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array:24 [ "pii" => "S2173578622000610" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2021.12.014" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1477" "copyright" => "AEU" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2022;46:531-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0210480622001012" "issn" => "02104806" "doi" => "10.1016/j.acuro.2021.12.016" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1477" "copyright" => "AEU" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2022;46:531-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo original</span>" "titulo" => "Orquialgia aguda aislada como síntoma inicial del trastorno de la médula torácica: informe de 2 casos y revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "531" "paginaFinal" => "535" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute isolated orchalgia as the initial symptom in thoracic cord disorder: 2 case report and literature review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1607 "Ancho" => 2407 "Tamanyo" => 375017 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En el caso 1, la resonancia magnética espinal mostró masas extradurales en T3-T4 y T10-T11 y múltiples metástasis vertebrales (A). La médula torácica estaba comprimida y desplazada a nivel de T3-T4 (B) y T10-T11 (C). En el caso 2, se observa un edema agudo a nivel de T2-T3 (D). La intensidad ponderada en T2 a nivel de C3-C4 se consideraba un cambio residual en la mielitis anterior.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I.C. Kao, W.H. Chen, H.L. Yin" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I.C." "apellidos" => "Kao" ] 1 => array:2 [ "nombre" => "W.H." "apellidos" => "Chen" ] 2 => array:2 [ "nombre" => "H.L." "apellidos" => "Yin" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173578622000610" "doi" => "10.1016/j.acuroe.2021.12.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578622000610?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480622001012?idApp=UINPBA00004N" "url" => "/02104806/0000004600000009/v1_202211020637/S0210480622001012/v1_202211020637/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173578622000580" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2022.06.007" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1474" "copyright" => "AEU" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2022;46:536-43" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Online surgical education adopted among urology residency programs in response to COVID-19: A pilot study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "536" "paginaFinal" => "543" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La educación quirúrgica en línea implementada en los programas de residencia urológica como respuesta a la COVID-19: estudio piloto" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1982 "Ancho" => 3175 "Tamanyo" => 562933 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Engagement of residents with online education models and in-person meetings. A. Location of where residents feel most comfortable asking questions. B. Stress and anxiety with online education models. C. Facial expression influence on question asking. D. How residents feel Online education models influences time flexibility.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Z.M. Connelly, R. Abou Ghayda, T. Paneque, J. Gómez Rivas, F. Esperto, A. Azzawe, J. Orzel, M. Kathrins, M.E. Ahmed, N. Khater" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Z.M." "apellidos" => "Connelly" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Abou Ghayda" ] 2 => array:2 [ "nombre" => "T." "apellidos" => "Paneque" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Gómez Rivas" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Esperto" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Azzawe" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Orzel" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "Kathrins" ] 8 => array:2 [ "nombre" => "M.E." "apellidos" => "Ahmed" ] 9 => array:2 [ "nombre" => "N." "apellidos" => "Khater" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210480622000985" "doi" => "10.1016/j.acuro.2021.12.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480622000985?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578622000580?idApp=UINPBA00004N" "url" => "/21735786/0000004600000009/v1_202211020736/S2173578622000580/v1_202211020736/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173578622000889" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2022.08.013" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1483" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2022;46:521-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "A systematic review and meta-analysis of CK20, CD44, Ki67 and p53 as immunohistochemical markers in bladder carcinoma in situ" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "521" "paginaFinal" => "530" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Revisión sistemática y metaanálisis sobre CK20, CD44, Ki67 y p53 como marcadores inmunohistoquímicos en el carcinoma in situ vesical" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1140 "Ancho" => 1675 "Tamanyo" => 169038 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Symmetric funnel plot consistent with lower likelihood of publication bias. The x-axis indicates CK20, CD44, Ki67 and p53 markers expression and the y-axis is the standard error.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Straccia, V. Fiorentino, M. Martini, F. Pierconti" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Straccia" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Fiorentino" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Martini" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Pierconti" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210480622001073" "doi" => "10.1016/j.acuro.2022.02.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480622001073?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578622000889?idApp=UINPBA00004N" "url" => "/21735786/0000004600000009/v1_202211020736/S2173578622000889/v1_202211020736/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Acute isolated orchalgia as the initial symptom in thoracic cord disorder: 2 case report and literature review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "531" "paginaFinal" => "535" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I.-C. Kao, W.-H. Chen, H.-L. Yin" "autores" => array:3 [ 0 => array:3 [ "nombre" => "I.-C." "apellidos" => "Kao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "W.-H." "apellidos" => "Chen" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "H.-L." "apellidos" => "Yin" "email" => array:1 [ 0 => "schoolyin@cc.kmu.edu.tw" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Shu-Te University, Kaohsiung City, Taiwan" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Neurology, Kaohsiung Chang Gang Memorial Hospital, College of Medicine, Chang Gung Memorial Hospital, Kaohsiung City, Taiwan" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Clinical Forensic Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Orquialgia aguda aislada como síntoma inicial del trastorno de la médula torácica: informe de 2 casos y revisión de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2008 "Ancho" => 3008 "Tamanyo" => 508482 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In Case 1, spinal magnetic resonance imaging showed extradural masses at T3-T4 and T10-T11 and multiple vertebral metastases (A). The thoracic cord was compressed and displaced at T3-T4 (B) and T10-T11 level (C). In Case 2, acute edema was seen at T2-T3 level (D). T<span class="elsevierStyleInf">2</span>-weighted intensity at C3-C4 level was considered residual change in previous myelitis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Acute non-traumatic orchalgia mostly results from testicular torsion in children and adolescence whereas testicular torsion, ischemia or infection in adult men.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However, idiopathicity is still reported in 25% of pediatric patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> whereas 25.2%–51.22% of adult patients<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> after extensive survey, and that renders a high risk of underdiagnosis, an exposure to unnecessary examinations, and legal disputes. A few abdominal pathologies, such as pancreatitis,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> aortic dissection,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> aortic aneurysm or adrenal pheochromocytoma, provoked referred pain in scrotum mimicking acute orchalgia through the sensory interconnections below the lower thoracic spinal cord. Herein, we firstly report two men who suffered an acute, isolated orchalgia was found to have upper thoracic spinal cord disorders later.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Patients and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">Two men who initially suffered an acute, isolated orchalgia, following by an exacerbation of urological, sexual and neurological dysfunction due to upper thoracic cord lesion, were reported. A literature review of spinal orchalgia from PUBMED was also completed. This study has been approved by the Chang Gung Medical Foundation Institutional Review Board (file number: 201701510B0).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Case 1. A 63-year-old man had had prostate cancer 3 years ago and completed surgical ablation and radiotherapy. Patient remained well until when a sudden onset of pain at testes occurred without antecedent trauma, infection or exercise. Erectile function was preserved. Testes did not enlarge. Pain was not provoked by palpation of testis. Cremasteric and anal reflex were preserved. Prostate cancer metastasis to testes was initially considered. A detailed urological survey, including doppler sonography, urinalysis and prostate specific antigen, did not reveal abnormal finding. Abdominal aneurysm, dissection or urolithiases was not found. While the intensity of orchalgia progressively decreased, numbness below umbilical region, weakness of both legs, urine retention and erectile dysfunction rapidly occurred at one week later. Lumbar spine radiography showed osteolytic foci suspecting for metastases. Incomplete transverse myelopathy below T7 level and anal and cremasteric areflexia were found. Spinal magnetic resonance imaging (MRI) disclosed multiple vertebral metastases and two extradural masses at T3-T4 level and T10-T11 level, respectively (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A to <a class="elsevierStyleCrossRef" href="#fig0005">1</a>C). Histopathological study of the masses was compatible with adenocarcinoma of prostate. Although orchalgia subsided within 2 days and numbness gradually improved after emergent surgical measure, dysuria, erectile dysfunction and paraparesis persisted. On a follow-up of 1 year, there was no recurrence of orchalgia.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Case 2. A 59-year-old man had had hypertension and prostate hyperplasia for 3 years and received transurethral ablation before. Patient remained well until when a sudden onset of weakness of both legs occurred due to C3/4 myelitis. Residual weakness was complicated after corticosteroid pulse therapy. Two months later, a sudden onset of orchalgia of both testes occurred without antecedent trauma, infection or exercise. Erectile function was preserved. Testes did not enlarge. Pain was not provoked by palpation of testes. Cremasteric and anal reflex were preserved. Prostate cancer metastasis to testes was initially considered. A detailed urological survey, including doppler sonography, urinalysis and prostate specific antigen, did not reveal abnormal finding. Abdominal aneurysm, dissection or urolithiases was not found. Two days later, urine retention, exacerbation of previous weakness and erectile dysfunction rapidly occurred. Incomplete transverse myelopathy below T5 level and anal and cremasteric areflexia were found. Spinal MRI disclosed acute edema of thoracic spinal cord at T2-T4 level (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). Laboratory tests disclosed moderate lymphocytic pleocytosis. Neuromyelitis optica was finally diagnosed. Although orchalgia and numbness subsided whereas dysuria improved after corticosteroid pulse therapy, erectile dysfunction and paraparesis persisted. On a follow-up of 2 years, there was no recurrence of orchalgia.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">The responsible lesions were identified at T2/3 level of spinal cord in our two patients. Neurogenic orchalgia has occasionally reported to arise from an involvement of peripheral nerves, lumbar plexuses, or lumbosacral nerve roots that innervate the testes. On the other hand, spinal orchalgia was reported in only four patients after a literature review of PUBMED (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>),<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–10</span></a> including primary tumor at T10 and T11 level, conus medullaris tumor, and T11-L5 spinal stenosis, in that the sensory innervations of testes are affected. Therefore, the results of our patients extend the pathognomonic sensory level from T10/11 upwards to T2/3 for orchalgia. A careful evaluation of spinal cord at upper thoracic cord is suggested for acute or chronic orchalgia, in especially without determined cause.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">A rapid and accurate diagnosis was greatly challenged in our patients by an absence of antecedent or concomitant neurological, sexual or vertebral symptom at initial until when their paraparesis abruptly occurred at 2–7 days later. Interestingly, the time interval between orchalgic onset and final diagnosis ranged from 6 weeks to 1 year in previously reported patients of spinal orchalgia,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–10</span></a> suggesting that spinal orchalgia is seriously neglected even ancillary symptom was present. Although a restricted somatosensory deficit is not rare for remote spinal cord disorder,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> we strive to search if the experiences in our patients can fill the gap of difficult diagnosis under similar situations. Reviewing the clinical course, our patients have had have a history of antecedent malignancy or myelitis that risks for metastasis or recurrent myelitis, and also a negative physical and sonographic result on presentation. Accordingly, a negative urological survey, together with a previous history of pathogenicity with a high risk of spinal cord involvement, should consider the possibility of spinal orchalgia.</p><p id="par0035" class="elsevierStylePara elsevierViewall">A poor prognosis of urological and sexual ability is common in our and previous patients.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–10</span></a> Indeed, erectile and fertile dysfunction prevalently complicate and poorly improve than motor component in spinal cord disorder in men.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Accordingly, a rapid and accurate diagnosis is necessary for minimizing urological and sexual dysfunction and preventing legal dispute in spinal orchalgia.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1795337" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1571577" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1795338" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1571578" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-12-16" "fechaAceptado" => "2021-12-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1571577" "palabras" => array:5 [ 0 => "Orchalgia" 1 => "Scrotum" 2 => "Spinal cord" 3 => "Pain" 4 => "Erectile dysfunction" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1571578" "palabras" => array:5 [ 0 => "Orquialgia" 1 => "Escroto" 2 => "Medula espinal" 3 => "Dolor" 4 => "Disfunción eréctil" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Orchalgia is a common andrological disorder and usually results from pathognomonic change of testes and regional structures. However, responsible cause is still unknown in more than one-fourth of patients.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We report two men who initially suffered an acute, isolated orchalgia and posteriorly complicated with paraparesis. They had previous history of prostate cancer and cervical myelitis. The urological examination was negative in both of them. Finally, prostate cancer metastasis and recurrent myelitis at T2/3 level was identified, respectively. Although their orchalgia progressively subsided, their urological, sexual and neurological dysfunction persisted.