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Case study
Primary Rhinopharyngeal Tuberculosis: An Unusual Location
Tuberculosis rinofaríngea primaria: una localización infrecuente
Alfonso Martínez
Corresponding author
alfonso_m_f@hotmail.com

Corresponding author.
, Ángel Lede, José A. Fernández
Servicio de Otorrinolaringología, Hospital da Costa, Burela (Lugo), Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Up to 10&#37; of tuberculosis &#40;TB&#41; cases have some manifestation in the head and neck region&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Although the upper respiratory tract is the entry point of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#44; its involvement is rare &#40;less than 2&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and a nasopharyngeal location is exceptional and generally isolated&#44; with no pulmonary or systemic involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most frequent form of presentation is high jugular adenopathy &#40;50&#37;&#8211;90&#37;&#41;&#44; followed by nasal obstruction&#44; snoring&#44; rhinorrhoea&#44; serous otitis&#44; hearing loss&#44; tinnitus&#44; and otalgia&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Endoscopy can present a varied range&#44; from an apparently normal mucosa&#44; to an evident mass&#44; or a mucosa with an adenoid or swollen appearance&#44; ulcers&#44; leukoplakic areas&#44; and various combinations thereof&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Radiologically&#44; there are 2 patterns&#58; either a polypoid mass or a diffuse thickening of the nasopharyngeal walls&#46; Extension to the prevertebral musculature&#44; skull base bone&#44; etc&#46; is infrequent&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The symptoms &#40;high cervical adenopathy and rhinopharyngeal mass&#41; and the radiological findings make it difficult to distinguish from undifferentiated carcinoma&#44; especially in areas where both are endemic&#44; such as Southeast Asia&#44; making it necessary to carry out a biopsy for histological and bacteriological studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Case</span><p id="par0030" class="elsevierStylePara elsevierViewall">We present the case of a female patient&#44; 72 years old&#44; with no history of interest&#44; with an incidental finding on an MRI performed due to headaches &#40;finally diagnosed as tension headache&#41;&#44; of an asymptomatic mass on the posterior rhinopharyngeal wall&#46; The mass had cystic areas&#44; post-contrast enhancement&#44; and no deep invasion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No cervical adenopathy was observed on the MRI scan&#46; The patient did not present systemic or pulmonary symptoms and the chest X-ray was normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Nasofibroscopy revealed a polypoid lesion occupying the entire rhinopharynx&#44; with mucosa of normal appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Biopsy under local anaesthesia and the subsequent anatomopathological analysis of the tissue showed granulomas with histiocytic&#44; epithelioid&#44; and giant multinucleated Langhans cells&#44; as well as caseous necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Ziehl-Neelsen staining was positive for acid-fast bacilli &#40;AFB&#41;&#46; After the patient received a positive intradermal tuberculin test&#44; we introduced treatment with rifampicin&#44; isoniazid&#44; and pyrazinamide for 6 months&#44; after which the endoscopy was normal and the biopsy showed unaltered respiratory epithelium&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Radiological and immunological tests carried out on the patient&#39;s close contacts revealed no other TB cases in any localisations&#44; so it was not considered necessary to administer treatment to these individuals&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">To date&#44; only 4 series &#40;including between 7 and 17 cases&#41; and the odd case of rhinopharyngeal TB have been described in the English-language literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;10</span></a> mainly in young patients and endemic areas&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The presentation form in over 50&#37; of cases is the presence of cervical adenopathy&#44; followed by other nasal symptoms &#40;airway obstruction&#44; rhinorrhoea&#44; snoring&#44; etc&#46;&#41; or otological symptoms &#40;hearing loss&#44; autophony&#44; and sensation of blockage&#41;&#46; In our patient&#44; we did not detect any of the commonly referred symptoms or signs because&#44; as explained&#44; a chance discovery led to the performance of the various tests leading to the final diagnosis&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Pulmonary or systemic involvement associated to this location is rare &#40;25&#37;&#8211;30&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and was absent in the case of this patient&#46; Conversely&#44; rhinopharyngeal involvement is very unusual in pulmonary TB&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;11</span></a> Nasopharyngeal TB is consequently generally considered primary &#40;by direct inhalation of <span class="elsevierStyleItalic">Mycobacterium</span>&#41;&#46; In the rest of the upper aerodigestive tract &#40;such as the larynx&#41;&#44; lung involvement is very high &#40;95&#37;&#41;&#44; because spread takes place through sputum from the pulmonary lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The most frequent endoscopic image is the combination of over-elevated areas accompanying a frank mass &#40;70&#37;&#8211;75&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In our case&#44; the mass occupied the entire space of the cavum&#44; without areas of other type&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Diagnosis is based on the histological finding of granulomas of Langhans cells with caseous necrosis or the detection of AFB in Ziehl-Neelsen staining &#40;less common&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Other causes of granulomas to be considered are sarcoidosis&#44; Wagener&#39;s disease&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> fungal infections&#44; reactions to carcinomas&#44; lymphomas &#40;especially Hodgkin&#39;s&#41; and radiotherapy&#44; among others&#46; Finding AFB in Lowenstein culture or staining distinguishes them&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">We conclude that it is necessary to consider TB in the differential diagnosis of nasopharyngeal lesions &#40;even when asymptomatic and without lymph node involvement&#44; as in this case&#41;&#46; As indicated above&#44; it should mainly be distinguished from undifferentiated carcinoma and the granulomatosis mentioned&#44; by biopsy and histological and bacteriological studies&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interests</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We describe a primary rhinopharyngeal tuberculosis case in a woman who presented with an asymptomatic mass found incidentally on a MRI scan&#46; Histopathological examination of the biopsy specimen showed granulomatous inflammation and caseous necrosis&#46; Anti-tuberculosis therapy was applied for a 6-month period&#44; after which nasopharyngeal examination was normal&#46; This case supports the necessity of including tuberculosis in the differential diagnosis for a rhinopharyngeal mass&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Describimos un caso de tuberculosis primaria rinofar&#237;ngea&#44; como el hallazgo casual en un examen por resonancia magn&#233;tica de una masa asintom&#225;tica&#46; El estudio anatomo-patol&#243;gico tras biopsia mostr&#243; granulomas con necrosis caseosa&#46; Se instaur&#243; tratamiento antituberculoso de 6 meses&#44; tras el cual la endoscopia rinofar&#237;ngea fue normal&#46; Este caso plantea la necesidad de incluir la tuberculosis en el diagn&#243;stico diferencial de las masas de rinofaringe&#46;</p>"
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Article information
ISSN: 21735735
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos