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Original article
Peritonsillar Infections: Prospective Study of 100 Consecutive Cases
Infecciones periamigdalinas: estudio prospectivo de 100 casos consecutivos
María Costales-Marcos
Corresponding author
Costi2@hotmail.com

Corresponding author.
, Fernando López-Álvarez, Faustino Núñez-Batalla, Carla Moreno-Galindo, César Álvarez Marcos, José Luis Llorente-Pendás
Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Principado de Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Peritonsillar infections are the most common infections of deep tissues of the head and neck region both in adults and children&#44; with an incidence of approximately 30 cases per 100<span class="elsevierStyleHsp" style=""></span>000 population per year&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Furthermore&#44; despite the widespread use of antibiotics&#44; they are the most common suppurative complication in tonsillar infections&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The natural history of infections in the peritonsillar region is represented by 2 main entities&#58; phlegmon and peritonsillar abscess&#46; Each reflects a separate stage in the evolution of the inflammatory process originating from an exudative tonsillar infection&#46; Peritonsillar abscess is defined as a purulent collection located between the tonsillar capsule&#44; the superior constrictor muscle of the pharynx and the palatopharyngeal muscle&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the pathophysiology of peritonsillar infections&#44; phlegmon would represent a stage prior to an abscess&#44; in which the peritonsillar inflammation process is not limited&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although group A &#946;-haemolytic streptococcus &#40;<span class="elsevierStyleItalic">Streptococcus pyogenes</span>&#41; is usually the pathogen involved in the aetiology of this entity&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> in most cases the infection corresponds to a mixed flora of aerobic and anaerobic agents&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Since there are no clinical guidelines for the management of this disease&#44; treatment varies between countries and even between hospitals within the same country&#44; in aspects such as treatment regime &#40;outpatient or inpatient&#41;&#44; method of drainage and antibiotic therapy employed&#46; If peritonsillar infections are not treated properly there is a risk of developing serious complications such as thrombosis of the internal jugular vein&#44; mediastinitis&#44; pericarditis&#44; pneumonia&#44; formation of pseudoaneurysms and even sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The mortality rate of patients who develop these complications can reach 42&#37; in cases of mediastinitis or serositis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Nevertheless&#44; although occasionally the development of peritonsillar infection is torpid&#44; morbidity and mortality are low if it is treated correctly&#44; and hence the importance of knowing its anatomical characteristics&#44; triggering factors&#44; clinical aspects and therapeutic alternatives&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study is to review the diagnostic and therapeutic management of 100 consecutive cases collected at our service between the years 2008 and 2010&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We performed a descriptive&#44; prospective study of the management of patients who were diagnosed and treated for peritonsillar infection between April 2008 and October 2010&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The diagnosis of peritonsillar infection was mainly based on anamnesis and physical examination&#46; We collected the following clinical variables&#58; age&#44; gender&#44; history of recurrent tonsillitis&#44; previous episodes of phlegmon&#47;abscess&#44; evolution&#44; previous antibiotic therapy and its duration &#40;the information was provided by patients or their relatives&#41;&#44; symptoms at onset&#44; physical examination findings and therapeutic procedure applied&#46; We also recorded the length of hospital stay&#44; treatment prescribed at discharge&#44; recurrence of the process and performance of subsequent tonsillectomy&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Following the protocol used in our department for the management of peritonsillar infections&#44; all patients attending the Emergency Service with symptoms and exploration consistent with the diagnosis of peritonsillar infection were admitted for intravenous antibiotic therapy&#44; analgesia and possible intravenous corticosteroids&#46; According to Szuhay and Tewfik&#44; a diagnosis of phlegmon or peritonsillar abscess was based primarily on the obtention of pus with needle aspiration performed on patients upon admission&#44; in the region of maximum peritonsillar bulging&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The criteria for hospital discharge included clinical and analytical improvement of the patient&#46;We used the statistical software SPSS 19&#46;0 for Windows to conduct the statistical analysis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">We analysed 100 consecutive patients diagnosed with peritonsillar infection at our hospital between April 2008 and October 2010&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the main clinical and epidemiological characteristics of patients included in the study&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The ages of the patients included in the study ranged from 4 to 81 years&#44; with a mean value of 34 years&#46; As for gender&#44; the ratio in adults was 1&#46;1&#47;1 in favour of males &#40;53 males and 47 females&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In total&#44; 77&#37; of patients had no documented history of repeated bacterial tonsillitis&#46; In most patients &#40;86&#37;&#41;&#44; the episode of peritonsillar infection was the first with these characteristics&#46; However&#44; in 9&#37; of cases&#44; the episode was a second occurrence and in 5&#37; it was a third&#44; fourth and even in 1 case&#44; the fifth episode with the same characteristics&#46; The vast majority &#40;97&#37;&#41; had no prior history of tonsillectomy&#59; nevertheless&#44; 2 patients had undergone tonsillectomy in