metricas
covid
Buscar en
Acta Colombiana de Cuidado Intensivo
Toda la web
Inicio Acta Colombiana de Cuidado Intensivo The double gut point: A case report of a novel sonographic sign of localized pne...
Journal Information

Statistics

Follow this link to access the full text of the article

Case report
The double gut point: A case report of a novel sonographic sign of localized pneumoperitoneum
El doble punto visceral: un reporte de caso de signo precoz de neumoperitoneo localizado
Yale Tung-Chena,
Corresponding author
yale.tung.chen@gmail.com

Corresponding author.
, Tomás Villén-Villegasb, Elmo Pereira-Juniorc
a Internal Medicine Department, Hospital Universitario La Paz, Madrid, Spain
b Medicine Department, Universidad Francisco de Vitoria, Madrid, Spain
c Intensive Care Department, Hospital Copa Star. Arbo Education, Río de Janeiro, Brazil
Read
33
Times
was read the article
7
Total PDF
26
Total HTML
Share statistics
 array:23 [
  "pii" => "S0122726223000149"
  "issn" => "01227262"
  "doi" => "10.1016/j.acci.2023.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2023-04-01"
  "aid" => "391"
  "copyright" => "Asociación Colombiana de Medicina Crítica y Cuidado lntensivo"
  "copyrightAnyo" => "2023"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Acta Colomb Cuid Intensivo. 2023;23:160-3"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0122726223000265"
    "issn" => "01227262"
    "doi" => "10.1016/j.acci.2023.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2023-04-01"
    "aid" => "403"
    "copyright" => "Asociación Colombiana de Medicina Crítica y Cuidado lntensivo"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "pgl"
    "cita" => "Acta Colomb Cuid Intensivo. 2023;23:164-201"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">DOCUMENTO DE CONSENSO</span>"
      "titulo" => "Consenso colombiano de calidad en cuidados intensivos&#58; <span class="elsevierStyleItalic">task force</span> de la Asociaci&#243;n Colombiana de Medicina Cr&#237;tica y Cuidados Intensivos &#40;AMCI&#174;&#41;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "164"
          "paginaFinal" => "201"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Colombian consensus on quality in intensive care&#58; task force of the Colombian Association of Critical Medicine and Intensive Care &#40;AMCI&#174;&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Camilo Ernesto Pizarro G&#243;mez, Julio C&#233;sar Dur&#225;n, V&#237;ctor Hugo Nieto Estrada, Bladimir Alejandro Gil Valencia, Leopoldo Ferrer Zaccaro, Carmelo Due&#241;as Castell, Carmen Chica Meza, Yulieth Zabaleta Polo, Fabio Var&#243;n Vega, Manuel Garay Fern&#225;ndez, Ronald Medina Lombo, Juan Luis Echeverri Ospina, Maria Cristina Flori&#225;n, C&#233;sar Orlando Enciso, Mario G&#243;mez Duque, Agamenon Quintero Villareal, Jos&#233; Antonio Rojas Su&#225;rez, Byron Pi&#241;eres, Guillermo Ortiz, Liliana Paola Correa, Mauricio Vasco Ram&#237;rez, Paula Velasquez Trujillo, Camilo Andr&#233;s Bello Mu&#241;oz, Daniel Molano Franco, Albert Valencia Moreno"
          "autores" => array:25 [
            0 => array:2 [
              "nombre" => "Camilo Ernesto"
              "apellidos" => "Pizarro G&#243;mez"
            ]
            1 => array:2 [
              "nombre" => "Julio C&#233;sar"
              "apellidos" => "Dur&#225;n"
            ]
            2 => array:2 [
              "nombre" => "V&#237;ctor Hugo"
              "apellidos" => "Nieto Estrada"
            ]
            3 => array:2 [
              "nombre" => "Bladimir Alejandro"
              "apellidos" => "Gil Valencia"
            ]
            4 => array:2 [
              "nombre" => "Leopoldo"
              "apellidos" => "Ferrer Zaccaro"
            ]
            5 => array:2 [
              "nombre" => "Carmelo"
              "apellidos" => "Due&#241;as Castell"
            ]
            6 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "Chica Meza"
            ]
            7 => array:2 [
              "nombre" => "Yulieth"
              "apellidos" => "Zabaleta Polo"
            ]
            8 => array:2 [
              "nombre" => "Fabio"
              "apellidos" => "Var&#243;n Vega"
            ]
            9 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Garay Fern&#225;ndez"
            ]
            10 => array:2 [
              "nombre" => "Ronald"
              "apellidos" => "Medina Lombo"
            ]
            11 => array:2 [
              "nombre" => "Juan Luis"
              "apellidos" => "Echeverri Ospina"
            ]
            12 => array:2 [
              "nombre" => "Maria Cristina"
              "apellidos" => "Flori&#225;n"
            ]
            13 => array:2 [
              "nombre" => "C&#233;sar Orlando"
              "apellidos" => "Enciso"
            ]
            14 => array:2 [
              "nombre" => "Mario"
              "apellidos" => "G&#243;mez Duque"
            ]
