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la Rosa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651910001585" "doi" => "10.1016/j.otorri.2010.07.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651910001585?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573511000901?idApp=UINPBA00004N" "url" => "/21735735/0000006200000006/v1_201304231505/S2173573511000901/v1_201304231505/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173573511000949" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2011.06.002" "estado" => "S300" "fechaPublicacion" => "2011-11-01" "aid" => "307" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2011;62:443-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1913 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 1334 "PDF" => 539 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Predictive Ability of the CT to Evaluate Cervical Lymph Nodes in Head and Neck Tumours" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "443" "paginaFinal" => "447" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Capacidad predictiva de la TC para evaluar las adenopatías cervicales en los tumores de cabeza y cuello" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Esther Iñarra Unzurrunzaga, Miren Gorriño Angulo, Luisa Vidales Arechaga, Urko Aguirre Larracoechea, Juan Ramón Iriondo Bedialauneta" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Esther" "apellidos" => "Iñarra Unzurrunzaga" ] 1 => array:2 [ "nombre" => "Miren" "apellidos" => "Gorriño Angulo" ] 2 => array:2 [ "nombre" => "Luisa" "apellidos" => "Vidales Arechaga" ] 3 => array:2 [ "nombre" => "Urko" "apellidos" => "Aguirre Larracoechea" ] 4 => array:2 [ "nombre" => "Juan Ramón" "apellidos" => "Iriondo Bedialauneta" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651911001415" "doi" => "10.1016/j.otorri.2011.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651911001415?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573511000949?idApp=UINPBA00004N" "url" => "/21735735/0000006200000006/v1_201304231505/S2173573511000949/v1_201304231505/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Closure of Recurrent Cleft Palate Fistulas With Plasma Rich in Growth Factors" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "448" "paginaFinal" => "453" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jorge Glicerio González-Sánchez, Karina Jiménez-Barragán" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Jorge Glicerio" "apellidos" => "González-Sánchez" ] 1 => array:4 [ "nombre" => "Karina" "apellidos" => "Jiménez-Barragán" "email" => array:1 [ 0 => "karinitas@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Otorrinolaringología y Cirugía de Cabeza y Cuello, Hospital Dr. Valentín Gómez Farías, ISSSTE, Zapopan, Jalisco, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cierre de fístulas nasopalatinas recurrentes con plasma rico en factores de crecimiento en pacientes con paladar hendido" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 654 "Ancho" => 951 "Tamanyo" => 95985 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Introduction of the PRGF mixed with bone within the bone defect.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Palatal fistulas are a major problem in the treatment of patients with cleft palate. The formation of fistulas after primary palatoplasty has been variably described, since the classification systems for fistulas differ. Cohen et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> described a 23% incidence of palatal fistula formation after primary palatoplasty. Emory et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> carried out a literature review, which found the presence of up to 36% of palatal fistulas. Smith et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> described an incidence between 0% and 76% of palatal fistula after primary palatoplasty. Recurrence after repair of a palatal fistula is even higher, with reports that range from 25% to 33%<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,4</span></a> to nearly 100%.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The most common sites of fistulization are the hard palate and the junction of the hard and soft palates, although it can also occur in the soft palate.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Cohen et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> classified fistulas by their size into small (1–2<span class="elsevierStyleHsp" style=""></span>mm), medium (3–5<span class="elsevierStyleHsp" style=""></span>mm) and large (more than 5<span class="elsevierStyleHsp" style=""></span>mm).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> By their location, the Pittsburgh classification divides them into: (1) uvular, (2) soft palate, (3) junction between hard and soft palate, (4) hard palate, (5) junction between primary and secondary palate, (6) lingual alveolar and (7) labial alveolar.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It has been suggested that the variables that increase the risk of palate fistula are the type of primary defect (Veau classification), the type of primary repair surgery (significantly more frequent in Wardill–Kilner type closures) and the experience of the surgeon.