Case Study
Inflammatory Myofibroblastic Tumour of the Tonsil: Case Report and Literature Review
Tumor miofibroblástico inflamatorio de amígdala: informe de un caso con revisión de la literatura
Read
2034
Timeswas read the article
646
Total PDF
1388
Total HTML
Share statistics
array:24 [ "pii" => "S2173573512000245" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2012.03.002" "estado" => "S300" "fechaPublicacion" => "2012-03-01" "aid" => "244" "copyright" => "Elsevier España, S.L.. All rights reserved" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2012;63:141-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2034 "formatos" => array:3 [ "EPUB" => 45 "HTML" => 1370 "PDF" => 619 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001651910002037" "issn" => "00016519" "doi" => "10.1016/j.otorri.2010.11.011" "estado" => "S300" "fechaPublicacion" => "2012-03-01" "aid" => "244" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2012;63:141-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5863 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 4996 "PDF" => 812 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso clínico</span>" "titulo" => "Tumor miofibroblástico inflamatorio de amígdala: informe de un caso con revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "143" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Inflammatory myofibroblastic tumour of the tonsil: case report and literature review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1688 "Ancho" => 2238 "Tamanyo" => 763777 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estroma con proliferación de haces densos de colágeno (A), infiltrado inflamatorio polimórfico con células plasmáticas (B). Reacciones de inmunohistoquímica: vimentina (C) y cd20 (D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Peter Grube-Pagola, Daniel Carrasco-Daza, Georgia Alderete-Vázquez, Juan Gutiérrez-Butanda" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Peter" "apellidos" => "Grube-Pagola" ] 1 => array:2 [ "nombre" => "Daniel" "apellidos" => "Carrasco-Daza" ] 2 => array:2 [ "nombre" => "Georgia" "apellidos" => "Alderete-Vázquez" ] 3 => array:2 [ "nombre" => "Juan" "apellidos" => "Gutiérrez-Butanda" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173573512000245" "doi" => "10.1016/j.otoeng.2012.03.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573512000245?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651910002037?idApp=UINPBA00004N" "url" => "/00016519/0000006300000002/v1_201304231446/S0001651910002037/v1_201304231446/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173573512000257" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2012.03.003" "estado" => "S300" "fechaPublicacion" => "2012-03-01" "aid" => "245" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2012;63:144-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2323 "formatos" => array:3 [ "EPUB" => 48 "HTML" => 1690 "PDF" => 585 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case study</span>" "titulo" => "Association Between Cerebrospinal Fluid Leakage and Persistence of Sternberg's Canal: Coincidence or Cause?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "144" "paginaFinal" => "146" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Asociación entre fístula de líquido cefalorraquídeo y persistencia del canal de Sternberg: ¿coincidencia o causa?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 852 "Ancho" => 948 "Tamanyo" => 110077 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preoperative computed tomography scan showing the bony defect in the left lateral wall of the left sphenoid sinus (arrow 1), as well as the presence of mucosal thickening and a small amount of free intrasinusal fluid due to a CSF leak. Arrow 2 indicates the maxillary nerve canal (V2) and arrow 3 indicates the pterygoid (vidian) nerve canal.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marcos Rossi Izquierdo, Carlos Martín Martín, Torcuato Labella Caballero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Marcos" "apellidos" => "Rossi Izquierdo" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Martín Martín" ] 2 => array:2 [ "nombre" => "Torcuato" "apellidos" => "Labella Caballero" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651910002049" "doi" => "10.1016/j.otorri.2010.11.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651910002049?