            15 => array:2 [
              "nombre" => "Agamenon"
              "apellidos" => "Quintero Villareal"
            ]
            16 => array:2 [
              "nombre" => "Jos&#233; Antonio"
              "apellidos" => "Rojas Su&#225;rez"
            ]
            17 => array:2 [
              "nombre" => "Byron"
              "apellidos" => "Pi&#241;eres"
            ]
            18 => array:2 [
              "nombre" => "Guillermo"
              "apellidos" => "Ortiz"
            ]
            19 => array:2 [
              "nombre" => "Liliana Paola"
              "apellidos" => "Correa"
            ]
            20 => array:2 [
              "nombre" => "Mauricio"
              "apellidos" => "Vasco Ram&#237;rez"
            ]
            21 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Velasquez Trujillo"
            ]
            22 => array:2 [
              "nombre" => "Camilo Andr&#233;s"
              "apellidos" => "Bello Mu&#241;oz"
            ]
            23 => array:2 [
              "nombre" => "Daniel"
              "apellidos" => "Molano Franco"
            ]
            24 => array:2 [
              "nombre" => "Albert"
              "apellidos" => "Valencia Moreno"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0122726223000265?idApp=UINPBA00004N"
    "url" => "/01227262/0000002300000002/v1_202306081058/S0122726223000265/v1_202306081058/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0122726222000866"
    "issn" => "01227262"
    "doi" => "10.1016/j.acci.2022.12.001"
    "estado" => "S300"
    "fechaPublicacion" => "2023-04-01"
    "aid" => "384"
    "copyright" => "Asociaci&#243;n Colombiana de Medicina Cr&#237;tica y Cuidado lntensivo"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Acta Colomb Cuid Intensivo. 2023;23:154-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Reporte de caso</span>"
      "titulo" => "Af&#233;resis terap&#233;utica en paciente con h&#237;gado graso agudo del embarazo&#58; reporte de caso"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "154"
          "paginaFinal" => "159"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Therapeutic apheresis in acute fatty liver of pregnancy&#58; A case report"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1501
              "Ancho" => 2508
              "Tamanyo" => 136237
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Representaci&#243;n del monitoreo diario de paracl&#237;nicos&#59; el punto negro marca el inicio de la af&#233;resis terap&#233;utica&#46; En este caso existe normalizaci&#243;n de los niveles de INR&#44; de bilirrubina total y de creatinina&#44; asociado a ascenso de fibrin&#243;geno&#44; evidenciando la mejor&#237;a progresiva de las funciones hep&#225;tica&#44; hematol&#243;gica y renal&#46; a&#41;<span class="elsevierStyleHsp" style=""></span>INR&#59; b&#41;<span class="elsevierStyleHsp" style=""></span>fibrin&#243;geno&#59; c&#41;<span class="elsevierStyleHsp" style=""></span>bilirrubina total&#59; d&#41;<span class="elsevierStyleHsp" style=""></span>creatinina&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Francisco Viera Molina"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Viera Molina"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0122726222000866?idApp=UINPBA00004N"
    "url" => "/01227262/0000002300000002/v1_202306081058/S0122726222000866/v1_202306081058/es/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "The double gut point&#58; A case report of a novel sonographic sign of localized pneumoperitoneum"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "160"
        "paginaFinal" => "163"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Yale Tung-Chen, Tom&#225;s Vill&#233;n-Villegas, Elmo Pereira-Junior"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Yale"
            "apellidos" => "Tung-Chen"
            "email" => array:1 [
              0 => "yale.tung.chen@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Tom&#225;s"
            "apellidos" => "Vill&#233;n-Villegas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Elmo"
            "apellidos" => "Pereira-Junior"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Internal Medicine Department&#44; Hospital Universitario La Paz&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Medicine Department&#44; Universidad Francisco de Vitoria&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Intensive Care Department&#44; Hospital Copa Star&#46; Arbo Education&#44; R&#237;o de Janeiro&#44; Brazil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "El doble punto visceral&#58; un reporte de caso de signo precoz de neumoperitoneo localizado"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Abdominal pain is one of the most common presenting complaints to the Emergency Department &#40;ED&#41;&#46; The differential diagnosis is extensive&#44; with many etiologies having the same initial presentation&#44; which