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Palatal fistulas have traditionally been closed using local mucoperiosteal flaps. However, they recur in 1 out of every 3–4 patients. The risk of recurrent fistula increases once the closure of the primary defect has failed. The fibrosis and decreased vascularization that occur with each surgery could explain this increase in risk. Several authors have described different surgical techniques for recurrent palatal fistulas closure to decrease this recurrence, such as using lingual flaps,<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> buccal flaps,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> bone grafts,<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–14</span></a> buccal musculomucosal flaps,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> buccal fat flaps,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> conchal cartilage,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> acellular dermal matrix<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and turbinal flaps<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Plasma rich in growth factors (PRGF) is an autologous blood product with a high platelet concentration. It is used to manage and maximise both surgical and nonsurgical wound repair. The main components of PRGF are the following types of growth factors: platelet-derived, vascular endothelial, beta-type transforming, epidermal, fibroblast and insulin-like I. These factors promote the synthesis of the extracellular matrix, stimulate the synthesis of type I collagen, fibronectin and osteonectin, deposition of extracellular matrix and chemotaxis. They also decrease the synthesis of metalloproteins and plasminogen activating factor, thereby reducing the destruction of the extracellular matrix. They inhibit osteoclast formation as well, but promote bone resorption by the mechanism of prostaglandins.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Cell repair and regeneration are also promoted by stimulation of mitosis and cell migration, and the synthesis of proteins such as fibronectin is also promoted.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> They also contain chemotactic agents for endothelial vascular cells, thereby promoting wound neovascularization. A pro-angiogenic action has been observed by chemotactic action on endothelial cells.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The main uses of PRGF to date are in dental and maxillofacial surgery, to repair defects caused by dental extraction<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> or tumour resection,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> as well as for alveoloplasty.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Other specialties have studied its effect in surgical procedures such as acromioplasty,<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> arthroscopy,<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> rhytidectomy with fat grafts,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> skin wounds<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> and infiltration due to ankle ligament injury.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Accelerated healing, decreased risk of infection, less postoperative discomfort and faster recovery were reported in these publications.</p><p id="par0030" class="elsevierStylePara elsevierViewall">There have been no studies on the closure of palatal fistulas using PRGF with autologous bone grafts in patients with cleft palate sequelae. The aim of this study was to evaluate the effectiveness of PRGF in the surgical closure of palatal fistulas.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study Design</span><p id="par0035" class="elsevierStylePara elsevierViewall">We carried out a prospective, longitudinal, cohort study that included all patients with a history of cleft palate, with or without cleft lip, presenting at least one recurrent palatal fistula, who attended the Otorhinolaryngology Service at Dr. Valentin Gomez Farias Regional Hospital (ISSSTE) during the period between April 2008 and July 2010. The study was approved by the research and bioethics committee of the hospital and all patients gave their informed consent.</p><p id="par0040" class="elsevierStylePara elsevierViewall">We recorded the variables studied, including: gender, age, type of primary defect according to the Veau classification, size of fistula according to Cohen and location of fistula according to Pittsburgh, as well as the number of prior closure attempts. We documented the study with photographs of the patient and a computed tomography study performed one day before surgery. All patients were referred for assessment and management by the psychology service.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Surgical Technique</span><p id="par0045" class="elsevierStylePara elsevierViewall">Minutes before the surgery, we extracted 10–20<span class="elsevierStyleHsp" style=""></span>ml of venous blood from each patient, depending on the size of the defect. This was centrifuged to obtain PRGF by the technique described by Anitua<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">30</span></a> and reserved until 15<span class="elsevierStyleHsp" style=""></span>min before its use. Under general anaesthesia, we evaluated the nasal floor by endoscopic approach in search of the fistula (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). We infiltrated the region around the fistula via the palate with lidocaine at 2% with epinephrine 1:100 000. We designed local mucoperiosteal flaps by separating the oral mucosa from the palatal mucosa. Then we took the bone graft, crushed it to mix with the activated PRGF gel (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and placed it between two sheets of solid collagen. The nasal mucosa was closed to introduce the mixture between the palatal and nasal mucosa, filling the bone defect (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The palatal mucosa was closed with Vicryl 5-0. All patients were operated on by the same surgeon.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Follow-up</span><p id="par0050" class="elsevierStylePara elsevierViewall">A photographic record of the palate was prepared by photographs during surgery, at 2 and 4 weeks, and later at 2, 4, 6, and 12 months (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The preoperative and postoperative CT scans were also recorded (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). Assessment of fistula closure was performed subjectively, using the evaluation by each patient (passage of solid or liquid food into the nostrils), and objectively, using a test with dyed mouthwashes, as well as through intraoral and endoscopic nasal inspection.