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Journal Information
Vol. 57. Issue 9.
Pages 419-424 (November 2006)
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Vol. 57. Issue 9.
Pages 419-424 (November 2006)
Carcinoma epidermoide de laringe estadio IV. Evolución a largo plazo
Epidermoid carcinoma larynx in stage IV
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2080
J. Herranz González-Botas1
Corresponding author
jhg@canalejo.org

Correspondencia: Jesús Herranz González-Botas Rua Courel, 6 15179 Oleiros (A Coruña)
, J.C. Vázquez Barro
Servicio de Otorrinolaringología. Hospital Universitario Juan Canalejo. A Coruña
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Resumen
Objetivo

Analizar supervivencia, recidiva local, regional, a distancia y segundos primarios en estadios IV de laringe tratados con cirugía y radioterapia.

Material

Estudio retrospectivo de 147 pacientes tratados con cirugía ± radioterapia, con un seguimiento mínimo de 5 años.

Resultados

Supervivencia global y causa específica a 5 y 10 años de 42%, 35% y 49%, 45,8% respectivamente. Control locoregional del 57,7 % y 54,7% a los 5 y 10 años. Recidivas locales 25,7%, recidivas regionales 74,2%, y metástasis a distancia 10,9%. Segundos primarios 12%, el 50% en pulmón. Se analizan factores que pueden influir en la supervivencia.

Conclusiones

En nuestra experiencia, la cirugía, con radioterapia complementaria en N+, permite curar un 45% de los estadios IV de laringe. La recidiva regional es la causa más frecuente de fracaso, influida por el N+, apareciendo en los primeros 36 meses de evolución.

Palabras clave:
Cáncer de laringe
Cirugía
Recidiva
Metástasis
Segundo primario
Abstract
Objective

To determine the survival, loco-regional control, distant metastases and second primary in stage IV laryngeal carcinoma treated by surgery and radiotherapy.

Material

Retrospective study of 147 patients treated with surgery and radiotherapy with a 5 year minimun follow-up.

Results

Overall and cause specific survival at 5 and 10 years was 42%, 35% and 49%, 45.8% respectively. Loco-regional control was 57.7 % and 54.7% at 5 and 10 years. Local recurrences presented in 25.7%, regional recurrences in 74.2%, and distant metastases 10.9%. Second primary tumors developed in 12% of the patients, 50% of the cases in the lungs. Factors related to survival are evaluated.

Conclusions

In our experience, surgery with postoperative radiotherapy in N+, controls 45% of stage IV laryngeal carcinoma. Regional recurrencies are the main cause of failure, more frequent in N+ patientes, present in the first 36 months after treatment.

Key words:
Larynx carcinoma
Surgery
Recurrence
Distant metastasis
Second primary

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