could change the management and therefore the prognosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Pneumoperitoneum can be a life-threatening situation&#44; caused by hollow organ perforation&#46; The first diagnostic approach is made with the help of abdominal or chest X-ray&#44; however according to an early study&#44; in almost 50&#37; of cases&#44; plain film radiography is unable to demonstrate pneumoperitoneum&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Abdominal CT&#44; the gold standard investigation for pneumoperitoneum&#44; is not always readily available and can be contraindicated in the setting of severe hemodynamic instability&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In the diagnostic evaluation&#44; Point-of-care ultrasound &#40;POCUS&#41; can be useful to distinguish between different conditions and guide early surgical intervention&#46; It allows the practitioner to rule-in the presence of different conditions such as biliary disease&#44; nephrolithiasis&#44; gynecologic problems&#44; bowel disease&#44; vascular complications or existence of internal bleeding&#44; which could modify the management or even set the indication of urgent surgery&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The typical ultrasound findings in pneumoperitoneum are an enhancement of the peritoneal stripe sign &#40;EPSS&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> the presence of free fluid and a ring-down artifact that shift with patient position&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> these findings require a certain degree of expertise to detect&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">We herein report a case of a 90-year-old Caucasian man with previous history of hypertension&#44; cholecystectomy&#44; appendectomy and benign prostate hypertrophy&#44; who presented in the ED with sudden increase in upper abdominal pain and distension&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient had been experiencing intermittent abdominal pain&#44; vomiting and diarrhea for the past 3 days&#44; unrelieved with omeprazole and loperamide&#44; prescribed by his primary care physician&#46; Physical exam showed abdominal rebound tenderness&#46; He had a BP of 108&#47;68<span class="elsevierStyleHsp" style=""></span>mmHg&#44; Heart rate 96<span class="elsevierStyleHsp" style=""></span>bpm&#44; axillary temperature 35&#46;3<span class="elsevierStyleHsp" style=""></span>&#176;C and SpO<span class="elsevierStyleInf">2</span> 96&#37;&#46; Laboratory workup was remarkable for WBC 12&#44;100&#47;&#956;L &#91;3700&#8211;11&#44;600&#93; &#40;91&#37; neutrophils&#59; 3&#46;9&#37; lymphocytes&#41;&#44; hemoglobin 9&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dL &#91;11&#46;5&#8211;15&#46;5&#93;&#44; platelet 230&#44;000&#47;&#956;L &#91;150&#44;000&#8211;400&#44;000&#93;&#44; Na 129&#46;5<span class="elsevierStyleHsp" style=""></span>mmol&#47;L &#91;135&#8211;145&#93;&#44; urea 217<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;10&#8211;40<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#93;&#44; ALT 34<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#91;10&#8211;35&#93;&#44; total bilirrubin 0&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;0&#46;3&#8211;1&#46;9&#93;&#44; albumin 17<span class="elsevierStyleHsp" style=""></span>g&#47;L &#91;34&#8211;50&#93;&#44; creatinine 6&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;0&#46;7&#8211;1&#46;3&#93; &#40;GFR 7&#46;4<span class="elsevierStyleHsp" style=""></span>mL&#47;mn&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> &#91;&#62;90&#93;&#41;&#44; CRP 382<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#91;0&#46;0&#8211;3&#46;0&#93;&#46; The rest of laboratory tests were normal&#46; Decubitus abdominal X-ray was unremarkable&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was diagnosed with a small bowel obstruction &#40;SBO&#41; on ultrasound using a curvilinear probe &#40;2&#8211;3<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#44; following a mowing-the-lawn technique &#40;surveying the entire intestine&#44; compressing slowly&#44; making vertical&#44; overlapping lanes over the abdominal cavity&#41;&#46; No signs of hydronephrosis&#44; abdominal aortic aneurism &#40;AAA&#41; or biliary complication were detected&#46; Initial decompression was performed by placement of a nasogastric tube&#44; which did not improve the comfort&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In this critically ill patient&#44; in whom SBO could not explain the severity of the symptoms and the lack of pain relief with therapy&#44; the ultrasound was repeated using a linear probe &#40;10&#8211;12<span class="elsevierStyleHsp" style=""></span>MHz&#41;&#44; positioning it at the right midclavicular line at the level of the epigastrium&#44; exploring the right hypochondrium and epigastrium&#44; detecting two points at