</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical Analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">No statistical analysis was performed due to the sample size.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">None of the patients were excluded or eliminated because all continued their evaluations for at least 6 months. We performed 11 surgical closures of palatal fistulas in 6 patients, 50% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3) female and 50% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3) male. The ages of patients at the time of surgery were between 10 and 33 years. Two patients presented double palatal fistula and one presented triple fistula. We studied the closure of 11 palatal fistulas in all. The type of cleft palate according to Veau was incomplete unilateral in 67% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) and unilateral complete cleft palate in 33% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2). According to the Cohen<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> classification for the size of the fistulas, we found 3 small (27%), 4 medium (36%) and 4 large (36%) fistulas. All patients had previously undergone surgical closure of the fistula, without success in 3 of 5 times. According to their location, 45% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) were found between hard and soft palate, 27% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3) in the hard palate, 18% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2) in the junction between the primary and secondary palate and 9% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1) were labial alveolar. Fistulas were found in the left side in 81.8% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9) of cases and in the right in 18.2% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2).</p><p id="par0065" class="elsevierStylePara elsevierViewall">With respect to autologous bone grafts, we obtained 4 from the perpendicular plate of the ethmoid, 2 from the middle turbinate (concha bullosa), 1 from the mastoid and 1 from the iliac crest. All patients presented an abundant production of fibrin during the first week, which decreased until its disappearance within 2 weeks. Palate pain was almost nil in all patients. There were no cases of infection in any of the patients.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Closure was demonstrated in 90.9% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>10) of the palatal fistulas.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Patients with cleft palates are subjected to an average of 4 surgical procedures, including primary palatoplasty, pharyngeal flap, pharyngoplasty, recurrent fistula closure and placement of ventilation tubes, among others. This is an exhausting process for patients and also represents a significant expense to healthcare systems.<span class="elsevierStyleSup">31</span> A patient with palatal fistula suffers passage of solids and liquids into the nasal cavity, increased frequency of upper respiratory tract infections and changes in voice resonance; all this in turn leads to low self-esteem. Having noted the benefits that PRGF offered in other surgical procedures, we decided to study whether its application during palatal fistula closure decreased recurrence.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The results in our study were satisfactory, as it was possible to reduce the recurrence rate compared to others described in the literature, ranging from 40% to nearly 100% in recurrent palatal fistulas.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–19</span></a> These authors agree that the rate of fistula recurrence increases in accordance to the number of closure attempts. In our study, all fistulas had a minimum of 3 prior surgical failures.</p><p id="par0085" class="elsevierStylePara elsevierViewall">In this study, we decided to obtain the graft from a previous pathological area in each patient. We obtained improvement in nasal function, while the palatal fistula was closed. It is important to point out that patients must follow postoperative care, which is sometimes difficult due to their age. In the case of our patient who presented recurrence of the fistula, there had been good evolution during the first 3 weeks, until she injured her hard palate with solid food. In addition, this patient presented a triple fistula, which may have led to increased risk of flap ischemia due to increased tension. This patient was reoperated one year later using PRGF, achieving successful closure.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In Mexico, there is a significant surgical delay in the comprehensive treatment of patients with cleft lip and palate due to population marginalisation issues and to the high cost for patients, who must often relocate to receive healthcare.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">31</span></a> This is why we consider it essential to reduce the recurrence of fistulas, so as to reduce the number of surgical procedures, as well as the expenses involved.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0095" class="elsevierStylePara elsevierViewall">The use of PRGF mixed with autologous bone graft for the closure of palatal fistulas by local mucoperiosteal flaps is an innovative alternative that can offer significant benefits for patients with a history of cleft palate. Being completely autologous, it is a safe option because infectious or rejection risks are not added. It seems to be an effective technique, demonstrating success in over 90% of patients in our study. However, we believe it is important to extend this study to obtain significant results.