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573512000257?idApp=UINPBA00004N" "url" => "/21735735/0000006300000002/v1_201304231511/S2173573512000257/v1_201304231511/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173573512000270" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2012.03.005" "estado" => "S300" "fechaPublicacion" => "2012-03-01" "aid" => "251" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Acta Otorrinolaringol Esp. 2012;63:132-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3150 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 2378 "PDF" => 714 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Neurolaryngology" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "132" "paginaFinal" => "140" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neurolaringología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1048 "Ancho" => 1588 "Tamanyo" => 144076 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Parkinson syndrome. Narrow-band spectrogram. Extremely aerial voice.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Faustino Núñez-Batalla, Juan Pablo Díaz-Molina, María Costales-Marcos, Carla Moreno Galindo, Carlos Suárez-Nieto" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Faustino" "apellidos" => "Núñez-Batalla" ] 1 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Díaz-Molina" ] 2 => array:2 [ "nombre" => "María" "apellidos" => "Costales-Marcos" ] 3 => array:2 [ "nombre" => "Carla" "apellidos" => "Moreno Galindo" ] 4 => array:2 [ "nombre" => "Carlos" "apellidos" => "Suárez-Nieto" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651910002104" "doi" => "10.1016/j.otorri.2010.12.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651910002104?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573512000270?idApp=UINPBA00004N" "url" => "/21735735/0000006300000002/v1_201304231511/S2173573512000270/v1_201304231511/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Study</span>" "titulo" => "Inflammatory Myofibroblastic Tumour of the Tonsil: Case Report and Literature Review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "143" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Peter Grube-Pagola, Daniel Carrasco-Daza, Georgia Alderete-Vázquez, Juan Gutiérrez-Butanda" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Peter" "apellidos" => "Grube-Pagola" "email" => array:1 [ 0 => "grubejr78@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Daniel" "apellidos" => "Carrasco-Daza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Georgia" "apellidos" => "Alderete-Vázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Juan" "apellidos" => "Gutiérrez-Butanda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Consultorio de Anatomía Patológica y Patología Pediátrica, Veracruz, Veracruz, Mexico" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Anatomía Patológica, Instituto Nacional de Pediatría (INP), México City, Mexico" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Otorrinolaringología, Instituto Nacional de Pediatría (INP), MéxicoCity, Mexico" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor miofibroblástico inflamatorio de amígdala: informe de un caso con revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1009 "Ancho" => 1349 "Tamanyo" => 184538 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Macroscopic appearance of the outer surface (left) and section (right).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Inflammatory myofibroblastic tumour (IMT) is a rare lesion which primarily affects soft tissue, the lungs and orbits. It was first described in 1905 by Birch–Hirschfeld in a patient with unilateral proptosis<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and subsequently designated as inflammatory pseudotumor by Umiker in 1954.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Its location in the head and neck (extraorbital) is exceptional, with isolated cases being described in the skull base, parapharyngeal space, paranasal sinuses, pterygopalatine fossa and oral cavity.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> The specialised literature only contains 2 previous cases reported in the palatine tonsil.