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array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Roberto" "apellidos" => "Méndez Gallart" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Carlos" "apellidos" => "Aliste Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Máximo Francisco" "apellidos" => "Fraga Rodriguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Adolfo" "apellidos" => "Bautista Casasnovas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía Pediátrica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Castleman cervical pediátrica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1066 "Ancho" => 2834 "Tamanyo" => 1029887 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(H&E, 200×): lymphoid follicles with atrophic/regressive germinal centres, with an increase in vessels showing hyalinisation of the vessel wall and onion-skin arrangement of the mantle cells. (A). IHC staining for CD21: the dendritic follicular cell network is enhanced with IHC staining for CD21 (B).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 12-year-old male with a history of asthma, chronic rhinitis, eczema, dust mite allergy and 3 episodes of pneumonia in the past 7 years, presented with a tumour on the right side of his neck of progressive, rapid growth, with no other accompanying symptoms. On physical examination a tumour in the lower right side of the neck was palpated of about 6×4<span class="elsevierStyleHsp" style=""></span>cm, painless, oval shaped, indurated and mobile (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). Ultrasound showed a solid, isoechoic, well-defined mass with blood flow on Doppler ultrasound (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). Given the characteristics of the lesion and its unfavourable progression, we decided to surgically excise the mass.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The patient underwent complete resection of the tumour (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a><span class="elsevierStyleSmallCaps">C</span> and D). Macroscopic analysis revealed a lobulated mass of 6×4×2.8<span class="elsevierStyleHsp" style=""></span>cm with a greyish brown surface of elastic consistency. Histological examination showed lymph node tissue where follicles with expanded mantle zones showing an “onion skin” pattern and regressive/atrophic germinal centres were observed, with increased small vessels showing hyaline changes in the vessel wall. Increased perifollicular vascularisation was also observed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). Networks of follicular dendritic cells arranged concentrically were observed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). IHC study for EBV and HHV-8 was negative.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Given the histopathological features, a definitive diagnosis was made of angiofollicular lymphoid hyperplasia or hyaline vascular Castleman's disease (CD), with no histological signs of lymphoma infiltration.</p><p id="par0020" class="elsevierStylePara elsevierViewall">After clinical follow up of 8 months the patient was asymptomatic, with no recurrence and disease-free.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">CD or angiofollicular lymphoid hyperplasia is a benign reactive lymphoproliferative disorder that was first described by the pathologist Benjamin Castleman between 1954 and 1956 from a series of 13 cases that were initially diagnosed as thymomas.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> This is a rare disease with a global incidence of <1/100,000 and is particularly rare in children. It is believed to be caused by antigen stimulation probably of viral aetiology or as a consequence of a proliferation of plasma cells due to altered growth factor regulation. There are three histological variants: hyaline vascular, plasma cell, and mixed. The <span class="elsevierStyleItalic">hyaline-vascular form</span> is characterised by atrophic/regressive germinal centres surrounded by mantle lymphocytes simulating the typical onion-skin appearance with hyperplasia of hyalinised vessels that penetrate the follicle (lollipop-like histological appearance). There are 2 subtypes: classic lymphoid and stromal cell-rich. This pattern can also be found in the lymph nodes of patients with AIDS and angioimmunoblastic lymphadenopathy. <span class="elsevierStyleItalic">Plasma cell</span> CD is characterised by preserved architecture of the lymph node with hyperplastic germinal centres and interfollicular regions that contain abundant polyclonal plasma cells.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The vascular proliferation characteristic of the hyaline-vascular variant is not observed. And finally, the histological variant termed <span class="elsevierStyleItalic">plasmablastic</span> or <span class="elsevierStyleItalic">mixed</span> (associating cases of HHV-8 CD and POEMS syndrome).