array:23 [ "pii" => "S0210480607736288" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73628-8" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73628" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2007;31:233-43" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1213 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 756 "PDF" => 450 ] ] "itemSiguiente" => array:18 [ "pii" => "S021048060773629X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73629-X" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73629" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:244-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 936 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 576 "PDF" => 355 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Cáncer renal incidental en pacientes menores de 40 años: hallazgos clínicos e histopatológicos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "244" "paginaFinal" => "249" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Incidental renal cancer in young adults: clinical and histopathological findings" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "L. Gómez Pérez, F.J. Delgado Oliva" "autores" => array:2 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Gómez Pérez" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Delgado Oliva" ] ] ] 1 => array:2 [ "autoresLista" => "A. Budía Alba, J.L. Ruiz Cerdá, M. Trassiera Villa, F. Jiménez Cruz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Budía Alba" ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "Ruiz Cerdá" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Trassiera Villa" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Jiménez Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060773629X?idApp=UINPBA00004N" "url" => "/02104806/0000003100000003/v1_201304251835/S021048060773629X/v1_201304251835/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480607736276" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73627-6" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73627" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2007;31:211-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 622 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 202 "PDF" => 412 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Criocirugía en el tratamiento del cáncer de próstate" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "211" "paginaFinal" => "232" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cryosurgery in the management of prostate cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Pontones Moreno, J.F. Morera Martínez, C.D. Vera Donoso, J.F. Jiménez Cruz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Pontones Moreno" ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Morera Martínez" ] 2 => array:2 [ "nombre" => "C.D." "apellidos" => "Vera Donoso" ] 3 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607736276?idApp=UINPBA00004N" "url" => "/02104806/0000003100000003/v1_201304251835/S0210480607736276/v1_201304251835/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Biología molecular del carcinoma de células claras renales: Principios para un tratamiento selectivo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "233" "paginaFinal" => "243" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. Grande Pulido, A. Martín Centeno, P. Maroto Rey, E. Solsona Narbón" "autores" => array:4 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Grande Pulido" "email" => array:1 [ 0 => "enrique.grandepulido@pfizer.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Martín Centeno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Maroto Rey" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Solsona Narbón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento Médico de Pfizer" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Oncología Médica Hospital Santa Creu i Sant Pau de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urología. Instituto Valenciano de Oncología" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. E. Grande Pulido Departamento Médico de Pfizer. Avda. de Europa, 20B. 28050 Alcobendas. Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Molecular biology of the clear cell renal cell carcinoma: principles for a selective treatment" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-12-01" "fechaAceptado" => "2007-02-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88147" "palabras" => array:5 [ 0 => "Biología molecular" 1 => "Cáncer" 2 => "Renal" 3 => "VHL" 4 => "VEGF" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88148" "palabras" => array:5 [ 0 => "Molecular biology" 1 => "Cancer" 2 => "Renal" 3 => "VHL" 4 => "VEGF" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El cáncer de células renales (CCR) y más concretamente el subtipo más frecuente de células claras, se he mostrado resistente al tratamiento con quimioterapia y radioterapia cuando afecta a pacientes con metástasis a distancia. En los últimos años se han realizado grandes avances en el campo de la biología molecular que origina este tipo de tumores. Esto ha conducido a un mejor conocimiento del origen de la enfermedad y ha permitido el desarrollo de nuevos fármacos que actúan sobre los factores de crecimiento implicados en el desarrollo del tumor. En este artículo de revisión se resumen de manera concisa los hitos a nivel molecular que originan el desarrollo de los tumores renales de células claras.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Abstract</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Renal cell carcinoma (RCC) and its most frequent subtype, the clear cell hystology type, has shown resistance to chemotherapy and radiotherapy treatment when disease was already spread in patients. Recently, a huge advance in the molecular biology of this tumor has been performed. This fact allowed a deeper and better knowledge of the disease and the development of new drugs that work against the growth factors involved in tumor origin. In this review article it is summarized the molecular milestones that are involved in the development of clear cell renal cell carcinomas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:88 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Schoffski" 1 => "H. Dumez" 2 => "P. Clement" 3 => "A. Hoeben" 4 => "H. Prenen" 5 => "P. 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Journal Information
Biología molecular del carcinoma de células claras renales: Principios para un tratamiento selectivo
Molecular biology of the clear cell renal cell carcinoma: principles for a selective treatment