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Vol. 57. Issue 2.
Pages 90-95 (February 2006)
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Vol. 57. Issue 2.
Pages 90-95 (February 2006)
Perfil de la viscosidad sanguínea en la hipoacusia rápidamente progresiva con Western-blot positivo
Blood viscosity profile in rapidly progressive sensorineural hearing loss with positive Western-blot
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F.J. García Callejo
Corresponding author
jgarciacall@hotmail.com

Correspondencia: C/ Luis Oliag 71-8 46006 Valencia
, C. de Paula Vernetta, A. Platero Zamarreño, M.H. Orts Alborch, L.M. Gil-Carcedo, J. Marco Algarra
Servicio de ORL. Hospital Clínico Universitario. Valencia
M.M. Velert Vila*, C. Morera Pérez**
* Centro de Investigación. Hospital La Fe. Valencia
** Servicio de ORL. Hospital La Fe.Valencia
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Resumen
Objetivo

Valorar la posible asociación de modificaciones de la viscosidad sanguínea en la hipoacusia neurosensorial rápidamente progresiva (HNSRP) de origen autoinmune.

Pacientes y métodos

En 43 sujetos afectos de HNSRP con Western-blot positivo para anticuerpos anticocleares se estudiaron las propiedades viscoelásticas de la sangre: viscosidad en sangre total (VST) a diferentes velocidades de cizallamiento (VC) y filtrabilidad eritrocitaria. Estos resultados se correlacionaron con la pérdida auditiva inicialmente detectada y el grado de recuperación al año del tratamiento esteroideo.

Resultados

Sólo la VST a VC de 230 seg-1 resultó significativamente mayor en casos que entre controles (p<0,01). El porcentaje de recuperación auditiva se correlacionó de forma estadísticamente significativa con valores elevados en la FE (p<0,01). La pérdida auditiva inicial no se correlacionó con ningún valor reológico.

Conclusiones

La HNSRP autoinmune no presenta una fisiopatología asociada a hiperviscosidad sanguínea, por lo que las terapias reoactivas como la plasmaféresis no garantizan mejoría clínica.

Palabras clave:
Hipoacusia neurosensorial
Enfermedad autoinmune
Viscosidad sanguínea
Western-blot
Abstract
Objective

To value a possible association between disorders in blood viscosity of patients with rapidly progressive sensorineural hearing loss (RPSHL) of autoimmune origin.

Patients and methods

We studied the viscoelastic properties of blood in 43 subjects bearing of RPSHL and a positive Western-blot for anticochlear antibodies: whole blood viscosity (WBV) at different shear rates and erythrocyte filterability (EF). These results were related to hearing loss initially detected and recovery average one year later from steroid therapy.

Results

Just WBV at 230 sec-1 shear rate was significatively higher in cases than in controls (p<0.01). Hearing recovery degree correlated in an statistically way to increased values of EF (p<0.01). There was no relation between initial hearing loss level and any rheology parameter.

Conclusions

Autoimmune RPSHL does not show a pathophysiology mechanism associated to blood hyperviscosity. So, rheoactive therapies as plasmapheresis warrant no clinical improvement.

Key words:
Sensorineural hearing loss
Autoimmune disease
Blood viscosity
Western-blot

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