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Fernández Belda, J.J. Barajas de Prat" "autores" => array:3 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Zenker Castro" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Fernández Belda" ] 2 => array:2 [ "nombre" => "J.J." "apellidos" => "Barajas de Prat" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651906787350?idApp=UINPBA00004N" "url" => "/00016519/0000005700000009/v1_201304231454/S0001651906787350/v1_201304231454/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Presbiacusia: degeneración neuronal y envejecimiento en el receptor auditivo del ratón C57/BL6J" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "383" "paginaFinal" => "387" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Castillo, F. Carricondo, M.V. Bartolomé, A. Vicente-Torres, J. Poch Broto, P. Gil-Loyzaga" "autores" => array:7 [ 0 => array:3 [ "nombre" => "E." "apellidos" => "Castillo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Carricondo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M.V." "apellidos" => "Bartolomé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Vicente-Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Vicente-Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Poch Broto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 6 => array:4 [ "nombre" => "P." "apellidos" => "Gil-Loyzaga" "email" => array:1 [ 0 => "loyzaga@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Laboratorio de Neurobiología de la Audición. Dpto. Oftalmología y Otorrinolaringología. Facultad de Medicina. Universidad Complutense de Madrid" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Otorrinolaringología. Hospital Clínico “San Carlos”. Dpto. Oftalmología y Otorrinolaringología. Facultad de Medicina. Universidad Complutense de Madrid" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Pablo Gil-Loyzaga Apdo. Correos 60075 28080 Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Presbycusis: neural degeneration and aging on the auditory receptor of C57/BL6J mice" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-09-29" "fechaAceptado" => "2006-08-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec81816" "palabras" => array:4 [ 0 => "Presbiacusia" 1 => "Potenciales auditivos" 2 => "Ratón C57/BL6J" 3 => "Modelo experimental de Presbiacusia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec81817" "palabras" => array:4 [ 0 => "Presbycusis" 1 => "Auditory potential" 2 => "C57/BL6J mice" 3 => "Presbycusis experimental model" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La presbiacusia es una pérdida auditiva progresiva, ligada al envejecimiento, que se manifiesta como una sordera asociada a cambios degenerativos cocleares. En el presente estudio se analizan los efectos del envejecimiento sobre el sistema auditivo del ratón c57/bl6j mediante técnicas electrofisiológicas y morfológicas. Con este fin se registraron los potenciales auditivos en animales de 1, 3, 6, 9, 12, 15, 18, 21 y 24 meses de edad, con posterior análisis morfológico de sus cócleas. Los potenciales auditivos mostraron un incremento de latencia y una disminución de amplitud progresivos con la edad. Los estudios morfológicos demostraron una total degeneración del órgano de Corti, que aparecía reemplazado por un epitelio plano con ausencia de células ciliadas.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Abstract</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. In this paper we analyze the effects of aging on the auditory system of c57/bl6j mice, with electrophysiological and morphological studies. With this aim the auditory potentials of mice aging 1, 3, 6, 9, 12, 15, 18, 21 and 24 months were recorded, and then the morphology of the cochleal were analyzed. Auditory potentials revealed an increase in wave latencies, as well as a decrease in their amplitudes during aging. Morphological results showed a total Corti´s organ degeneration, being replaced by a flat epithelial layer, and a total absence of hair cells.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Presbiacusia: degeneración neuronal y envejecimiento en el receptor auditivo del ratón C57/BL6J
Presbycusis: neural degeneration and aging on the auditory receptor of C57/BL6J mice
E. Castillo1,2, F. Carricondo1, M.V. Bartolomé1, A. Vicente-Torres1, A. Vicente-Torres1, J. Poch Broto2, P. Gil-Loyzaga1,1
Corresponding author
1 Laboratorio de Neurobiología de la Audición. Dpto. Oftalmología y Otorrinolaringología. Facultad de Medicina. Universidad Complutense de Madrid
2 Servicio de Otorrinolaringología. Hospital Clínico “San Carlos”. Dpto. Oftalmología y Otorrinolaringología. Facultad de Medicina. Universidad Complutense de Madrid