childhood&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The time elapsed between onset of symptoms and diagnosis of the episode was a minimum of 2 and a maximum of 6 days&#44; with a mean latency of 3 days&#46; Less than half of patients &#40;45&#37;&#41; had not received any doses of antibiotic treatment before attending the Emergency Service&#46; Within the group of patients &#40;55&#37;&#41; who were being treated with antibiotics as prescribed by their primary care physician&#44; the most frequently used drug &#40;49 patients&#41; was a combination of amoxicillin&#47;clavulanate at a dose of 500<span class="elsevierStyleHsp" style=""></span>mg&#47;125<span class="elsevierStyleHsp" style=""></span>mg in 42 patients and 875<span class="elsevierStyleHsp" style=""></span>mg&#47;125<span class="elsevierStyleHsp" style=""></span>mg in 7 patients&#46; Only 2 patients were prescribed a macrolide &#40;azithromycin 500<span class="elsevierStyleHsp" style=""></span>mg&#41; and 4 patients had taken both drugs consecutively before attending the Emergency Service&#46; The mean duration of treatment prior to diagnosis was 2 days &#40;range&#58; 1&#8211;12 days&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the clinical characteristics of patients&#46; The clinical symptoms characterised by odynodysphagia&#44; fever&#44; trismus&#44; bulging of the anterior pillar&#44; deviation of the uvula to the contralateral side and laterocervical lymphadenopathy were present in 77&#37; of cases&#46; In 30&#37; of patients we did not find fever and trismus was absent in 23&#37; of cases&#46; The absence of trismus did not rule out the presence of peritonsillar abscess&#46; In the haemogram which patients underwent upon admission&#44; the mean value of leukocytes was 16&#44;922&#47;&#956;l &#40;7300&#8211;33<span class="elsevierStyleHsp" style=""></span>400&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">As mentioned previously&#44; upon admission all patients underwent puncture-aspiration in the most convex part of the anterior tonsillar pillar&#46; No purulent material was obtained in 62 cases &#40;62&#37;&#41;&#44; leakage of pus was observed in 32 cases &#40;32&#37;&#41;&#44; in 5 patients &#40;5&#37;&#41; we noted a spontaneous drainage of purulent material and in 1 case &#40;1&#37;&#41; puncture was not performed at the time of diagnosis due to trismus&#46; Based on this result we classified patients into those with a diagnosis of phlegmon&#44; when there was no discharge of pus &#40;62&#37;&#41;&#44; or abscess&#44; when puncture led to the leakage of purulent material &#40;38&#37;&#41;&#46; Clinical signs significantly associated with the presence of peritonsillar abscess were the presence of trismus &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; contralateral deviation of the uvula &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and bulging of the anterior pillar of the affected side &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; We did not find a significant association with the rest of the clinical data recorded&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">All patients were hospitalised and treated with intravenous antibiotics&#46; The combination of amoxicillin&#47;clavulanate 1000<span class="elsevierStyleHsp" style=""></span>mg&#47;200<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h was the most widely used antibiotic treatment &#40;83&#37; of patients&#41;&#44; followed by the association between clindamycin 600<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h and gentamicin 240<span class="elsevierStyleHsp" style=""></span>mg every 24<span class="elsevierStyleHsp" style=""></span>h &#40;14&#37; of patients&#41;&#46; Three patients received amoxicillin&#47;clavulanate according to the previous dosage but&#44; due to lack of favourable evolution after 5 days&#44; were changed to a combination of clindamycin and gentamicin as described above&#46; In all cases&#44; antibiotic treatment was carried out empirically and duration of intravenous therapy varied between 1 day &#40;only 1 case was treated for 24<span class="elsevierStyleHsp" style=""></span>h&#41; and 7 days&#46; Most patients &#40;82&#37;&#41; received intravenous antibiotic treatment for at least 3 days&#46; All patients were given a dose of intravenous corticosteroids &#40;methylprednisolone 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#41; upon admission&#44; as well as intravenous analgesia&#46; All patients evolved satisfactorily and we did not observe progress of the infection to more serious complications&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">All patients received oral antibiotic therapy at discharge for 7 days&#46; Treatment consisted in amoxicillin&#47;clavulanate 1000<span class="elsevierStyleHsp" style=""></span>mg&#47;62&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#44; in 2 tablets every 12<span class="elsevierStyleHsp" style=""></span>h in 83&#37; of cases and clindamycin 300<span class="elsevierStyleHsp" style=""></span>mg every 6<span class="elsevierStyleHsp" style=""></span>h in 17&#37; of cases&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">These cases of peritonsillar infection were the first collected during the time of study in 95&#37; of patients&#44; whilst 1&#37; experienced a new episode and 4&#37; presented 2 consecutive episodes&#46; In 26 cases &#40;26&#37;&#41; we suggested performing tonsillectomy after the episode of peritonsillar infection&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Most studies published in current literature are based on a retrospective analysis of cases&#46; Thus&#44; their results reflect the management of this condition in 10&#8211;15 years evolution&#46; In order to reduce the heterogeneity inherent to most retrospective series&#44; we have chosen to analyse prospectively 100 consecutive cases treated at our hospital according to the same diagnostic and therapeutic protocol&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In our series&#44; 55&#37; of patients were receiving antibiotic therapy for the treatment of pharyngotonsillitis&#46; This finding is more consistent with the classical concept that peritonsillar infection is due to a torpid evolution of bacterial tonsillitis&#46; However&#44; this percentage is higher than that described in the literature&#44; where prior pharyngotonsillar infection