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Original article
Thickness of the renal pelvis smooth muscle indicates the postoperative course of ureteropelvic junction obstruction treatment
El grosor del músculo liso de la pelvis renal indica el curso postoperatorio del tratamiento de la obstrucción de la unión ureteropélvica
C. Kaselasa,
Corresponding author
xkaselas@otenet.gr

Corresponding author.
, S. Aggelidoub, G. Papouisc, C. Kazakisa, A. Philippopoulosa
a Servicio Secundario de Cirugía Pediátrica, Hospital Universitario Aristotle, Hospital General Papageorgiou, Thessaloniki, Greece
b Servicio de Patología, Hospital General Hippokration, Thessaloniki, Greece
c Servicio de Cirugía Pediátrica, Hospital General Hippokration, Thessaloniki, Greece
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with the majority of patients being in between the two extremes&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Based on these observations&#44; there are surgeons that propose an early surgical intervention&#44; others that operate for certain reasons&#44; and the rest suggest that surgery is rarely needed&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Regarding the above-mentioned controversy&#44; the first author &#40;together with others&#41; has published an article that indicates which parameters should be taken into consideration in order to recognize earlier that the child will finally need to be operated&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">On the other hand&#44; although there are many reports regarding the preoperative approach of patients with UPJ obstruction&#44; the time to expected postoperative radiographic improvement has not been fully investigated&#46; Up to date&#44; there are some reports in the literature that try to identify any objective parameters indicative of which cases will have a delayed improvement at follow-up&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We attempted to examine the possible relationship between the histopathologic findings of the excised renal pelvis and the postoperative course of surgically treated patients with UPJ obstruction in order to determine a possible pattern of the onset and timing of their improvement&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">The medical files of all the children that were surgically treated for UPJ obstruction from 1998 to 2005 in a single tertiary Pediatric Surgery Unit were retrospectively reviewed&#46; Data collected included age at diagnosis&#44; gender&#44; side of the lesion&#44; age at operation&#44; time and results of postoperative radiographic examination&#44; and time of definite improvement&#46; The existence of adequate histopathologic specimens in our Pathology Department&#44; and complete postoperative follow-up were inclusion criteria to the study&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Patients with prenatal diagnosis were evaluated initially at the age of 1 month with renal ultrasound&#44; and at the age of 3 months with diuretic renogram&#46; The protocol for the management of patients with confirmed diagnosis of unilateral UPJ obstruction was initial observation with regular follow-ups with renal ultrasound and diuretic renogram every 6 months for 1 year&#44; and every year thereafter&#46; Criteria for the change to surgical intervention were further increase of the anteroposterial renal pelvis diameter&#44; worsening of the obstructive curve in the diuretic renogram&#44; and drop of relative renal function &#40;RRF&#41; below 40&#37;&#44; as it was published in a previous report&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">All the patients were operated with the Anderson&#8211;Hynes dismembered pyeloplasty technique&#46; Excised UPJ complex specimens were sent to the Pathology Department&#46; Upon completion of the operation&#44; the patient had a nephrostomy tube and an additional tube of appropriate diameter in the upper ureter that served as a stent&#46; The stent was removed on the 8th postoperative day&#44; and a pyelography was performed through the nephrostomy tube that confirmed the surgical success&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Follow-up consisted of a renal U&#47;S at the third postoperative month followed by a repeated renal U&#47;S and diuretic renogram at the sixth postoperative month&#46; If the radiographic results were not satisfactory&#44; the same examinations were repeated every three months&#46; A fully successful surgical management was defined in normal values of the renal pelvis diameter in the renal U&#47;S&#44; combined with a diuretic renogram washout pattern not indicative of UPJ obstruction&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">For the purpose of this study&#44; the histopathological samples were examined and appropriately managed by our Pathology Department&#46; These were fixed in 10&#37; buffered formalin for 24<span class="elsevierStyleHsp" style=""></span>h&#44; and then embedded in paraffin blocks maintaining the native orientation&#46; Afterwards&#44; the samples were horizontally sectioned in 4<span class="elsevierStyleHsp" style=""></span>&#956;m slides and were stained using elastic van Geisson to differentiate the renal pelvis smooth muscle from collagen and elastin&#46; This highlights the smooth muscle as red-light brown&#44; collagen as shiny orange&#44; and elastic fibers as black &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The measurement of pre-stenotic renal pelvis smooth muscle thickness was performed with an intraocular ruler under 40&#215; magnification&#46; The widest thickness of the lamina muscularis propria was measured from the luminal to adluminal surface&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Statistical evaluation of any relation between the histopathologic findings and the patients&#8217; postoperative course&#44; this being defined from the time of final improvement&#44; was performed by the use of the Pearson correlation coefficient&#46; A two-sided <span class="elsevierStyleItalic">p</span> value of &#8804;0&#46;05 indicated statistical significance&#46; Statistical analysis was performed by using the Statistical Package for the Social Sciences SPSS for Windows &#40;Edition 17&#46;0&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">Thirty-four patients were operated on for unilateral UPJ obstruction from 1998 to 2005&#46; 28 of them had adequate histopathological specimens and complete follow-up radiographic examination&#44; and they constituted our study group&#46; The rest of the patients were either lost during the follow-up or their histopathological samples could not be retrieved&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">17 male and 11 female patients were identified &#40;male to female ratio<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;5&#58;1&#41;&#46; The left to right side of the lesion ratio was 1&#46;5&#58;1&#44; and the median age at operation was 2 years &#40;range&#58; 3 months to 13 years&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Improvement was noticed in all patients&#46; No recurrence or further deterioration was noted&#44; hence&#44; no re-operation was needed&#46; The time over which improvement was observed according to radiological findings ranged from the sixth and the twelfth postoperative month&#46; Interestingly&#44; the 12 patients that improved at the sixth postoperative month had a mean renal pelvis smooth muscle thickness &#40;mRPSMT&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>136&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&#46;17 &#40;range&#58; 100<span class="elsevierStyleHsp" style=""></span>&#956;m to 237&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; mean&#58; 137&#46;5&#41;&#46; The 9 patients that improved at the ninth postoperative month had a mRPSMT<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>173&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;91 &#40;range&#58; 112&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;m to 237&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; mean&#58;175<span class="elsevierStyleHsp" style=""></span>&#956;m&#41;&#46; The 7 patients with improvement at the twelfth postoperative month had a mRPSMT<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>258&#46;78<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>96&#46;09 &#40;range&#58; 137&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;m to 375<span class="elsevierStyleHsp" style=""></span>&#956;m&#44; mean<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>&#956;m&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The correlation between the renal pelvis smooth muscle thickness and time of postoperative improvement proved to be extremely significant &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;7928&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">We also measured the percentile presence of collagen and elastin content of the obstructed UPJ&#44; and no correlation was detected between those and the postoperative time of recovery of hydronephrosis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; no correlation was identified between the time of postoperative radiologically confirmed improvement&#44; and the ages at operation&#44; the presence of prenatal diagnosis&#44; gender&#44; or side of the lesion&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The success rate of the surgical intervention in UPJ obstruction is reported to be greater than 95&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However&#44; the post-operative course of these patients until they achieve a satisfactory non-obstructive pattern of renal function is not always uneventful&#46; It is not uncommon in such cases that the initial postoperative radiographic examinations are not suggestive of a successful surgical management&#44; loading both the parents and the surgeon with increased anxiety&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Reasons for initially unresolved hydronephrosis include irreversible histopathological changes in the renal pelvis and the caliceal collecting system&#44; transient obstruction due to edema at the site of repair&#44; and persistent obstruction because of failed pyeloplasty&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In most cases&#44; however&#44; hydronephrosis resolves&#44; and an improvement in renal function and drainage is achieved in subsequent studies during the follow-up&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">More specifically&#44; the upper urinary tract responds to the obstruction with a series of histological changes&#46; The compliance of the renal pelvis is determined by the structure of the smooth muscle tissue&#44; as well as the extracellular matrix collagen deposition&#44; and that compliance is lost when the renal pelvic wall smooth muscle thickness and collagen increase&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">With regard to the renal pelvis smooth muscle thickness that follows UPJ obstruction&#44; previous studies describe conflicting results&#46; There are investigators that report that UPJ obstruction is associated with hypotrophy of the smooth muscle of the obstructed segment&#44; or even atrophy that follows nerve fibers depletion&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a> On the other hand&#44; there are those that report an increased proportion of smooth muscle cells in the obstructed UPJ leading to hypertrophy&#47;hyperplasia&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;10</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In this study&#44; although we did not compare the thickness of the renal pelvis smooth muscle of patients with obstructed and non-obstructed UPJ&#44; when we compared it to that reported in the literature&#44; we too concluded that there was an increased thickness of the lamina muscularis propria&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Kim WJ et al&#46; and Kim DS et al&#46; have reported that collagen to smooth muscle ratio and elastin content of the renal pelvis determine post-pyeloplasty recovery&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;11</span></a> They have found that increased collagen to smooth muscle ratio and increased elastin content in the obstructed UPJ contributes to inelasticity and low compliance&#44; resulting in slower recovery of the hydronephrosis after pyeloplasty&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">On the other hand&#44; Han et al&#46; have reported that the thickness of the lamina muscularis propria can be used as a predictive parameter of the time of the post-pyeloplasty hydronephrosis recovery&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> They reported that the increased thickness of the UPJ smooth muscle correlates with slower improvement&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Our results keep up with those of Han et al&#46; We found that the increased renal pelvis smooth muscle thickness correlates with delayed postoperative radiographic improvement&#46; No correlation between the percentile presence of collagen or elastin content with the time of postoperative radiographic improvement was observed&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">These results clearly indicate that important information can be obtained by the histopathological examination of the obstructed UPJ samples after a dismembered pyeloplasty&#46; During the time of the patient&#39;s postoperative recovery&#44; and until the first postoperative radiographic examination&#44; the surgeon can retrieve useful information regarding the patient&#39;s postoperative course and expected timing of hydronephrosis improvement&#44; based on the thickness of the renal pelvis smooth muscle&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This way&#44; the parents and the treating surgeon should only be worried about possible persistent obstruction if the appropriate time interval is prolonged&#46; Such knowledge can be extremely helpful and reassuring&#44; not only for the surgeon but for the patients&#8217; families as well&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">All of the above indicates that in patients that are operated on for UPJ obstruction&#44; the pattern of postoperative improvement correlates with the thickness of their renal pelvis smooth muscle&#46; This is significantly correlated with the postoperative course of patients with UPJ obstruction&#44; and it could be used as a prognostic tool for the onset of their improvement&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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            0 => "Pyeloplasty"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To investigate the relationship between the histopathologic findings and the postoperative course of children surgically treated for ureteropelvic junction &#40;UPJ&#41; obstruction&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Twenty-eight patients operated for unilateral UPJ obstruction from 1998 to 2005 with adequate histopathologic specimens and postoperative follow up were retrospectively reviewed&#46; Specimens were stained using elastic van Geisson to differentiate smooth muscle from collagen and elastin&#46; Postoperative follow up included renal ultrasound &#40;U&#47;S&#41; and diuretic renogram studies&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Twelve patients with mean renal pelvis smooth muscle thickness &#40;mRPSMT&#41; of 136&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>34&#46;17 improved on the 6th postoperative month&#46; Nine patients that improved after 9 months postoperatively had mRPSMT<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>173&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;91&#46; The rest 7 patients that improved on the 12th postoperative month had mRPSMT<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>258&#46;78<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>96&#46;09&#46; Correlation between renal pelvis smooth muscle and time of postoperative improvement was extremely significant &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;7928&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The thickness of the renal pelvis smooth muscle is significantly correlated to the postoperative course of patients with UPJ obstruction and can be used as a prognostic tool for the onset of their improvement&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Investigar la relaci&#243;n entre los resultados histopatol&#243;gicos y el curso postoperatorio de ni&#241;os tratados quir&#250;rgicamente por obstrucci&#243;n de la uni&#243;n ureterop&#233;lvica &#40;UUP&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se examin&#243; retrospectivamente a 28 pacientes operados por obstrucci&#243;n unilateral de la UUP desde 1998 hasta 2005 con muestras histopatol&#243;gicas suficientes&#44; as&#237; como su seguimiento postoperatorio&#46; Se tintaron las muestras utilizando la el&#225;stica van Gieson para diferenciar el m&#250;sculo liso del col&#225;geno y la elastina&#46; El seguimiento postoperatorio incluy&#243; la ecograf&#237;a renal &#40;EcoR&#41; y estudios de renograma diur&#233;tico&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">12 pacientes con un grosor medio del m&#250;sculo liso de la pelvis renal &#40;GmMLPR&#41; de 136&#44;97 &#177; 34&#44;17 mejoraron en 6 meses despu&#233;s de la operaci&#243;n&#46; Nueve pacientes que mejoraron 9 meses despu&#233;s ten&#237;an un GmMLPR de 173&#44;61 &#177; 33&#44;91&#46; Los 7 pacientes restantes&#44; al duod&#233;cimo mes&#44; ten&#237;an un GmMLPR de 258&#44;78 &#177; 96&#44;09&#46; La correlaci&#243;n entre el m&#250;sculo liso de la pelvis renal y el tiempo de mejor&#237;a postoperatoria fue extremadamente significativo &#40;p &#61; 0&#44;7928&#59; m &#60; 0&#44;0001&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El grosor del m&#250;sculo liso de la pelvis renal est&#225; considerablemente correlacionado con el curso postoperatorio de los pacientes con obstrucci&#243;n de la UUP&#44; y se puede utilizar como herramienta de pron&#243;stico del comienzo de su mejor&#237;a&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Kaselas C&#44; et al&#46; El grosor del m&#250;sculo liso de la pelvis renal indica el curso postoperatorio del tratamiento de la obstrucci&#243;n de la uni&#243;n ureterop&#233;lvica&#46; Actas Urol Esp&#46; 2011&#59;35&#58;605&#8211;9&#46;</p>"
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                    0 => array:2 [
                      "titulo" => "Structural changes of smooth muscle in congenital ureteropelvic junction obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Hosgor"
                            1 => "I&#46; Karaca"
                            2 => "C&#46; Ulucus"
                            3 => "E&#46; Ozer"
                            4 => "E&#46; Ozkara"
                            5 => "B&#46; Sam"
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                      "doi" => "10.1016/j.jpedsurg.2005.06.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "2005"
                        "volumen" => "40"
                        "paginaInicial" => "1632"
                        "paginaFinal" => "1636"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16226997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen studies for pediatric ureteropelvic junction obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;Y&#46; Yoon"
                            1 => "J&#46;C&#46; Kim"
                            2 => "T&#46;K&#46; Hwang"
                            3 => "M&#46;S&#46; Yoon"
                            4 => "Y&#46;H&#46; Park"
                          ]
                        ]
                      ]
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