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Ojea Calvo, A. Núñez López, F. Domínguez Freire, A. Alonso Rodrigo, B. Rodríguez Iglesias, J. Benavente Delgado, J.M. Barros Rodríguez, A. González Piñeiro, M. Otero García, D. López Bellido" "autores" => array:10 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Ojea Calvo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Núñez López" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Domínguez Freire" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Alonso Rodrigo" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Rodríguez Iglesias" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Benavente Delgado" ] 6 => array:2 [ "nombre" => "J.M." "apellidos" => "Barros Rodríguez" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "González Piñeiro" ] 8 => array:2 [ "nombre" => "M." "apellidos" => "Otero García" ] 9 => array:2 [ "nombre" => "D." "apellidos" => "López Bellido" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480603728927?idApp=UINPBA00004N" "url" => "/02104806/0000002700000002/v1_201304251708/S0210480603728927/v1_201304251708/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480603728903" "issn" => "02104806" "doi" => "10.1016/S0210-4806(03)72890-3" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "72890" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2003;27:123-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1165 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 826 "PDF" => 333 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Tumores vesicales inusuales: carcinoma epidermoide, adenocarcinoma y sarcoma primarios. comportamiento clínico. nuestra experiencia" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "123" "paginaFinal" => "131" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "“Unusual tumours of the bladder: primary epidermoid carcinoma, adenocarcinoma and sarcoma. Clinical behaviour. our experience”" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. Queipo Zaragozá, F. Chicote Pérez, A. Borrell Palanca, J.F. Beltrán Meseguer, C. Alcalá-Santaella Casanova, B. Martínez García, F. Pastor Sempere" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Queipo Zaragozá" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Chicote Pérez" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Borrell Palanca" ] 3 => array:2 [ "nombre" => "J.F." "apellidos" => "Beltrán Meseguer" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Alcalá-Santaella Casanova" ] 5 => array:2 [ "nombre" => "B." "apellidos" => "Martínez García" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Pastor Sempere" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480603728903?idApp=UINPBA00004N" "url" => "/02104806/0000002700000002/v1_201304251708/S0210480603728903/v1_201304251708/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Análisis multivariado de recidiva y progresión en el carcinoma de células transicionales de vejiga en estadio t1. valor pronóstico de p53 y ki67" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "132" "paginaFinal" => "141" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Rodríguez Alonso, S. Pita Fernández, J. González-Carreró, J.L. Nogueira March" "autores" => array:4 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Rodríguez Alonso" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Pita Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "González-Carreró" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J.L." "apellidos" => "Nogueira March" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">****</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital Arquitecto Marcide. El Ferrol (La Coruña)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Epidemiología Clínica y Bioestadística. Hospital Juan Canalejo. La Coruña. Servicios de" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Anatomía Patológica y" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Urología. Hospital Xeral-Cíes. Vigo (Pontevedra)" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. A. Rodríguez Alonso Servicio de Urología Hospital Arquitecto Marcide Ctra. San Pedro de Leixa, s/n 15405 El Ferrol (A Coruña)" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "“Multivariate analysis of recurrence and progression in stage t1 transitional cell bladder carcinoma. Prognostic value of p53 and ki67”" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-06-13" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec86810" "palabras" => array:6 [ 0 => "p53" 1 => "ki67" 2 => "Neoplasia vesical" 3 => "Recidiva" 4 => "Progresión" 5 => "Pronóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86809" "palabras" => array:6 [ 0 => "p53" 1 => "ki67" 2 => "Bladder neoplasm" 3 => "Recurrence" 4 => "Progression" 5 => "Prognosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Establecer los factores pronósticos de recidiva y progresión en el carcinoma de células transicionales de vejiga en estadio T1, prestando especial atención al valor pronóstico de p53 y ki67.</p> <span class="elsevierStyleSectionTitle">Material y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">175 pacientes con tumor vesical incidente de la categoría T1. El estudio inmunohistoquímico fue realizado con los anticuerpos monoclonales DO7, para p53 y MIB-1, para ki67. Se utilizó la metodología de Kaplan-Meier y se realizó un análisis multivariado de regresión de Cox, para determinar variables asociadas a recidiva y progresión. Se realizaron asimismo curvas ROC para p53 y ki67.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El seguimiento medio fue de 8,55 años. La supervivencia libre de recidiva a los 5 y 12 años fue 57,98% y 48,47%. Las variables independientes de recidiva fueron: grado histológico, multifocalidad tumoral, tamaño tumoral >3 cm, presencia de carcinoma in situ y expresión de ki67. La supervivencia libre de progresión a los 5 y 12 años fue 83,12% y 75,63%. Las variables independientes de progresión fueron: edad, multifocalidad tumoral, morfología microscópica sólida, expresión de p53 y expresión de ki67.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La morfología microscópica sólida y la expresión de p53 son las variables con mayor capacidad para predecir progresión tumoral. Se observa una correlación positiva entre la expresión de p53 y la progresión, de forma que cuanto mayor es la expresión de p53, mayor es la probabilidad de progresión. La multifocalidad tumoral y la expresión de ki67 >27% son los principales factores pronósticos de recidiva.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To establish prognostic factors of recurrence and progression in stage T1 transitional cell bladder carcinoma, paying special attention to prognostic value of p53 and ki67.</p> <span class="elsevierStyleSectionTitle">Materials And Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">175 patients with incident bladder tumour at T1 category. The immunohistochemical study was performed using the monoclonal antibodies DO-7, for p53 and MIB-1, for ki67. Kaplan-Meier methodology was used, and a multivariate analysis using Cox’s proportional hazards model was carried out in order to determine the variables associated with recurrence and progression. ROC curves were also drawn up.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average follow up period was 8.55 years. 5 and 12-year recurrence-free survival rates were 57.98% and 48.47%. The independent variables for recurrence were histological grade, tumour multifocality, tumour size >3 cm, presence of carcinoma in situ and ki67 expression. 5 and 12-year progression-free survival rates were 83.12% and 75.63%. The independent variables for progression were age, tumour multifocality, solid microscopic morphology, p53 expression and ki67 expression.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Solid microscopic pattern and p53 expression are the variables which best predict progression. A positive relationship was observed between p53 and progression: the greater the expression of p53, the greater the progression. Tumour multifocality and ki67 expression >27% are the main prognostic factors for recurrence.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influence of review pathology on study outcome of a randomized multicentre superficial bladder cancer trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.A. Witjes" 1 => "Kiemeney Lalm" 2 => "H.E. Schaafsma" 3 => "F.M.J. 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Journal Information
Análisis multivariado de recidiva y progresión en el carcinoma de células transicionales de vejiga en estadio t1. valor pronóstico de p53 y ki67
“Multivariate analysis of recurrence and progression in stage t1 transitional cell bladder carcinoma. Prognostic value of p53 and ki67”