was only reported in between 11&#37; and 45&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> The absence of prior tonsillar infection would support the theory that the origin of peritonsillar infection is cellulitis of Weber&#39;s salivary glands&#46; These small mucous glands are located in the superior pole of the tonsillar bed and the soft palate&#46; When cellulitis of these glands takes place and inflammation progresses&#44; it leads to symptoms which are clinically indistinguishable from those caused when a tonsillar infection does not evolve favourably&#46; This observation would also justify the development of peritonsillar infections in patients who had undergone prior tonsillectomy&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The diagnosis of this entity is simple and is based on clinical data and physical exploration&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is characterised by the presence of unilateral inflammatory signs and symptoms&#44; even in the absence of febrile syndrome&#46; The presence of trismus&#44; bulging of the anterior pillar and deviation of the uvula to the contralateral side can help to distinguish between a phlegmonous early stage and peritonsillar abscess without requiring puncture&#46; While this datum confirms the reports published by Kilty et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> it should be taken with caution since&#44; as seen in our study&#44; up to 23&#37; of cases do not present significant trismus&#46; Some authors advocate the use of ultrasound for diagnosis and to conduct guided punctures&#44; as well as computed tomography &#40;CT&#41; in uncooperative paediatric patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">One of the hypotheses which we considered at the beginning of the study was that an inappropriate use of antibiotics in the treatment of pharyngitis favoured the development of complications&#44; specifically the use of macrolides&#44; due to the high rate of resistance among the Spanish population&#46; However&#44; although most patients were taking antibiotics at the time of diagnosis of peritonsillar infection&#44; we found that only 3&#37; of patients who had taken antibiotics previously had taken a macrolide and most were being treated adequately with amoxicillin&#47;clavulanate&#46; Nevertheless&#44; we believe that not taking the appropriate dosage or failure to adequately comply with the correct antibiotic pattern could be a favouring factor since most authors report a higher rate of peritonsillar infections in patients treated with macrolides&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In our series we found no relationship between a history of repeated pharyngotonsillitis and the development of peritonsillar infection&#46; This coincides with the findings in other series&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; we did observe a relationship between suffering repeated pharyngotonsillitis and suffering more than one episode of phlegmon&#47;abscess&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Management on an outpatient basis or hospitalisation of these patients is a source of disagreement between various authors &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; While in countries such as the United Kingdom the vast majority of patients are admitted&#44; in the United States they are mostly managed as outpatients&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In our series&#44; following the protocol at our service&#44; we admitted these patients in order to administer intravenous antibiotics and provide hydration and nutritional support&#46; Nevertheless&#44; we believe that&#44; following the therapeutic regime of Al Yaghchi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> certain patients without risk factors could benefit from outpatient management&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Drainage of the purulent material is part of the treatment &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The most appropriate method for this task remains controversial&#44; although both puncture-aspiration and incision-drainage seem to be equally effective&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;21</span></a> In our action protocol&#44; we use puncture-aspiration at the time of diagnosis&#46; According to the leakage or not of purulent material&#44; we classify the infection as phlegmon or abscess&#46; The management guide for peritonsillar abscesses proposed by Herzon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> suggests that puncture-aspiration can be used as the only drainage procedure&#44; as it obtains a resolution rate of 96&#37;&#44; and leaves incision-drainage as an alternative for cases of failure of the first technique&#46; These authors emphasise the scarce discomfort&#44; technical simplicity and low cost of the technique&#44; as well as the fact that it does not require specialised equipment&#46; Some authors advocate performing tonsillectomy immediately after draining the abscess &#40;quinsy or hot tonsillectomy&#41; due to the low rate of complications and recurrences&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> In our study&#44; most patients evolved adequately without having to repeat the puncture or perform an incision for drainage&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Antibiotic treatment was established empirically&#44; with the first option being intravenous amoxicillin-clavulanate at high doses&#46; This treatment progressed adequately in 84&#37; of cases&#44; including those previously treated with this same combination&#46; From this we can conclude that most resistances remain dose-dependent&#46; We believe that a combination of clindamycin and gentamicin may be an adequate alternative in cases of &#946;-lactam allergy or unfavourable evolution with the first option&#46; Other authors advocate the use of cefotaxime or penicillin alone or combined with metronidazole&#44; with similar results&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;27</span></a> We believe that administration of a single dose of corticosteroids can be very useful&#44; having observed&#44; like other authors&#44; a faster improvement of symptoms such as dysphagia&#44; pain and trismus&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In accordance with other authors&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> we