array:22 [ "pii" => "S0001651901782349" "issn" => "00016519" "doi" => "10.1016/S0001-6519(01)78234-9" "estado" => "S300" "fechaPublicacion" => "2001-05-01" "aid" => "78234" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Acta Otorrinolaringol Esp. 2001;52:442-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4884 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 3101 "PDF" => 1731 ] ] "itemAnterior" => array:18 [ "pii" => "S0001651901782337" "issn" => "00016519" "doi" => "10.1016/S0001-6519(01)78233-7" "estado" => "S300" "fechaPublicacion" => "2001-05-01" "aid" => "78233" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2001;52:438-41" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1572 "formatos" => array:3 [ "EPUB" => 32 "HTML" => 1097 "PDF" => 443 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Carcinoma microcítico de lengua. A propósito de un caso" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "438" "paginaFinal" => "441" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oat-Cell Carcinoma Of The Tongue: Report Of A Case" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "J.R. Benito, M. De Mier, F. Morote, E. Porras" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.R." "apellidos" => "Benito" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "De Mier" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Morote" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Porras" ] ] ] 1 => array:2 [ "autoresLista" => "N. GarcÍa, J. PéRez-Requena" "autores" => array:2 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "GarcÍa" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "PéRez-Requena" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651901782337?idApp=UINPBA00004N" "url" => "/00016519/0000005200000005/v1_201304231332/S0001651901782337/v1_201304231332/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Empleo simultáneo de antihistamínicos h1 y anticoagulantes orales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "442" "paginaFinal" => "445" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "F.J. García Callejo, M. Marco Sanz, E.N. Fernández Julián" "autores" => array:3 [ 0 => array:3 [ "nombre" => "F.J." "apellidos" => "García Callejo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Marco Sanz" ] 2 => array:2 [ "nombre" => "E.N." "apellidos" => "Fernández Julián" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de orl. Hospital clínico universitario. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "F. Javier García Callejo. Avda. Archiduque Carlos, n.º 111-14. 46014 Valencia." ] ] ] 1 => array:3 [ "autoresLista" => "M.M. Velert Vila" "autores" => array:1 [ 0 => array:3 [ "nombre" => "M.M." "apellidos" => "Velert Vila" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Centro De Investigación. HOspital la fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Coadministration of histamine h1 antagonist and oral anticoagulants" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec79356" "palabras" => array:3 [ 0 => "Antihistamínicos H1" 1 => "Acenocumarol" 2 => "Interferencias medicamentosas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec79355" "palabras" => array:3 [ 0 => "Histamine H1 antagonists" 1 => "Acenocumarin" 2 => "Drug interferences" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las indicaciones terapéuticas de los anticoagulantes orales y los antihistaminícos H1 son cada vez mayores. Por ello no resulta infrecuente encontrar individuos que precisan ambos tratamientos. El desconocimiento de las potenciales interacciones medicamentosas de los antagonistas de la histamina sobre el acenocumarol hace que a menudo se evite su asociación. La revisión de una población atendida en un Control de Terapéutica Anticoagulante nos ha permitido objetivar los trastornos originados por la introducción de algún antihistamínico en su esquema terapéutico. Loratadina, ebastina y cetirizina presentaron índices similares de interacción en el perfil farmacocinético del acenocumarol, probablemente por inducción enzimática hepática inactivadora del anticoagulante, lo que originó una disminución en los valores de INR con los que se mide el nivel de hipocoagulabilidad. Ello puede hacer necesario elevar temporalmente las dosis de acenocumarol. Durante el tratamiento sincrónico no se registró ningún evento tromboembólico ni hemorrágico en los pacientes seguidos.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Indications for oral anticoagulation and antihistamine H1antagonists therapies are increasingly. So, it is easy to find individuals who need both treatments. The unknowledgment about possible interferences of antihistamines over acenocumarin often makes to avoid them at the same time. A review on a population receiving anticoagulation on a Therapeutic Center allowed us to verify disorders secondary to the association of antihistamines into their therapeutic scheme. Loratadine, ebastine and cetirizine show similar records of interaction into acenocumarin pharmacokinetics, probably due to a liver enzymatic induction on the anticoagulant drug, producing a decrease on INR values in which anticoagulation is measured. This could make necessary to increase temporally acenocumarin dose. During coadministration no thromboembolic event nor bleeding were registered.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anticoagulantes orales: su manejo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Iberoamer Trom Hemostasia" "fecha" => "1990" "volumen" => "1" "paginaInicial" => "7" "paginaFinal" => "18" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective ligands as tools to study histamine receptors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Van der Goot" 1 => "H. Timmerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Med Chem" "fecha" => "2000" "volumen" => "35" "paginaInicial" => "5" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10733599" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-inflammatory actions of new antihistamines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Hayashi" 1 => "S. Hashimoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "1999" "volumen" => "29" "paginaInicial" => "1681" "paginaFinal" => "1691" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10594545" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pharmacokinetics and histaminic effects of the H1 receptor antagonist hydroxyzine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.E.R. Simons" 1 => "K.J. Simons" 2 => "E.M. Frith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1984" "volumen" => "73" "paginaInicial" => "69" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6141198" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.M. Nicolas" 1 => "R. Whomsley" 2 => "P. Collart" 3 => "J. Roba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chem Biol Interact" "fecha" => "1999" "volumen" => "123" "paginaInicial" => "63" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10597902" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Probable interaction between cetirizine and acenocumarol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Berod" 1 => "I. Mathiot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "1997" "volumen" => "31" "paginaInicial" => "122" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8997485" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00016519/0000005200000005/v1_201304231332/S0001651901782349/v1_201304231332/es/main.assets" "Apartado" => array:4 [ "identificador" => "5846" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Carta al editor" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00016519/0000005200000005/v1_201304231332/S0001651901782349/v1_201304231332/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651901782349?idApp=UINPBA00004N" ]
Journal Information
Empleo simultáneo de antihistamínicos h1 y anticoagulantes orales
Coadministration of histamine h1 antagonist and oral anticoagulants