Multicenter study on costs associated with two surgical procedures: GreenLight XPS 180W versus the gold standard transurethral resection of the prostate | Actas Urológicas Españolas (English Edition)

array:24 ["pii" => "S2173578614000304" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2014.02.014" "estado" => "S300" "fechaPublicacion" => "2014-07-01" "aid" => "606" "copyright" => "AEU" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2014;38:373-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 367 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 281 "PDF" => 79 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0210480613003859" "issn" => "02104806" "doi" => "10.1016/j.acuro.2013.10.011" "estado" => "S300" "fechaPublicacion" => "2014-07-01" "aid" => "606" "copyright" => "AEU" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2014;38:373-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 711 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 588 "PDF" => 113 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Artículo original" "titulo" => "Estudio multicéntrico de costes de 2 técnicas quirúrgicas: láser GreenLight XPS 180W vs resección transuretral de la próstata" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "373" "paginaFinal" => "377" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multicenter Study on Costs Associated With Two Surgical Procedures: GreenLight XPS 180W Versus the Gold Standard Transurethral Resection of the Prostate" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 819 "Ancho" => 1612 "Tamanyo" => 80146 ] ] "descripcion" => array:1 [ "es" => "Dispersión de los resultados económicos en función de la estancia hospitalaria asociada a cada centro." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Benejam-Gual, Á. Sanz-Granda, A. Budía, J. Extramiana, C. Capitán" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Benejam-Gual" ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "Sanz-Granda" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Budía" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Extramiana" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Capitán" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173578614000304" "doi" => "10.1016/j.acuroe.2014.02.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000304?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003859?idApp=UINPBA00004N" "url" => "/02104806/0000003800000006/v1_201406240031/S0210480613003859/v1_201406240031/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173578614000407" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2014.02.017" "estado" => "S300" "fechaPublicacion" => "2014-07-01" "aid" => "602" "copyright" => "AEU" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2014;38:378-84" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 480 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 370 "PDF" => 101 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Pre-operative training induces changes in the histomorphometry and muscle function of the pelvic floor in patients with indication of radical prostatectomy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "378" "paginaFinal" => "384" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El entrenamiento preoperatorio induce cambios en la histomorfometría y función de los músculos del suelo pélvico en pacientes con indicación de prostatectomía radical" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 370 "Ancho" => 1000 "Tamanyo" => 139186 ] ] "descripcion" => array:1 [ "en" => "H–E staining (×400 magnification). Photomicrographs of the external sphincter muscle of the urethra. A. Intervention group. B. Control group. Muscle fibers of various sizes were identified in both groups. Hypertrophic fibers can be observed, as well as atrophic muscle fibers with abundant surrounding connective tissue distributed among the hypertrophic muscle fibers. Note the presence of central nuclei suggestive of regenerative changes in the fibers." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Á. Ocampo-Trujillo, J. Carbonell-González, A. Martínez-Blanco, A. Díaz-Hung, C.A. Muñoz, R. Ramírez-Vélez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Á." "apellidos" => "Ocampo-Trujillo" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Carbonell-González" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Martínez-Blanco" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Díaz-Hung" ] 4 => array:2 [ "nombre" => "C.A." "apellidos" => "Muñoz" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Ramírez-Vélez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210480613003811" "doi" => "10.1016/j.acuro.2013.10.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003811?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000407?idApp=UINPBA00004N" "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000407/v1_201406240033/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173578614000298" "issn" => "21735786" "doi" => "10.1016/j.acuroe.2014.02.013" "estado" => "S300" "fechaPublicacion" => "2014-07-01" "aid" => "600" "copyright" => "AEU" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2014;38:367-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 501 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 297 "PDF" => 195 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Simulators help improve student confidence to acquire skills in urology" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "367" "paginaFinal" => "372" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La simulación mejora la confianza de los estudiantes para adquirir competencias en urología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 579 "Ancho" => 773 "Tamanyo" => 71972 ] ] "descripcion" => array:1 [ "en" => "Urological examination workshop." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.C. Rodríguez-Díez, N. Díez, I. Merino, J.M. Velis, A. Tienza, J.E. Robles-García" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M.C." "apellidos" => "Rodríguez-Díez" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Díez" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Merino" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Velis" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Tienza" ] 5 => array:2 [ "nombre" => "J.E." "apellidos" => "Robles-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210480613003793" "doi" => "10.1016/j.acuro.2013.10.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003793?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000298?idApp=UINPBA00004N" "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000298/v1_201406240033/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Multicenter study on costs associated with two surgical procedures: GreenLight XPS 180W versus the gold standard transurethral resection of the prostate" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "373" "paginaFinal" => "377" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.M. Benejam-Gual, Á. Sanz-Granda, A. Budía, J. Extramiana, C. Capitán" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Benejam-Gual" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Á." "apellidos" => "Sanz-Granda" "email" => array:1 [ 0 => "a.sanzgranda@terra.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Budía" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Extramiana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Capitán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Urología, Hospital de Manacor, Mallorca, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Proyectos de Farmacoeconomía, Navacerrada, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urología, Hospital de La Fe, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Urología, Hospital de Vitoria, Álava, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Urología, Hospital de Alcorcón, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio multicéntrico de costes de 2 técnicas quirúrgicas: láser GreenLight XPS 180W vs resección transuretral de la próstata" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 819 "Ancho" => 1612 "Tamanyo" => 75119 ] ] "descripcion" => array:1 [ "en" => "Dispersion of economic performance in terms of hospital stay associated with each center." ] ] ] "textoCompleto" => "IntroductionTransurethral resection of prostate (TURP) is the endoscopic surgical technique of reference in the treatment of lower urinary tract symptomatology (LUTS) secondary to benign prostatic hyperplasia (BPH). However, this procedure has complications and is associated with high incidence of reoperations.Photoselective vaporization of the prostate with 532nm wavelength green laser (120W) is an efficient surgical alternative to TURP because it has a similar efficacy<a class="elsevierStyleCrossRefs" href="#bib0005">1–3</a> at lower cost.<a class="elsevierStyleCrossRefs" href="#bib0020">4,5</a> This technology has evolved to achieve a power of 180W (GreenLight XPS). This power allows managing higher-volume prostates and at the same time preserves fiber integrity, being possible to use only one fiber per patient.<a class="elsevierStyleCrossRef" href="#bib0030">6</a>The allocation of resources for health – new technologies should be accompanied by the corresponding economic assessment demonstrating its efficiency. For this reason, the objective of this study was to analyze, from the perspective of National Health System, the costs associated with surgical treatment of LUTS secondary to BPH using GL 180-W XPS and TURP in a time horizon of 3 months.MethodsA multicenter retrospective study of costs was performed using the bottom-up methodology to estimate the average cost per patient associated with surgical treatment with the new technology GL XPS 180W of LUTS secondary to BPH. Endoscopic surgical technology was used as a comparator. The study was performed in a time horizon of 3 months from the perspective of National Health System.PopulationData were obtained from clinical histories of patients who were operated sequentially between July 2012 and October 2012 with the surgical alternatives assessed in 4 Spanish hospitals. Inclusion criteria were: previous diagnosis of LUTS secondary to BPH, IPSS≥15, Qmax≤15ml/sec and prostatic volume ≥40ml and ≤80ml. Exclusion criteria were the lack of follow-up of patient as well as the lack of values for necessary variables in the study.ModelMathematical model was performed to estimate the total average cost per patient intervened with surgical alternative (x):<elsevierMultimedia ident="eq0005"></elsevierMultimedia>in which c(i,t) stands for the cost (c) of the resource (i) in process phase (t). Phase process is calculated by the product (q(i,t)*p(i,t)), in which q(i,t) stands for the quantity (q) of the resource (i) and p(i,t) for its unitary price (p).The outcome variable was estimated as the difference between the average total cost per patient and the technologies evaluated, x y x′ (ΔĈ(x−x′)).Costs dataFrom the perspective of Spanish National Health System, only direct health costs were included, therefore indirect costs associated with patients’ lost work productivity were ignored. Average cost was estimated using bottom-up method,<a class="elsevierStyleCrossRef" href="#bib0035">7</a> counting the resources consumed in hospital stay (operating room, recovery room and hospital stay), in diagnostics and analytical procedures and in differentiated equipment necessary to carry out both surgical options. Finally, the resources necessary for the management of complications were estimated. Unitary prices of resources were obtained from specialized literature,<a class="elsevierStyleCrossRefs" href="#bib0040">8–10</a> as well as from public<a class="elsevierStyleCrossRefs" href="#bib0055">11,12</a> and professional<a class="elsevierStyleCrossRef" href="#bib0065">13</a> agencies. All costs were presented in 2013 euros, and, if necessary, yearly adjusted according to the General Index of Consumer Prices.