believe that microbiological identification studies are unnecessary&#44; since empirical therapy is generally effective before culture results are obtained&#46; In addition&#44; many patients take antibiotics previously&#44; so&#44; very often&#44; the results of the culture do not identify the causative agent&#46; Conducting cultures and antibiograms would only be useful in cases of infections with very unfavourable evolution and in immunocompromised patients&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">According to Wikst&#233;n et al&#46; the risk of recurrence is 10&#37;&#8211;15&#37; depending on the follow-up period&#46; This rate increases to 50&#37; in patients younger than 40 years and in those with a history of repeated infections&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> Our recurrence rate was 5&#37;&#44; which would confirm the effectiveness of our protocol&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Regarding the indication for tonsillectomy after an episode of peritonsillar infection&#44; as described in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;31</span></a> we do not consider having suffered such an episode as an absolute criterion for the intervention&#46; However&#44; in patients with repeated pharyngotonsillitis and in those cases with more than one peritonsillar event&#44; we support the indication of delayed tonsillectomy&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We have not collected any cases of serious complications during this time period&#44; since cases of mediastinitis&#44; necrotising fasciitis or septic embolisms are more common in severely immunocompromised patients or in those who have suffered a major delay in diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0150" class="elsevierStylePara elsevierViewall">Peritonsillar infection is the most common complication of bacterial pharyngotonsillitis&#46; Although this entity is likely to cause high morbidity and mortality&#44; it has an excellent prognosis when properly treated&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Due to the absence of clinical practice guidelines for the management of this disorder there are various treatment protocols&#46; From our experience&#44; we believe that puncture-aspiration in the most convex peritonsillar region and administration of intravenous antibiotics represents a safe and effective protocol in the management of these patients&#46; Further&#44; controlled studies would be required in order to determine the efficacy and safety of management on an outpatient basis compared to hospital admission&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interests</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Resumen"
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    "fechaRecibido" => "2011-10-25"
    "fechaAceptado" => "2012-01-02"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Peritonsillar infection"
            1 => "Abscess"
            2 => "Cellulitis"
            3 => "Tonsillitis"
          ]
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Infecci&#243;n periamigdalina"
            1 => "Absceso"
            2 => "Flem&#243;n"
            3 => "Amigdalitis"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Peritonsillar infection is the most frequent complication of acute tonsillitis&#46; Peritonsillar infections are collections of purulent material&#44; usually located between the tonsillar capsule and the superior constrictor of the pharynx&#46; Peritonsillar infection can be divided into abscess and cellulitis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We prospectively analysed the clinical data from 100 patients with peritonsillar infection from 2008 to 2010&#46; The diagnosis of abscess or peritonsillar cellulitis was primarily based on obtaining pus through fine-needle aspiration&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seventy-seven percent of patients had no history of recurrent tonsillitis and 55&#37; were receiving antibiotic treatment&#46; Sixty-two cases were peritonsillar abscess and the rest were cellulitis&#46; <span class="elsevierStyleItalic">Trismus</span>&#44; uvular deviation and anterior pillar bulging were statistically associated with peritonsillar abscess &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;005&#41;&#46; All patients were admitted to hospital and treated with puncture-drainage&#44; intravenous antibiotics &#40;amoxicillin&#47;clavulanate in 83&#37; of cases&#41; and a single dose of steroids&#46; All patients were discharged on oral antibiotic therapy&#46; The mean length of hospital stay was 3 days and the recurrence rate was 5&#37;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Due to the absence of clinical practice guidelines&#44; there are different therapeutic protocols&#46; According to our experience&#44; puncture-aspiration and administration of intravenous antibiotics is a safe&#44; effective way to treat these patients&#46; To determine the efficacy and safety of outpatient management&#44; controlled studies would be needed&#46;</p>"
      ]
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La infecci&#243;n periamigdalina supone la complicaci&#243;n m&#225;s frecuente de una amigdalitis&#46; Se define como una colecci&#243;n purulenta localizada entre la c&#225;psula amigdalar y el m&#250;sculo constrictor superior de la faringe&#46; Puede clasificarse en flem&#243;n y absceso periamigdalino&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presentamos un estudio prospectivo descriptivo de 100 infecciones periamigdalinas diagnosticadas entre los a&#241;os 2008 y 2010&#46; Se analizaron diversas variables cl&#237;nico-epidemiol&#243;gicas y el manejo de estos pacientes&#46; El diagn&#243;stico de flem&#243;n o absceso periamigdalino se bas&#243; fundamentalmente en la obtenci&#243;n de pus mediante punci&#243;n-aspiraci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 77&#37; de los pacientes no ten&#237;an antecedentes de amigdalitis de repetici&#243;n y el 55&#37; estaban recibiendo tratamiento antibi&#243;tico&#46; En el 62&#37; de los casos se clasific&#243; como absceso y en el 38&#37; como flem&#243;n periamigdalino&#46; La presencia de <span class="elsevierStyleItalic">trismus</span>&#44; desviaci&#243;n contralateral de la &#250;vula y el abombamiento del pilar anterior se relacion&#243; con la presencia de absceso &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Todos los pacientes fueron ingresados y tratados con punci&#243;n-drenaje&#44; antibioterapia intravenosa &#40;amoxicilina&#47;clavul&#225;nico en el 83&#37; de los casos&#41; y una dosis de corticoides&#46; Al alta&#44; todos los pacientes recibieron antibioterapia oral&#46; La estancia media fue de 3 d&#237;as y la tasa de recurrencias del 5&#37;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Debido a la ausencia de gu&#237;as de pr&#225;ctica cl&#237;nica&#44; existen diversos protocolos terap&#233;uticos&#46; De acuerdo a nuestra experiencia&#44; la punci&#243;n-aspiraci&#243;n y la administraci&#243;n de antibioterapia intravenosa&#44; es una opci&#243;n segura y eficaz en el manejo de estos pacientes&#46; Para determinar la eficacia y seguridad del manejo ambulatorio o mediante ingreso de estos pacientes&#44; ser&#237;an necesarios estudios controlados&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Costales-Marcos M&#44; et al&#46; Infecciones periamigdalinas&#58; estudio prospectivo de 100 casos consecutivos&#46; Acta Otorrinolaringol Esp&#46; 2012&#59;63&#58;212&#8211;7&#46;</p>"
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        "tabla" => array:1 [
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gender</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;53&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;47&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mean age</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 years &#40;4&#8211;81 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Repeated tonsillitis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;23&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Previous peritonsillar infection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laterality</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;59&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;41&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mean latency until diagnosis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 days &#40;2&#8211;7 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Prior antibiotic therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;55&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diagnosis</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Phlegmon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;62&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;38&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Treatment</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Intravenous amoxicillin&#47;clavulanate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;83&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mean hospital stay</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 days &#40;1&#8211;7 days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Recurrences</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Subsequent tonsillectomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;26&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main Clinical and Epidemiological Characteristics&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Symptom&#47;sign&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">No&#46; of patients&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Odynodysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bulging of anterior pillar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contralateral displacement of uvula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95 &#40;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cervical lymphadenopathies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 &#40;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fever&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Trismus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77 &#40;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ptyalism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dysphonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Uvula hydrops&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dyspnoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "nota" => "<p class="elsevierStyleNotepara">Patients normally presented more than 1 symptom&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Presentation Symptoms in 100 Patients With Peritonsillar Infection&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment regime&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Number of patients&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Method&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Success&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Mehanna et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#37; hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#37; punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#37; outpatient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#37; incision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#37; incision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#37; punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stringer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; outpatient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Incision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Herzon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; outpatient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ophir et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#37; outpatient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#37; hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">75&#46;4&#37; punction 23&#46;8&#37; incision 0&#46;8&#37; <span class="elsevierStyleItalic">quinsy</span> tonsillectomy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spires et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; outpatient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Punction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                          "etal" => false
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                            0 => "G&#46; Szuhay"
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                    0 => array:1 [
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Article information
ISSN: 21735735
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos