ISSN: 1807-5932
e-ISSN: 1980-5322

Clinics is a gold open access electronic international journal that publishes peer-reviewed research in continuous flow of interest to clinicians and researchers in medical and biomedical sciences based on its originality, importance, conclusions and interest to readers. CLINICS also publishes Comments and Editorials. The journal is committed to the principles of ethics, respect for the individual, humanization, honesty, pioneering spirit and excellence.Clinics is the Official Scientific journal of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP).

Indexed in:

Clarivate/ISI: Web of Sciences, SCOPUS, PubMed Central (PMC), SciELO Brasil, SciELO Public Health, Redalyc, EMBASE, Nutrition Abstracts & Reviews, POPLINE, Tropical Diseases Bulletin, LILACS

Keywords
Introduction
Materials and methods
Ethics statement
Reagents
Ssc patients and healthy individuals
Isolation and identification of ssc patient-derived dvsmcs
Dvsmc culture and stimulation
Cck-8
Cell fluorescence staining
Western blotting
Transwell
Statistical analysis
Results
Tanshinone iia inhibits il-17a-induced proliferation of ssc patient-derived dvsmcs
Tanshinone iia attenuates il-17a-induced collagen synthesis in ssc patient-derived dvsmcs
Tanshinone iia suppresses il-17a-induced migration of ssc patient-derived dvsmcs
Tanshinone iia reduces il-17a-induced erk phosphorylation in ssc patient-derived dvsmcs
Discussion
Author contributions
Acknowledgments
Bibliography

CLINICAL SCIENCE

DOI: 10.6061/clinics/2015(04)06

Open Access

Tanshinone IIA attenuates interleukin-17A-induced systemic sclerosis patient-derived dermal vascular smooth muscle cell activation via inhibition of the extracellular signal-regulated kinase signaling pathway

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