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66,8%-96,1% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Especificidad \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">91,3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79,8%-100% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Valor predictivo positivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">91,7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80,6%-100% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Valor predictivo negativo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80,8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65,6%-95,9% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cociente de probabilidades (+) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9,37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,46-35,66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cociente de probabilidades (−) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,09-0,45 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab264213.png" ] ] ] ] "descripcion" => array:1 [ "es" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Índices de validez de criterio del cuestionario diagnóstico de migraña adaptado para encuesta telefónica</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Migraine frequency and intensity: relationship with disability and psychological factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Magnusson" 1 => "W.J. Becker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2003" "volumen" => "43" "paginaInicial" => "1049" "paginaFinal" => "1059" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14629240" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost of migraine and other headaches in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Berg" 1 => "L.J. Stovner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2005.01192.x" "Revista" => array:7 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2005" "volumen" => "12" "numero" => "Suppl 1" "paginaInicial" => "59" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15877781" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of headache in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.J. Stovner" 1 => "J.A. Zwart" 2 => "K. Hagen" 3 => "G.M. Terwindt" 4 => "J. Pascual" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2006.01184.x" "Revista" => array:6 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2006" "volumen" => "13" "paginaInicial" => "333" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16643310" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The international classification of headache disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Olesen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2008.01121.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "691" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18471112" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The International Classification of Headache Disorders, 2nd edition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Headache Classification Subcommittee of the International Headache Society" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cephalalgia" "fecha" => "2004" "volumen" => "24" "numero" => "Suppl 1" "paginaInicial" => "9" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14979299" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence and disability burden of adult migraine in England and their relationships to age, gender and ethnicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.J. Steiner" 1 => "A.I. Scher" 2 => "W.F. Stewart" 3 => "K. Kolodner" 4 => "J. Liberman" 5 => "R.B. Lipton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "519" "paginaFinal" => "527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12950377" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a brief nurse-administered migraine assessment tool" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.A. Marcus" 1 => "C. Kapelewski" 2 => "R.G. Jacob" 3 => "T.E. Rudy" 4 => "J.M. Furman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2004.04076.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2004" "volumen" => "44" "paginaInicial" => "328" "paginaFinal" => "332" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15109357" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Questionnaire versus clinical interview in the diagnosis of headache" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.B. Lipton" 1 => "W.C. Stewart" 2 => "S. Solomon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "1992" "volumen" => "32" "paginaInicial" => "55" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1555934" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Questionnaire versus clinical interview in the diagnosis of headache" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.K. Rasmussen" 1 => "R. Jensen" 2 => "J. Olesen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "1991" "volumen" => "31" "paginaInicial" => "290" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1860786" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of migraine according to the questionnaire’Alcoi-92’ in the Comtat area" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Sánchez-Pérez" 1 => "M. Asensio" 2 => "A. Melchor" 3 => "I. Montiel" 4 => "R. Falip" 5 => "J.M. Moltó" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "1999" "volumen" => "28" "paginaInicial" => "459" "paginaFinal" => "463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10229957" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening for migraine in the general population: validation of a simple questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Gervil" 1 => "V. Ulrich" 2 => "J. Olesen" 3 => "M.B. Russell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "342" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9731939" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Head-HUNT: Validity and reliability of a headache questionnaire in a large population-based study in Norway" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Hagen" 1 => "A. Zwart J-" 2 => "L. Vatten" 3 => "L.J. Stovner" 4 => "G. Bovim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2000" "volumen" => "20" "paginaInicial" => "244" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10999674" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a new instrument for determining migraine prevalence: The UCSD Migraine Questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Tom" 1 => "M. Brody" 2 => "A. Valabhji" 3 => "L. Turner" 4 => "C. Molgaard" 5 => "J. Rothrock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1994" "volumen" => "44" "paginaInicial" => "925" "paginaFinal" => "928" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8190298" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of migraine in Japan: A nationwide survey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Sakai" 1 => "H. Igarashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "1997" "volumen" => "17" "paginaInicial" => "15" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9399013" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic screening for assessment of the IHS criteria for migraine by general practitioners" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Michel" 1 => "P. Henry" 2 => "L. Letenneur" 3 => "M. Jogeix" 4 => "A. Corson" 5 => "J.F. Dartigues" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cephalalgia" "fecha" => "1993" "volumen" => "13" "numero" => "Suppl 12" "paginaInicial" => "54" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8500149" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a questionnaire for the diagnosis of headache in an outpatient clinic at a university hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.J. Benseñor" 1 => "P.A. Lotufo" 2 => "A.C. Pereira" 3 => "A.C. Tannuri" 4 => "F.K. Issa" 5 => "D. Akashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arq Neuropsiquiatr" "fecha" => "1997" "volumen" => "55" "paginaInicial" => "364" "paginaFinal" => "369" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9629350" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a Spanish Questionnaire to perform a population-based study of the prevalence of headache" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Galiano" 1 => "I.H. Montiel" 2 => "A. Melchor" 3 => "R. Falip" 4 => "M. Asensio" 5 => "J. Matias-Guiu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Headache Classification and Epidemiology" "paginaInicial" => "213" "paginaFinal" => "215" "serieFecha" => "1994" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Headache diagnosis. Comparison of questionnaire with clinical interview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Pereira-Monteiro" 1 => "R.JAR. Maio" 2 => "J.M. Calheiros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Headache Classification and Epidemiology" "paginaInicial" => "217" "paginaFinal" => "220" "serieFecha" => "1994" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of migraine in Spain. An assessment of the questionnaire's validity by the clinical interview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.JA. Láinez" 1 => "J. Vioque" 2 => "I. Hernández-Aguado" 3 => "F. Titus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Headache Classification and Epidemiology" "paginaInicial" => "221" "paginaFinal" => "225" "serieFecha" => "1994" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development and validation of the Migraine Screen Questionnaire (MS-Q)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.JA. Láinez" 1 => "M. Domínguez" 2 => "J. Rejas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2005.00265.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2005" "volumen" => "45" "paginaInicial" => "1328" "paginaFinal" => "1338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16324165" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of a new questionnaire in Spanish for diagnosis of migraine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Montiel" 1 => "R. Muñiz" 2 => "M. Asensio" 3 => "M.J. González" 4 => "R. Martín" 5 => "C. Díaz-Marín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "1997" "volumen" => "25" "paginaInicial" => "2056" "paginaFinal" => "2057" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9580295" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validity and reliability of the migraine self-questionnaire Alcoi-1995" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Montiel" 1 => "R. Muñiz" 2 => "M. Asensio" 3 => "C. Ruiz" 4 => "C. Díaz-Marín" 5 => "J. Matías-Guiu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "1997" "volumen" => "25" "paginaInicial" => "1173" "paginaFinal" => "1177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9340140" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Population-based validation of a German-language self-administered headache questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.S. Yoon" 1 => "M. Obermann" 2 => "G. Fritsche" 3 => "M. Slomke" 4 => "P. Dommes" 5 => "C. Schilf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-2982.2008.01560.x" "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2008" "volumen" => "28" "paginaInicial" => "605" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18422724" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a questionnaire in the diagnosis of headache" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Fritsche" 1 => "M. Hueppe" 2 => "M. Kukava" 3 => "A. Dzagnidze" 4 => "M. Schuerks" 5 => "M.S. Yoon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2007.00758.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2007" "volumen" => "47" "paginaInicial" => "546" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17445104" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a Georgian language headache questionnaire in a population-based sample" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kukava" 1 => "A. Dzagnidze" 2 => "M. Janelidze" 3 => "E. Mirvelashvili" 4 => "M. Djibuti" 5 => "G. Fritsche" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Headache Pain" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "321" "paginaFinal" => "324" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Agreement of self-reported migraine with ICHD-II criteria in the Women's Health Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Schürks" 1 => "J.E. Buring" 2 => "T. Kurth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-2982.2008.01835.x" "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2009" "volumen" => "29" "paginaInicial" => "1086" "paginaFinal" => "1090" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19735535" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a migraine screening questionnaire in a Colombian university population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Rueda-Sánchez" 1 => "L.A. Díaz-Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-2982.2004.00765.x" "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2004" "volumen" => "24" "paginaInicial" => "894" "paginaFinal" => "899" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15377322" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of a migraine-specific questionnaire for use in family studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Kallela" 1 => "M. Wessman" 2 => "M. Färkkilä" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2001" "volumen" => "8" "paginaInicial" => "61" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11509082" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adapted Finnish Migraine-Specific Questionnaire for family studies (FMSQ(FS)): a validation study in two languages" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.F. Facheris" 1 => "F.D. Vogl" 2 => "S. Hollmann" 3 => "G. Sixt" 4 => "C. Pattaro" 5 => "R. Schönhuber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2008.02248.x" "Revista" => array:6 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2008" "volumen" => "15" "paginaInicial" => "1071" "paginaFinal" => "1074" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18715259" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Migraine in adolescents: validation of a screening questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Valentinis" 1 => "F. Valent" 2 => "M. Mucchiut" 3 => "F. Barbone" 4 => "P. Bergonzi" 5 => "G. Zanchin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2008.01261.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2009" "volumen" => "49" "paginaInicial" => "202" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19222594" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A self-administered screener for migraine in primary care: The ID Migraine validation study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.B. Lipton" 1 => "D. Dodick" 2 => "R. Sadovsky" 3 => "K. Kolodner" 4 => "J. Endicott" 5 => "J. Hettiarachchi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2003" "volumen" => "61" "paginaInicial" => "375" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12913201" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the Portuguese Version of ID-Migraine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Gil-Gouveia" 1 => "I. Martins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2009. 01449.x" "Revista" => array:2 [ "tituloSerie" => "Headache" "fecha" => "2009" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A validation study of an Italian version of the ID Migraine: preliminary results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Brighina" 1 => "G. Salemi" 2 => "B. Fierro" 3 => "A. Gasparro" 4 => "G. Balletta" 5 => "A. Aloisio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10194-005-0189-7" "Revista" => array:6 [ "tituloSerie" => "J Headache Pain" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "216" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16362668" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A validation study of an Italian version of the ID Migraine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Brighina" 1 => "G. Salemi" 2 => "B. Fierro" 3 => "A. Gasparro" 4 => "A. Balletta" 5 => "A. Aloisio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1526-4610.2006.00628.x" "Revista" => array:6 [ "tituloSerie" => "Headache" "fecha" => "2007" "volumen" => "47" "paginaInicial" => "905" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17578542" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The validation of ID Migraine screener in neurology outpatient clinics in Turkey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Karli" 1 => "M. Ertas" 2 => "B. Baykan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10194-007-0397-4" "Revista" => array:6 [ "tituloSerie" => "J Headache Pain" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "217" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17901923" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validity of the ID-Migraine screener in the workplace" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Siva" 1 => "M. Zarifoglu" 2 => "M. Ertas" 3 => "S. Saip" 4 => "H.N. Karli" 5 => "B. Baykan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/01.wnl.0000309221.85545.0d" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2008" "volumen" => "70" "paginaInicial" => "1337" "paginaFinal" => "1345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18413587" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can ID Migraine be used as a screening test for adolescent migraine?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Zarifoglu" 1 => "N. Karli" 2 => "O. Taskapilioglu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-2982.2007.01470.x" "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2008" "volumen" => "28" "paginaInicial" => "65" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17986273" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Migraine in the United States: epidemiology and patterns of health care use" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.B. Lipton" 1 => "A.I. Scher" 2 => "K. Kolodner" 3 => "J. Liberman" 4 => "T.J. Steiner" 5 => "W.F. Stewart" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2002" "volumen" => "58" "paginaInicial" => "885" "paginaFinal" => "894" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11914403" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic daily headache in adolescents: an 8-year follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.J. Wang" 1 => "J.L. Fuh" 2 => "S.R. Lu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/WNL.0b013e3181ae2377" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2009" "volumen" => "73" "paginaInicial" => "416" "paginaFinal" => "422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19605771" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic post-traumatic headache after head injury in children and adolescents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Kirk" 1 => "G. Nagiub" 2 => "I. Abu-Arafeh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-8749.2008.02063.x" "Revista" => array:6 [ "tituloSerie" => "Dev Med Child Neurol" "fecha" => "2008" "volumen" => "50" "paginaInicial" => "422" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18422678" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the deCODE Migraine Questionnaire (DMQ3) for use in genetic studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kirchmann" 1 => "E. Seven" 2 => "A. Björnsson" 3 => "G. Björnssdóttir" 4 => "J.R. Gulcher" 5 => "K. Stefánsson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2006.01491.x" "Revista" => array:6 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2006" "volumen" => "13" "paginaInicial" => "1239" "paginaFinal" => "1244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17038039" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and sex-ratio of the subtypes of migraine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.B. Russell" 1 => "B.K. Rasmussen" 2 => "P. Thorvaldsen" 3 => "J. Olesen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Epidemiol" "fecha" => "1995" "volumen" => "24" "paginaInicial" => "612" "paginaFinal" => "618" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7672904" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1130862108723842" "estado" => "S300" "issn" => "11308621" ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of migraine and other headaches in Hong Kong" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.W. Wong" 1 => "K.S. Wong" 2 => "T.S. Yu" 3 => "R. Kay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuroepidemiology" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "82" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7891818" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One-year prevalence of migraine in Sweden: a population-based study in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Dahlöf" 1 => "M. Linde" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cephalalgia" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "664" "paginaFinal" => "671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11531898" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Applications of computerized adaptive testing (CAT) to the assessment of headache impact" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Ware Jr." 1 => "M. Kosinski" 2 => "J.B. Bjorner" 3 => "M.S. Bayliss" 4 => "A. Batenhorst" 5 => "C.G. Dahlöf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Qual Life Res" "fecha" => "2003" "volumen" => "12" "paginaInicial" => "935" "paginaFinal" => "952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14651413" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02134853/0000002500000003/v1_201305151020/S0213485310700049/v1_201305151020/es/main.assets" "Apartado" => array:4 [ "identificador" => "9397" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02134853/0000002500000003/v1_201305151020/S0213485310700049/v1_201305151020/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485310700049?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/02134853/addon/S0213485310700049/S300/en/295v25n03a13150938pdf001_2.pdf" "portada" => "295v25n03a13150938pdf001_2.png" ] ] ]
