array:22 [ "pii" => "S0210480607737695" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73769-5" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73769" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:1082-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1133 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 655 "PDF" => 470 ] ] "itemAnterior" => array:18 [ "pii" => "S0210480607737683" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73768-3" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73768" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:1076-81" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1171 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 807 "PDF" => 357 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Cirugía de Mohs: Aplicación de la técnica a neoplasias del pene" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1076" "paginaFinal" => "1081" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mohs micrographic surgery: aplication of this technique to penile neoplasms" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Cuevas, E. de Eusebio, E. Díez, I. Castiñeira" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Cuevas" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "de Eusebio" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Díez" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Castiñeira" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737683?idApp=UINPBA00004N" "url" => "/02104806/0000003100000009/v1_201304251851/S0210480607737683/v1_201304251851/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Aplicación de arrays de anticuerpos en el estudio del cáncer vesical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1082" "paginaFinal" => "1088" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Sánchez-Carbayo" "autores" => array:1 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Sánchez-Carbayo" "email" => array:1 [ 0 => "mscarbayo@cnio.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Grupo de Marcadores Tumorales. Centro Nacional de Investigaciones Oncológicas. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1." "correspondencia" => "Correspondencia autora: Dra. M. Sánchez-Carbayo Grupo de Marcadores Tumorales, 208A Centro Nacional de Investigaciones Oncológicas Melchor Fernández Almagro 3. 28029 Madrid. Tel.: +34 917 328 053" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Use of antibodies arrays in the study of bladder cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88406" "palabras" => array:3 [ 0 => "Arrays de anticuerpos" 1 => "Cáncer vesical" 2 => "Proteómica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88405" "palabras" => array:3 [ 0 => "Antibody arrays" 1 => "Bladder cancer" 2 => "Proteomics" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los arrays de anticuerpos representan una tecnología de alto rendimiento muy versátil que permite la detección de múltiples proteínas simultáneamente. Al permitir cuantificar los niveles proteicos multiparamétricamente y analizar modificaciones post-translacionales, permiten mejorar la caracterización funcional de los procesos moleculares asociados con procesos neoplásicos. Más aun, la identificación de los patrones de expresión proteicos característicos de la progresión tumoral y de los distintos subtipos tumorales puede mejorar el manejo clínico del paciente con cáncer vesical y permitir en un futuro próximo el diseño de terapias adaptadas a la agresividad de cada tumor.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Antibodies arrays represent a very versatile high-throughput technology that enables multiple protein detection simultaneously. It allows quantifying protein levels multiparametrically, and analyzing their post-translational modifications, thus improving the funtional characterization of molecular processes associated with neoplasic diseases. Moreover, the identification of protein expression patterns characteristic of tumor progression and of different tumor subtypes can improve the clinical management of patients with bladder cancer. In the near future, they may allow establishing tailored therapies according to the aggresiveness of each specific tumor.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.B. Haab" 1 => "M.J. Dunham" 2 => "P.O. Brown" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Genome Biol" "fecha" => "2001" "volumen" => "2" "numero" => "2" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody arrays: technical considerations and clinical applications in cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Sanchez-Carbayo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1373/clinchem.2005.059592" "Revista" => array:7 [ "tituloSerie" => "Clin Chem" "fecha" => "2006" "volumen" => "52" "numero" => "9" "paginaInicial" => "1651" "paginaFinal" => "1659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16809399" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiplexed protein measurement: technologies and applications of protein and antibody arrays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.F. Kingsmore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrd2006" "Revista" => array:7 [ "tituloSerie" => "Nat Rev Drug Discov" "fecha" => "2006" "volumen" => "5" "numero" => "4" "paginaInicial" => "310" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16582876" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "J.C. Miller" 1 => "H. Zhou" 2 => "J. Kwekel" 3 => "R. Cavallo" 4 => "J. Burke" 5 => "E.B. Butler" 6 => "B.S. Teh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pmic.200390009" "Revista" => array:7 [ "tituloSerie" => "Proteomics" "fecha" => "2003" "volumen" => "3" "numero" => "1" "paginaInicial" => "56" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12548634" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparability study of the emerging protein array platforms with established ELISA procedures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Pang" 1 => "J. Smith" 2 => "D. Onley" 3 => "J. Reeve" 4 => "M. Walker" 5 => "C. Foy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol Meth" "fecha" => "2005" "volumen" => "302" "numero" => "1-2" "paginaInicial" => "1" "paginaFinal" => "12" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solid-phase and bead-based cytokine immunoassay: a comparison" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Jager W De" 1 => "G.T. Rijkers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ymeth.2005.11.008" "Revista" => array:7 [ "tituloSerie" => "Methods" "fecha" => "2006" "volumen" => "38" "numero" => "4" "paginaInicial" => "294" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481197" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profiling bladder cancer using targeted antibody arrays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Sanchez-Carbayo" 1 => "N.D. Socci" 2 => "J.J. Lozano" 3 => "B.B. Haab" 4 => "C. Cordon-Cardo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2353/ajpath.2006.050601" "Revista" => array:7 [ "tituloSerie" => "Am J Pathol" "fecha" => "2006" "volumen" => "168" "numero" => "1" "paginaInicial" => "93" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16400012" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profiling receptor tyrosine kinase activation by using Ab microarrays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "U.B. Nielsen" 1 => "M.H. Cardone" 2 => "A.J. Sinskey" 3 => "G. MacBeath" 4 => "P.K. Sorger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.1633513100" "Revista" => array:8 [ "tituloSerie" => "Proc Natl Acad Sci. U S A" "fecha" => "2003" "volumen" => "100" "numero" => "16" "paginaInicial" => "9330" "paginaFinal" => "9335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12876202" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204505017614" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.S. Gembitsky" 1 => "K. Lawlor" 2 => "A. Jacovina" 3 => "M. Yaneva" 4 => "P. Tempst" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/mcp.M400075-MCP200" "Revista" => array:7 [ "tituloSerie" => "Mol Cell Proteomics" "fecha" => "2004" "volumen" => "3" "numero" => "11" "paginaInicial" => "1102" "paginaFinal" => "1118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15358805" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibodies immobilized as arrays to profile protein post-translational modifications in mammalian cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.S. Ivanov" 1 => "A.S. Chung" 2 => "Z.L. Yuan" 3 => "Y.J. Guan" 4 => "K.V. Sachs" 5 => "J.S. Reichner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/mcp.M300130-MCP200" "Revista" => array:7 [ "tituloSerie" => "Mol Cell Proteomics" "fecha" => "2004" "volumen" => "3" "numero" => "8" "paginaInicial" => "788" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15123764" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samples" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Rai" 1 => "C.A. Gelfand" 2 => "B.C. Haywood" 3 => "D.J. Warunek" 4 => "J. Yi" 5 => "M.D. Schuchard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pmic.200401245" "Revista" => array:7 [ "tituloSerie" => "Proteomics" "fecha" => "2005" "volumen" => "5" "numero" => "1" "paginaInicial" => "3262" "paginaFinal" => "3277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16052621" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.J. States" 1 => "G.S. Omenn" 2 => "T.W. Blackwell" 3 => "D. Fermin" 4 => "J. Eng" 5 => "D.W. Speicher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nbt1183" "Revista" => array:7 [ "tituloSerie" => "Nat Biotechnol" "fecha" => "2006" "volumen" => "24" "numero" => "3" "paginaInicial" => "333" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16525410" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003100000009/v1_201304251851/S0210480607737695/v1_201304251851/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003100000009/v1_201304251851/S0210480607737695/v1_201304251851/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737695?idApp=UINPBA00004N" ]
Journal Information
Aplicación de arrays de anticuerpos en el estudio del cáncer vesical
Use of antibodies arrays in the study of bladder cancer
M. Sánchez-Carbayo1
Corresponding author
mscarbayo@cnio.es
Correspondencia autora: Dra. M. Sánchez-Carbayo Grupo de Marcadores Tumorales, 208A Centro Nacional de Investigaciones Oncológicas Melchor Fernández Almagro 3. 28029 Madrid. Tel.: +34 917 328 053
Correspondencia autora: Dra. M. Sánchez-Carbayo Grupo de Marcadores Tumorales, 208A Centro Nacional de Investigaciones Oncológicas Melchor Fernández Almagro 3. 28029 Madrid. Tel.: +34 917 328 053
Grupo de Marcadores Tumorales. Centro Nacional de Investigaciones Oncológicas. Madrid