epigastrium &#40;<a class="elsevierStyleCrossRef" href="#sec0065">Figure and video 1</a>&#41; very similar to the &#8220;double lung point&#8221; seen in thoracic ultrasound&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> This &#8220;double gut point&#8221; is explained by the presence of air that is not free in the peritoneal cavity&#44; and forms a bulla surrounded by adherent peritoneal layers&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bowel ischemia leading to intestinal necrosis and perforation&#44; in the setting of small bowel obstruction&#44; was diagnosed on the basis of these results&#44; confirmed later with abdominal CT&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">General surgery was consulted&#44; who after assessing the high mortality risk of surgery&#44; followed by family and patient consent&#44; decided to start palliative care measures&#46; The patient died 36<span class="elsevierStyleHsp" style=""></span>h later&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">Acute abdominal pain is one of the most common complaints seen in the Emergency Department &#40;ED&#41;&#44; and it can be a life threatening if not early evaluated and correctly diagnosed&#46; The increasing demand for a quality and timely emergency care&#44; might increase the number of unnecessary investigations&#44; such as plain abdominal radiography&#44; leading to an overwhelming number of ionizing tests with normal results&#44; waste of time and financial resources&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The definitive need of a computed tomography &#40;CT&#41; in complicated cases is undeniable&#44; as management of many diseases is largely determined by CT findings as well as ruling out other differentials diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> However&#44; CT scans cost more&#44; take more time&#44; require evaluation of kidney function&#44; require contrast a lot of the times and expose patients to high doses of ionizing radiation&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The utility and scope of point-of-care ultrasound &#40;POCUS&#41; for evaluating and managing abdominal complaints in the ED has grown rapidly with little change in physician practice or patient awareness&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Despite its increasing availability in every ED&#44; POCUS is underused in evaluating many common abdominal chief complaints in the ED&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In 2012 the &#8220;Ultrasound First Forum&#8221; met and created the Ultrasound First Campaign<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> to encourage research and change practices in clinical situations where initial evaluation with POCUS may be safer&#44; less costly and time consuming&#46; Ultrasound First resulting in equivocal or indeterminate results would guide further imaging decisions&#46; Therefore&#44; ultrasound should be considered the first imaging study performed&#44; particularly when the patient is hemodynamic unstable&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Although POCUS is not meant to diagnose pneumoperitoneum&#44; it can be detected during a focused study to rule-in other pathologies&#46; When compared to X-ray&#44; it showed a much higher sensitivity &#40;93&#37; versus 79&#37;&#41;&#44; accuracy &#40;90&#37; versus 77&#37;&#41;&#44; specificity &#40;64&#37; versus 64&#37;&#41;&#44; and positive predictive value &#40;97&#37; versus 96&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In supine position&#44; free air will tend to accumulate anterior over the liver and epigastrium&#46; A curvilinear probe &#40;2&#8211;3<span class="elsevierStyleHsp" style=""></span>MHz&#41; can be used to initiate the abdominal POCUS examination&#44; in the search of free fluid and rule-in causes of abdominal pain&#44; but a second scan with a linear probe &#40;10&#8211;12<span class="elsevierStyleHsp" style=""></span>MHz&#41; can be more sensitive to detect signs such as the EPSS&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> which is the presence of air against the anterior abdominal wall&#44; resulting in an enhancement of the peritoneum&#46; Depth and gain are mainly determined by the patient body habitus&#46; Consequently&#44; switching probes should be part of our dynamic examination of the pneumoperitoneum&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In our case&#44; it was possible to visualize 2 gut points &#40;&#8220;double gut point&#8221;&#41;&#44; which was found at epigastrium&#46; This abdominal &#8220;double gut point&#8221; has not been previously labeled as such&#44; being a novel sign to diagnose small amounts of free air in the peritoneal cavity &#40;not only over the liver or epigastrium&#41;&#44; and searching for this specific sign&#44; in combination with the previously described&#44; could aid to diagnose