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"apellidos" => "Plaza Martos" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480602727575?idApp=UINPBA00004N" "url" => "/02104806/0000002600000003/v1_201304251651/S0210480602727575/v1_201304251651/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480602727551" "issn" => "02104806" "doi" => "10.1016/S0210-4806(02)72755-1" "estado" => "S300" "fechaPublicacion" => "2002-01-01" "aid" => "72755" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2002;26:182-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1243 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 778 "PDF" => 458 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Efectos hidrodinámicos y bioquímicos de la perfusión hipotérmica de riñón aislado según el tipo de bombautilizada" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "182" "paginaFinal" => "189" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Lledó García, C. Hernández Fernández, C. Llorente Abarca, J.F. Del Cañizo López" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Lledó García" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Hernández Fernández" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Llorente Abarca" ] 3 => array:2 [ "nombre" => "J.F." "apellidos" => "Del Cañizo López" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480602727551?idApp=UINPBA00004N" "url" => "/02104806/0000002600000003/v1_201304251651/S0210480602727551/v1_201304251651/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Valoración del estado de la membrana basal como factor pronóstico en el carcinoma renal" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "190" "paginaFinal" => "195" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Rubio Briones, L. Morell Quadreny, J.A. López Guerrero, J. Casanova Ramón-borja, C. Mejía Vázquez, I. Iborra Juan, A. Pellín Pérez, E. Solsona Narbón, A. Llombart Bosch" "autores" => array:9 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Rubio Briones" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Morell Quadreny" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.A." "apellidos" => "López Guerrero" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Casanova Ramón-borja" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Mejía Vázquez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "I." "apellidos" => "Iborra Juan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "A." "apellidos" => "Pellín Pérez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "E." "apellidos" => "Solsona Narbón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "A." "apellidos" => "Llombart Bosch" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Instituto Valenciano de Oncología. Valencia. Departamento de Anatomía Patológica. Facultad de Medicina. Universidad de Valencia. Valencia" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología. Instituto Valenciano de Oncología. Valencia. Departamento de Anatomía Patológica. Facultad de Medicina. Universidad de Valencia. Valencia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. J. Rubio Briones Servicio de Urología Instituto Valenciano de Oncología C/ Profesor Beltrán Báguena, 8 46009 Valencia" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-12-03" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec86575" "palabras" => array:4 [ 0 => "Carcinoma renal" 1 => "Laminina" 2 => "Colágeno IV" 3 => "Inmunohistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86576" "palabras" => array:4 [ 0 => "Renal carcinoma" 1 => "Laminin" 2 => "Collagen IV" 3 => "Immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Fundamentos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer el estado de la membrana basal (MB) en el carcinoma renal (CR) y su importancia como factor pronóstico.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar00010" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 73 pacientes con CR. Se realizó inmunohistoquímica con anticuerpos monoclonales contra las proteínas basales laminina y colágeno IV. La valoración de los resultados consideró la integridad de la MB dentro del tumor tomando como punto de corte un 75 % de basales fragmentadas en el tumor.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El seguimiento fue de 6,3 ± 4,3 años, durante el cual hubo progresión de la enfermedad en 27 pacientes. La correlación en la expresión de ambas moléculas fue significativa (p=0,000). La fragmentación de la MB en más del 75% del tumor expresada con laminina se relacionó con una presencia de clínica por el tumor (p=0,019), con un peor grado de diferenciación celular (p=0,004) y con más del 10% de necrosis (p=0,001). Una fragmentación mayor del 75% expresada con colágeno IV se asoció a tumores mayores de 7 cm (p=0,014). Se observó una peor supervivencia en aquellos pacientes con tumores con más del 75% de fragmentación de la MB medida con colágeno IV (p=0,042), mientras que con la laminina se apreció una tendencia similar que no alcanzó la significación estadística (p=0,119). En el análisis univariado resultaron factores pronósticos el grado III-IV, la presencia de más de un 10% de necrosis en el tumor, la presentación clínica del tumor y con una fragmentación de la MB mayor del 75% analizada con colágeno IV, persistiendo los dos primeros en el análisis multivariado.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Colágeno IV y laminina representan correctamente y de forma paralela el grado de fragmentación de la MB en el CR. Dentro de una batería de factores inmunohistoquímicos en CR se debería incluir al menos una de ellas por su implicación pronóstica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objetives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To know the basal membrane (BM) integrity in renal cell carcinoma (RC) and its importance as prognostic factor.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">73 patients with RC were selected. Immunohistochemistry with monoclonal antibodies against basal proteins laminin and collagen IV was performed. Percentage for BM fragmentation in the whole tumour was considered taking 75% as cut off.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Follow-up was 6.3 ± 4.3 years and 27 patients progressed. Correlation between laminin and collagen IV was significative (p=0.000). A BM fragmentation expressed with laminin bigger than 75% was related to tumoural symphtoms (p=0.019), worse grade (p=0.004) and necrosis in more than 10% of the tumour (p=0.000). Fragmentation observed with collagen IV was associated to tumours greater than 7 cm (p=0.014). Those patients whose tumours displayed more than 75% of BM fragmentation, measured with collagen IV, presented worse survival (p=0.042). A similar trend was observed in the case of laminin, but it did not reach statistic significance (p=0.119). In the univariated analysis grade III-IV, more than 10% of necrosis within the tumour, tumoural symphtoms and BM fragmentation bigger than 75% measured with collagen IV were prognostic, while only grade and necrosis did so in the multivariate analysis.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Collagen IV and laminin represent nicely, with a similar expression pattern, the BM fragmentation in RC. Within a battery of immunohistochemical markers to study RC at least one of them should be included because their prognostic implication.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Journal Information
Valoración del estado de la membrana basal como factor pronóstico en el carcinoma renal
J. Rubio Briones1,a, L. Morell Quadreny*,a, J.A. López Guerrero*,a, J. Casanova Ramón-borjaa, C. Mejía Vázquez*,a, I. Iborra Juana, A. Pellín Pérez*,a, E. Solsona Narbóna, A. Llombart Bosch*,a
* Servicio de Urología. Instituto Valenciano de Oncología. Valencia. Departamento de Anatomía Patológica. Facultad de Medicina. Universidad de Valencia. Valencia
a Servicio de Urología. Instituto Valenciano de Oncología. Valencia. Departamento de Anatomía Patológica. Facultad de Medicina. Universidad de Valencia. Valencia