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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2004;55:81-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1325 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 558 "PDF" => 729 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Efecto del ácido hialurónico sobre la cicatrización traqueal en un modelo experimental canino" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "87" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effect of the hyaluronic acid on tracheal healing. A canine experimental mode" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "J.R. Olmos-Zúñiga, R. Jasso-Victoria, A. Sotres-Vega, J.A. Franco-Oropeza" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.R." "apellidos" => "Olmos-Zúñiga" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Jasso-Victoria" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sotres-Vega" ] 3 => array:2 [ "nombre" => "J.A." "apellidos" => "Franco-Oropeza" ] ] ] 1 => array:2 [ "autoresLista" => "J.A. Santos-Cordero, M.O. Gaxiola-Gaxiola, J.R. Mora-Fol, P. Santillan-Doherty" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Santos-Cordero" ] 1 => array:2 [ "nombre" => "M.O." "apellidos" => "Gaxiola-Gaxiola" ] 2 => array:2 [ "nombre" => "J.R." "apellidos" => "Mora-Fol" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Santillan-Doherty" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651904784873?idApp=UINPBA00004N" "url" => "/00016519/0000005500000002/v1_201304231415/S0001651904784873/v1_201304231415/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Amplificación del gen de la ciclina d1 en los carcinomas adenoides quísticos de glándulas salivares menores" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "88" "paginaFinal" => "92" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G. Sequeiros Santiago, J.P. Rodrigo Tapia, D. GarcÍa-Carracedo, J. García Pedrero, C. Suárez Nieto, M.V. González Meana" "autores" => array:6 [ 0 => array:4 [ "nombre" => "G." "apellidos" => "Sequeiros Santiago" "email" => array:1 [ 0 => "gsequeiros_orl@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.P." "apellidos" => "Rodrigo Tapia" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "D." "apellidos" => "GarcÍa-Carracedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "García Pedrero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Suárez Nieto" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "M.V." "apellidos" => "González Meana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de orl. hospital central de asturias. oviedo" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto universitario de oncología. universidad de oviedo. asturias" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: C/o.Baldomero Fernández 14, 3º. 33006 Oviedo" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "CCND1 gene amplification in the adenoid cystic carcinoma of the minor salivary glands" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-11-03" "fechaAceptado" => "2004-01-29" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec80582" "palabras" => array:4 [ 0 => "Carcinoma adenoide quístico" 1 => "lándulas salivares menores" 2 => "Ciclina D1" 3 => "Pronóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec80581" "palabras" => array:4 [ 0 => "Adenoid cystic carcinoma" 1 => "Minor salivary glands" 2 => "Cyclin D1" 3 => "Prognosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción/Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El carcinoma adenoide quístico (CAQ) es un tumor de estirpe epitelial y representa el tumor maligno más frecuente de las glándulas salivares menores. Sin embargo, se conoce poco de los genes implicados en el desarrollo y progresión de estos tumores. El gen de la ciclina D1 (CCND1) juega un papel clave en el control del ciclo celular, y su anomalía está descrita en numerosos cánceres. El objetivo de este estudio es determinar si existe amplificación del CCND1 en los CAQ de glándulas salivares menores y su posible relación con el pronóstico</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiza un estudio retrospectivo de 12 pacientes intervenidos de CAQ de fosas nasales y senos paranasales. Se determinó la existencia de amplificación del CCND1 mediante PCR múltiple</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontró amplificación del CCND1 en 4 casos (33,3%). No se halló relación significativa con ninguno de los parámetros clínico-patológicos analizados (localización, tipo histológico, estadio; p>0,05). La supervivencia fue menor en los pacientes que presentaban amplificación de CCND1</p> <span class="elsevierStyleSectionTitle">Discusión/Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio es el primero que demuestra la amplificación del gen de la ciclina D1 en los CAQ. La amplificación del CCND1 parece tener relación con un peor pronóstico en estos tumores, aunque es necesario confirmar esta relación en estudios más amplios</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adenoid cystic carcinoma (ACC) is a tumour of epithelial origin that represents the most common malignant neoplasm of the minor salivary glands. However, little is known about the genes involved in the development and progression of this tumour. Cyclin D1 gene (CCND1) plays a key role in the control of the cell cycle, and its amplification is described in numerous cancers. The aim of this study is to determine the amplification of the CCND1 gene in the ACC of the minor salivary glands</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A retrospective study was performed on 12 patients with ACC of the head and neck. The amplification of the CCND1 was determined using multiple PCR</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Amplification of the CCND1 was found in 4 patients (33,3%). No correlation was found between CCND1 amplification and clinicopathological parameters, although disease-free survival was diminished in patients with amplification</p> <span class="elsevierStyleSectionTitle">Discussion/Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our study demonstrates for the first time the amplification of the CCND1 gene in ACC. We have found an amplification rate similar to others neoplasms. CCND1 amplification seems to be associated with a poorer prognosis in these tumours, although this needs to be confirmed in larger studies</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenoid cystic carcinoma: factors influencing survival" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.H. Spiro" 1 => "A.G. Hooves" 2 => "E.W. Strong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg" "fecha" => "1979" "volumen" => "138" "paginaInicial" => "579" "paginaFinal" => "583" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/225961" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenoid cystic carcinoma of the head and neck: Predictors of morbidity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Fordice" 1 => "C. Kershaw" 2 => "A. El-Naggar" 3 => "H. Goepfert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Arch Otolaryngol Head Neck Surg" "fecha" => "1999" "volumen" => "125" "paginaInicial" => "149" "paginaFinal" => "152" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cyclin D-dependent kinases, INK4 inhibitors and cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Ortega" 1 => "M. Malumbres" 2 => "M. Barbacid" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "2002" "volumen" => "1602" "paginaInicial" => "73" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11960696" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes-a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Schuuring" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gene" "fecha" => "1995" "volumen" => "159" "paginaInicial" => "83" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7607576" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.P. Rodrigo" 1 => "L.A. Garcia" 2 => "S. Ramos" 3 => "P.S. Lazo" 4 => "C. Suarez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "3177" "paginaFinal" => "3182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10955801" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenoid cystic carcinoma: DNA as a prgnostic indicator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Franzen" 1 => "O.G. klausen" 2 => "R.T. Grenko" 3 => "J. Carstensen" 4 => "B. Nordenskjold" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1288/00005537-199106000-00016" "Revista" => array:6 [ "tituloSerie" => "Laryngoscope" "fecha" => "1991" "volumen" => "101" "paginaInicial" => "669" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1645833" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of nucleolar organizer regions in adenoid cystic carcinomas of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "X. Xie" 1 => "S. Nordgard" 2 => "T.B. Halvorsen" 3 => "G. Franzen" 4 => "M. Boysen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Arch Otolaryngol Head Neck Surg" "fecha" => "1997" "volumen" => "123" "paginaInicial" => "620" "paginaFinal" => "623" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ki-67 as a pronostic marker in adenoid cystic carcinoma assessed with the monoclonal antibody MIB1 in paraffin sections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Nordgard" 1 => "G. Franzen" 2 => "M. Boysen" 3 => "T.B. Halvorsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Laryngoscope" "fecha" => "1997" "volumen" => "107" "paginaInicial" => "531" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9111386" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA flow cytometry of reclassified subtypes of malignant salivary glands tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Bang" 1 => "K. Donath" 2 => "S. Thoresen" 3 => "O.P.F. Clausen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Oral Pathol Med" "fecha" => "1994" "volumen" => "23" "paginaInicial" => "291" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7965883" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenoid cystic carcinoma: use of cell proliferation, BCL-2 expression, histologic grade, and clinical stage as predictors of clinical outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Dardick" 1 => "T. Ledin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Head Neck" "fecha" => "2000" "volumen" => "22" "paginaInicial" => "489" "paginaFinal" => "497" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10897109" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proliferating cell nuclear antigen and c-erbB-2 oncoprotein expression in adenoid cystic carcinomas of the salivary glands" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K-J. Cho" 1 => "S-S. Lee" 2 => "Y-S. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Head Neck" "fecha" => "1999" "volumen" => "21" "paginaInicial" => "414" "paginaFinal" => "419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10402521" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of transforming growth factoralpha in adenoid cystic carcinoma of the salivary gland" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Chiang" 1 => "C.H. Chen" 2 => "B.Y. Liu" 3 => "A. Sun" 4 => "J.S. Leu" 5 => "J.T. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2001" "volumen" => "100" "paginaInicial" => "471" "paginaFinal" => "477" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11579613" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Vered" 1 => "E. Braunstein" 2 => "A. Buchner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hed.10104" "Revista" => array:6 [ "tituloSerie" => "Head Neck" "fecha" => "2002" "volumen" => "24" "paginaInicial" => "632" "paginaFinal" => "636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12112535" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical evaluation of estrogen and progesterone receptors in adenoid cystic carcinoma of salivary gland origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Dori" 1 => "P. Trougouboff" 2 => "R. David" 3 => "A. Buchner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Oncol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "450" "paginaFinal" => "453" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10964052" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expressión of the c.kit protein is associated with certain subtypes of salivary gland carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y.M. Jeng" 1 => "C.Y. Lin" 2 => "H.C. Hsu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Lett" "fecha" => "2000" "volumen" => "154" "paginaInicial" => "107" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10799746" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inactivation of p53 and amplificación of cyclin D1 correlate with clinical outcome in head and neck cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.P. Nogueira" 1 => "R.W. Dolan" 2 => "J. Gooey" 3 => "S. Byahatti" 4 => "C.W. Vaughan" 5 => "N.S. Fuleihan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Laryngoscope" "fecha" => "1998" "volumen" => "108" "paginaInicial" => "345" "paginaFinal" => "350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9504605" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Large scale molecular analysis Identifies genes with Altered Expression in Salivary Adenoid Cystic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.F. Frierson" 1 => "A.K. El-Naggar" 2 => "J.B. Welsh" 3 => "L.M. Sapinoso" 4 => "A.I. Su" 5 => "J. Cheng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J of Pathol" "fecha" => "2002" "volumen" => "161" "paginaInicial" => "1315" "paginaFinal" => "1322" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "D11s287, a putative oncogen on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.A. Lammie" 1 => "V. Fanti" 2 => "R. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1991" "volumen" => "6" "paginaInicial" => "439" "paginaFinal" => "444" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2011398" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00016519/0000005500000002/v1_201304231415/S0001651904784885/v1_201304231415/es/main.assets" "Apartado" => array:4 [ "identificador" => "5847" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Investigación básica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00016519/0000005500000002/v1_201304231415/S0001651904784885/v1_201304231415/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651904784885?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/00016519/addon/S0001651904784885/S300/en/102v55n2a13097178pdf001_2.pdf" "portada" => "102v55n2a13097178pdf001_2.png" ] ] ]
Journal Information
Amplificación del gen de la ciclina d1 en los carcinomas adenoides quísticos de glándulas salivares menores
CCND1 gene amplification in the adenoid cystic carcinoma of the minor salivary glands