pneumoperitoneum&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Authors&#8217; contributions</span><p id="par0085" class="elsevierStylePara elsevierViewall">All authors have contributed to this work&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethics approval</span><p id="par0090" class="elsevierStylePara elsevierViewall">A case report is a medical&#47;educational activity that does not meet the definition of &#8220;research&#8221;&#44; which is&#58; &#8220;a systematic investigation&#44; including research development&#44; testing and evaluation&#44; designed to develop or contribute to generalizable knowledge&#46;&#8221; Therefore&#44; the activity <span class="elsevierStyleUnderline">does not</span> have to be reviewed by an IRB&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Consent to participate</span><p id="par0095" class="elsevierStylePara elsevierViewall">Written informed consent was obtained from the patient and&#47;or family&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Consent for publication</span><p id="par0100" class="elsevierStylePara elsevierViewall">Written informed consent was obtained from the patient and&#47;or family&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Availability of data and material</span><p id="par0105" class="elsevierStylePara elsevierViewall">Data available upon justifiable request to the correspondent author&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Code availability</span><p id="par0110" class="elsevierStylePara elsevierViewall">Not applicable&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Funding</span><p id="par0115" class="elsevierStylePara elsevierViewall">This work has not been supported by any public grants or other kind of financial support&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">No sources of funding were used to assist in the preparation of this letter&#46; The author certifies that he has no commercial associations that might pose a conflict of interest in connection with the submitted article&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:17 [
        0 => array:3 [
          "identificador" => "xres1910612"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1650044"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1910611"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1650045"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case report"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Authors&#8217; contributions"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Ethics approval"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Consent to participate"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Consent for publication"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Availability of data and material"
        ]
        12 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Code availability"
        ]
        13 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Funding"
        ]
        14 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conflict of interest"
        ]
        15 => array:2 [
          "identificador" => "xack670369"
          "titulo" => "<span class="elsevierStyleBold">Acknowledgements</span>"
        ]
        16 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-11-15"
    "fechaAceptado" => "2023-02-21"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1650044"
          "palabras" => array:5 [
            0 => "Pneumoperitoneum"
            1 => "Ultrasound"
            2 => "Intestinal perforation"
            3 => "Point of care technology"
            4 => "Case reports"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1650045"
          "palabras" => array:5 [
            0 => "Neumoperitoneo"
            1 => "Ecograf&#237;a"
            2 => "Perforaci&#243;n intestinal"
            3 => "Tecnolog&#237;a en el punto de atenci&#243;n"
            4 => "Reporte de casos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pneumoperitoneum is a life-threatening condition&#44; caused by hollow organ perforation&#46; The diagnosis is often difficult&#44; and Point-of-care ultrasound can be useful to distinguish from different conditions&#44; and early set the indication of urgent surgery&#46; We report on a critically ill patient&#44; who presented to the Emergency Department with sudden increase in upper abdominal pain and distension with a diagnosis of small bowel obstruction on ultrasound using a curvilinear probe&#46; After repeating the ultrasound using a linear probe&#44; two dynamic points at mesogastrium very similar to the &#8220;double lung point&#8221; seen in thoracic ultrasound was detected&#46; This &#8220;double gut point&#8221; due to bowel ischemia and perforation was confirmed on a computed tomography scan&#46; In this case&#44; the finding of an abdominal &#8220;double gut point&#8221; allowed us to diagnose localized pneumoperitoneum&#44; being a novel sign&#44; that could aid to diagnose small amounts of free air in the peritoneal cavity&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El neumoperitoneo es una afecci&#243;n potencialmente mortal causada por la perforaci&#243;n de un &#243;rgano hueco&#46; El diagn&#243;stico es a menudo dif&#237;cil&#44; y la ecograf&#237;a en el punto de atenci&#243;n puede ser &#250;til para distinguirlo de las diferentes opciones y establecer tempranamente la indicaci&#243;n de cirug&#237;a urgente&#46; Presentamos el caso de un paciente en estado cr&#237;tico que acudi&#243; al servicio de urgencias con un aumento repentino del dolor y la distensi&#243;n abdominal superior&#44; con el diagn&#243;stico de obstrucci&#243;n del intestino delgado en la ecograf&#237;a realizada con una sonda c&#243;nvex&#46; Tras repetir la ecograf&#237;a con una sonda lineal se detectaron dos puntos din&#225;micos en el mesogastrio muy similares al &#171;doble punto pulm&#243;n&#187; visto en la ecograf&#237;a tor&#225;cica&#46; Este &#171;doble punto visceral&#187;&#44; debido a la isquemia intestinal y a la perforaci&#243;n&#44; se confirm&#243; en una tomograf&#237;a computarizada&#46; En este caso&#44; el hallazgo de un &#171;doble punto visceral&#187; abdominal nos permiti&#243; diagnosticar un neumoperitoneo localizado&#44; siendo un signo novedoso no descrito anteriormente que podr&#237;a ayudar a diagnosticar peque&#241;as cantidades de aire libre en la cavidad peritoneal&#46;</p></span>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0145" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0065"
          ]
        ]
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "upi0005"
        "etiqueta" => "Figure and video 1&#46;"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:3 [
          "fichero" => "mmc1.mp4"
          "ficheroTamanyo" => 593104
          "Video" => array:2 [
            "flv" => array:5 [
              "fichero" => "mmc1.flv"
              "poster" => "mmc1.jpg"
              "tiempo" => 0
              "alto" => 0
              "ancho" => 0
            ]
            "mp4" => array:5 [
              "fichero" => "mmc1.m4v"
              "poster" => "mmc1.jpg"
              "tiempo" => 0
              "alto" => 0
              "ancho" => 0
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Linear probe&#46; Midline abdominal longitudinal view&#44; showing a double gut point &#40;asterisk&#41;&#44; compatible with localized pneumoperitoneum&#46; &#40;B&#41; Correlation with abdominal computed tomography image&#46;</p>"
        ]
      ]
      1 => array:6 [
        "identificador" => "202306081058529741"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 39
            "Ancho" => 48
            "Tamanyo" => 996
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "sat0005"
            "detalle" => "Twitter Ico"
            "rol" => "short"
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pneumoperitoneum&#58; importance of right upper quadrant features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Menuck"
                            1 => "P&#46;T&#46; Siemers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Roentgenol"
                        "fecha" => "1976"
                        "volumen" => "127"
                        "paginaInicial" => "753"
                        "paginaFinal" => "756"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A specific sign of pneumoperitoneum on sonography&#58; enhancement of the peritoneal stripe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Muradali"
                            1 => "S&#46; Wilson"
                            2 => "P&#46;N&#46; Burns"
                            3 => "H&#46; Shapiro"
                            4 => "D&#46; Hope-Simpson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Roentgenol"
                        "fecha" => "1999"
                        "volumen" => "173"
                        "paginaInicial" => "1257"
                        "paginaFinal" => "1262"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recognition of pneumoperitoneum using bedside ultrasound in critically ill patients presenting with acute abdominal pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajem.2007.02.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Emerg Med"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "838"
                        "paginaFinal" => "841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17870492"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abdominal a-lines&#58; a simpler sonographic sign of pneumoperitoneum&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Scott Bomann"
                            1 => "R&#46; Van Tonder"
                            2 => "S&#46; Hernandez"
