Journal Information
Vol. 55. Issue 8.
Pages 356-363 (October 2004)
Vol. 55. Issue 8.
Pages 356-363 (October 2004)
Alteraciones en la viscosidad sanguínea en pacientes con presbiacusia
Blood viscosity modifications in patients bearing of presbyacusis
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Objetivo:Evaluar la presencia de alteraciones en la visco-sidad sanguínea en la presbiacusia como eventual mecanismo fisiopatológico. Material y métodos:Fueron incluídos 9 sujetos de 75 años de edad con hipoacusianeurosensorial bilateral lentamente progresiva, estudiados unavez anualmente durante 10 años consecutivos, valorando pérdidaauditiva binaural en frecuencias conversacionales (500, 1000,2000 y 3000 Hz). El perfil hemorreológico en sangre periférica valoró viscosidad en sangre total (VST) a diferentes velocidades decizallamiento (VC), filtrabilidad sanguínea (FS), deformabilidad yagregabilidad eritrocitarias (AE). Resultados:Todos los parámetros tendieron a la hiperviscosidad, con VST a altas VC y AE enestasis total elevadas a los 10 años de forma estadísticamentesignificativa. La intensidad de la hipoacusia se correlacionó significativamente con los valores bajos de FS y los incrementos enVST a altas VC. Conclusiones:Los pacientes presbiacúsicosmuestran evidencias hemorreológicas que sugieren tendencia a lahiperviscosidad como factor predisponente de la hipoacusia.
Palabras clave:
Presbiacusia
Hiperviscosidad
Viscosidad sanguínea
Objetive:To evaluate the existence of blood viscosity altera-tions in presbyacusis as an eventual pathophysiologicalmechanism. Material and methods: Nine 75 year old subjects bearing of bilateral slowly progressive sensorineural deafnesswere considered to be studied on a yearly basis in a ten year folow-up period, evaluating the binaural hearing loss in speech tones(500, 1000, 2000 and 3000 Hz). Hemorheological profile on peripheral blood included total blood viscosity (BV) at different shear ra-tes (SR), blood filterability (BF), erythrocyte deformability and aggregability (EA). Results: There was a trend of all parameters to wards hyperviscosity, with an increase at ten years of BV at highSR and EA at total stasis which were statistically significant. The level of deafness correlated significativelly to low values of BF andincreases on BV at high SR. Conclusions:Presbyacustic patientsdo show hemorheological evidences that suggest a tendency to wards hyperviscosity as a predisposing factor for hearing loss.
Keywords:
Presbyacusis
Hyperviscosity
Blood viscosity
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