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Case</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a girl aged 10 years and 11 months, with a sudden onset of cervical pain and arthralgia. She was treated with paracetamol, which partially improved her symptoms. Subsequently, she suffered cough and vomiting of gastric contents with traces of blood, as well as foreign body sensation in the throat which limited speech, so she was referred to our hospital. Physical examination revealed a good general condition and the presence of a tumour with irregular edges in the oropharyngeal area. This tumour was dependent on the left tonsil and displaced the uvula, causing pain when touched. The contralateral tonsil showed no abnormalities and the rest of the physical examination was normal. She underwent flexible nasofibrolaryngoscopy, which revealed a grade I adenoid hyperplasia. In addition, we observed that the lesion was in contact with the posterior pharyngeal wall. We performed bilateral tonsillectomy and the pathological findings were as follows: cylindrical left amygdala, yellow-grey in colour, coated with fibrin, measuring 5.2<span class="elsevierStyleHsp" style=""></span>cm×2.4<span class="elsevierStyleHsp" style=""></span>cm×1.5<span class="elsevierStyleHsp" style=""></span>cm and with a firm and smooth consistency (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Histologically, we observed granulation tissue on the surface, with partial absence of epithelial lining. Within the tumour we observed a disorderly proliferation of dense collagenous bands with stellar and tapered myofibroblasts, as well as a polymorphic, inflammatory infiltrate composed of lymphocytes, plasma cells, mast cells, neutrophils and eosinophils (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A and B). Immunohistochemical stains of the stromal cells were positive for vimentin, CD34 and muscle-specific actin, revealing myofibroblastic differentiation, as well as for CD3, CD20, CD68 and CD21, which confirmed the polyclonal nature of the inflammatory infiltrate (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>C and D). With this evidence, we reported a diagnosis of inflammatory myofibroblastic tumour. We also conducted an ALK1 test, which was negative.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">IMT has been recently classified as a neoplastic process with myofibroblastic differentiation, accompanied by dense and polymorphic inflammatory infiltrate.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The histological image of inflammatory myofibroblastic tumour is variable and because of this it has had several names throughout history, such as inflammatory pseudotumor or plasma cell granuloma, among others. It mainly affects soft tissues and the lungs.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Its location in the head and neck region (extraorbital) is very rare. There have been reports of cases located in the skull base, parapharyngeal space, paranasal sinuses, pterygopalatine fossa, oral cavity and parotid.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4,8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">At the moment, treatment for IMT is controversial. Throughout history, several authors have proposed therapies based on steroids, excisional biopsy with wide resection, radiotherapy and even chemotherapy, although these treatment models have been described in various locations.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The medical literature only contains 2 reported cases of IMT located in the palatine tonsil. In 1984, Weilbaecher published the case of a 63-year-old man, who was asymptomatic despite presenting an enlarged, right palatine tonsil. This had a firm consistency, measured 3<span class="elsevierStyleHsp" style=""></span>cm×2.5<span class="elsevierStyleHsp" style=""></span>cm×2<span class="elsevierStyleHsp" style=""></span>cm and was reported as a plasma cell granuloma.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> One decade later, in 1995, Newman reported the case of a 62-year-old woman who presented odynophagia as a main symptom, along with an enlarged, left palatine tonsil. This had a firm consistency, an erythematous appearance and measured 3.5<span class="elsevierStyleHsp" style=""></span>cm×2.5<span class="elsevierStyleHsp" style=""></span>cm×2<span class="elsevierStyleHsp" style=""></span>cm. It was reported as an inflammatory pseudotumor.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, we present a case of primary IMT in the palatine tonsil, which represents the third case described in the literature and the first in a paediatric patient. Our patient presented enhanced symptoms compared with previous cases, probably owing to the fact that this tumour was the largest one reported so far. From a clinical standpoint, it is important to be aware that IMT can affect the palatine tonsil, so it should be included in the differential diagnosis of primary lesions which appear with unilateral tonsillar hypertrophy. Unilateral tonsillectomy is controversial in such cases, but we believe that it should be the treatment of choice.