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Herrera Puerto, J. Herrera Flores, J.M. Barragán Casas, J.J. Galán Velasco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Herrera Puerto" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Herrera Flores" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Barragán Casas" ] 3 => array:2 [ "nombre" => "J.J." "apellidos" => "Galán Velasco" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480602728039?idApp=UINPBA00004N" "url" => "/02104806/0000002600000006/v1_201304251656/S0210480602728039/v1_201304251656/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480602728015" "issn" => "02104806" "doi" => "10.1016/S0210-4806(02)72801-5" "estado" => "S300" "fechaPublicacion" => "2002-01-01" "aid" => "72801" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2002;26:398-406" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3717 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 2711 "PDF" => 999 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Citología exfoliativa prostática obtenida en muestras de orina tras masaje. primeros resultados" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "398" "paginaFinal" => "406" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Varo Solís, A. Hens Pérez, J. Bachiller Burgos, E. Figueroa Murillo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Varo Solís" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Hens Pérez" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Bachiller Burgos" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Figueroa Murillo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480602728015?idApp=UINPBA00004N" "url" => "/02104806/0000002600000006/v1_201304251656/S0210480602728015/v1_201304251656/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Expresión de la proteína p21ras en el adenocarcinoma renal localmente confinado y sus implicaciones pronósticas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "408" "paginaFinal" => "412" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Tejido Sánchez, J. Passas Martínez, J.D. Piedra Lara, M. Sánchez Chapado, C. Capitán Manjón, P. Ramos Guillén, O. Leiva Galvis" "autores" => array:7 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Tejido Sánchez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Passas Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J.D." "apellidos" => "Piedra Lara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Sánchez Chapado" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Capitán Manjón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "P." "apellidos" => "Ramos Guillén" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "O." "apellidos" => "Leiva Galvis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario 12 de Octubre. Madrid. Servicio de Urología. Servicio de Anatomía Patológica. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid." "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid." "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. A. Tejido Sánchez Hospital Universitario 12 de Octubre Servicio de Urología Ctra. de Andalucía km. 5,400 28041-Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-05-14" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec86665" "palabras" => array:3 [ 0 => "p21" 1 => "Adenocarcinoma renal" 2 => "Inmunohistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec86666" "palabras" => array:3 [ 0 => "p21" 1 => "Renal cell carcinoma" 2 => "Immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La proteína p21ras es codificada por los tres genes de la familia ras (H-, K- y N-ras), participando en la regulación del crecimiento y la diferenciación celular. El objetivo de este estudio es determinar la expresión de esta proteína en el adenocarcinoma renal localmente confinado, así como sus relaciones con diferentes variables histopatológicas y sus implicaciones pronósticas.</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">58 adenocarcinomas renales, estadios pT1-T3a N0 M0 (TNM 1997), tratados mediante nefrectomía radical o parcial con intención curativa. Analizamos diferentes variables clínicas y anatomopatológicas, así como la expresión de p21ras en tejido parafinado, mediante técnicas de inmunohistoquímica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El porcentaje medio de núcleos teñidos fue de 6,1%, con un rango comprendido entre 0 y 45%. No obtuvimos asociación estadísticamente significativa de la expresión de p21ras y el tamaño tumoral (p=0,698), el grado nuclear (p=0,676) o el estadio histopatológico (p=0,095). El análisis de supervivencia tampoco demostró diferencias significativas cuando estratificamos a los pacientes utilizando como punto de referencia el valor medio de la muestra (p=0,134).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La expresión de p21ras no ha demostrado relacionarse con ninguna de las variables histopatológicas analizadas; tamaño, grado y estadio, ni con la supervivencia, por lo que esta proteína no parece relacionarse con la evolución del adenocarcinoma renal.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The p21ras protein is encoded by the three ras genes (H-, K- and N-ras) and participate in the regulation of normal cell growth and cell differenciation. The objective of this study is to determine the expression of this protein in locally confined renal cell carcinoma, as well as its relations with different histopathological variables and their prognostic implications.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">58 renal cell carcinomas, in pT1-T3a N0 M0 (TNM 1997) stages, treated by radical or partial nephrectomy with curative intention. We analysed different clinical and anatomopathological variables, as well as expression of p21ras in paraffinated tissue, using immunohistochemical techniques.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The mean percentage of stained nuclei was 6.1%, with a range lying between 0 and 45%. We did not obtain statistically significant association between expression of p21ras and the tumour size (p=0.698), the nuclear grade (p=0.676) or the histopathological stage (p=0.095). The survival analysis also did not show significant differences when we stratified the patients using the mean value of the sample as reference point (p=0.134).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Expression of p21ras was not demonstrated to be related to any of the histopathological variables analysed: size, grade and stage, or with survival. Therefore, this protein does not appear to be related to the evolution of renal cell carcinoma.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Expresión de la proteína p21ras en el adenocarcinoma renal localmente confinado y sus implicaciones pronósticas
A. Tejido Sánchez1,a, J. Passas Martíneza, J.D. Piedra Laraa, M. Sánchez Chapado*,a, C. Capitán Manjóna, P. Ramos Guillén**,a, O. Leiva Galvisa
a Servicio de Urología. Hospital Universitario 12 de Octubre. Madrid. Servicio de Urología. Servicio de Anatomía Patológica. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid.
* Servicio de Urología. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid.
** Servicio de Anatomía Patológica. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid.