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Planelles Gómez, J.R. Beltrán Armada, M. Tarín Planes, A. Vergés Prosper, I. Rubio Tortosa, M. Gil Salom" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Planelles Gómez" ] 1 => array:2 [ "nombre" => "J.R." "apellidos" => "Beltrán Armada" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Tarín Planes" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Vergés Prosper" ] 4 => array:2 [ "nombre" => "I." "apellidos" => "Rubio Tortosa" ] 5 => array:2 [ "nombre" => "M." 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Álvarez-Múgica, J.Mª Fernández Gómez, A. Jalón Monzón, R.C. González Álvarez, J. García Rodríguez, J.L. Martín Benito" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Álvarez-Múgica" ] 1 => array:2 [ "nombre" => "J.Mª" "apellidos" => "Fernández Gómez" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Jalón Monzón" ] 3 => array:2 [ "nombre" => "R.C." "apellidos" => "González Álvarez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "García Rodríguez" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Martín Benito" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737713?idApp=UINPBA00004N" "url" => "/02104806/0000003100000010/v1_201304251853/S0210480607737713/v1_201304251853/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Expresion del receptor de esteroides y xenobioticos (SXR) y del gen de multirresistencia drogas (MDR1) y de los polimorfismos de las enzimas GSTs, SULTs y CYP en tumores vesicales profundos, analisis de su expresion y correlación con otros factores pronósticos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1107" "paginaFinal" => "1116" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Rioja Zuazu, E. Bandrés Elizalde, D. Rosell Costa, A. Rincón Mayans, J. Zudaire Bergera, Mª.J. Gil Sanz, L.A. Rioja Sanz, J. García Foncillas, J.Mª. Berián Polo" "autores" => array:9 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Rioja Zuazu" "email" => array:1 [ 0 => "jriojazu@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Bandrés Elizalde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "D." "apellidos" => "Rosell Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Rincón Mayans" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Zudaire Bergera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Mª.J." "apellidos" => "Gil Sanz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "L.A." "apellidos" => "Rioja Sanz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "J." "apellidos" => "García Foncillas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "J.Mª." "apellidos" => "Berián Polo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Urología. Clínica Universitaria. Universidad de Navarra" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Farmogenómica. Centro de Investigación Médica Aplicada. Universidad de Navarra" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario Miguel Servet. Zaragoza" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urología Clínica Universitaria. Universidad de Navarra Av. Pio XII 36, Pamplona 31080. Tel.: 948 255 400" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Steroid and xenobiotic receptor (sxr), multidrug resistance gene (mdr1) and gsts, sults and cyp polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-04-01" "fechaAceptado" => "2007-06-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88421" "palabras" => array:3 [ 0 => "Tumores vesical profundos" 1 => "Biología molecular" 2 => "Factores pronósticos" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88422" "palabras" => array:3 [ 0 => "Invasive bladder cancer" 1 => "Molecular biology" 2 => "Prognostic factors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El receptor de esteroides y xenobióticos SXR se ha demostrado su activación por parte de numerosos medicamentos, incluidos potentes inductores del citocromo p450, como la rifampicina y el cotrimazol. La función del SXR es bien conocida, y consiste en regular de manera positiva la trascripción del citocromo p450 3a4 (cyp3a4) y el gen de multirresistencia a drogas (multidrug resistance gene) mdr1, se considera una llave clave en el mecanismo regulador del metabolismo de los xenobióticos encontrándose involucrado en todas las fases de detoxificación</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Múltiples enzimas involucradas en el metabolismo y la degradación de hidrocarburos policíclicos aromáticos (PAH) son polimórficas en humanos, incluyendo la glutation S-transferasa (GSTs), N-acetiltransferasa (NATs), sulfotransferas (SULTs)1A1 y el citocromo p450 (CYP)1B1.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los objetivos que nos hemos planteado son los siguientes: 1. Analizar la expresión del factor de trascripción SXR y del mdr1 en vejiga mediante RT-PCR en tiempo real, tanto en vejiga tumoral como vejiga normal. 2. Analizar la relación de los factores clínicos y patológicos con la expresión del SXR y del mdr1. 3. Analizar la expresión de los polimorfismos de cyp1b1, gstm1 gstt1 y sult1a1, y su correlación con distintos factores clínico patológicos y moleculares.</p> <span class="elsevierStyleSectionTitle">Material y Métodos</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">De manera prospectiva se calculó un tamaño muestral necesario para este estudio. Se incluyeron 67 pacientes de dos instituciones distintas (Hospital Universitario Miguel Servet (49 HUMS) y Clínica Universitaria de Navarra (18 CUN)), diagnosticados de cáncer vesical infiltrante y tratados mediante cistectomía radical, se le realizó la determinación de la expresión de SXR y mdr1 mediante PCR cuantitativa en tiempo real, así como de los polimorfismos cyp1b1, gstm1 gstt1 y sult1a1 mediante RFLP (restricción de la longitud del fragmento del polimorfismo). Se correlaciona mediante tablas de contingencia la correlación con el resto de los factores pronósticos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La media de seguimiento de los pacientes fue de 23,7 meses, con una mediana de 28,26 meses. De los 67 pacientes estudiados, 31 pacientes (46,3%) presentaron progresión de la enfermedad, bien en forma de recidiva local, metástasis a distancia o ambos, con un tiempo medio a recidiva de 12,4 meses, mediana de 10 meses, con un rango de 1,1 mes a 31,9 meses. 36 pacientes (53,7%) no presentaron evidencia de progresión de la enfermedad.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El receptor de esteroides y xenobióticos SXR así como el gen de multirresistenia a drogas (Multidrug resistance gene (MDR1)), se expresan en vejiga normal (0,94?Ct y 0,94?Ct) y en vejiga tumoral de la pieza de cistectomía (1,09 ?Ct y 0,45 ?Ct). Hemos analizado su expresión de manera cuantitativa y de manera cualitativa. La expresión de SXR se correlaciona con la presencia de carcinoma in situ (p=0,024), infiltración vasculo-linfática (p=0,05) mientras que MDR1 se correlaciona con la presencia de infiltración vasculo linfática (p=0,05) A su vez ambos la presencia de ambos factores se correlaciona entre ellos (p=0,011)</p> <span class="elsevierStyleSectionTitle">Los polimorfismos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">cyp1b1, gstm1, gstt1 y sult1a1, se expresan en vejiga pero su expresión no guarda correlación con ningún factor pronóstico</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El SXR y el MDR1 se expresan tanto en vejiga normal y tumoral. Y que dicha expresión guarda una correlación con factores pronósticos con influencia en la supervivencia descritas en la literatura.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Steroid and Xenobiotic Receptor (SXR) has demonstrated its activation by numerous drugs, including cytochrome p450 potent inducers like rifampicina or cotrimazol. The role of SXR is well known, and lies regulating in a positive manner cytochrome p450 3a4 (cyp3a4) transcription and the multidrug resistance gene (mdr1), it’s considered a key in the xenobiotic detoxification mechanism, being involved in all phases of the detoxification process.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Enzymes involved in Policyclic Aromatic hidrocarbures (PAH) metabolism and degradation are polymorphic in humans, including glutation S-transferases (GSTs), N-acetiltransferases (NATs), sulfotransferases (SULTs)1a1 and cytochrome p450 (CYP)1b1.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The objectives we’ve planned are: 1. Analyze the expression of the transcription factor SXR and mdr1 in bladder by means of RT-PCR real time, both in normal bladder and in tumoral bladder. 2. Analyze the relation between clinical and pathological factors with the expression of SXR and mdr1. 3. Analyze the expression of the polymorphims cyp1b1, gstm1 gstt1 and sult1a1 and their correlation with different clinic-pathological and molecular factors.</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">In a prospective way the size of the sample was estimated. In 67 patients from two institutions (Hospital Universitario Miguel Servet (49 HUMS) and Clinica Universitaria de Navarra (18 CUN)), diagnosed of invasive bladder cancer and treated by means of radical cystectomy, were determined the expression of both SXR and mdr1 by means of real time PCR, as well as the polymorphisms cyp1b1, gstm1 gstt1 y sult1a1 by means of RFLP (Restriction fragment length polymorphism). Correlations with other prognostic factors by contingency tables were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Average follow up was 23,7 months with a median of 28,26 months. Of the 67 patients studied, 31 patients (46,3) presented disease progression, in form of local recurrence or in distant metastasis or both. With a average time to progression of 12,4 months and a median of 10 months, with a range of 1,1 month to 31,9 month. 36 patients (53,7%) did not have any evidence of disease progression during follow up.</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">The Steroid and Xenobiotic Receptor as well as the Multidrug Resistance Gene (MDR1) are expressed in both normal bladder (0,94?Ct y 0,94?Ct) and tumoral bladder in the cystectomy specimen(1,09 ?Ct y 0,45 ?Ct). We’ve analyzed their expression in a quantitative manner and in a qualitative manner. The expression of SXR correlates with the presence of ca. in situ (p=0,024), vasculo-lymphatic invasion (p=0,05) mean while MDR1 correlates with presence of vasculo-lymphatic invasion (p=0,05) Both factors are correlate between each others (p=0,011).