<a class="elsevierStyleCrossRef" href="#bib0070">14</a>Direct costs were analyzed in a disaggregated way, depending on three temporary phases: pre-surgical phase, gathering the costs incurred from initial surgical consultation until the day preceding surgery; surgical phase, covering surgery period; and post-surgical phase, comprising the resources used since operating room exit up to 3 following months. In both surgical procedures, differences among estimated values were analyzed using Student's t test for samples with unequal variances at the 0.05 significance level. The degree of outcome dispersion was calculated by bootstrap method<a class="elsevierStyleCrossRef" href="#bib0075">15</a> or resampling with repetition, in which 500 iterations were performed and the 95% confidence interval was calculated for the trimmed mean differences,<a class="elsevierStyleCrossRef" href="#bib0080">16</a> in order to remove extreme values.Effectiveness dataThe result of effectiveness was healing at 3 months, defined as unobstructed patient (a post-operative reduction ≥5 points according to International Prostate Symptom Score [IPSS] and an increase in maximum flow ≥5ml/s. measured in flowmetry).Sensibility analysisFinally, results obtained were analyzed by univariate sensitivity analysis of the most relevant variables: hospital stay and prostate size.ResultsDuring the period from July 2012 until October 2012, 79 patients randomly underwent prostate surgery, 40 of them using TURP and the other 39 with laser new technology GL XPS. Baseline characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>The clinical outcome of healing was equivalent for both the procedures (94.9 and 92.5% for GL XPS and TURP, respectively) and did not show statistically significant differences (p=0.67).Bootstrap result after 500 iterations showed a statistically significant difference of –121€ (CI 95%: −91; −151; p<0.01) between total average cost per patient treated with GL XPS (3277€; DE:6.56) and TURP (3398€; DE: 13.80) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). In patients who underwent GL XPS, cost disaggregation according to temporary phases of surgical process was higher (difference: 1209€; CI 95%: 1200; 1217; p<0.001), whilst in post-surgical phase it was lower (difference: −1351€; CI 95%: −1322; 1380; p<0.001) (<a class="elsevierStyleCrossRefs" href="#tbl0015">Tables 3 and 4</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia>Sensibility univariate analysis for hospital stay time after surgery reports that in GL XPS under outpatient regime or surgery without admission compared with TURP. the cost reduction can reach up to 698€ per patient in the first 3 months (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Prostate size is also a cost moderator variable. Linear regression model correlating both variables shows that total average cost per patient is slightly dependent on size in GL XPS procedure (R2: 0.248) and independent in TURP (R2: 0.007). Final outcomes are strongly influenced by variations in clinical practice.DiscussionTotal average cost per patient in the first 3 months has been associated with a statistically significant saving of 121€ per patient who underwent to GL XPS (CI 95%: 91; 151). This difference is caused by a significant cost reduction (−1351€) in the post-surgical phase, which is associated with a shorter hospital stay in GL XPS patients (this fact had already been shown in cases involving GreenLight HPS 120W laser<a class="elsevierStyleCrossRef" href="#bib0085">17</a>). This cost reduction offsets the increase in the same in the surgical phase (+1209€) associated with the allocation of the necessary equipment for surgery by GL XPS.Dispersion in outcomes is associated with variation in clinical practice, mainly with hospital stay, set in a range from 0.1 to 2.2 days (mean: 1.31 days) for GL XPS, and from 3.5 to 5.5 days (mean: 4.05 days) for TURP. A study performed in Spain<a class="elsevierStyleCrossRef" href="#bib0020">4</a> showed that the GL XPS carried out in outpatient surgery regime had a lower cost. Additionally, allocated cost to the technology – responsible for the increase in cost in surgical phase – depends on the price thereof, its utilization level and amortization time as well as the usage of fibers. In our study, the equipment price (90,000€) has been decreased compared to that in the preceding years. The same happens with the price of fiber (950€). All of this increases the efficiency. When utilization level of GL XPS is higher than 100 patients per year, its cost decreases and, consequently, its efficiency enhances. On the other hand, fiber usage has been reduced to almost one per patient (mean: 1.03 fibers per patient).According to our knowledge, this is the first economic study published comparing the new technology GL XPS 180W versus TURP. Outcomes obtained newly report a similar efficacy and the lower cost for GL XPS and are in line with previously published findings for GL HPS 120W.<a class="elsevierStyleCrossRefs" href="#bib0020">4,5</a>When health resources are limited, it is necessary to allocate them in the most efficient way so that better outcomes are obtained at lower cost. Thus, opportunity cost will reduce and, as a consequence, it might be able to use surplus resources for other purposes. Outcomes obtained show that surgery using GL XPS in patients with LUTS secondary to BPH might allow a cost reduction, even in the short term, maintaining the health outcomes achieved by using a common procedure of TURP. This cost reduction will be more important for the higher proportion of patients who undergo outpatient surgery.The study has some limitations. First, the size of the sample is limited, reducing statistical power; however, given the size of the phases, detailed phase function analysis of costs shows significant differences. In order to resolve this limitation, a bootstrap resampling analysis was performed, showing statistically significant total cost differences. Second, the variability in medical practice results in a remarkable dispersion in economic performance (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). For this reason, the study was been performed in four different hospitals to minimize the positive or negative impact that would occur in one single center.<elsevierMultimedia ident="fig0010"></elsevierMultimedia>In order to minimize these limitations, randomized, controlled trials with enough population are necessary to reach enough statistical power.In light of the results obtained in this study, we can conclude that the intervention of patients with LUTS secondary to BPH using the new GreenLight Photovaporization XPS 180-W laser technology is associated with a reduction in costs due to a shorter duration of hospital stay, which offsets the cost incurred for such technology.FundingThis study was funded by an unrestricted grant from American Medical Systems.Conflict of interestDr. Sanz-Granda, specialist in economic evaluation of health technologies, received an unrestricted grant for the study. Remaining authors have no conflict of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:2 [ "identificador" => "xres347984" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objective" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec329621" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres347985" "titulo" => array:5 [ 0 => "Resumen" 1 => "Objetivo" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec329620" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Population" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Model" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Costs data" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Effectiveness data" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Sensibility analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflict of interest" ] 10 => array:2 [ "identificador" => "xack85647" "titulo" => "Acknowledgment" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-10-22" "fechaAceptado" => "2013-10-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec329621" "palabras" => array:4 [ 0 => "Green Light Photovaporization 180W" 1 => "Transurethral resection of the prostate" 2 => "Cost" 3 => "Benign prostate hyperplasia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec329620" "palabras" => array:4 [ 0 => "Green Light Photovaporization 180W" 1 => "Resección transuretral de la próstata" 2 => "Coste" 3 => "Hiperplasia benigna de próstata" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "ObjectiveTo analyze the costs associated with two surgical procedures for lower urinary tract symptoms secondary to benign prostatic hyperplasia: GreenLight XPS 180W versus the gold standard transurethral resection of the prostate. MethodsA multicenter, retrospective cost study was carried out from the National Health Service perspective, over a 3-month time period. Costs were broken down into pre-surgical, surgical and post-surgical phases. Data were extracted from records of patients operated sequentially, with IPSS=15, Qmax=15mL/seg and a prostate volume of 40–80mL, adding only direct healthcare costs (€, 2013) associated with the procedure and management of complications. ResultsA total of 79 patients sequentially underwent GL XPS (n: 39) or TURP (n: 40) between July and October 2013. Clinical outcomes were similar (94.9% and 92.5%, GL XPS and TURP, respectively) without significant differences (p=0.67). The average direct cost per patient was reduced by 114€ in GL XPS versus TURP patients; the cost was higher in the surgical phase with GL XPS (difference: 1209€; p<0.001) but was lower in the post-surgical phase (difference: €−1351; p<0.001). ConclusionsThe GreenLight XPS 180-W laser system is associated with a reduction in costs with respect to transurethral resection of prostate in the surgical treatment of LUTS secondary to PBH. This reduction is due to a shorter inpatient length of stay that offsets the cost of the new technology." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "ObjetivoAnalizar los costes asociados al tratamiento quirúrgico de la sintomatología del tracto urinario inferior secundaria a hiperplasia benigna de próstata mediante el láser GreenLigh XPS 180W respecto a la técnica quirúrgica endoscópica de referencia, resección transuretral de la próstata. MétodosSe realizó un estudio retrospectivo y multicéntrico de costes desde la perspectiva del Sistema Nacional de Salud y en un horizonte temporal de 3 meses, desagregándolos en fases temporales: prequirúrgica, quirúrgica y posquirúrgica. Los datos fueron extraídos de las historias de los pacientes intervenidos secuencialmente, con IPSS=15, Qmax=15ml/seg y volumen prostático de 40-80ml, incorporando solo costes sanitarios directos (euros de 2013) asociados a la intervención y al manejo de complicaciones. ResultadosEntre julio y octubre de 2012 se intervinieron de forma secuencial 39 pacientes con láser GL XPS y 40 con RTUP. El resultado clínico fue equivalente (94,9 y 92,5%, respectivamente) no mostrando diferencias estadísticamente significativas (p=0,67). El coste medio total por paciente se redujo en 121€ en el grupo láser GL XPS respecto de RTUP; en la fase quirúrgica el coste fue superior con láser GL XPS (diferencia: 1.209€; p<0,001) mientras que fue inferior en la fase posquirúrgica (diferencia: –1.351€, p<0,001). ConclusionesLa intervención de los pacientes con STUI secundario a HBP mediante la nueva tecnología láser GL XPS se asocia a una reducción de costes respecto de la RTUP, debida a una menor duración de la estancia hospitalaria, la cual compensa el coste imputado a dicha tecnología." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Benejam-Gual JM, Sanz-Granda Á, Budía A, Extramiana J, Capitán C. Estudio multicéntrico de costes de 2 técnicas quirúrgicas: láser GreenLight XPS 180W vs resección transuretral de la próstata. Actas Urol Esp. 2014;38:373–377." ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1017 "Ancho" => 1616 "Tamanyo" => 69766 ] ] "descripcion" => array:1 [ "en" => "Sensitivity analysis of hospital stay after surgery." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 819 "Ancho" => 1612 "Tamanyo" => 75119 ] ] "descripcion" => array:1 [ "en" => "Dispersion of economic performance in terms of hospital stay associated with each center." ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "SD, standard deviation; GL XPS, GreenLight laser XPS 180W; IPSS, International Prostate Symptom Score; PSA, prostatic specific antigen; Qmax, maximum flow rate; TURP, transurethral resection of the prostate." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">GL XPS (DE) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">RTUP (DE) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.33 (7.89) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.28 (8.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.999 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prostatic vol. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.00 (18.70) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44.83 (16.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.421 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PSA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.54 (2.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.09 (2.58) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.293 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IPSS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.08 (5.92) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.00 (6.55) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.685 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Qmax \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.19 (3.12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.50 (4.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.511 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab518734.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Baseline characteristics of surgical patients; mean and standard deviation." ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "SE, error standard; GL XPS, GreenLight XPS laser 180W; TURP, transurethral resection of the prostate." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">GL XPS (SE) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TURP (SE) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total cost (€) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3277 (6.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3398 (13.80) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pre-surgical phase (€) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">249 (1.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">227 (0.95) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical phase (€) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2330 (3.19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1121 (2.60) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Post-surgical phase (€) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">699 (5.57) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2050 (13.80) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab518733.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Cost per surgical patient." ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "GL XPS, GreenLight XPS 180W laser; CI 95%, confidence interval at 95%; n.a., not applicable; TURP. transurethral resection of the prostate." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">GL XPS (CI 95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">RTUP (CI 95%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Operating theater \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">916 (467; 1463) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">910 (466; 1359) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urologist 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 (18; 62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 (20; 63) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urologist 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (0; 50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (0; 53) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Anesthesiologist \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 (6; 80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 (7; 79) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nursing S. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88 (41; 137) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80 (31; 119) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Support staff 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (10; 36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (8; 30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Support staff 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (0; 35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (0; 30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GreenLight \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">225 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n.a. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fiber \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">974.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n.a. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab518731.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Costs incurred in surgical phase." ] ] 5 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "GL XPS, GreenLight XPS 180W laser; CI 95%, confidence interval at 95%; TURP, transurethral resection of the prostate." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">GL XPS (CI 95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TURP (CI 95%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Recovery room \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (8; 60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 (4; 128) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hospital stay \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">584 (0; 2281) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1811 (894; 3231) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Consultation with urologist \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 (0; 55) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 (0; 55) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Flowmetry \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (0; 37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 (0; 38) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ultrasonography \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0; 0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0; 41) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CBC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (0; 15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (0; 15) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PSA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (0; 12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (0; 11) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urea \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0; 3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0; 3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Creatinine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0; 1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1; 5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urinary sediment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0; 4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0; 4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Urine culture \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (0; 13) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (0; 13) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Complications \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (0; 19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">106 (0; 117) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab518732.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Incurred costs (CI 95%) in post-surgical phase." ] ] 6 => array:5 [ "identificador" => "eq0005" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:5 [ "Matematica" => "Cˆx=∑c(i,t)=∑q(i,t)*p(i,t)=q(i,t)*pi1t1+q(i,t)*pi2,t2+⋯+q(i,t)*pin.tn" "Fichero" => "si1.jpeg" "Tamanyo" => 4169 "Alto" => 47 "Ancho" => 372 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GreenLight HPS 120-W Laser Vaporization versus transuretral resection of the prostate for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia: a randomized clinical trial with 2-year follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Capitán" 1 => "C. Blázquez" 2 => "D. Martín" 3 => "V. Hernández" 4 => "E. de la Peña" 5 => "C. Llorente" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2011.05.043" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2011" "volumen" => "60" "paginaInicial" => "734" "paginaFinal" => "749" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21658839" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GreenLight HPS 120-W Laser Vaporization versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia: a randomized clinical trial with midterm follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Al. Ansari" 1 => "A. Younes" 2 => "N. Sampige" 3 => "V. Al-Rumaihi" 4 => "K. Ghafouri" 5 => "A. Gul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2010.05.026" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2010" "volumen" => "58" "paginaInicial" => "349" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20605316" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photoselective vaporization of the prostate with GreenLight 120-W laser compared with monopolar transurethral resection of the prostate: A multicenter randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Lukacs" 1 => "J. Loeffler" 2 => "F. Bruyère" 3 => "P. Blanchet" 4 => "A. Gelet" 5 => "P. Coloby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2012.01.052" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2012" "volumen" => "61" "paginaInicial" => "1165" "paginaFinal" => "1173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22341632" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "(Proyectos de farmacoeconomía) Análisis de costes a corto plazo de la vaporización fotoselectiva de la próstata mediante GreenLight-Photovaporization – HPS 120 system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Sanz-Granda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:2 [ "fecha" => "2009" "editorial" => "Informe final American Medical Systems, Inc. (EE. UU.)" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis coste efectividad a 2 años del tratamiento quirúrgico de la hiperplasia benigna de próstata mediante vaporización fotoselectiva de la próstata con GreenLight-Photo Vaporization 120W versus resección transuretral de la próstata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.M. Benejam" 1 => "A. Sanz-Granda" 2 => "R. García-Miralles" 3 => "A. Severa" 4 => "J. Pons" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.acuro.2013.09.012" "Revista" => array:3 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2013" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24210656" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GreenLight 180W XPS photovaporization of the prostate: How I do it" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Zorn" 1 => "D. Liberman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Can J Urol" "fecha" => "2011" "volumen" => "18" "paginaInicial" => "5918" "paginaFinal" => "5926" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22018158" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The main methodological issues in costing health care services – a literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Z. Mogyorosy" 1 => "P.C. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "fecha" => "2005" "paginaInicial" => "242" "editorial" => "Centre for Health Economics" "editorialLocalizacion" => "York, UK" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis de decisión en la evaluación económica del tratamiento de la uropatía obstructiva de larga duración" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Llanes" 1 => "A. Linares" 2 => "E. Redondo" 3 => "J. Rendón" 4 => "M. Fernández" 5 => "A. Páez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "LXXIV Congreso Nacional de Urología Valencia" "paginaInicial" => "12" "paginaFinal" => "15" "serieFecha" => "2009" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluación económica del tratamiento médico de la hiperplasia benigna de próstata (HBP) en España en atención especializada. Aplicación al coste-efectividad de dos fármacos habitualmente utilizados en su tratamiento" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Carballido" 1 => "J. Ruiz" 2 => "M. Unda" 3 => "V. Baena" 4 => "P. Campoy" 5 => "J. Manasanch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "916" "paginaFinal" => "925" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19044302" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utilización y coste de los modificadores biológicos de la artritis reumatoide en España (Estudio PRAXIS)" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "por el grupo de investigadores del estudio PRAXIS" "etal" => false "autores" => array:6 [ 0 => "C. Rubio-Terrés" 1 => "B. Ordovás" 2 => "R. Pla" 3 => "C. Martínez" 4 => "M. Sánchez" 5 => "M. Rosado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Farm Hosp" "fecha" => "2007" "volumen" => "31" "paginaInicial" => "78" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17590116" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Precios Públicos a satisfacer por la prestación de servicios por los centros. Orden de 17 de mayo de 2007. Bol. of. Región de Murcia. Número 23, sábado 28 de enero de 2012, p. 4092." ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Servicio Aragonés de Salud. Anuncio del Servicio Aragonés de Salud, por el que se publica la adjudicación por procedimiento negociado del suministro de fibras Greenlight HPS para los dos equipos de fotovaporización prostática láser. Boletín oficial de Aragón n.° 1, de 4 de enero de 2010. p. 74." ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Consejo General de Colegios Oficiales de Farmacéuticos. Bot Plus WEB. Available from: <a id="intr0010" class="elsevierStyleInterRef" href="http://www.portalfarma.com/inicio/botplus20/Paginas/Bot-PLUS-2-0.aspx">http://www.portalfarma.com/inicio/botplus20/Paginas/Bot-PLUS-2-0.aspx</a> [accessed 03.06.13]." ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Instituto Nacional de Estadística. España: Índice General de Precios al Consumo. Available from: <a id="intr0015" class="elsevierStyleInterRef" href="http://www.ine.es/ss/Satellite%3FL=es_ES%26c=Page%26cid=1254735893337%26p=1254735893337%26pagename=ProductosYServicios%2FPYSLayout">http://www.ine.es/ss/Satellite?L=es_ES&c=Page&cid=1254735893337&p=1254735893337&pagename=ProductosYServicios%2FPYSLayout</a> [accessed 03.06.13]." ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bootstrap methods: another look at the jacknife" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Efron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Stat" "fecha" => "1979" "volumen" => "1" "paginaInicial" => "1" "paginaFinal" => "26" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Sociedad Española de Bioquímica Clínica y Patología Molecular. Curso de Estadística. Estadística robusta. Documento electrónico. Available from: <a id="intr0020" class="elsevierStyleInterRef" href="http://www.seqc.es/es/Varios/7/Curso_Estadistica/">http://www.seqc.es/es/Varios/7/Curso_Estadistica/</a> [accessed 05.06.13]." ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fotovaporización prostática láser GreenLight HPS en régimen de cirugía mayor ambulatoria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Benejam-Gual" 1 => "F. Díez-Caballero" 2 => "R. García-Miralles" 3 => "A. Servera Ruiz de Velasco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2010" "volumen" => "34" "paginaInicial" => "170" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20403281" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack85647" "titulo" => "Acknowledgment" "texto" => "To the American Medical Systems for unrestricted funding that has made possible the implementation of the study." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000304/v1_201406240033/en/main.assets" "Apartado" => array:4 [ "identificador" => "6274" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735786/0000003800000006/v1_201406240033/S2173578614000304/v1_201406240033/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000304?idApp=UINPBA00004N"]

