array:23 [ "pii" => "S0210480601725648" "issn" => "02104806" "doi" => "10.1016/S0210-4806(01)72564-8" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72564" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2001;25:32-45" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 568 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 354 "PDF" => 207 ] ] "itemSiguiente" => array:18 [ "pii" => "S021048060172565X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(01)72565-X" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72565" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2001;25:46-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1369 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1078 "PDF" => 282 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Efectos adversos de la biopsia prostática transrectal. un análisis de 303 procedimientos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "49" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Luján galán, A. Páez bordá, I. Fernández gonzález, I. Romero cajigal, J.M. Gómez de vicente, A. Berenguer sánchez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Luján galán" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Páez bordá" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Fernández gonzález" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Romero cajigal" ] 4 => array:2 [ "nombre" => "J.M." "apellidos" => "Gómez de vicente" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Berenguer sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060172565X?idApp=UINPBA00004N" "url" => "/02104806/0000002500000001/v1_201304251627/S021048060172565X/v1_201304251627/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480601725636" "issn" => "02104806" "doi" => "10.1016/S0210-4806(01)72563-6" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "72563" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2001;25:14-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 56509 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 13067 "PDF" => 43432 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "síndrome de reabsorción postresección transuretral (r.t.u.) de próstata: revisión de aspectos fisiopatológicos, diagnósticos y terapéuticos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "14" "paginaFinal" => "31" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "L.M. Clemente ramos, A. Allona almagro" "autores" => array:2 [ 0 => array:2 [ "nombre" => "L.M." "apellidos" => "Clemente ramos" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Allona almagro" ] ] ] 1 => array:2 [ "autoresLista" => "F. Ramasco rueda, A. Platas sancho, J. Archilla esteban, I. Romero cajigal, C. Corbacho fabregat" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Ramasco rueda" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Platas sancho" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Archilla esteban" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Romero cajigal" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Corbacho fabregat" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480601725636?idApp=UINPBA00004N" "url" => "/02104806/0000002500000001/v1_201304251627/S0210480601725636/v1_201304251627/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Determinación de ploidía de adn mediante citometría de flujo, índice ki-67 y sobre-expresión de proteína p53 en 121 carcinomas superficiales de vejiga t1. estudio retrospectivo. 2ª parte: valor pronóstico y utilidad en la indicación de tratamiento profiláctico con bcg" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "32" "paginaFinal" => "45" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J.L. Moyano calvo, J.M. Poyato galán, A. Ortíz gamiz, A. Molina carranza, J.J. Zerpa railey, H. Toro cepeda, D. Sánchez-barriga peña, J. Castiñeiras fernández" "autores" => array:8 [ 0 => array:3 [ "nombre" => "J.L." "apellidos" => "Moyano calvo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Poyato galán" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Ortíz gamiz" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Molina carranza" ] 4 => array:2 [ "nombre" => "J.J." "apellidos" => "Zerpa railey" ] 5 => array:2 [ "nombre" => "H." "apellidos" => "Toro cepeda" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Sánchez-barriga peña" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Castiñeiras fernández" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. J.L. Moyano Calvo C/ Bogotá, 19, 3 -2º B 41013 Sevilla" ] ] ] 1 => array:3 [ "autoresLista" => "M. De miguel rodríguez, H. Galera davidson" "autores" => array:2 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "De miguel rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "H." "apellidos" => "Galera davidson" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Universitario “Virgen Macarena”. Sevilla" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2000-06-05" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec86279" "palabras" => array:4 [ 0 => "Tumores de vejiga" 1 => "Ploidía" 2 => "Ki-67" 3 => "Proteína p53" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86280" "palabras" => array:4 [ 0 => "Bladder tumors" 1 => "Ploidy" 2 => "Ki-67" 3 => "p53 protein" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar la utilidad del índice Ki-67, la expresión de proteína p53 y la ploidía de ADN para seleccionar grupos que se beneficien de terapia profiláctica con BCG y la capacidad pronóstica comparándola con las variables clásicas (grado, permeación linfática, volumen tumoral, multiplicidad, primario)</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">121 carcinomas vesicales T 1. Nivel de corte para Ki- 67 y p 53 del 10%. Se considera aneuploide cuando el tumor tiene un índice de ADN distinto de 1 ó más del 20% de la población en fase G 2-M. 71 (58,7%) recibieron BCG</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ninguna de las variables clásicas tiene valor pronóstico para recidiva, y de las tres técnicas utilizadas sólo el ser Ki-67 positivo (p.001), confirmándose en el estudio multivariante.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Para progresión tumoral alcanzan significación, la permeación linfática (p.0003), el volumen tumoral (p.016), la ploidía (p.022) y la positividad para p53 (p.007), confirmándose en el estudio multivariante el volumen tumoral y la positividad para p53. Ninguna de las variables fue útil para seleccionar grupos que disminuyeran su recidiva tumoral. Sin embargo los tumores aneuploides y/o Ki-67 positivos que recibieron tratamiento profiláctico progresaron menos (p.009 y p.025 respectivamente). Los p53 negativos tratados también progresaron menos (p.040).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Combinando las variables, sólo los Ki-67 positivo y aneuploides se benefician de tratamiento (p.031)</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ki-67 es la única variable que se correlaciona con recidiva tumoral. La progresión a estadio infiltrante se correlaciona con la positividad para p53 y el volumen tumoral.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Si los resultados se confirman en series más amplias, los tumores Ki-67 positivos y/o aneuploides se beneficiarían de tratamiento profiláctico con BCG</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evaluate the utility of Ki-67 label index, p53 expression and flow cytometry-DNA ploidy in the selection of groups to be treated with prophylactic BCG and the prognostic value compared with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary)</p> <span class="elsevierStyleSectionTitle">Material & method</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">121 superficial bladder tumors T 1. 10% Cut-off level for Ki- 67 and p 53. Aneuplody is defined as a tumor with DNA index different of 1 or more than 20% in G 2-M phase. 71 (58,7%) received BCG</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">In uni and multivariate analysis positivity to Ki-67 is correlated with recurrence.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Progression is correlated with lymphatic permeation (p.0003), volumen (p. 016), ploidy (p.022) and postitivity to p53 (p.007). In multivariate analysis, volume and positivity to p53 are independent variables.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">None were of utility to prevent recurrence, but Ki-67 positive or aneuploid treated tumors had less progression (p.025 and p.009 respectivily). The p53 negative treated tumors had less progression too</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Only Ki- 67 is correlated with tumoral recurrence. P 53 and tumor volume are correlated with stage progression.</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">If the results are confirmed with bigger series, the Ki- 67 positive and/or aneuploid tumors would obtain beneficts of prophylactic treatment with BCG</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:97 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treated history on non-invasive grade I transitional cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.R. Prout" 1 => "B.A. Barton" 2 => "P.P. Giffin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1992" "volumen" => "148" "paginaInicial" => "1" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1613843" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification of bladder tumours based on the cellular patterns: preliminary report of clinical pathological study of 300 cases with a minimum followup of eighty years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Bergkvist" 1 => "A. Ljunqvist" 2 => "G. Mornerger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Chir Scand" "fecha" => "1985" "volumen" => "130" "paginaInicial" => "371" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5842510" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological typing of urinary bladder tumours. International histological classification of tumours, nº 10" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Mostofi" 1 => "L. Sobin" 2 => "H. Torloni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1973" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Current topics in bladder cancer. Short Course # 52" ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1988" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Grading in superficial bladder cancer 1 Morphological criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.R. Pauwels" 1 => "R. Schapers" 2 => "F. Smeets" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1988" "volumen" => "61" "paginaInicial" => "129" "paginaFinal" => "134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3349277" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Grading of human urothelial carcinoma based on nuclear atypia and mitotic frequency II. Prognostic importance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.E. Carbin" 1 => "P. Ekman" 2 => "H. Gustafson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Urol" "fecha" => "1991" "volumen" => "145" "paginaInicial" => "972" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2016812" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of surgical diseases of the urinary tract. Short course #18" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Mostofi" 1 => "I. Sesterhenn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "1989" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Valoración anatomo-clínica de las neoplasias malignas de la vejiga urinaria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Algaba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Act Fund Puigvert" "fecha" => "1989" "volumen" => "8" "paginaInicial" => "77" "paginaFinal" => "102" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors influencing the subjective grading of bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Colpaert" 1 => "G. Goovaerts" 2 => "N. Buyssens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Virchows Arch A" "fecha" => "1987" "volumen" => "411" "paginaInicial" => "479" "paginaFinal" => "484" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the performance of pathologist in the grading of bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Ooms" 1 => "W. Anderson" 2 => "C. Alosns" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Path" "fecha" => "1983" "volumen" => "14" "paginaInicial" => "140" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6832758" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Longitudinal study of patients with bladder cancer: factors associated with disease recurrence and progression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.J. Cutler" 1 => "N.M. Heney" 2 => "G.H. Friedell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "AUA Monographs, Bladder cancer" "paginaInicial" => "35" "paginaFinal" => "46" "serieFecha" => "1982" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.W. Hedley" 1 => "M.L. Friedlander" 2 => "I.W. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Histochem Cytochem" "fecha" => "1983" "volumen" => "31" "paginaInicial" => "1333" "paginaFinal" => "1335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6619538" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA flow citometry in solid tumours: Practical aspects and clinical applications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.G. Dressler" 1 => "S.A. Barrow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Diagn Pathol" "fecha" => "1989" "volumen" => "6" "paginaInicial" => "55" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2645625" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routine clinical flow cytometric DNA analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.L. Vindelov" 1 => "I.J. Christensen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cyto.990110702" "Revista" => array:6 [ "tituloSerie" => "Cytometry" "fecha" => "1990" "volumen" => "11" "paginaInicial" => "753" "paginaFinal" => "770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2272241" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flow Citometric DNA analysis of human solid tumours: a review of the interpretation on DNA Histograms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.P. Wersto" 1 => "R.L. Liblit" 2 => "L.G. Kos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "1991" "volumen" => "22" "paginaInicial" => "1085" "paginaFinal" => "1098" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1743692" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic parameters in superficial bladder cancer: an analysis of 315 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W. Lutzeyer" 1 => "W. Rubben" 2 => "H. Dahm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1982" "volumen" => "127" "paginaInicial" => "250" "paginaFinal" => "252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7062375" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Superficial bladder cancer: progression and recurrence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.M. Heney" 1 => "S. Ahmed" 2 => "M.J. Flanagan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Urol" "fecha" => "1983" "volumen" => "113" "paginaInicial" => "1083" "paginaFinal" => "1086" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in superficial bladder tumours. A study of the European Organisation for research on treatment of cancer: genitourinary tract cancer cooperative group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "O. Dalesio" 1 => "C.C. Schulman" 2 => "R. Sylvester" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1983" "volumen" => "129" "paginaInicial" => "730" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6405056" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrence, progression and survival in bladder cancer. A retrospective analysis of 232 patients with mores than 5 year follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.U. Malmström" 1 => "B.J. Norken" 2 => "B. Andersson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Urol Nephrol" "fecha" => "1987" "volumen" => "21" "paginaInicial" => "185" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3433019" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacillus Calmette-Guerin versus doxorrubicin versus thiotepa: a randomized prospective study in 202 patients with superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.A. Martínez Piñeiro" 1 => "J. Jiménez León" 2 => "L. Martínez Piñero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1990" "volumen" => "143" "paginaInicial" => "502" "paginaFinal" => "506" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2106041" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis de los factores pronósticos en los tumores superficiales de vejiga" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Páez Borda" 1 => "E. Martín Oses" 2 => "M. De La Cal López" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Esp de Urol" "fecha" => "1997" "volumen" => "50" "paginaInicial" => "121" "paginaFinal" => "126" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation and prognostic significance of p53, p21 WAF1/CIP1 and Ki-67 expression in patients with superficial bladder tumors treated with bacillus Calmette-Guerin intravesical therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "A.R. Zlotta" 1 => "J.C. Noel" 2 => "I. Fayt" 3 => "A. Drowart" 4 => "J.P. Van Vooren" 5 => "K. Huygen" 6 => "J. Simon" 7 => "C.C. Schulmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1999" "volumen" => "161" "paginaInicial" => "792" "paginaFinal" => "798" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10022686" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores pronósticos en el carcinoma superficial de vejiga T1. Nuestra experienca" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.L. Moyano Calvo" 1 => "A. Romero Díaz" 2 => "A. Ortíz Gamiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Esp de Urol" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "465" "paginaFinal" => "470" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Herr HW, Jakse G, Sheinfeld J: El tumor vesical T1. Casos prácticos en Urología. Tratamiento del cáncer vesical (primera parte), edición española. Editores Dr. Karl Baraslis y Dr. Mark Soloway, 1996" ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Superficial bladder cancer: the primacy of grade in the development ofinvasive disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F.L. Torti" 1 => "B.L. Lum" 2 => "D. Aston" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1987.5.1.125" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "125" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3806155" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stage T1 bladder cancer: grade is the primary determinant for risk of muscle invasion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Kaubisch" 1 => "B.L. Lum" 2 => "J. Reese" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1991" "volumen" => "146" "paginaInicial" => "28" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2056599" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treated natural history of high risk superficial bladder cancer: 15-year outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.S. Cookson" 1 => "H.W. Herr" 2 => "Z.F. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00005392-199707000-00017" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "158" "paginaInicial" => "62" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9186324" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Irwing" 1 => "H. Zincke" 2 => "M. Droller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Seminars in Urology" "fecha" => "1984" "volumen" => "7" "paginaInicial" => "1" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2499916" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytologic and histologic features of superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.Y. Ro" 1 => "G.A. Staerkel" 2 => "A.G. Ayala" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Urol North Am" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "435" "paginaFinal" => "453" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictability of recurrent and progressive disease in individual patients with primary superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Kiemeney Lalm" 1 => "J.A. Witjes" 2 => "R.P. Heijbroek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1993" "volumen" => "150" "paginaInicial" => "60" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8510276" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La predicción de pronóstico en pacientes con carcinoma de células transicionales de la vejiga urinaria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Angulo" 1 => "M. Sánchez Chapado" 2 => "P. Domínguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Esp de Urol" "fecha" => "1996" "volumen" => "49" "paginaInicial" => "374" "paginaFinal" => "384" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Appropiate endpoints for superficial bladder cancer trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.A. Kalish" 1 => "M.B. Garnick" 2 => "J.P. Richie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1987.5.12.2004" "Revista" => array:5 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "2004" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3681382" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in pTa, pT1 superficial bladder tumours treated with intravesical instillations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.F.A. Mulders" 1 => "A.P.M. Van Der Meyden" 2 => "W.H. Doesburg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1994" "volumen" => "73" "paginaInicial" => "403" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8199828" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progression and survival in transitional bladder cancer: a comparison of established prognostic factors, S-phase fraction and DNA ploidy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.K. Liponnen" 1 => "M.J. Eskelinen" 2 => "S. Nordling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Cancer" "fecha" => "1991" "volumen" => "27" "paginaInicial" => "881" "paginaFinal" => "887" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Superficial bladder cancer treated with BCG: a multivariate analysis of factors affecting tumour progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.W. Herr" 1 => "R.A. Badalament" 2 => "D. Amato" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Urol" "fecha" => "1989" "volumen" => "141" "paginaInicial" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2908949" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of lamina propia invasion on the prognosis of patients with bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Anderstrom" 1 => "S. Johansson" 2 => "S. Nilsson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1980" "volumen" => "124" "paginaInicial" => "23" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7411714" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic significance of vascular invasion in stage T1 bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. López" 1 => "J.C. Angulo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Histopathology" "fecha" => "1995" "volumen" => "27" "paginaInicial" => "278" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Papilloma of the urinary bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.L. Lerman" 1 => "R.V.P. Hutter" 2 => "W.F. Whitmore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1970" "volumen" => "25" "paginaInicial" => "333" "paginaFinal" => "342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5413504" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T1 bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Williams" 1 => "J.C. Hammond" 2 => "N. Saunders" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1977" "volumen" => "49" "paginaInicial" => "663" "paginaFinal" => "668" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/597705" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical significance of flow cytometric deoxyribonucleic acid measurements of deparaffined specimens in bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Miao" 1 => "Z. Wang" 2 => "N. Snag" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1992" "volumen" => "21" "paginaInicial" => "98" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1499623" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study of cellular DNA content by flow cytometry in primary bladder carcinomas. Significance of monoclonal and multiclonal varieties of DNA aneuploidy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Campanella" 1 => "A. Russo" 2 => "S. Plaja" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1992" "volumen" => "21" "paginaInicial" => "58" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1606985" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA pattern, histological grade and multiplicity related to recurrence rate in superficial bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Gustafson" 1 => "B. Tribukait" 2 => "P.L. Eposti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Scand J Urol Hephrol" "fecha" => "1982" "volumen" => "16" "paginaInicial" => "135" "paginaFinal" => "139" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flow cytometry: role in monitoring transitional cell carcinoma of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.W. Devere White" 1 => "C.A. Olsson" 2 => "A.D. Deitch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1986" "volumen" => "28" "paginaInicial" => "15" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3727223" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biological characteristics of T1 papillary bladder cancer: Flow cytometric study of paraffin embedded material" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Bucci" 1 => "V. Pansadoro" 2 => "F. De Paula" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anal Quant Cytol Histol" "fecha" => "1995" "volumen" => "17" "paginaInicial" => "121" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7612132" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deoxyribonucleic acid profile and tumour progression in primary carcinoma in situ of the bladder: a study of 63 patients with grade 3" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "U. Norming" 1 => "B. Tribukait" 2 => "H. Gustafson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1992" "volumen" => "147" "paginaInicial" => "11" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1729494" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multivariate analysis of flow cytometric deoxyribonucleic acid parameters and histological features for prognosis of bladder cancer patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Tachibana" 1 => "N. Deguchi" 2 => "S. Baba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1991" "volumen" => "146" "paginaInicial" => "1530" "paginaFinal" => "1534" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1942334" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.E.M. Blomjous" 1 => "N.W. Schipper" 2 => "J.P.A. Baak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1988" "volumen" => "41" "paginaInicial" => "21" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3343376" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis in bladder cancer. A study of cytometric, morphometric and inmunohistochemical techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Urol Nephrol Suppl" "fecha" => "1994" "volumen" => "160" "paginaInicial" => "1" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical DNA flow cytometry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Oncol Tumor Pharmacoter" "fecha" => "1984" "volumen" => "1" "paginaInicial" => "211" "paginaFinal" => "218" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flow cytometry of depparaffined nuclei compared to histological grading for the pathological evaluation of transitional cell carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1986" "volumen" => "135" "paginaInicial" => "694" "paginaFinal" => "697" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination of Blood group ABH antigen status and DNA ploidy as independent prognostic factor in transitional cell carcinoma of the urinary bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "British J Urol" "fecha" => "1989" "volumen" => "64" "paginaInicial" => "49" "paginaFinal" => "55" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "P53 accumulation, deoxyribonucleic acid ploidy and progression of bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "157" "paginaInicial" => "1250" "paginaFinal" => "1253" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA ploidy, morphometric stereological and P-glycoprotein study of superficial bladder carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1992" "volumen" => "21" "numero" => "suppl" "paginaInicial" => "16" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The DNA content of bladder carcinoma in relation to pathological grading, staging and prognosis: a flow cytometric study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chung Hua Wai Ko Tsa Chih" "fecha" => "1989" "volumen" => "27" "paginaInicial" => "650" "paginaFinal" => "653" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of DNA content in bladder cancer based on flow cytometric ana1ysis of 249 transitional cell carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cyto.990220204" "Revista" => array:6 [ "tituloSerie" => "Cytometry" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "93" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flow cytometry in surgical pathology and cytology of tumours of the genito-urinary tract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Adv Clin Cytol" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "163" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical evaluation of cell deoxyribonucleic acid content measurement by flow cytometry in bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1996" "volumen" => "155" "paginaInicial" => "1887" "paginaFinal" => "1891" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "P53 expression, ploidy and progression in pT1 transitional cell carcinoma of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1994" "volumen" => "73" "paginaInicial" => "533" "paginaFinal" => "537" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of nuclear DNA content and S-phase fraction by flow cytometry in primary papillary superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "1996" "volumen" => "27" "paginaInicial" => "922" "paginaFinal" => "926" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of bromodeoxiurydine high labelled bladder cancer measured by flow cytometry: Does flow cytometric determination predict the prognosis of patients with transitional cell carcinoma of the bladder?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1993" "volumen" => "149" "paginaInicial" => "739" "paginaFinal" => "743" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Stravopoulos EN, Ioackim-Velogianni E, Hastazeris K, etal" ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of Ki-67 for recurrence and progression of superficial bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "158" "paginaInicial" => "385" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of Mib-1 score, p53, EGFr, mitotic index and papillary status in primary superficial (stage pTa/t1) bladder cancer: a prospective comparative study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "20039" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1999" "volumen" => "36" "paginaInicial" => "393" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monoclonal antibody Ki-67 in the study of proliferative activity of bladder carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1992" "volumen" => "148" "paginaInicial" => "1149" "paginaFinal" => "1151" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proliferative activity of urothelial neoplasms: comparison of BrDU incorporation, Ki-67 expression, and nuclear organiser regions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1993" "volumen" => "46" "paginaInicial" => "159" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence of bcl-2, p53 and Ki-67 inmunoreactivity in transitional bladder carcinomas and their clinicopathologic correlates" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "1998" "volumen" => "29" "paginaInicial" => "146" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth fractions of transitional cell carcinomas of the bladder defined by the monoclonal antibody Ki- 67" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1990" "volumen" => "144" "paginaInicial" => "875" "paginaFinal" => "878" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in bladder carcinoma: histological parameters and expression of a cell cycle-related nuclear antigen Ki-67" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/path.1711660107" "Revista" => array:6 [ "tituloSerie" => "J Pathol" "fecha" => "1992" "volumen" => "166" "paginaInicial" => "37" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic value of p53 nuclear overexpression and MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1997" "volumen" => "80" "paginaInicial" => "1472" "paginaFinal" => "1481" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of Ki-67 antigen y p53 protein in urinary bladder cancer: inmunohistochemical analysis of radical cystectomy specimens" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1997" "volumen" => "79" "paginaInicial" => "367" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Accumulation of nuclear p53 and tumour progression in bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199411103311903" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1994" "volumen" => "331" "paginaInicial" => "1259" "paginaFinal" => "1264" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of the proliferation status PCNA and p53 inmunohistochemistry as a prognostic factor for the clinical course of superficial cancer of the urinary bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urologe A" "fecha" => "1995" "volumen" => "34" "paginaInicial" => "146" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of p53 protein overexpression with p53 mutation in bladder cancer: clinical and biologic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lab Inves" "fecha" => "1995" "volumen" => "73" "paginaInicial" => "837" "paginaFinal" => "843" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of overexpression of p53 tumour supressor protein in superficial and invasive transitional cell bladder cancer: comparison with DNA ploidy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0090-4295(99)80216-7" "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1995" "volumen" => "46" "paginaInicial" => "334" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expresión del gen supresor tumoral p53 en los carcinomas transicionales superficiales de vejiga" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "1998" "volumen" => "22" "paginaInicial" => "642" "paginaFinal" => "649" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "P53 status does not predict initial clinical response to bacillus Calmette-Guerin intravesical therapy in T1 bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1988" "volumen" => "159" "paginaInicial" => "1079" "paginaFinal" => "1084" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1993" "volumen" => "85" "paginaInicial" => "53" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 inmunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J of Cancer" "fecha" => "1995" "volumen" => "71" "paginaInicial" => "201" "paginaFinal" => "205" ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Co-operative effects of p53 and pRb alterations in the primary superficial bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1997" "volumen" => "57" "paginaInicial" => "1217" "paginaFinal" => "1221" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluations de la surexpression de la protéine p53 dans le cancer de la vessie: valeur pronostique" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chirugie" "fecha" => "1996" "volumen" => "121" "paginaInicial" => "461" "paginaFinal" => "469" ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic value of p53 in superficially infiltrating transitional cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Urol Nephrol" "fecha" => "1995" "volumen" => "29" "paginaInicial" => "491" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overexpression of p53 protein in a high risk population of patients with superficial bladder cancer before and after bacillus Calmette-Guerin therapy: correlation to clinical outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Onco" "fecha" => "1996" "volumen" => "14" "paginaInicial" => "2646" "paginaFinal" => "2652" ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inmunohistochemical determination of p53 overexpression. AN easy and readily method to identify progression in superficial bladder cancer?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Res" "fecha" => "1997" "volumen" => "25" "numero" => "Suppl 1" "paginaInicial" => "31" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib0420" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of p53 nuclear overexpression and tumour progression in carcinoma in situ of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1994" "volumen" => "152" "paginaInicial" => "388" "paginaFinal" => "392" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib0425" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inmunohistochemical expression of p53 in primary pt1 transitional cell bladder cancer in relation to tumour progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1994" "volumen" => "73" "paginaInicial" => "526" "paginaFinal" => "532" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib0430" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overexpression of p53 protein and its significance for recurrent progressive bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1996" "volumen" => "77" "paginaInicial" => "659" "paginaFinal" => "666" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib0435" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utilidad de la oncoproteina p53-IHQ en el seguimiento del carcinoma vesical: estudio a 5 años" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Esp de Urol" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "840" "paginaFinal" => "848" ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib0440" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inmunohistochemistry of p53 protein in p53 protein transitional cell carcinoma of the bladder using an image analyser. Oncology 1996; 53: 233-240. Grade, category and recurrence rate of superficial lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1993" "volumen" => "72" "paginaInicial" => "736" "paginaFinal" => "739" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib0445" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between p53 overexpression and response to baci1lus Calmette-Guerin therapy in a high risk select population of patients with T1G3 bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1998" "volumen" => "159" "paginaInicial" => "788" "paginaFinal" => "791" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib0450" "etiqueta" => "90." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuclear accumulation of mutant p53 protein: a possible predictor of failure of intravesical therapy in bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1997" "volumen" => "79" "paginaInicial" => "373" "paginaFinal" => "377" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib0455" "etiqueta" => "91." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "P53 mutations in bladder tumors inactivate the transactivation of the p21 and Bax genes, and have a predictive value for clinical outcome after bacillus Calmette-Guerin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00005392-199907000-00017" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1999" "volumen" => "162" "paginaInicial" => "69" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib0460" "etiqueta" => "92." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic markers of intravesical bacillus Calmette-Guerin therapy for multiple high grade stage T1 bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Urol" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "552" "paginaFinal" => "556" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib0465" "etiqueta" => "93." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term efficacy of intravesical bacillus Calmette-Guerin for carcinoma in situ: relationship of progression to histological response and p53 nuclear accumulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "157" "paginaInicial" => "1655" "paginaFinal" => "1659" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib0470" "etiqueta" => "94." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significance of p53 overexpression in urinary bladder transitional cell carcinoma in situ before and after bacillus Calmette-Guerin treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1997" "volumen" => "49" "paginaInicial" => "541" "paginaFinal" => "546" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib0475" "etiqueta" => "95." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative analysis of MIB1 and p53 expression in human bladder tumours and their correlation with cancer progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1998" "volumen" => "33" "paginaInicial" => "278" "paginaFinal" => "284" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib0480" "etiqueta" => "96." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacillus Calmette-Güerin treatment of superficial bladder carcinoma by serial flow cytometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1986" "volumen" => "58" "paginaInicial" => "2751" "paginaFinal" => "2757" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib0485" "etiqueta" => "97." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Flow cytometry as predictor of response and progression in patients with superficial bladder cancer treated with bacillus Calmette-Guerin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1989" "volumen" => "141" "paginaInicial" => "1332" "paginaFinal" => "1336" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000002500000001/v1_201304251627/S0210480601725648/v1_201304251627/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000002500000001/v1_201304251627/S0210480601725648/v1_201304251627/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480601725648?idApp=UINPBA00004N" ]
Journal Information
Determinación de ploidía de adn mediante citometría de flujo, índice ki-67 y sobre-expresión de proteína p53 en 121 carcinomas superficiales de vejiga t1. estudio retrospectivo. 2ª parte: valor pronóstico y utilidad en la indicación de tratamiento profiláctico con bcg