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interests</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:2 [ "identificador" => "xres94883" "titulo" => array:5 [ 0 => "Abstract" 1 => "Introduction and objective" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec82034" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres94882" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción y objetivo" 2 => "Pacientes y método" 3 => "Resultados" 4 => "Conclusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec82035" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study Design" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Surgical Technique" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Follow-up" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistical Analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of Interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-09-15" "fechaAceptado" => "2011-06-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82034" "palabras" => array:4 [ 0 => "Cleft palate" 1 => "Fistula" 2 => "Platelet-rich plasma" 3 => "Growth factors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82035" "palabras" => array:4 [ 0 => "Paladar hendido" 1 => "Fístula" 2 => "Plasma rico en plaquetas" 3 => "Factores de crecimiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fistulas represent a significant challenge in the treatment of cleft palate. The best outcome of a palatoplasty is obtained with a competent velopharyngeal sphincter and a palate without fistulas. The recurrence of primary cleft palate fistula is reported as high as up to 76%, and to nearly 100% in recurrent fistulas.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Plasma rich in growth factors (PRGF) is an autologous blood product with biologically active substances that enhance tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis, osteogenesis and remodeling. Its use in cleft palate fistulas has not been reported.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Our objective was to evaluate closure of recurrent cleft palate fistulas using PRGF mixed with autologous bone graft.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">An experimental, prospective, longitudinal study was carried out from April 2008 to July 2010 on 11 recurrent cleft palate fistulas that were closed with local mucoperiosteal flaps and placement of autologous bone graft mixed with PRGF.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Complete closure of palate fistulas was achieved in 90.9% (follow-up of 6–24 months), decreasing the reported incidence for the recurrence by other authors with other techniques.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The use of PRGF mixed with autologous bone graft seems to be an effective, safe and low-cost technique for the closure of recurrent cleft palate fistulas. However, we consider its study must be extended.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las fístulas palatinas representan un desafío importante en el tratamiento del paladar hendido. Los mejores resultados de una palatoplastia se obtienen con un esfínter velofaríngeo competente y un paladar sin fístulas. En la literatura se describe que la recurrencia de fístulas palatinas primarias es de hasta el 76% y las recurrentes es de aproximadamente el 100%.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El plasma rico en factores de crecimiento (PRGF) es un hemoderivado autólogo con sustancias biológicamente activas que promueven los mecanismos de reparación tisular como quimiotaxis, proliferación celular, angiogénesis, osteogénesis y remodelación. No se ha descrito su uso en reparación de fístulas nasopalatinas.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Nuestro objetivo fue evaluar el cierre exitoso de fístulas palatinas recurrentes con el uso del PRGF combinado con injerto óseo autólogo.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio experimental, prospectivo, longitudinal desde abril 2008 a julio 2010, con un total de 11 fístulas nasopalatinas, las cuales se cerraron por medio de colgajos mucoperiósticos locales y colocación de injerto óseo autólogo mezclado con PRGF.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Con un seguimiento de 6–24 meses, se demostró el cierre completo de las fístulas en el 90,9%, disminuyendo el índice de recurrencia descrito con otras técnicas por otros autores.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El uso de PRGF mezclado con injerto óseo autólogo parece ser una alternativa eficaz, segura y de bajo costo para el cierre de fístulas palatinas, sin embargo su estudio debe ser ampliado.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: González-Sánchez JG, Jiménez-Barragán K. Cierre de fístulas nasopalatinas recurrentes con plasma rico en factores de crecimiento en pacientes con paladar hendido. Acta Otorrinolaringol Esp. 2011;62:448–53.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 769 "Ancho" => 863 "Tamanyo" => 68278 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Nasopalatine fistula observed endoscopically through right nostril.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1092 "Ancho" => 801 "Tamanyo" => 113800 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Activated gel of plasma rich in growth factors.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 654 "Ancho" => 951 "Tamanyo" => 95985 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Introduction of the PRGF mixed with bone within the bone defect.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 668 "Ancho" => 1402 "Tamanyo" => 140854 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">(A) Preoperative photograph. (B) Postoperative photograph after 4 months.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 731 "Ancho" => 1429 "Tamanyo" => 109267 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">(A) Preoperative CT scan showing the nasopalatine fistula. 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