                            3 => "C&#46; Moore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Ultrasound J"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "paginaInicial" => "41"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The double lung point&#58; an unusual sonographic sign of juvenile spontaneous pneumothorax"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Volpicelli"
                            1 => "B&#46; Audino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Emerg Med"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "355&#46;e1"
                        "paginaFinal" => "355&#46;e2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plain abdominal radiography in acute abdominal pain&#59; past&#44; present&#44; and future"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;L&#46; Gans"
                            1 => "J&#46; Stoker"
                            2 => "M&#46;A&#46; Boermeester"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/IJGM.S17410"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Gen Med"
                        "fecha" => "2012"
                        "volumen" => "5"
                        "paginaInicial" => "525"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22807640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Understanding&#44; justifying&#44; and optimizing radiation exposure for CT imaging in nephrourology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Ferrero"
                            1 => "N&#46; Takahashi"
                            2 => "T&#46;J&#46; Vrtiska"
                            3 => "A&#46;E&#46; Krambeck"
                            4 => "J&#46;C&#46; Lieske"
                            5 => "C&#46;H&#46; McCollough"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/s41585-019-0148-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Urol"
                        "fecha" => "2019"
                        "volumen" => "16"
                        "paginaInicial" => "231"
                        "paginaFinal" => "244"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30728476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transabdominal ultrasound for bowel evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;M&#46; Rodgers"
                            1 => "R&#46; Verma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rcl.2012.09.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiol Clin North Am"
                        "fecha" => "2013"
                        "volumen" => "51"
                        "paginaInicial" => "133"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23182513"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2012 ultrasound first forum proceedings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;K&#46; Minton"
                            1 => "A&#46; Abuhamad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Ultrasound Med"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "paginaInicial" => "555"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23525380"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Selective use of ultrasonography for the detection of pneumoperitoneum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;-C&#46; Chen"
                            1 => "H&#46;-P&#46; Wang"
                            2 => "W&#46;-J&#46; Chen"
                            3 => "F&#46;-Y&#46; Lin"
                            4 => "C&#46;-Y&#46; Hsu"
                            5 => "K&#46;-J&#46; Chang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acad Emerg Med Off J Soc Acad Emerg Med"
                        "fecha" => "2002"
                        "volumen" => "9"
                        "paginaInicial" => "643"
                        "paginaFinal" => "645"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack670369"
        "titulo" => "<span class="elsevierStyleBold">Acknowledgements</span>"
        "texto" => "<p id="par0125" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0130" class="elsevierStylePara elsevierViewall">Yale Tung Chen is the guarantor of the content of the present letter&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors certify that have no commercial associations that might pose a conflict of interest in connection with this editorial letter&#46;</p></li></ul></p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/01227262/0000002300000002/v1_202306081058/S0122726223000149/v1_202306081058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "39562"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reportes de caso"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/01227262/0000002300000002/v1_202306081058/S0122726223000149/v1_202306081058/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0122726223000149?idApp=UINPBA00004N"
]
Article information
ISSN: 01227262
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 October 2 0 2
2024 June 1 0 1
2024 April 1 1 2
2023 November 5 0 5
2023 July 1 0 1
2023 June 4 1 5
2023 May 11 5 16
2023 April 1 0 1

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos