We compare three groups: donors aged between 50-60 years (n = 32), donors aged over 60 years(n = 25) and a control group formed by donors of ¿ideal¿ ages. The results show that kidneys fromdonors over 60 years evidence, as compared to the control group, a higher incidence of acute tubularnecrosis (p = 0,032), significantly higher blood creatinine levels in all the intervals considered, and agraft survival wich is 14% less at 12 months and 40% less at 36 months (p = 0,0009). These differencesare most probably to be attributed to the changes caused in these organs by advancing ageand by previous pathological situations, as we have not detected a higher incidence of inmunologic orsurgical complications.
Journal Information
Vol. 24. Issue 4.
Pages 330-343 (April 2000)
Vol. 24. Issue 4.
Pages 330-343 (April 2000)
Los injertos renales de donantes cadáver mayores de 60 años deben ser considerados subóptimos.
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Ante la escasez de órganos para trasplante una posible solución es la utilización de injertos procedentesde donantes añosos (mayores de 50 años). Revisamos nuestra experiencia en el periodo entre1989-1994, para obtener un seguimiento mínimo de 36 meses. Para ello, comparamos tres grupos:donantes entre 50-60 años (N = 32), donantes mayores de 60 años (N = 25) y un control de edades¿ideales¿ (N = 73). Los resultados han puesto de manifiesto que los donantes mayores de 60 años presentan,con respecto al control, una mayor incidencia de NTA (p = 0,032), una creatininemia significativamentemayor en todos los intervalos considerados y una supervivencia del injerto inferior en un14% y un 40% a los 12 y 36 meses respectivamente (p = 0,0009). Los motivos de estas diferenciascabe atribuirlos a factores intrínsecos relacionados con los cambios que la edad y condiciones patológicasejercen sobre estos órganos, ya que no se ha detectado una mayor incidencia de complicacionesinmunológicas o quirúrgicas.
Palabras clave:
Trasplante renal
Donantes añosos
Necrosis tubular aguda
Supervivencia del injerto
Considering the scarcity of organs for transplantation, one possible solution is the use of graftsfron aged donors (over 50 years). We have reviewed our experience in the case of kidney transplantationconsidering the period from 1989-1994 in order to attain a minimum follow-up of 36 months.
We compare three groups: donors aged between 50-60 years (n = 32), donors aged over 60 years(n = 25) and a control group formed by donors of ¿ideal¿ ages. The results show that kidneys fromdonors over 60 years evidence, as compared to the control group, a higher incidence of acute tubularnecrosis (p = 0,032), significantly higher blood creatinine levels in all the intervals considered, and agraft survival wich is 14% less at 12 months and 40% less at 36 months (p = 0,0009). These differencesare most probably to be attributed to the changes caused in these organs by advancing ageand by previous pathological situations, as we have not detected a higher incidence of inmunologic orsurgical complications.
We compare three groups: donors aged between 50-60 years (n = 32), donors aged over 60 years(n = 25) and a control group formed by donors of ¿ideal¿ ages. The results show that kidneys fromdonors over 60 years evidence, as compared to the control group, a higher incidence of acute tubularnecrosis (p = 0,032), significantly higher blood creatinine levels in all the intervals considered, and agraft survival wich is 14% less at 12 months and 40% less at 36 months (p = 0,0009). These differencesare most probably to be attributed to the changes caused in these organs by advancing ageand by previous pathological situations, as we have not detected a higher incidence of inmunologic orsurgical complications.
Keywords:
Renal transplantation
Aged donors
Acute tubular necrosis
Graft survival
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