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López Laur, J. Chiapetta Menéndez, R. Anchelerguez Moreno, J. Prats Roma" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.D." "apellidos" => "López Laur" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Chiapetta Menéndez" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Anchelerguez Moreno" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Prats Roma" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480602727393?idApp=UINPBA00004N" "url" => "/02104806/0000002600000002/v1_201304251649/S0210480602727393/v1_201304251649/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Valor pronóstico de la p53, ki67 y la proteína rb en los tumores vesicales infiltrantes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "98" "paginaFinal" => "103" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Sánchez zalabardo, D. Rosell costa, J.M. Fernández montero, J. López ferrandis, J. Arocena garcía-tapia, S. Jiménez garín, E. De álava casado, J.E. Robles garcía, J.J. Zudaire bergera, J.M. Berián polo" "autores" => array:10 [ 0 => array:3 [ "nombre" => "D." "apellidos" => "Sánchez zalabardo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "D." "apellidos" => "Rosell costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.M." "apellidos" => "Fernández montero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "López ferrandis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Arocena garcía-tapia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "S." "apellidos" => "Jiménez garín" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "E." "apellidos" => "De álava casado" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "J.E." "apellidos" => "Robles garcía" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "J.J." "apellidos" => "Zudaire bergera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "J.M." "apellidos" => "Berián polo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica. Clínica Universitaria.Universidad de Navarra. Pamplona (Navarra)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Urología. Departamento de Anatomía Patológica. Clínica Universitaria.Universidad de Navarra. Pamplona (Navarra)" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. D. Sánchez Zalabardo Departamento de Urología. Clínica Universitaria Apartado 420931080 Pamplona (Navarra)" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-07-18" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec86571" "palabras" => array:4 [ 0 => "p53" 1 => "Ki67" 2 => "Prot Rb" 3 => "Tumor vesical infiltrante" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86572" "palabras" => array:4 [ 0 => "p53" 1 => "Ki67" 2 => "Port Rb" 3 => "Invasive bladder cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar la capacidad pronóstica de la sobre-expresión de p53, la expresión del factor de proliferaciónnuclear Ki67 y de la pérdida de expresión de la proteína del retinoblastoma (prot. Rb), valorados mediante inmunohistoquímica,en los tumores vesicales infiltrantes</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">47 pacientes diagnosticados de tumor vesical profundo. 42 varones y 5 mujeres. Edadmedia 63 años. Mediana de seguimiento 10 meses. Recidiva en 19 pacientes (40%). Tiempo medio hasta la recidiva8,5 meses. Se valoró la expresión de p53 y Ki67 en 47 pacientes y la de la prot. Rb en 40 pacientes</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">p53: La media de expresión fue del 41%. Existen diferencias significativas en la expresión de p53entre los pacientes que no presentaron recidiva y los que si lo hicieron (p = 0,03). Los pacientes con p53 > 20% tienenuna supervivencia libre de progresión significativamente menor que los pacientes con p53 < 20% (p = 0,04). Ki67y prot. Rb: No existen diferencias significativas en la aparición de recidivas ni en el tiempo libre de progresión con lasobre-expresión de Ki67 ni con la pérdida de expresión de prot. Rb. Existe una correlación estadísticamente significativaentre la expresión de p53 con la de Ki67 (p = 0,001) y la de prot. Rb (p = 0,03)</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La oncoproteína p53 es un buen marcador para el pronóstico de recidivas y de supervivencialibre de enfermedad en los tumores vesicales profundos</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determinate whether increased expression of the p53 and Ki67 and the of the tumour supressorgene retinoblastoma (prot Rb), in an inmunohistochemistry study, were associated with relapse in invasive bladdercancer</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">47 patients with invasive bladder cancer. 42 men and 5 women. Mean age 63 yearsold. Relapse in 19 patients (40%). Mean time until recurrence 8.5 months. p53 and Ki67 were study in 47 patientsand prot Rb in 40 patients</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">p53: Mean expression 41%.There were significant differences in the increased expression of p53 betweenpatients with and without relapse (p = 0.03). A statistically significant association was then observed betweenpatients with p53 > 20% (vs p53 < 20%) and adverse outcome of the disease (p = 0.04). Ki67 and prot Rb: There wereno significant differences in relapse and progression free survival between Ki67 > 40% (vs Ki67 < 40%) and prot Rb < 10% (vs prot Rb > 10%). p53 expression showed a statistically significant correlation with Ki67 and prot Rb</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">p53 is a good prognostic marker for the relapse and progression free survival in invasive bladdercancer</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53: Gen supresor de tumores.arán ed" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Núñez doménech" 1 => "D. Escuín borrás" 2 => "A. 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Journal Information
Valor pronóstico de la p53, ki67 y la proteína rb en los tumores vesicales infiltrantes