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In the literature, the responsible pathology of spinal orchalgia was exclusively found below T10 level, frequently delaying affirmative diagnosis. Therefore, a thorough evaluation of spinal cord above T10 level should be alerted for idiopathic orchalgia with a pre-existing history or risk of spinal cord disorder and a negative urological examination.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducción</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La orquialgia es un trastorno andrológico frecuente y suele darse como resultado de un cambio patognomónico en los testículos y estructuras adyacentes. Sin embargo, su causa sigue siendo desconocida en más de una cuarta parte de los pacientes.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Informamos de dos varones que sufrieron inicialmente una orquialgia aguda y aislada, que se complicó conduciendo posteriormente a una paraparesia. Los dos tenían antecedentes de cáncer de próstata y mielitis cervical. El examen urológico fue negativo en ambos. Finalmente, se identificó metástasis del cáncer de próstata y mielitis recurrente a nivel de T2 y T3, respectivamente. Aunque la orquialgia cedió progresivamente, las disfunciones urológicas, sexuales y neurológicas persistieron en los dos pacientes.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Según la literatura existente, la patología responsable de la orquialgia espinal se hallaba exclusivamente por debajo del nivel T10, lo que solía demorar el diagnóstico confirmatorio. Por lo tanto, en el caso de la orquialgia idiopática con una historia preexistente o riesgo de trastorno de la médula espinal y un estudio urológico negativo, se debe recomendar la evaluación exhaustiva de la médula espinal por encima del nivel T10.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2008 "Ancho" => 3008 "Tamanyo" => 508482 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In Case 1, spinal magnetic resonance imaging showed extradural masses at T3-T4 and T10-T11 and multiple vertebral metastases (A). The thoracic cord was compressed and displaced at T3-T4 (B) and T10-T11 level (C). In Case 2, acute edema was seen at T2-T3 level (D). T<span class="elsevierStyleInf">2</span>-weighted intensity at C3-C4 level was considered residual change in previous myelitis.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">DOP: diagnosis of underlying cause under first presentation; NR: Not reported.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Author, year \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age (Year) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Etiology and location \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Interval<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Associated symptom(s) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chen & Yin, Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prostate cancer intradural metastasis at T3−5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initially only acute orchalgia for 1 week, following by dysuria, erectile dysfunction, paraparesis and numbness below T9 level; no vertebral symptom \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical removal relieved scrotal pain. Dysuria and numbness improved but paraparesis and erectile dysfunction persisted \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kao et al., Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Postinfectious myelitis at T3 level \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initially only acute orchalgia for 2 days, following by dysuria, erectile dysfunction, paraparesis and numbness below T5 level; no vertebral symptom \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulse therapy abolished scrotal pain and numbness. Dysuria improved. Erectile dysfunction and paraparesis persisted \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dawson et al., 2014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ependymoma at T11-L2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lumbago, scrotal pain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pain was relieved by palliative gabapentin, amitriptyline and morphine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doubleday et al., 2003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Central disc herniation at T12-L1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 month \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vertebral symptom for 5 years; acute orchalgia, buttock pain, paresthesia and weakness of leg at right side \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Physical therapy relieved deficits \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kawsar & Goh, 2002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Spinal schwannoma at T10-L2 level \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Erectile dysfunction, dysuria, groin pain, orchalgia, gait instability \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical removal improved paraparesis partially but no benefit for other deficits \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kosar et al., 1999 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Conus medullaris meningioma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initially only orchalgia of both testes; lumbago and leg pain occurred at 9 months later \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical removal abolished pain within 1 month \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Interval: time interval between onset of orchalgia and diagnosis of underlying cause.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Summary of spinal orchalgia in PUBMED.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute scrotum pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. 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