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Two well-defined forms of the disease can be differentiated according to the location: unicentric CD and multicentric CD. <span class="elsevierStyleItalic">Unicentric CD</span> is the most common in children. Ninety percent are the hyaline-vascular variant. The most common presentation is an isolated tumour that is generally asymptomatic and principally located in the mediastinum (70%), neck and abdomen. Only 14% of cases are located in the neck. To date, 32 paediatric cases of unicentric CD in the neck have been described in the literature. The mean age of diagnosis is around 12 years with no significant differences between the sexes. Bearing in mind that in some of the cases published the location is wholly descriptive, we note that lymph node level V (posterior triangle of the neck bordered by the sternocleidomastoid, trapezius and clavicle) is the most common location.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Symptoms caused by the compression of neighbouring structures occur in a very few cases. The most common laboratory test abnormalities are iron deficiency anaemia, hypoalbuminaemia, hypoalbuminaemia, hypergammaglobulinaemia and elevated VSG or PCR. Elevated IL-6 levels are found in some cases, which increases the acute phase reactants and endothelial factor levels that cause local inflammation and hypervascularisation of the lymph nodes. This would indicate a probable viral aetiology or altered growth factor regulation. In general, the prognosis is good and complete resection of the lesion is curative. There are no published paediatric cases of recurrence after complete resection.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> When operating, the marked vascularisation should be taken into account that increases the risk of bleeding, and the lesion must be fully resected. Needle biopsy is not indicated. Some authors perform prior vascular embolisation to reduce the risk of bleeding.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> In cases of large tumours that are difficult to access, prior use is possible of steroids, rituximab or radiotherapy,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> although this treatment is curative in only 50% of cases.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Multicentric CD</span> is very rare in children. Various lymph nodes are affected and the patients generally present with generalised symptoms and multiple laboratory test abnormalities at diagnosis. HHV-8, a precursor of Kaposi's sarcoma, might be involved in its aetiopathogenesis, which will cause hypersecretion of homologous IL-6 which will stimulate an increase in B lymphocytes perpetuating inflammatory changes, which might encourage the onset of lymphomas. A third of patients with multicentric forms will develop non-Hodgkin lymphomas, Kaposi's sarcomas and other carcinomas.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Some cases are associated with HIV (ECM HHV-8<span class="elsevierStyleSup">+</span>, HIV<span class="elsevierStyleSup">+</span>).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Although the prognosis is much poorer than that of unicentric CD (up to 50% mortality), in paediatric cases the response to treatment is better. Treatment must be systemic and although there is no consensus on the regimen of choice, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy is recommended, which can be combined with siltuximab, tocilizumab, rituximab and antiretrovirals in cases of ECM HIV/HHV-8.</p><p id="par0040" class="elsevierStylePara elsevierViewall">To conclude, the anodyne presentation of unicentric CD of the neck and the frequency of infectious adenitis and lymphoproliferative disorders in paediatric patients requires knowledge of CD in the differential diagnosis of neck masses in children.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Discussion" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-02-20" "fechaAceptado" => "2017-03-01" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Marco Martin C, Méndez Gallart R, Aliste Santos C, Fraga Rodriguez MF, Bautista Casasnovas A. Enfermedad de Castleman cervical pediátrica. Acta Otorrinolaringol Esp. 2018;69:117–119.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1023 "Ancho" => 1600 "Tamanyo" => 265369 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ultrasound of the neck: solid lesion, isoechoic to muscle and well-defined with blood flow on colour Doppler ultrasound (A). An oval-shaped tumour, 6<span class="elsevierStyleHsp" style=""></span>cm in length, on the lower right neck (B). Surgical resection of the lesion, oval-shaped mass of elastic consistency with marked hypervascularisation (C and D).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1066 "Ancho" => 2834 "Tamanyo" => 1029887 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(H&E, 200×): lymphoid follicles with atrophic/regressive germinal centres, with an increase in vessels showing hyalinisation of the vessel wall and onion-skin arrangement of the mantle cells. (A). IHC staining for CD21: the dendritic follicular cell network is enhanced with IHC staining for CD21 (B).