Images in Otorhinolaryngology
Metastatic Cervical Carcinoma of Unknown Primary
Carcinoma escamoso cervical metastásico de origen desconocido
a Servicio de Otorrinolaringología y Cirugía de Cabeza y Cuello, Hospital Clínic de Barcelona, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, Spain
c Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), Barcelona, Spain
d Facultad de Medicina, Universitat de Barcelona, Barcelona, Spain
e Head Neck Clínic, Agència de Gestió d’Ajuts Universitaris i de Recerca AGAUR, 2017-SGR-01581, Barcelona, Spain
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We present a case of a smoker and drinker, who consulted with a cervical tumour of 3 months’ duration. FNA showed metastasis of squamous cell carcinoma with a pattern suggestive of p16+, although limited by the scarce material in the cell block. No tumour was evident in the airway with white light or narrow band light (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Computed tomography and positron emission tomography (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) showed no evidence of primary tumour either. Bilateral palatine and lingual tonsillectomy with lymph node emptying helped detect the tumour.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Pathological anatomy confirmed a non-keratinizing squamous cell carcinoma associated with human papillomavirus in the right palatine tonsil (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), A) Panoramic view of H&E staining of a section of the right palatine tonsil. B) Panoramic view of immunohistochemistry against p16, showing intense and diffuse expression highlighting the neoplastic areas. C) Higher magnification view of the carcinoma (H&E 10×), highlighting the endophytic growth and solid nests towards the tonsillar crypts. D) Higher magnification view (10×) of the neoplasm showing positivity for p16 in the tumour nests.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histological aspect of the lymph node metastasis (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). A) Panoramic view of H&E staining of a section of the adenopathic conglomerate showing infiltration by non-keratinising cystic squamous cell carcinoma. B) Panoramic view of immunohistochemistry against p16, showing intense and diffuse positivity in the metastatic carcinoma.</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Remacha J, Castillo P, Vilaseca I. Carcinoma escamoso cervical metastásico de origen desconocido. 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