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Delgado Oliva, M.A. Bonillo García, L. Gómez Pérez, F. Oliver Amorós, V. Gimeno Argente, J.F. Jiménez Cruz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "F.J." "apellidos" => "Delgado Oliva" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Bonillo García" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Gómez Pérez" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Oliver Amorós" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Gimeno Argente" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607736100?idApp=UINPBA00004N" "url" => "/02104806/0000003100000002/v1_201304251832/S0210480607736100/v1_201304251832/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480607736082" "issn" => "02104806" "doi" => "10.1016/S0210-4806(07)73608-2" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "73608" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2007;31:113-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1076 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 646 "PDF" => 421 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Nuestra experiencia en el priapismo de alto flujo por fístula arterio-lacunar uni y bilateral" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "119" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Our experience in high-flow priapism due to uni-or bilateral arterio-lacunar fistula" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Rodriguez Tolrá, J.M. Cuadrado Campaña, J. Ropero Valverde, V. Ruiz Salas, E. Franco Miranda" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Rodriguez Tolrá" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Cuadrado Campaña" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ropero Valverde" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Ruiz Salas" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Franco Miranda" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607736082?idApp=UINPBA00004N" "url" => "/02104806/0000003100000002/v1_201304251832/S0210480607736082/v1_201304251832/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Evaluación del daño en el DNA espermático" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "120" "paginaFinal" => "131" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E.I. Cortés-Gutiérrez, M.I. Dávila-Rodríguez, C. López-Fernández, J.L. Fernández, J. Gosálvez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "E.I." "apellidos" => "Cortés-Gutiérrez" "email" => array:1 [ 0 => "jaime.gosalvez@uam.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "M.I." "apellidos" => "Dávila-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "López-Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J.L." "apellidos" => "Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Gosálvez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Genética. Centro de Investigación Biomédica del Noreste. Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León. México" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Biología. Unidad de Genética. Universidad Autónoma de Madrid (UAM). Madrid" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Investigación. Hospital Juan Canalejo. La Coruña" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Prof. J. Gosálvez Departamento de Biología. Unidad de Genética Universidad Autónoma de Madrid (UAM) 20849-Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Assessing sperm dna damage" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88141" "palabras" => array:4 [ 0 => "Fragmentación del DNA en espermatozoides" 1 => "Esterilidad masculina" 2 => "Fertilidad" 3 => "Calidad seminal" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88142" "palabras" => array:4 [ 0 => "Sperm DNA fragmentation" 1 => "Male sterility" 2 => "Fertility" 3 => "Semen quality" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La esterilidad afecta a casi un 20% de las parejas en edad reproductiva y en la mitad de los casos el factor masculino tiene un papel relevante. Entre los parámetros clásicos que determinan una buena calidad seminal, tales como, la motilidad espermática, la morfología o el estado de los acrosomas y de las membranas, la integridad de la molécula de DNA es crucial para llevar a cabo una fecundación con éxito. Sin embargo, el estudio de este último parámetro no es sencillo, hecho que ha dificultado su incorporación rutinaria en la elaboración de los seminogramas. La presente revisión tiene dos objetivos: 1) presentar una visión actualizada de aquellas tecnologías que se consideran más eficaces para el estudio de la fragmentación del DNA en el espermatozoide, teniendo en cuenta la posibilidad de su uso en los laboratorios de andrología y de acuerdo con la complejidad intrínseca al proceso, el equipamiento y los recursos disponibles, y 2) analizar sus efectos e implicaciones sobre la fecundación, desarrollo embrionario y fertilidad.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Infertility affects almost 20% of couples in reproductive age and the male factor being responsible of 50% of this infertility. Among the classic parameters that determine a good seminal quality such as sperm motility, sperm morphology or the quality of the of acrosomes and/or sperm membranes, the integrity of the DNA molecule is crucial to carry out a successful fertilization. Nevertheless, the study of this parameter has not been straightforward approached. This fact has shunned its incorporation, as a routine technique, within a standard seminogram. The aim of the present review is to summarize and update those technologies that are considered more successful to study sperm DNA fragmentation with special emphasis to: 1) the levels of technological complexity and the possibility of its use in laboratories of andrology, according with the equipment and the resources available, and 2) the effects and possible implications of high level of sperm DNA fragmentation for fecundation, embryo development and fertility.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:75 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Evaluación del daño en el DNA espermático
Assessing sperm dna damage
E.I. Cortés-Gutiérrez1,
, M.I. Dávila-Rodríguez*, C. López-Fernández**, J.L. Fernández***, J. Gosálvez**
* Departamento de Genética. Centro de Investigación Biomédica del Noreste. Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León. México
** Departamento de Biología. Unidad de Genética. Universidad Autónoma de Madrid (UAM). Madrid
*** Unidad de Investigación. Hospital Juan Canalejo. La Coruña