Statistics

Original article

Multicenter study on costs associated with two surgical procedures: GreenLight XPS 180W versus the gold standard transurethral resection of the prostate

Estudio multicéntrico de costes de 2 técnicas quirúrgicas: láser GreenLight XPS 180W vs resección transuretral de la próstata

J.M. Benejam-Guala, Á. Sanz-Grandab,

Corresponding author

a.sanzgranda@terra.com

Corresponding author.

, A. Budíac, J. Extramianad, C. Capitáne

a Servicio de Urología, Hospital de Manacor, Mallorca, Spain

b Proyectos de Farmacoeconomía, Navacerrada, Madrid, Spain

c Servicio de Urología, Hospital de La Fe, Valencia, Spain

d Servicio de Urología, Hospital de Vitoria, Álava, Spain

e Servicio de Urología, Hospital de Alcorcón, Madrid, Spain

Read

361

Times
was read the article

Total PDF

282

Total HTML

Share statistics

 array:24 [
  "pii" => "S2173578614000304"
  "issn" => "21735786"
  "doi" => "10.1016/j.acuroe.2014.02.014"
  "estado" => "S300"
  "fechaPublicacion" => "2014-07-01"
  "aid" => "606"
  "copyright" => "AEU"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Urol Esp. 2014;38:373-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 367
    "formatos" => array:3 [
      "EPUB" => 7
      "HTML" => 281
      "PDF" => 79
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210480613003859"
      "issn" => "02104806"
      "doi" => "10.1016/j.acuro.2013.10.011"
      "estado" => "S300"
      "fechaPublicacion" => "2014-07-01"
      "aid" => "606"
      "copyright" => "AEU"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "fla"
      "cita" => "Actas Urol Esp. 2014;38:373-7"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 711
        "formatos" => array:3 [
          "EPUB" => 10
          "HTML" => 588
          "PDF" => 113
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo original</span>"
        "titulo" => "Estudio multic&#233;ntrico de costes de 2 t&#233;cnicas quir&#250;rgicas&#58; l&#225;ser GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W vs resecci&#243;n transuretral de la pr&#243;stata"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "373"
            "paginaFinal" => "377"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Multicenter Study on Costs Associated With Two Surgical Procedures&#58; GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W Versus the Gold Standard Transurethral Resection of the Prostate"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 819
                "Ancho" => 1612
                "Tamanyo" => 80146
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dispersi&#243;n de los resultados econ&#243;micos en funci&#243;n de la estancia hospitalaria asociada a cada centro&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;M&#46; Benejam-Gual, &#193;&#46; Sanz-Granda, A&#46; Bud&#237;a, J&#46; Extramiana, C&#46; Capit&#225;n"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Benejam-Gual"
              ]
              1 => array:2 [
                "nombre" => "&#193;&#46;"
                "apellidos" => "Sanz-Granda"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Bud&#237;a"
              ]
              3 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Extramiana"
              ]
              4 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Capit&#225;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173578614000304"
          "doi" => "10.1016/j.acuroe.2014.02.014"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000304?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003859?idApp=UINPBA00004N"
      "url" => "/02104806/0000003800000006/v1_201406240031/S0210480613003859/v1_201406240031/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173578614000407"
    "issn" => "21735786"
    "doi" => "10.1016/j.acuroe.2014.02.017"
    "estado" => "S300"
    "fechaPublicacion" => "2014-07-01"
    "aid" => "602"
    "copyright" => "AEU"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Urol Esp. 2014;38:378-84"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 480
      "formatos" => array:3 [
        "EPUB" => 9
        "HTML" => 370
        "PDF" => 101
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Pre-operative training induces changes in the histomorphometry and muscle function of the pelvic floor in patients with indication of radical prostatectomy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "378"
          "paginaFinal" => "384"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El entrenamiento preoperatorio induce cambios en la histomorfometr&#237;a y funci&#243;n de los m&#250;sculos del suelo p&#233;lvico en pacientes con indicaci&#243;n de prostatectom&#237;a radical"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 370
              "Ancho" => 1000
              "Tamanyo" => 139186
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">H&#8211;E staining &#40;&#215;400 magnification&#41;&#46; Photomicrographs of the external sphincter muscle of the urethra&#46; A&#46; Intervention group&#46; B&#46; Control group&#46; Muscle fibers of various sizes were identified in both groups&#46; Hypertrophic fibers can be observed&#44; as well as atrophic muscle fibers with abundant surrounding connective tissue distributed among the hypertrophic muscle fibers&#46; Note the presence of central nuclei suggestive of regenerative changes in the fibers&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "&#193;&#46; Ocampo-Trujillo, J&#46; Carbonell-Gonz&#225;lez, A&#46; Mart&#237;nez-Blanco, A&#46; D&#237;az-Hung, C&#46;A&#46; Mu&#241;oz, R&#46; Ram&#237;rez-V&#233;lez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Ocampo-Trujillo"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Carbonell-Gonz&#225;lez"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-Blanco"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "D&#237;az-Hung"
            ]
            4 => array:2 [
              "nombre" => "C&#46;A&#46;"
              "apellidos" => "Mu&#241;oz"
            ]
            5 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ram&#237;rez-V&#233;lez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210480613003811"
        "doi" => "10.1016/j.acuro.2013.10.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003811?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000407?idApp=UINPBA00004N"
    "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000407/v1_201406240033/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173578614000298"
    "issn" => "21735786"
    "doi" => "10.1016/j.acuroe.2014.02.013"
    "estado" => "S300"
    "fechaPublicacion" => "2014-07-01"
    "aid" => "600"
    "copyright" => "AEU"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Urol Esp. 2014;38:367-72"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 501
      "formatos" => array:3 [
        "EPUB" => 9
        "HTML" => 297
        "PDF" => 195
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Simulators help improve student confidence to acquire skills in urology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "367"
          "paginaFinal" => "372"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La simulaci&#243;n mejora la confianza de los estudiantes para adquirir competencias en urolog&#237;a"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 579
              "Ancho" => 773
              "Tamanyo" => 71972
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Urological examination workshop&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;C&#46; Rodr&#237;guez-D&#237;ez, N&#46; D&#237;ez, I&#46; Merino, J&#46;M&#46; Velis, A&#46; Tienza, J&#46;E&#46; Robles-Garc&#237;a"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;C&#46;"
              "apellidos" => "Rodr&#237;guez-D&#237;ez"
            ]
            1 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "D&#237;ez"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Merino"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Velis"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tienza"
            ]
            5 => array:2 [
              "nombre" => "J&#46;E&#46;"
              "apellidos" => "Robles-Garc&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210480613003793"
        "doi" => "10.1016/j.acuro.2013.10.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480613003793?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000298?idApp=UINPBA00004N"
    "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000298/v1_201406240033/en/main.assets"
  ]
  "en" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Multicenter study on costs associated with two surgical procedures&#58; GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W versus the gold standard transurethral resection of the prostate"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "373"
        "paginaFinal" => "377"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;M&#46; Benejam-Gual, &#193;&#46; Sanz-Granda, A&#46; Bud&#237;a, J&#46; Extramiana, C&#46; Capit&#225;n"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Benejam-Gual"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "&#193;&#46;"
            "apellidos" => "Sanz-Granda"
            "email" => array:1 [
              0 => "a&#46;sanzgranda&#64;terra&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Bud&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Extramiana"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Capit&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Servicio de Urolog&#237;a&#44; Hospital de Manacor&#44; Mallorca&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Proyectos de Farmacoeconom&#237;a&#44; Navacerrada&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Urolog&#237;a&#44; Hospital de La Fe&#44; Valencia&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Urolog&#237;a&#44; Hospital de Vitoria&#44; &#193;lava&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Urolog&#237;a&#44; Hospital de Alcorc&#243;n&#44; Madrid&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Estudio multic&#233;ntrico de costes de 2 t&#233;cnicas quir&#250;rgicas&#58; l&#225;ser GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W vs resecci&#243;n transuretral de la pr&#243;stata"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 819
            "Ancho" => 1612
            "Tamanyo" => 75119
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dispersion of economic performance in terms of hospital stay associated with each center&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Transurethral resection of prostate &#40;TURP&#41; is the endoscopic surgical technique of reference in the treatment of lower urinary tract symptomatology &#40;LUTS&#41; secondary to benign prostatic hyperplasia &#40;BPH&#41;&#46; However&#44; this procedure has complications and is associated with high incidence of reoperations&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Photoselective vaporization of the prostate with 532<span class="elsevierStyleHsp" style=""></span>nm wavelength green laser &#40;120<span class="elsevierStyleHsp" style=""></span>W&#41; is an efficient surgical alternative to TURP because it has a similar efficacy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> at lower cost&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> This technology has evolved to achieve a power of 180<span class="elsevierStyleHsp" style=""></span>W &#40;GreenLight XPS&#41;&#46; This power allows managing higher-volume prostates and at the same time preserves fiber integrity&#44; being possible to use only one fiber per patient&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The allocation of resources for health &#8211; new technologies should be accompanied by the corresponding economic assessment demonstrating its efficiency&#46; For this reason&#44; the objective of this study was to analyze&#44; from the perspective of National Health System&#44; the costs associated with surgical treatment of LUTS secondary to BPH using GL 180-W XPS and TURP in a time horizon of 3 months&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">A multicenter retrospective study of costs was performed using the bottom-up methodology to estimate the average cost per patient associated with surgical treatment with the new technology GL XPS 180<span class="elsevierStyleHsp" style=""></span>W of LUTS secondary to BPH&#46; Endoscopic surgical technology was used as a comparator&#46; The study was performed in a time horizon of 3 months from the perspective of National Health System&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Population</span><p id="par0025" class="elsevierStylePara elsevierViewall">Data were obtained from clinical histories of patients who were operated sequentially between July 2012 and October 2012 with the surgical alternatives assessed in 4 Spanish hospitals&#46; Inclusion criteria were&#58; previous diagnosis of LUTS secondary to BPH&#44; IPSS<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>15&#44; Qmax<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>ml&#47;sec and prostatic volume &#8805;40<span class="elsevierStyleHsp" style=""></span>ml and &#8804;80<span class="elsevierStyleHsp" style=""></span>ml&#46; Exclusion criteria were the lack of follow-up of patient as well as the lack of values for necessary variables in the study&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Model</span><p id="par0030" class="elsevierStylePara elsevierViewall">Mathematical model was performed to estimate the total average cost per patient intervened with surgical alternative &#40;<span class="elsevierStyleItalic">x</span>&#41;&#58;<elsevierMultimedia ident="eq0005"></elsevierMultimedia>in which <span class="elsevierStyleItalic">c</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic">i</span>&#44;<span class="elsevierStyleItalic">t</span>&#41;</span> stands for the cost &#40;<span class="elsevierStyleItalic">c</span>&#41; of the resource &#40;<span class="elsevierStyleItalic">i</span>&#41; in process phase &#40;<span class="elsevierStyleItalic">t</span>&#41;&#46; Phase process is calculated by the product &#40;<span class="elsevierStyleItalic">q</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic">i</span>&#44;<span class="elsevierStyleItalic">t</span>&#41;</span>&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic">i</span>&#44;<span class="elsevierStyleItalic">t</span>&#41;</span>&#41;&#44; in which <span class="elsevierStyleItalic">q</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic">i</span>&#44;<span class="elsevierStyleItalic">t</span>&#41;</span> stands for the quantity &#40;<span class="elsevierStyleItalic">q</span>&#41; of the resource &#40;<span class="elsevierStyleItalic">i</span>&#41; and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic">i</span>&#44;<span class="elsevierStyleItalic">t</span>&#41;</span> for its unitary price &#40;<span class="elsevierStyleItalic">p</span>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The outcome variable was estimated as the difference between the average total cost per patient and the technologies evaluated&#44; <span class="elsevierStyleItalic">x y x</span>&#8242; &#40;&#916;<span class="elsevierStyleItalic">&#264;</span><span class="elsevierStyleInf">&#40;<span class="elsevierStyleItalic"><span class="elsevierStyleUnderline">x</span></span>&#8722;<span class="elsevierStyleItalic">x</span>&#8242;&#41;</span>&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Costs data</span><p id="par0040" class="elsevierStylePara elsevierViewall">From the perspective of Spanish National Health System&#44; only direct health costs were included&#44; therefore indirect costs associated with patients&#8217; lost work productivity were ignored&#46; Average cost was estimated using bottom-up method&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> counting the resources consumed in hospital stay &#40;operating room&#44; recovery room and hospital stay&#41;&#44; in diagnostics and analytical procedures and in differentiated equipment necessary to carry out both surgical options&#46; Finally&#44; the resources necessary for the management of complications were estimated&#46; Unitary prices of resources were obtained from specialized literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;10</span></a> as well as from public<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> and professional<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> agencies&#46; All costs were presented in 2013 euros&#44; and&#44; if necessary&#44; yearly adjusted according to the General Index of Consumer Prices&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Direct costs were analyzed in a disaggregated way&#44; depending on three temporary phases&#58; pre-surgical phase&#44; gathering the costs incurred from initial surgical consultation until the day preceding surgery&#59; surgical phase&#44; covering surgery period&#59; and post-surgical phase&#44; comprising the resources used since operating room exit up to 3 following months&#46; In both surgical procedures&#44; differences among estimated values were analyzed using Student&#39;s <span class="elsevierStyleItalic">t</span> test for samples with unequal variances at the 0&#46;05 significance level&#46; The degree of outcome dispersion was calculated by bootstrap method<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> or resampling with repetition&#44; in which 500 iterations were performed and the 95&#37; confidence interval was calculated for the trimmed mean differences&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> in order to remove extreme values&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Effectiveness data</span><p id="par0050" class="elsevierStylePara elsevierViewall">The result of effectiveness was healing at 3 months&#44; defined as unobstructed patient &#40;a post-operative reduction &#8805;5 points according to International Prostate Symptom Score &#91;IPSS&#93; and an increase in maximum flow &#8805;5<span class="elsevierStyleHsp" style=""></span>ml&#47;s&#46; measured in flowmetry&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Sensibility analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Finally&#44; results obtained were analyzed by univariate sensitivity analysis of the most relevant variables&#58; hospital stay and prostate size&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">During the period from July 2012 until October 2012&#44; 79 patients randomly underwent prostate surgery&#44; 40 of them using TURP and the other 39 with laser new technology GL XPS&#46; Baseline characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The clinical outcome of healing was equivalent for both the procedures &#40;94&#46;9 and 92&#46;5&#37; for GL XPS and TURP&#44; respectively&#41; and did not show statistically significant differences &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Bootstrap result after 500 iterations showed a statistically significant difference of &#8211;121<span class="elsevierStyleHsp" style=""></span>&#8364; &#40;CI 95&#37;&#58; &#8722;91&#59; &#8722;151&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; between total average cost per patient treated with GL XPS &#40;3277&#8364;&#59; DE&#58;6&#46;56&#41; and TURP &#40;3398&#8364;&#59; DE&#58; 13&#46;80&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; In patients who underwent GL XPS&#44; cost disaggregation according to temporary phases of surgical process was higher &#40;difference&#58; 1209&#8364;&#59; CI 95&#37;&#58; 1200&#59; 1217&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; whilst in post-surgical phase it was lower &#40;difference&#58; &#8722;1351&#8364;&#59; CI 95&#37;&#58; &#8722;1322&#59; 1380&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRefs" href="#tbl0015">Tables 3 and 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Sensibility univariate analysis for hospital stay time after surgery reports that in GL XPS under outpatient regime or surgery without admission compared with TURP&#46; the cost reduction can reach up to 698&#8364; per patient in the first 3 months &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Prostate size is also a cost moderator variable&#46; Linear regression model correlating both variables shows that total average cost per patient is slightly dependent on size in GL XPS procedure &#40;<span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span>&#58; 0&#46;248&#41; and independent in TURP &#40;<span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span>&#58; 0&#46;007&#41;&#46; Final outcomes are strongly influenced by variations in clinical practice&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Total average cost per patient in the first 3 months has been associated with a statistically significant saving of 121&#8364; per patient who underwent to GL XPS &#40;CI 95&#37;&#58; 91&#59; 151&#41;&#46; This difference is caused by a significant cost reduction &#40;&#8722;1351&#8364;&#41; in the post-surgical phase&#44; which is associated with a shorter hospital stay in GL XPS patients &#40;this fact had already been shown in cases involving GreenLight HPS 120<span class="elsevierStyleHsp" style=""></span>W laser<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#41;&#46; This cost reduction offsets the increase in the same in the surgical phase &#40;&#43;1209&#8364;&#41; associated with the allocation of the necessary equipment for surgery by GL XPS&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Dispersion in outcomes is associated with variation in clinical practice&#44; mainly with hospital stay&#44; set in a range from 0&#46;1 to 2&#46;2 days &#40;mean&#58; 1&#46;31 days&#41; for GL XPS&#44; and from 3&#46;5 to 5&#46;5 days &#40;mean&#58; 4&#46;05 days&#41; for TURP&#46; A study performed in Spain<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> showed that the GL XPS carried out in outpatient surgery regime had a lower cost&#46; Additionally&#44; allocated cost to the technology &#8211; responsible for the increase in cost in surgical phase &#8211; depends on the price thereof&#44; its utilization level and amortization time as well as the usage of fibers&#46; In our study&#44; the equipment price &#40;90&#44;000&#8364;&#41; has been decreased compared to that in the preceding years&#46; The same happens with the price of fiber &#40;950&#8364;&#41;&#46; All of this increases the efficiency&#46; When utilization level of GL XPS is higher than 100 patients per year&#44; its cost decreases and&#44; consequently&#44; its efficiency enhances&#46; On the other hand&#44; fiber usage has been reduced to almost one per patient &#40;mean&#58; 1&#46;03 fibers per patient&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">According to our knowledge&#44; this is the first economic study published comparing the new technology GL XPS 180<span class="elsevierStyleHsp" style=""></span>W versus TURP&#46; Outcomes obtained newly report a similar efficacy and the lower cost for GL XPS and are in line with previously published findings for GL HPS 120<span class="elsevierStyleHsp" style=""></span>W&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">When health resources are limited&#44; it is necessary to allocate them in the most efficient way so that better outcomes are obtained at lower cost&#46; Thus&#44; opportunity cost will reduce and&#44; as a consequence&#44; it might be able to use surplus resources for other purposes&#46; Outcomes obtained show that surgery using GL XPS in patients with LUTS secondary to BPH might allow a cost reduction&#44; even in the short term&#44; maintaining the health outcomes achieved by using a common procedure of TURP&#46; This cost reduction will be more important for the higher proportion of patients who undergo outpatient surgery&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The study has some limitations&#46; First&#44; the size of the sample is limited&#44; reducing statistical power&#59; however&#44; given the size of the phases&#44; detailed phase function analysis of costs shows significant differences&#46; In order to resolve this limitation&#44; a bootstrap resampling analysis was performed&#44; showing statistically significant total cost differences&#46; Second&#44; the variability in medical practice results in a remarkable dispersion in economic performance &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; For this reason&#44; the study was been performed in four different hospitals to minimize the positive or negative impact that would occur in one single center&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">In order to minimize these limitations&#44; randomized&#44; controlled trials with enough population are necessary to reach enough statistical power&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In light of the results obtained in this study&#44; we can conclude that the intervention of patients with LUTS secondary to BPH using the new GreenLight Photovaporization XPS 180-W laser technology is associated with a reduction in costs due to a shorter duration of hospital stay&#44; which offsets the cost incurred for such technology&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0120" class="elsevierStylePara elsevierViewall">This study was funded by an unrestricted grant from American Medical Systems&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interest</span><p id="par0125" class="elsevierStylePara elsevierViewall">Dr&#46; Sanz-Granda&#44; specialist in economic evaluation of health technologies&#44; received an unrestricted grant for the study&#46; Remaining authors have no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:2 [
          "identificador" => "xres347984"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Objective"
            2 => "Methods"
            3 => "Results"
            4 => "Conclusions"
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec329621"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres347985"
          "titulo" => array:5 [
            0 => "Resumen"
            1 => "Objetivo"
            2 => "M&#233;todos"
            3 => "Resultados"
            4 => "Conclusiones"
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec329620"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Population"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Model"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Costs data"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Effectiveness data"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Sensibility analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conflict of interest"
        ]
        10 => array:2 [
          "identificador" => "xack85647"
          "titulo" => "Acknowledgment"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-10-22"
    "fechaAceptado" => "2013-10-26"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec329621"
          "palabras" => array:4 [
            0 => "Green Light Photovaporization 180<span class="elsevierStyleHsp" style=""></span>W"
            1 => "Transurethral resection of the prostate"
            2 => "Cost"
            3 => "Benign prostate hyperplasia"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec329620"
          "palabras" => array:4 [
            0 => "Green Light Photovaporization 180<span class="elsevierStyleHsp" style=""></span>W"
            1 => "Resecci&#243;n transuretral de la pr&#243;stata"
            2 => "Coste"
            3 => "Hiperplasia benigna de pr&#243;stata"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the costs associated with two surgical procedures for lower urinary tract symptoms secondary to benign prostatic hyperplasia&#58; GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W versus the gold standard transurethral resection of the prostate&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A multicenter&#44; retrospective cost study was carried out from the National Health Service perspective&#44; over a 3-month time period&#46; Costs were broken down into pre-surgical&#44; surgical and post-surgical phases&#46; Data were extracted from records of patients operated sequentially&#44; with IPSS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#44; Qmax<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mL&#47;seg and a prostate volume of 40&#8211;80<span class="elsevierStyleHsp" style=""></span>mL&#44; adding only direct healthcare costs &#40;&#8364;&#44; 2013&#41; associated with the procedure and management of complications&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 79 patients sequentially underwent GL XPS &#40;<span class="elsevierStyleItalic">n</span>&#58; 39&#41; or TURP &#40;<span class="elsevierStyleItalic">n</span>&#58; 40&#41; between July and October 2013&#46; Clinical outcomes were similar &#40;94&#46;9&#37; and 92&#46;5&#37;&#44; GL XPS and TURP&#44; respectively&#41; without significant differences &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#46;67&#41;&#46; The average direct cost per patient was reduced by 114&#8364; in GL XPS versus TURP patients&#59; the cost was higher in the surgical phase with GL XPS &#40;difference&#58; 1209&#8364;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; but was lower in the post-surgical phase &#40;difference&#58; &#8364;<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>1351&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The GreenLight XPS 180-W laser system is associated with a reduction in costs with respect to transurethral resection of prostate in the surgical treatment of LUTS secondary to PBH&#46; This reduction is due to a shorter inpatient length of stay that offsets the cost of the new technology&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar los costes asociados al tratamiento quir&#250;rgico de la sintomatolog&#237;a del tracto urinario inferior secundaria a hiperplasia benigna de pr&#243;stata mediante el l&#225;ser GreenLigh XPS 180<span class="elsevierStyleHsp" style=""></span>W respecto a la t&#233;cnica quir&#250;rgica endosc&#243;pica de referencia&#44; resecci&#243;n transuretral de la pr&#243;stata&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio retrospectivo y multic&#233;ntrico de costes desde la perspectiva del Sistema Nacional de Salud y en un horizonte temporal de 3 meses&#44; desagreg&#225;ndolos en fases temporales&#58; prequir&#250;rgica&#44; quir&#250;rgica y posquir&#250;rgica&#46; Los datos fueron extra&#237;dos de las historias de los pacientes intervenidos secuencialmente&#44; con IPSS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#44; Qmax<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>ml&#47;seg y volumen prost&#225;tico de 40-80<span class="elsevierStyleHsp" style=""></span>ml&#44; incorporando solo costes sanitarios directos &#40;euros de 2013&#41; asociados a la intervenci&#243;n y al manejo de complicaciones&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Entre julio y octubre de 2012 se intervinieron de forma secuencial 39 pacientes con l&#225;ser GL XPS y 40 con RTUP&#46; El resultado cl&#237;nico fue equivalente &#40;94&#44;9 y 92&#44;5&#37;&#44; respectivamente&#41; no mostrando diferencias estad&#237;sticamente significativas &#40;p<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;67&#41;&#46; El coste medio total por paciente se redujo en 121<span class="elsevierStyleHsp" style=""></span>&#8364; en el grupo l&#225;ser GL XPS respecto de RTUP&#59; en la fase quir&#250;rgica el coste fue superior con l&#225;ser GL XPS &#40;diferencia&#58; 1&#46;209<span class="elsevierStyleHsp" style=""></span>&#8364;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; mientras que fue inferior en la fase posquir&#250;rgica &#40;diferencia&#58; &#8211;1&#46;351<span class="elsevierStyleHsp" style=""></span>&#8364;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La intervenci&#243;n de los pacientes con STUI secundario a HBP mediante la nueva tecnolog&#237;a l&#225;ser GL XPS se asocia a una reducci&#243;n de costes respecto de la RTUP&#44; debida a una menor duraci&#243;n de la estancia hospitalaria&#44; la cual compensa el coste imputado a dicha tecnolog&#237;a&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Benejam-Gual JM&#44; Sanz-Granda &#193;&#44; Bud&#237;a A&#44; Extramiana J&#44; Capit&#225;n C&#46; Estudio multic&#233;ntrico de costes de 2 t&#233;cnicas quir&#250;rgicas&#58; l&#225;ser GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W vs resecci&#243;n transuretral de la pr&#243;stata&#46; Actas Urol Esp&#46; 2014&#59;38&#58;373&#8211;377&#46;</p>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1017
            "Ancho" => 1616
            "Tamanyo" => 69766
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Sensitivity analysis of hospital stay after surgery&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 819
            "Ancho" => 1612
            "Tamanyo" => 75119
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dispersion of economic performance in terms of hospital stay associated with each center&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; GL XPS&#44; GreenLight laser XPS 180<span class="elsevierStyleHsp" style=""></span>W&#59; IPSS&#44; International Prostate Symptom Score&#59; PSA&#44; prostatic specific antigen&#59; Qmax&#44; maximum flow rate&#59; TURP&#44; transurethral resection of the prostate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">GL XPS &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">RTUP &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;33 &#40;7&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;28 &#40;8&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prostatic vol&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;00 &#40;18&#46;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;83 &#40;16&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;54 &#40;2&#46;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;09 &#40;2&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IPSS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;08 &#40;5&#46;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;00 &#40;6&#46;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;685&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qmax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;19 &#40;3&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;50 &#40;4&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;511&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab518734.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of surgical patients&#59; mean and standard deviation&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">SE&#44; error standard&#59; GL XPS&#44; GreenLight XPS laser 180<span class="elsevierStyleHsp" style=""></span>W&#59; TURP&#44; transurethral resection of the prostate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">GL XPS &#40;SE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">TURP &#40;SE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total cost &#40;&#8364;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3277 &#40;6&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3398 &#40;13&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pre-surgical phase &#40;&#8364;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">249 &#40;1&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">227 &#40;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical phase &#40;&#8364;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2330 &#40;3&#46;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1121 &#40;2&#46;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-surgical phase &#40;&#8364;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">699 &#40;5&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2050 &#40;13&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab518733.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Cost per surgical patient&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">GL XPS&#44; GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W laser&#59; CI 95&#37;&#44; confidence interval at 95&#37;&#59; n&#46;a&#46;&#44; not applicable&#59; TURP&#46; transurethral resection of the prostate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">GL XPS &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">RTUP &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Operating theater&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">916 &#40;467&#59; 1463&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">910 &#40;466&#59; 1359&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urologist 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;18&#59; 62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;20&#59; 63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urologist 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;0&#59; 50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;0&#59; 53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anesthesiologist&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;6&#59; 80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;7&#59; 79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nursing S&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;41&#59; 137&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 &#40;31&#59; 119&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Support staff 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;10&#59; 36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;8&#59; 30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Support staff 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;0&#59; 35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;0&#59; 30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GreenLight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;a&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fiber&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">974&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#46;a&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab518731.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Costs incurred in surgical phase&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">GL XPS&#44; GreenLight XPS 180<span class="elsevierStyleHsp" style=""></span>W laser&#59; CI 95&#37;&#44; confidence interval at 95&#37;&#59; TURP&#44; transurethral resection of the prostate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">GL XPS &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">TURP &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recovery room&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;8&#59; 60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;4&#59; 128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hospital stay&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">584 &#40;0&#59; 2281&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1811 &#40;894&#59; 3231&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Consultation with urologist&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;0&#59; 55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;0&#59; 55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Flowmetry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;0&#59; 37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;0&#59; 38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#59; 0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#59; 41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CBC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;0&#59; 15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;0&#59; 15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;0&#59; 12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;0&#59; 11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#59; 3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#59; 3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#59; 1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#59; 5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urinary sediment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#59; 4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#59; 4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urine culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;0&#59; 13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#59; 13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#59; 19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106 &#40;0&#59; 117&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab518732.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Incurred costs &#40;CI 95&#37;&#41; in post-surgical phase&#46;</p>"
        ]
      ]
      6 => array:5 [
        "identificador" => "eq0005"
        "tipo" => "MULTIMEDIAFORMULA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Formula" => array:5 [
          "Matematica" => "C&#710;x&#61;&#8721;c&#40;i&#44;t&#41;&#61;&#8721;q&#40;i&#44;t&#41;&#42;p&#40;i&#44;t&#41;&#61;q&#40;i&#44;t&#41;&#42;pi1t1&#43;q&#40;i&#44;t&#41;&#42;pi2&#44;t2&#43;&#8943;&#43;q&#40;i&#44;t&#41;&#42;pin&#46;tn"
          "Fichero" => "si1.jpeg"
          "Tamanyo" => 4169
          "Alto" => 47
          "Ancho" => 372
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:17 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GreenLight HPS 120-W Laser Vaporization versus transuretral resection of the prostate for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia&#58; a randomized clinical trial with 2-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Capit&#225;n"
                            1 => "C&#46; Bl&#225;zquez"
                            2 => "D&#46; Mart&#237;n"
                            3 => "V&#46; Hern&#225;ndez"
                            4 => "E&#46; de la Pe&#241;a"
                            5 => "C&#46; Llorente"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eururo.2011.05.043"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2011"
                        "volumen" => "60"
                        "paginaInicial" => "734"
                        "paginaFinal" => "749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21658839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GreenLight HPS 120-W Laser Vaporization versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia&#58; a randomized clinical trial with midterm follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Al&#46; Ansari"
                            1 => "A&#46; Younes"
                            2 => "N&#46; Sampige"
                            3 => "V&#46; Al-Rumaihi"
                            4 => "K&#46; Ghafouri"
                            5 => "A&#46; Gul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eururo.2010.05.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2010"
                        "volumen" => "58"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20605316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photoselective vaporization of the prostate with GreenLight 120-W laser compared with monopolar transurethral resection of the prostate&#58; A multicenter randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Lukacs"
                            1 => "J&#46; Loeffler"
                            2 => "F&#46; Bruy&#232;re"
                            3 => "P&#46; Blanchet"
                            4 => "A&#46; Gelet"
                            5 => "P&#46; Coloby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eururo.2012.01.052"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2012"
                        "volumen" => "61"
                        "paginaInicial" => "1165"
                        "paginaFinal" => "1173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22341632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#40;Proyectos de farmacoeconom&#237;a&#41; An&#225;lisis de costes a corto plazo de la vaporizaci&#243;n fotoselectiva de la pr&#243;stata mediante GreenLight-Photovaporization &#8211; HPS 120 system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Sanz-Granda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2009"
                        "editorial" => "Informe final American Medical Systems&#44; Inc&#46; &#40;EE&#46; UU&#46;&#41;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis coste efectividad a 2 a&#241;os del tratamiento quir&#250;rgico de la hiperplasia benigna de pr&#243;stata mediante vaporizaci&#243;n fotoselectiva de la pr&#243;stata con GreenLight-Photo Vaporization 120<span class="elsevierStyleHsp" style=""></span>W versus resecci&#243;n transuretral de la pr&#243;stata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Benejam"
                            1 => "A&#46; Sanz-Granda"
                            2 => "R&#46; Garc&#237;a-Miralles"
                            3 => "A&#46; Severa"
                            4 => "J&#46; Pons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.acuro.2013.09.012"
                      "Revista" => array:3 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2013"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24210656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GreenLight 180W XPS photovaporization of the prostate&#58; How I do it"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Zorn"
                            1 => "D&#46; Liberman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Urol"
                        "fecha" => "2011"
                        "volumen" => "18"
                        "paginaInicial" => "5918"
                        "paginaFinal" => "5926"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22018158"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The main methodological issues in costing health care services &#8211; a literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Z&#46; Mogyorosy"
                            1 => "P&#46;C&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2005"
                        "paginaInicial" => "242"
                        "editorial" => "Centre for Health Economics"
                        "editorialLocalizacion" => "York&#44; UK"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de decisi&#243;n en la evaluaci&#243;n econ&#243;mica del tratamiento de la uropat&#237;a obstructiva de larga duraci&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Llanes"
                            1 => "A&#46; Linares"
                            2 => "E&#46; Redondo"
                            3 => "J&#46; Rend&#243;n"
                            4 => "M&#46; Fern&#225;ndez"
                            5 => "A&#46; P&#225;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "LXXIV Congreso Nacional de Urolog&#237;a Valencia"
                        "paginaInicial" => "12"
                        "paginaFinal" => "15"
                        "serieFecha" => "2009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluaci&#243;n econ&#243;mica del tratamiento m&#233;dico de la hiperplasia benigna de pr&#243;stata &#40;HBP&#41; en Espa&#241;a en atenci&#243;n especializada&#46; Aplicaci&#243;n al coste-efectividad de dos f&#225;rmacos habitualmente utilizados en su tratamiento"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Carballido"
                            1 => "J&#46; Ruiz"
                            2 => "M&#46; Unda"
                            3 => "V&#46; Baena"
                            4 => "P&#46; Campoy"
                            5 => "J&#46; Manasanch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "916"
                        "paginaFinal" => "925"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19044302"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilizaci&#243;n y coste de los modificadores biol&#243;gicos de la artritis reumatoide en Espa&#241;a &#40;Estudio PRAXIS&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "por el grupo de investigadores del estudio PRAXIS"
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Rubio-Terr&#233;s"
                            1 => "B&#46; Ordov&#225;s"
                            2 => "R&#46; Pla"
                            3 => "C&#46; Mart&#237;nez"
                            4 => "M&#46; S&#225;nchez"
                            5 => "M&#46; Rosado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Farm Hosp"
                        "fecha" => "2007"
                        "volumen" => "31"
                        "paginaInicial" => "78"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17590116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Precios P&#250;blicos a satisfacer por la prestaci&#243;n de servicios por los centros&#46; Orden de 17 de mayo de 2007&#46; Bol&#46; of&#46; Regi&#243;n de Murcia&#46; N&#250;mero 23&#44; s&#225;bado 28 de enero de 2012&#44; p&#46; 4092&#46;"
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Servicio Aragon&#233;s de Salud&#46; Anuncio del Servicio Aragon&#233;s de Salud&#44; por el que se publica la adjudicaci&#243;n por procedimiento negociado del suministro de fibras Greenlight HPS para los dos equipos de fotovaporizaci&#243;n prost&#225;tica l&#225;ser&#46; Bolet&#237;n oficial de Arag&#243;n n&#46;&#176; 1&#44; de 4 de enero de 2010&#46; p&#46; 74&#46;"
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Consejo General de Colegios Oficiales de Farmac&#233;uticos&#46; Bot Plus WEB&#46; Available from&#58; <a id="intr0010" class="elsevierStyleInterRef" href="http://www.portalfarma.com/inicio/botplus20/Paginas/Bot-PLUS-2-0.aspx">http&#58;&#47;&#47;www&#46;portalfarma&#46;com&#47;inicio&#47;botplus20&#47;Paginas&#47;Bot-PLUS-2-0&#46;aspx</a> &#91;accessed 03&#46;06&#46;13&#93;&#46;"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#46; Espa&#241;a&#58; &#205;ndice General de Precios al Consumo&#46; Available from&#58; <a id="intr0015" class="elsevierStyleInterRef" href="http://www.ine.es/ss/Satellite%3FL=es_ES%26c=Page%26cid=1254735893337%26p=1254735893337%26pagename=ProductosYServicios%2FPYSLayout">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;ss&#47;Satellite&#63;L&#61;es&#95;ES&#38;c&#61;Page&#38;cid&#61;1254735893337&#38;p&#61;1254735893337&#38;pagename&#61;ProductosYServicios&#37;2FPYSLayout</a> &#91;accessed 03&#46;06&#46;13&#93;&#46;"
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bootstrap methods&#58; another look at the jacknife"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46; Efron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Stat"
                        "fecha" => "1979"
                        "volumen" => "1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "26"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Sociedad Espa&#241;ola de Bioqu&#237;mica Cl&#237;nica y Patolog&#237;a Molecular&#46; Curso de Estad&#237;stica&#46; Estad&#237;stica robusta&#46; Documento electr&#243;nico&#46; Available from&#58; <a id="intr0020" class="elsevierStyleInterRef" href="http://www.seqc.es/es/Varios/7/Curso_Estadistica/">http&#58;&#47;&#47;www&#46;seqc&#46;es&#47;es&#47;Varios&#47;7&#47;Curso&#95;Estadistica&#47;</a> &#91;accessed 05&#46;06&#46;13&#93;&#46;"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fotovaporizaci&#243;n prost&#225;tica l&#225;ser GreenLight HPS en r&#233;gimen de cirug&#237;a mayor ambulatoria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Benejam-Gual"
                            1 => "F&#46; D&#237;ez-Caballero"
                            2 => "R&#46; Garc&#237;a-Miralles"
                            3 => "A&#46; Servera Ruiz de Velasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "170"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20403281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack85647"
        "titulo" => "Acknowledgment"
        "texto" => "<p id="par0130" class="elsevierStylePara elsevierViewall">To the American Medical Systems for unrestricted funding that has made possible the implementation of the study&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735786/0000003800000006/v1_201406240033/S2173578614000304/v1_201406240033/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6274"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735786/0000003800000006/v1_201406240033/S2173578614000304/v1_201406240033/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578614000304?idApp=UINPBA00004N"
]

Article information

ISSN: 21735786
Original language: English

DOI:10.1016/j.acuroe.2014.02.014

The statistics are updated each day

Year/Month	Html	Pdf	Total

2022 June	1	0	1
2018 February	8	1	9
2018 January	10	0	10
2017 December	2	1	3
2017 November	14	0	14
2017 October	12	2	14
2017 September	12	2	14
2017 August	19	13	32
2017 July	14	5	19
2017 June	15	2	17
2017 May	13	2	15
2017 April	21	0	21
2017 March	21	5	26
2017 February	17	4	21
2017 January	11	4	15
2016 December	20	6	26
2016 November	17	3	20
2016 October	22	9	31
2016 September	15	5	20
2016 August	11	2	13
2016 July	5	2	7
2016 January	0	1	1
2015 December	0	1	1
2015 July	0	1	1
2015 March	0	3	3
2015 February	1	0	1
2014 September	0	1	1
2014 August	0	2	2
2014 July	1	1	2
2014 June	0	1	1

Show all

Indexed in:

Follow us:

Subscribe:

Statistics

Indexed in:

Follow us:

Subscribe:

Statistics

Subscribe to our newsletter