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Journal Information
Vol. 55. Issue 2.
Pages 55-61 (February 2004)
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Vol. 55. Issue 2.
Pages 55-61 (February 2004)
Condritis auricular. Modelo experimental en rata
Auricular chondritis. Experimental model in rat
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M.A. López González1,
Corresponding author
malopez@cica.es

Correspondencia: Centro de Especialidades Doctor Fleming. C/ Juan de Padilla, 8. 41005 Sevilla
, J.M. Loizaga Iriondo2, F. Delgado Moreno3
1 Servicio de otorrinolaringología
2 Servicio de anatomía patológica
3 Centro de especialidades doctor fleming, servicio andaluz de salud, sevilla. Hospitales universitarios virgen del rocío, servicio andaluz de salud, sevilla. USP-clínica sagrado corazón, sevilla
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Resumen

El modelo general de inflamación local en rata se desarrolla en la almohadilla plantar. En otorrinolaringología puede haber un modelo de inflamación local en la oreja de rata mediante la producción de una condritis auricular. Para ello hemos protocolizado la metodología. La inducción de la inflamación se realiza mediante la sustancia vegetal carrageenan. Se ha comprobado mediante estudio histológico la inflamación producida, así como se ha estudiado la acción de compuestos antiinflamatorios, proinflamatorios e inflamatorios. La inflamación se ha medido con nonius y con determinación de la actividad de la enzima mieloperoxidasa. Tras los estudios realizados podemos validar la condritis auricular en rata como un modelo experimental de inflamación local en otorrinolaringología

Palabras clave:
Condritis auricular
Inflamación local
Modelo experimental
Abstract

The general pattern of local inflammation in the rat is developed in the pad of the paw. In otorhinolaryngology a model of local inflammation can be reached in the rat ear by means of the production of an auricular chondritis. For that, we have protocolized the methodology. The induction of inflammation is carried out by the substance vegetable carrageenan. It has been verified by histological studies the inflammation generated, as well as studying the action of antiinflammatory, proinflammatory and inflammatory compounds. The inflammation has been measured by nonius and by determination of the activity of the myeloperoxidase enzyme. After these studies we can validate the auricular chondritis in rat as an experimental model of local inflammation in otorhinolaryngology

Key words:
Auricular chondritis
Local inflammation
Experimental model

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