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xres94952" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec82104" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres94953" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec82105" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical Case" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of Interests" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82104" "palabras" => array:5 [ 0 => "Inflammatory myofibroblastic tumour" 1 => "Inflammatory pseudotumor" 2 => "Head and neck" 3 => "Tonsil" 4 => "Paediatric" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82105" "palabras" => array:5 [ 0 => "Tumor miofibroblástico inflamatorio" 1 => "Seudotumor inflamatorio" 2 => "Cabeza y cuello" 3 => "Amígdala palatina" 4 => "Pediatría" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Inflammatory myofibroblastic tumour (inflammatory pseudotumor) is an idiopathic lesion, rare in the head and neck, of unknown aetiology. It is primarily a soft tissue, lung and orbital condition. In the world literature, only two cases with tonsillar disease have been found.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report a case of a 10-year-old girl admitted to our hospital with clinical complaints of pain in the neck region, cough with vomiting, dyspnoea and dyslexia. Clinical examination revealed halitosis and a neoformation dependent on the left tonsil. Bilateral tonsillectomy was performed.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El tumor miofibroblástico inflamatorio (seudotumor inflamatorio) es una lesión idiopática, poco frecuente en cabeza y cuello, de etiología desconocida, que se presenta más comúnmente en tejidos blandos, pulmón y órbita. En la literatura mundial solo se tiene conocimiento previo de 2 casos con afección amigdalar.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Informamos del caso de una niña de 10 años, que ingresó en nuestro hospital con cuadro clínico de dolor en la región cervical, tos con vómito, disnea y dislexia, la exploración física mostró halitosis y una neoformación dependiente de la amígdala izquierda, se le realizó amigdalectomía bilateral.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Grube-Pagola P, et al. Tumor miofibroblástico inflamatorio de amígdala: informe de un caso con revisión de la literatura. Acta Otorrinolaringol Esp. 2012;63:141–3.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1009 "Ancho" => 1349 "Tamanyo" => 184538 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Macroscopic appearance of the outer surface (left) and section (right).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1012 "Ancho" => 1343 "Tamanyo" => 586358 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Stroma presenting proliferation of dense collagen bundles (A) and polymorphic inflammatory infiltrate with plasma cells (B). Immunohistochemical reactions: vimentin (C) and CD20 (D).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumor of the tonsil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.P. Newman" 1 => "J.B. Shinn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0194-59989570025-0" "Revista" => array:6 [ "tituloSerie" => "Otolaryngol Head Neck Surg" "fecha" => "1995" "volumen" => "113" "paginaInicial" => "798" "paginaFinal" => "801" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7501397" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.D. Narla" 1 => "B. Newman" 2 => "S.S. Spottswood" 3 => "S. Narla" 4 => "R. Kolli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/rg.233025073" "Revista" => array:6 [ "tituloSerie" => "Radiographics" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "719" "paginaFinal" => "729" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12740472" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumor of the skull base" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Garg" 1 => "N. Temin" 2 => "P. Hildenbrand" 3 => "M. Silverman" 4 => "P.J. Catalano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.otohns.2009.10.010" "Revista" => array:7 [ "tituloSerie" => "Otolaryngol Head Neck Surg" "fecha" => "2010" "volumen" => "142" "paginaInicial" => "129" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20096237" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0959289X12000088" "estado" => "S300" "issn" => "0959289X" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumor of the parapharyngeal space: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.I. Maruya" 1 => "K. Miura" 2 => "Y.I. Tada" 3 => "T. Masabuchi" 4 => "N. Nakamura" 5 => "C. Fushimi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anl.2009.08.002" "Revista" => array:6 [ "tituloSerie" => "Auris Nasus Larynx" "fecha" => "2010" "volumen" => "37" "paginaInicial" => "397" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19857937" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma cell granuloma of the tonsil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.G. Weilbaecher" 1 => "D.P. Sarma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Surg Oncol" "fecha" => "1984" "volumen" => "27" "paginaInicial" => "228" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6503297" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How to manage oral inflammatory myofibroblastic tumor (inflammatory pseudotumor)?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Pankaj" 1 => "C. Uma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oral Dis" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "315" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12117208" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory myofibroblastic tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.M. Wenig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Pathology and genetics of head and neck tumors" "paginaInicial" => "150" "paginaFinal" => "151" "serieFecha" => "2005" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bening inflammatory pseudotumor of the parotid gland: a case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.W. Mielcarek" 1 => "C. Bates" 2 => "S. Uppal" 3 => "S. Nadig" 4 => "A.P. Coatesworth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Clin Pract" "fecha" => "2004" "volumen" => "58" "paginaInicial" => "527" "paginaFinal" => "529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15206513" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735735/0000006300000002/v1_201304231511/S2173573512000245/v1_201304231511/en/main.assets" "Apartado" => array:4 [ "identificador" => "5881" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Studies" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735735/0000006300000002/v1_201304231511/S2173573512000245/v1_201304231511/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573512000245?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2021 March | 0 | 4 | 4 |
| 2021 February | 0 | 1 | 1 |
| 2021 January | 0 | 2 | 2 |
| 2020 November | 0 | 3 | 3 |
| 2020 October | 0 | 1 | 1 |
| 2020 August | 0 | 2 | 2 |
| 2020 July | 0 | 1 | 1 |
| 2020 May | 0 | 1 | 1 |
| 2020 March | 14 | 6 | 20 |
| 2020 February | 13 | 8 | 21 |
| 2020 January | 30 | 13 | 43 |
| 2019 December | 22 | 12 | 34 |
| 2019 November | 12 | 4 | 16 |
| 2019 October | 15 | 8 | 23 |
| 2019 September | 15 | 2 | 17 |
| 2019 August | 13 | 9 | 22 |
| 2019 July | 14 | 15 | 29 |
| 2019 June | 47 | 25 | 72 |
| 2019 May | 91 | 53 | 144 |
| 2019 April | 33 | 31 | 64 |
| 2019 March | 11 | 1 | 12 |
| 2019 February | 19 | 5 | 24 |
| 2019 January | 13 | 5 | 18 |
| 2018 December | 12 | 7 | 19 |
| 2018 November | 20 | 8 | 28 |
| 2018 October | 8 | 1 | 9 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 36 | 4 | 40 |
| 2018 March | 12 | 3 | 15 |
| 2018 February | 5 | 2 | 7 |
| 2018 January | 9 | 2 | 11 |
| 2017 December | 9 | 2 | 11 |
| 2017 November | 10 | 4 | 14 |
| 2017 October | 12 | 3 | 15 |
| 2017 September | 9 | 2 | 11 |
| 2017 August | 17 | 7 | 24 |
| 2017 July | 19 | 4 | 23 |
| 2017 June | 16 | 5 | 21 |
| 2017 May | 32 | 10 | 42 |
| 2017 April | 19 | 5 | 24 |
| 2017 March | 18 | 18 | 36 |
| 2017 February | 17 | 7 | 24 |
| 2017 January | 13 | 4 | 17 |
| 2016 December | 19 | 2 | 21 |
| 2016 November | 17 | 7 | 24 |
| 2016 October | 14 | 9 | 23 |
| 2016 September | 21 | 6 | 27 |
| 2016 August | 22 | 2 | 24 |
| 2016 July | 18 | 3 | 21 |
| 2016 June | 17 | 13 | 30 |
| 2016 May | 21 | 14 | 35 |
| 2016 April | 26 | 23 | 49 |
| 2016 March | 28 | 15 | 43 |
| 2016 February | 20 | 20 | 40 |
| 2016 January | 20 | 18 | 38 |
| 2015 December | 15 | 15 | 30 |
| 2015 November | 2 | 13 | 15 |
| 2015 October | 12 | 12 | 24 |
| 2015 September | 13 | 14 | 27 |
| 2015 August | 7 | 5 | 12 |
| 2015 July | 9 | 5 | 14 |
| 2015 June | 6 | 9 | 15 |
| 2015 May | 15 | 6 | 21 |
| 2015 April | 24 | 12 | 36 |
| 2015 March | 24 | 11 | 35 |
| 2015 February | 19 | 7 | 26 |
| 2015 January | 35 | 9 | 44 |
| 2014 December | 28 | 11 | 39 |
| 2014 November | 13 | 5 | 18 |
| 2014 October | 30 | 9 | 39 |
| 2014 September | 36 | 6 | 42 |
| 2014 August | 20 | 7 | 27 |
| 2014 July | 19 | 4 | 23 |
| 2014 June | 22 | 2 | 24 |
| 2014 May | 20 | 1 | 21 |
| 2014 April | 18 | 3 | 21 |
| 2014 March | 15 | 4 | 19 |
| 2014 February | 6 | 9 | 15 |
| 2014 January | 5 | 6 | 11 |
| 2013 December | 13 | 4 | 17 |
| 2013 November | 10 | 6 | 16 |
| 2013 October | 23 | 5 | 28 |
| 2013 September | 12 | 3 | 15 |
| 2013 August | 13 | 1 | 14 |
| 2013 July | 1 | 0 | 1 |
Show all