</p> <span class="elsevierStyleSectionTitle">Polymorphisms</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">cyp1b1, gstm1, gstt1 and sult1a1, are expressed in these patients but their expression doesn’t correlates with any prognostic factor</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Both SXR and MDR1 are expressed in normal bladder as well as in tumoral bladder. And their expression correlates with different prognostic factors with influence in the survival described in the literature</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urothelial Tumors of the Urinary Tract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Messing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "2732" "paginaFinal" => "2785" "serieVolumen" => "4" "serieTitulo" => "Campbells Urology, 8 ed" "serieFecha" => "2002" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generalidades sobre los tumores vesicales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Collado Serra" 1 => "J. Rubio Briones" 2 => "J. Ricos Torrent" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "1851" "paginaFinal" => "1881" "serieVolumen" => "vol. IV" "serieTitulo" => "Tratado de Urología" "serieFecha" => "2006" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer statistics, 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Jemal" 1 => "T. Murray" 2 => "E. Ward" 3 => "A. Samuels" 4 => "R.C. Tiwari" 5 => "A. Ghafoor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer J Clin" "fecha" => "2005" "volumen" => "55" "numero" => "1" "paginaInicial" => "10" "paginaFinal" => "30" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Instituto Nacional de Mortalidad por cáncer de Vejiga: INE, 2007" ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Herr H, Jakse G, Sheinfeld J. El tumor vesical T1. In: Casos prácticos de Urología. Edited by K. Brasilis and M. Soloway: Ed. Ep, vol. 3, pp. 1-11, 1995" ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Blumberg" 1 => "H. Kang" 2 => "J. Bolado Jr." 3 => "H. Chen" 4 => "A.G. Craig" 5 => "T.A. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Genes Dev" "fecha" => "1998" "volumen" => "12" "numero" => "9" "paginaInicial" => "1269" "paginaFinal" => "1277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9573044" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Geick" 1 => "M. Eichelbaum" 2 => "O. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.M010173200" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2001" "volumen" => "276" "numero" => "18" "paginaInicial" => "14581" "paginaFinal" => "14587" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11297522" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.M. Lehmann" 1 => "D.D. McKee" 2 => "M.A. Watson" 3 => "T.M. Willson" 4 => "J.T. Moore" 5 => "S.A. Kliewer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI3703" "Revista" => array:7 [ "tituloSerie" => "J Clin Invest" "fecha" => "1998" "volumen" => "102" "numero" => "5" "paginaInicial" => "1016" "paginaFinal" => "1998" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9727070" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Bertilsson" 1 => "J. Heidrich" 2 => "K. Svensson" 3 => "M. Asman" 4 => "L. Jendeberg" 5 => "M. Sydow-Bäckman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "1998" "volumen" => "95" "numero" => "21" "paginaInicial" => "12208" "paginaFinal" => "12213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9770465" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Miki" 1 => "T. Suzuki" 2 => "C. Tazawa" 3 => "B. Blumberg" 4 => "H. Sasano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mce.2004.12.005" "Revista" => array:7 [ "tituloSerie" => "Mol Cell Endocrinol" "fecha" => "2005" "volumen" => "231" "numero" => "1-2" "paginaInicial" => "75" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15713537" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PXR, CAR and drug metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.M. Willson" 1 => "S.A. Kliewer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrd753" "Revista" => array:7 [ "tituloSerie" => "Nat Rev Drug Discov" "fecha" => "2002" "volumen" => "1" "numero" => "4" "paginaInicial" => "259" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12120277" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.W. Synold" 1 => "I. Dussault" 2 => "B.M. Forman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/87912" "Revista" => array:7 [ "tituloSerie" => "Nat Med" "fecha" => "2001" "volumen" => "7" "numero" => "5" "paginaInicial" => "584" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11329060" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orphan nuclear receptors: the exotics of xenobiotics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W. Xie" 1 => "R.M. Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.R100033200" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2001" "volumen" => "276" "numero" => "41" "paginaInicial" => "37739" "paginaFinal" => "37742" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11459851" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nuclear receptor PXR: a master regulator of “homeland” defense" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Dussault" 1 => "B.M. Forman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Crit Rev Eukaryot Gene Expr" "fecha" => "2002" "volumen" => "12" "numero" => "1" "paginaInicial" => "53" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12433065" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.A. Kliewer" 1 => "B. Goodwin" 2 => "T.M. Willson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/er.2001-0038" "Revista" => array:7 [ "tituloSerie" => "Endocr Rev" "fecha" => "2002" "volumen" => "23" "numero" => "5" "paginaInicial" => "687" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12372848" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of induction of MDR1 gene expression by anticancer chemotherapy in bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Nezasa" 1 => "S. Fujihiro" 2 => "T. Deguchi" 3 => "Y. Kawada" 4 => "S. Kawamoto" 5 => "M. Tamaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Hinyokika Kiyo" "fecha" => "1997" "volumen" => "43" "numero" => "9" "paginaInicial" => "629" "paginaFinal" => "636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9365841" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kogenvians" 1 => "D. Trichopoulus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Textbook of cancer epiemiology" "paginaInicial" => "446" "paginaFinal" => "466" "serieFecha" => "2002" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Hung" 1 => "P. Boffetta" 2 => "P. Brennan" 3 => "C. Malaveille" 4 => "A. Hautefeuille" 5 => "F. Donato" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.20157" "Revista" => array:7 [ "tituloSerie" => "Int J Cancer" "fecha" => "2004" "volumen" => "110" "numero" => "4" "paginaInicial" => "598" "paginaFinal" => "604" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15122594" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The glutathione S-transferases: influence of polymorphism on cancer susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Strange" 1 => "A. Fryer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "IARC Sci Publ" "fecha" => "1999" "numero" => "148" "paginaInicial" => "231" "paginaFinal" => "249" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mammalian class theta GST and differential susceptibility to carcinogens: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Landi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mutant Res" "fecha" => "2000" "volumen" => "463" "numero" => "3" "paginaInicial" => "247" "paginaFinal" => "283" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.S. Engel" 1 => "E. Taioli" 2 => "R. Pfeiffer" 3 => "M. Garcia-Closas" 4 => "P.M. Marcus" 5 => "Q. Lan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2002" "volumen" => "156" "numero" => "2" "paginaInicial" => "95" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12117698" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of N-acetyltransferase-2 and glutathione S-transferase on the risk and aggressiveness of bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X. Giannakopoulos" 1 => "K. Charalabopoulos" 2 => "D. Baltogiannis" 3 => "A. Chatzikiriakidou" 4 => "Y. Alamanos" 5 => "I. Georgiou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Anticancer Res" "fecha" => "2002" "volumen" => "22" "numero" => "6B" "paginaInicial" => "3801" "paginaFinal" => "3804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12552997" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.J. Lee" 1 => "S.H. Cho" 2 => "S.K. Park" 3 => "S.W. Kim" 4 => "M.S. Park" 5 => "H.Y. Choi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Lett" "fecha" => "2002" "volumen" => "177" "numero" => "2" "paginaInicial" => "173" "paginaFinal" => "179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11825664" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sulfotransferases: genetics and role in toxicology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Glatt" 1 => "C.E. Engelke" 2 => "U. Pabel" 3 => "W. Teubner" 4 => "A.L. Jones" 5 => "M.W. Coughtrie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Toxicol Lett" "fecha" => "2000" "paginaInicial" => "112" "paginaFinal" => "113" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Hengstler" 1 => "M. Arand" 2 => "M.E. Herrero" 3 => "F. Oesch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Recent Results Cancer Res" "fecha" => "1998" "volumen" => "154" "paginaInicial" => "47" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10026993" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.E. Engelke" 1 => "W. Meinl" 2 => "H. Boeing" 3 => "H. Glatt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pharmacogenetics" "fecha" => "2000" "volumen" => "10" "numero" => "2" "paginaInicial" => "163" "paginaFinal" => "169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10762004" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Catalytic properties of polymorphic human cytochrome P450 1B1 variants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Shimada" 1 => "J. Watanabe" 2 => "K. Kawajiri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Carcinogenesis" "fecha" => "1999" "volumen" => "20" "numero" => "8" "paginaInicial" => "1607" "paginaFinal" => "1613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426814" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.R. Bailey" 1 => "N. Roodi" 2 => "W.D. Dupont" 3 => "F.F. Parl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1998" "volumen" => "58" "numero" => "22" "paginaInicial" => "5038" "paginaFinal" => "5041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9823305" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I.H. Hanna" 1 => "S. Dawling" 2 => "N. Roodi" 3 => "F.P. Guengerich" 4 => "F.F. Parl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "2000" "volumen" => "60" "numero" => "13" "paginaInicial" => "3440" "paginaFinal" => "3444" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10910054" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Machin" 1 => "M. Campbell" 2 => "P. Fayers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1997" "editorial" => "Ed. Blackwell" "editorialLocalizacion" => "Oxford" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Applied., Biosystem.: ABI Prism 7700 Sequence Detection System" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "User Bulletin" "fecha" => "2001" "volumen" => "2" "paginaInicial" => "11" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "for the EAU Working Party on Non Muscle Invasive Bladder Cancer. EAU guidelines on the diagnosis and treatment of urothelial carcinoma in situ" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.P. Van der Meijden" 1 => "R. Sylvester" 2 => "W. Oosterlinck" 3 => "E. Solsona" 4 => "A. Boehle" 5 => "B. Lobel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2005.05.011" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2005" "volumen" => "48" "numero" => "3" "paginaInicial" => "363" "paginaFinal" => "371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994003" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bladder cancer. Clinical guidelines in oncology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Montie" 1 => "N.A. Abrahams" 2 => "R.R. Bahnson" 3 => "M.A. Eisenberger" 4 => "R. El-Galley" 5 => "H.W. Herr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Natl Compr Canc Netw" "fecha" => "2006" "numero" => "10" "paginaInicial" => "984" "paginaFinal" => "1014" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expresión del SXR en tumores vesicales infiltrantes. Abstract Congres" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Rioja Zuazu" 1 => "E. Bandrés" 2 => "D. Rosell Costa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "45" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Zhou" 1 => "M.M. Tabb" 2 => "A. Sadatrafiei" 3 => "F. Grün" 4 => "B. Blumberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Drug Metab Dispos" "fecha" => "2004" "numero" => "10" "paginaInicial" => "1075" "paginaFinal" => "1082" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case-control study on the effects of the genetic polymorphisms of N-acetyltransferase 2 and glutathione S-transferase mu and theta on the risk of bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Kim" 1 => "W.J. Kim" 2 => "H.-L Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Korean J Prev Med" "fecha" => "1998" "volumen" => "31" "paginaInicial" => "275" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Katoh" 1 => "H. Inatomi" 2 => "H. Kim" 3 => "M. Yang" 4 => "T. Matsumoto" 5 => "T. Kawamoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Lett" "fecha" => "1998" "volumen" => "132" "numero" => "1-2" "paginaInicial" => "147" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10397466" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003100000010/v1_201304251853/S0210480607737725/v1_201304251853/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003100000010/v1_201304251853/S0210480607737725/v1_201304251853/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480607737725?idApp=UINPBA00004N" ]
Journal Information
Expresion del receptor de esteroides y xenobioticos (SXR) y del gen de multirresistencia drogas (MDR1) y de los polimorfismos de las enzimas GSTs, SULTs y CYP en tumores vesicales profundos, analisis de su expresion y correlación con otros factores pronósticos
Steroid and xenobiotic receptor (sxr), multidrug resistance gene (mdr1) and gsts, sults and cyp polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors
J. Rioja Zuazu
, E. Bandrés Elizalde**, D. Rosell Costa*, A. Rincón Mayans*, J. Zudaire Bergera*, Mª.J. Gil Sanz***, L.A. Rioja Sanz***, J. García Foncillas**, J.Mª. Berián Polo*
,1
Corresponding author
jriojazu@gmail.com
Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urología Clínica Universitaria. Universidad de Navarra Av. Pio XII 36, Pamplona 31080. Tel.: 948 255 400
Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urología Clínica Universitaria. Universidad de Navarra Av. Pio XII 36, Pamplona 31080. Tel.: 948 255 400