array:23 [ "pii" => "S0210480603729635" "issn" => "02104806" "doi" => "10.1016/S0210-4806(03)72963-5" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "72963" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2003" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2003;27:501-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1069 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 712 "PDF" => 348 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480603729647" "issn" => "02104806" "doi" => "10.1016/S0210-4806(03)72964-7" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "72964" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2003;27:513-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1001 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 738 "PDF" => 257 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "¿Mejora un detector de humedad la calidad de vida de los pacientes con incontinencia urinaria?: un estudio piloto" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "513" "paginaFinal" => "516" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Do the incontinent patients improve their quality of life using a humidity detector device?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.L. Jauregui Abrisqueta, C. Domingo Rico, G. Grandes, A.M. López Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.L." "apellidos" => "Jauregui Abrisqueta" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Domingo Rico" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "Grandes" ] 3 => array:2 [ "nombre" => "A.M." "apellidos" => "López Rodríguez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480603729647?idApp=UINPBA00004N" "url" => "/02104806/0000002700000007/v1_201304251716/S0210480603729647/v1_201304251716/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480603729623" "issn" => "02104806" "doi" => "10.1016/S0210-4806(03)72962-3" "estado" => "S300" "fechaPublicacion" => "2003-01-01" "aid" => "72962" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2003;27:491-500" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1347 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 963 "PDF" => 379 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Exploración de raíces sacras: indicaciones, técnica y resultados" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "491" "paginaFinal" => "500" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Peripheral nerve evaluation: indications, technique and results" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Arlandis Guzmán, J.M. Alapont Alacreu, M.Á. Bonillo García, J.L. Ruiz Cerdá, E. Martínez Agulló, F. Jiménez Cruz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Arlandis Guzmán" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Alapont Alacreu" ] 2 => array:2 [ "nombre" => "M.Á." "apellidos" => "Bonillo García" ] 3 => array:2 [ "nombre" => "J.L." "apellidos" => "Ruiz Cerdá" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Martínez Agulló" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Jiménez Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480603729623?idApp=UINPBA00004N" "url" => "/02104806/0000002700000007/v1_201304251716/S0210480603729623/v1_201304251716/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Utilidad de los marcadores tumorales en el pronóstico del cáncer transicional de vejiga" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "501" "paginaFinal" => "512" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.F. Lorenzo Gómez, G. Schroeder" "autores" => array:2 [ 0 => array:3 [ "nombre" => "M.F." "apellidos" => "Lorenzo Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Schroeder" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Urology. University of Miami. Miami. Florida. USA" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dra. M.F. Lorenzo Gómez Department of Urology P.O. Box 016960 (M814) Miami, Florida 33101" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The role of tumor markers in prognosing transitional bladder cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-09-04" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palablas clave" "identificador" => "xpalclavsec86939" "palabras" => array:3 [ 0 => "Vejiga" 1 => "Tumor" 2 => "Marcadores pronóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86938" "palabras" => array:3 [ 0 => "Bladder" 1 => "Tumor" 2 => "Marker prognosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos del trabajo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Revisión del estado actual de los marcadores tumorales disponibles para el pronóstico y exposición de los problemas con el grado y el estadiaje local del cáncer transicional de vejiga.</p> <span class="elsevierStyleSectionTitle">Procedimientos básicos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisión de la literatura publicada en marcadores de cáncer transicional de vejiga mediante una búsqueda en Medline y análisis crítico de la misma.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hay diferencias estadísticamente significativas interobservador en la determinación del grado. Hay un nuevo sistema de combinación de grados. Existen problemas en la determinación del estadio local y baja correspondencia entre el estadio clínico y el patológico post-cistectomía radical. Los principales marcadores tumorales pronósticos considerados en este cáncer son citometría de flujo, estudio cariocitométrico, oncogenes (p53, bcl-2, Her2/Neu o c-erbB2), anomalías cromosómicas (cromosoma 9, cromosomas 7 y 17), marcadores de proliferación (Ki- 67, MIB-1), ciclinas dependientes de kinasas y sus inhibidores (ciclina D1, ciclina E, p21<span class="elsevierStyleSup">Waf1</span>, p27<span class="elsevierStyleSup">Kip1</span>), factor de crecimiento endotelial vascular, otros factores de crecimiento (fibroblástico, epidérmico, hepatocitario, derivado de plaquetas), metaloproteinasas, moléculas de adhesióny otros.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Actualmente, no hay un marcador tumoral pronóstico para el cáncer de vejiga superior al grado y estadio convencionales, a pesar de sus deficiencias. Se necesita una estandarización de los métodos de determinación de algunos marcadores que aporte resultados concluyentes y útiles en el terreno clínico. Algunas contradicciones en los resultados obtenidos por diferentes autores obligan a cuestionar el significado pronóstico de ciertos marcadores tumorales en el cáncer transicional de vejiga.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Review the literature on tumor markers used for prognosis of transitional bladder cancer. The existing problems regarding grading and local staging of these tumors are also discussed.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The published literature on transitional bladder cancer markers was identified using a Medline search and critically analysed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">There are significant interobserver differences in grading. There is a new grading system. There are also problems in local staging and low correlation between clinic stage and pathologic stage. Major tumor markers studied for prognosis of transitional bladder cancer are: flow cytometry, kariocytometric study, oncogenes (p53, bcl-2, Her2/Neu or c-erbB2), chromosomic alterations (chromosomes 9, 7 and 17), proliferation markers (Ki-67, MIB-1), cyclin-dependent kinases and its inhibitors (cyclin D1, cyclin E, p21<span class="elsevierStyleSup">Wafl</span>, p27<span class="elsevierStyleSup">Kipl</span>), vascular endothelial growth factor, other growth factors (fibroblastic, epidermal, hepatocyte, platelet-derived), metalloproteinases, cell adhesion molecules, and others.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">At present, there are no prognostic markers for bladder cancer that are superior to conventional grading and staging, despite its imperfections. Standarization of assay methods in bladder tumor markers is needed to permit more conclusive and reproducible results and become a clinic tool. Controversy resulting from several studies make the meaning of some putative prognostic markers in transitional bladder cancer questionable.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:106 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical prognostic factors in superficial cancer of the urinary bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Esp Urol" "fecha" => "2001" "volumen" => "54" "numero" => "2" "paginaInicial" => "131" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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Journal Information
Utilidad de los marcadores tumorales en el pronóstico del cáncer transicional de vejiga
The role of tumor markers in prognosing transitional bladder cancer
Department of Urology. University of Miami. Miami. Florida. USA