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localized mediastinal lymph node hyperplasia resembling thymoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Castleman" 1 => "L. Iverson" 2 => "V.P. Menendez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1956" "volumen" => "9" "paginaInicial" => "822" "paginaFinal" => "830" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13356266" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnóstico y tratamiento actual de la enfermedad de Castleman" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. González-García" 1 => "M.A. Moreno-Cobo" 2 => "J.L. Patier-Pena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rce.2015.11.008" "Revista" => array:6 [ "tituloSerie" => "Rev Clin Esp" "fecha" => "2016" "volumen" => "216" "paginaInicial" => "146" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26749192" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of Castleman's disease by identification of an immunophenotypically aberrant population of mantle zone B lymphocytes in paraffin-embedded lymph node biopsies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.M. Menke" 1 => "M. Tiemann" 2 => "J.K. Camoriano" 3 => "S.F. Chang" 4 => "A. Madan" 5 => "ChowM." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1996" "volumen" => "105" "paginaInicial" => "268" "paginaFinal" => "276" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8602606" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Castleman disease in the pediatric neck: a literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.R. Rabinowitz" 1 => "J. Levi" 2 => "K. Conard" 3 => "U.K. Shah" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0194599813479931" "Revista" => array:6 [ "tituloSerie" => "Otolaryngol Head Neck Surg" "fecha" => "2013" "volumen" => "148" "paginaInicial" => "1028" "paginaFinal" => "1036" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23459702" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Castleman disease: surgical cure in pediatric patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Buesing" 1 => "D. Perry" 2 => "C. Reyes" 3 => "S. Abdessalam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jpedsurg.2009.08.022" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Surg" "fecha" => "2009" "volumen" => "44" "paginaInicial" => "E5" "paginaFinal" => "E8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20006003" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Castleman's disease in children: report of 2 cases and clinicopathologic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.A. Palma" 1 => "A.R. Dar" 2 => "S.J. Millington" 3 => "C.L. Smits" 4 => "K. Rizkalla" 5 => "R. Inculet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Hematol Oncol" "fecha" => "2004" "volumen" => "26" "paginaInicial" => "264" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15087957" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preoperative embolization of hypervascular Castleman's disease of the mediastinum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.H. Robert" 1 => "G. Sgourdos" 2 => "N. Kritikos" 3 => "D. Didier" 4 => "S. Terraz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00270-006-0156-y" "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Intervent Radiol" "fecha" => "2008" "volumen" => "31" "paginaInicial" => "186" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17278035" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Castleman's disease in childhood: report of three cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Farruggia" 1 => "A. Trizzino" 2 => "N. Scibetta" 3 => "G. Cecchetto" 4 => "P. Guerrieri" 5 => "E.S. D’Amore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1824-7288-37-50" "Revista" => array:5 [ "tituloSerie" => "Ital J Pediatr" "fecha" => "2011" "volumen" => "37" "paginaInicial" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22014148" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation therapy in the treatment of unicentric. Castleman's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.A. Miranda" 1 => "V.H. Faria" 2 => "G.V. Arruda" 3 => "L.G. Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2013" "volumen" => "39" "paginaInicial" => "116" "paginaFinal" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23503497" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad de Castleman" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Sánchez de Toledo" 1 => "J. Fàbrega" 2 => "C. Marhuenda" 3 => "X. Lucaya" 4 => "N. Torán" 5 => "L. Gros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Pediatr" "fecha" => "2005" "volumen" => "63" "paginaInicial" => "68" "paginaFinal" => "71" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735735/0000006900000002/v1_201803220938/S2173573518300152/v1_201803220938/en/main.assets" "Apartado" => array:4 [ "identificador" => "5881" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Studies" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735735/0000006900000002/v1_201803220938/S2173573518300152/v1_201803220938/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573518300152?idApp=UINPBA00004N" ]
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