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Pentafecta outcomes after robot-assisted laparoscopic radical prostatectomy: First 100 cases in Latinoamerican Hospital
Resultados de pentafecta en prostatectomía radical robótica: primeros 100 casos en un hospital público latinoamericano
J. Gárate
Corresponding author
, R. Sánchez-Salas, R. Valero, R. Matheus, A. León, H. Dávila
Unidad de Cirugía Robótica, Servicio de Urología, Hospital Universitario de Caracas, Caracas, Venezuela
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Prostate cancer is the leading cause of cancer death among males in Venezuela, so its management represents a public health problem.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Despite multiple options, RP remains the treatment of choice for long-term control of this disease.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The emergence of minimally invasive surgery and new technologies, such as the Da Vinci<span class="elsevierStyleSup">&reg;</span> robotic surgical system, has yielded excellent outcomes and enabled us to aspire to more ambitious objectives.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In spite of this, the main research centers still use trifecta as the traditional form of presentation, but it does not properly cover all the aspects related to surgery.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It is within this context that pentafecta emerged as a new and broad methodology to report those results subsequent to the performance of RP, including complications and the state of surgical margins along with the 3 traditional parameters.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> The aim of this study was to report our initial experience with RALRP, by applying the concept of pentafecta.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methodology</span><p id="par0010" class="elsevierStylePara elsevierViewall">Patients who underwent RALRP performed at our institution from March 2009 to December 2012 through a six-port transperitoneal approach in forced Trendelenburg position and conducted by 6 different surgeons with previous experience in conventional laparoscopic radical prostatectomy (LRP). In the first 15 cases, we were advised by an internationally certified supervisor. We used the Da Vinci<span class="elsevierStyleSup">&reg;</span> robotic surgical system, model S, manufactured by Intuitive Surgical, Sunnyvale, CA and the corresponding set of instruments consisting of 0 and 30&deg; scopes, monopolar curved scissors, Maryland graspers, Prograsp forceps and long needle-holders (&times;2).</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Surgical technique</span><p id="par0015" class="elsevierStylePara elsevierViewall">W-shaped trocars were placed as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>, with the aim of performing an anterograde dissection of the prostate. Bladder descent was achieved through Retzius&#8217; space; then we cleaned the anterior side of the prostate and proceeded to the opening of the endopelvic fascia, ligation, section and the suspension of the dorsal venous complex to the pubic area with PDS<span class="elsevierStyleSup">&reg;</span> 0. Then, the vesicoprostatic junction was opened, the posterior side of the prostate was exposed and vas deferens and seminal vesicles were dissected out. Denonvilliers&#8217; fascia was then dissected, the prostatic pedicles were clipped with Hem-o-lok<span class="elsevierStyleSup">&reg;</span> ligating clips, and the neurovascular bands were released and non-thermally preserved using the intrafascial technique in selected cases. We continued with the cutting of the urethra, the introduction of the piece in the collection bag, the reconstruction of the bladder neck if necessary, the addition of the Rocco stitch using Vicryl<span class="elsevierStyleSup">&reg;</span> 3.0 in the inferior edge of the bladder and the urethra, ureterovesical anastomosis with Monocryl<span class="elsevierStyleSup">&reg;</span> 3.0 or self-anchoring barbed suture (<span class="elsevierStyleSmallCaps">V</span>-Loc<span class="elsevierStyleSup">&reg;</span> 90 Absorbable Wound Closure Device-Covidien), drainage and finally the extraction of the piece. Extended lymphadenectomy was only performed in high-risk patients (nomograms).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Positive surgical margin</span><p id="par0020" class="elsevierStylePara elsevierViewall">It is defined as the presence of neoplastic glands in direct contact with the ink on the surface of the piece, with no interposed connective tissue. The anatomopathological classification was done according to the 2002 TNM system.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Definition of complications, biochemical failure, continence and potency</span><p id="par0025" class="elsevierStylePara elsevierViewall">The follow-up of patients was performed as an examination at the medical consultation on a quarterly basis in the first year, and then on a semi-annual basis in the following controls. Complications were categorized according to the modified Clavien classification system.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Biochemical failure, in turn, was established by PSA level based on the EAU guidelines.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Continence was defined as patients who remain dry and who do not &#8220;require&#8221; any kind of protection (towel, sanitary napkin, diaper, etc.) in their everyday activities. Sexual potency was defined as the ability to get and keep an erection for long enough to have satisfying sexual relations with or without the use of type-5 phosphodiesterase inhibitors (PDE-5) and a Sexual Health Inventory for Men (SHIM) score greater or equal to 21.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">A prospective, descriptive study was conducted, where continuous parametric variables were expressed as average, standard deviation (SD), range, mean, percentage and interquartile range (IQR). The variables introduced in the study included age, body mass index (BMI), prostate antigen (PSA), clinical stage, Gleason classification, risk groups, surgical time, operative bleeding and conversions, besides the parameters that constitute the pentafecta (PSA, potency, continence, complications and surgical margin). Data were stored in Excel<span class="elsevierStyleSup">&reg;</span> sheets (Microsoft Inc, Redmond, WA) and analyzed using MedCalc<span class="elsevierStyleSup">&reg;</span> version 12.6.1.0 (MedCalc Software, Ostend-Belgium).</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">101 RALRPs were performed at our institution from March 2009 to December 2012. Patients&#8217; characteristics and preoperative parameters are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The average surgical time was 253.44<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>51.51<span class="elsevierStyleHsp" style=""></span>min (90&#8211;540); 4 out of 7 high-risk patients underwent extended lymphadenectomy and none was positive for cancer. In total, there were 13 complications (12.9%); out of these, 11 had a Clavien grade II complication (10.89%) and 2 a Clavien grade IIIa complication (1.98%) due to stenosis of the anastomosis which required endoscopic resolution. No deaths associated with the procedure were reported. 5 conversions to open surgery (4.95%) were necessary. In 3 cases (2.97%) due to uncontrolled bleeding (of the pubis area, upper bladder and the accessory pudendal area) and in 2 (1.98%) due to robotic instrument failure (irreversible blockage of the entire system). Intraoperative bleeding was of 309.8<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>296.89<span class="elsevierStyleHsp" style=""></span>cc (25&#8211;1500) and a total of 8 patients (7.92%) required transfusion. Hospitalization time was 3.53<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>0.73 days (1&#8211;11) with bladder tube placement for 8.04<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>3.19 days (7&#8211;21). Both neurovascular bands (NVB) were preserved in 45 patients (46.88%) and unilateral preservation was done in 12 (12.5%). Positive surgical margins were observed in 20 pieces (20.83%), most of them located at the level of the apex in 5 cases (25%), multifocal in 10 (50%) and larger than 1<span class="elsevierStyleHsp" style=""></span>mm in 10 (50%). Biochemical recurrence occurred in 12 patients (12.5%) with a follow-up from 6 to 44 months, as shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. Self-anchoring barbed suture (<span class="elsevierStyleSmallCaps">V</span>-Loc<span class="elsevierStyleSup">&reg;</span> 90 Absorbable Wound Closure Device-Covidien) was used in 23% of the anastomoses. After 12 months, 84 patients (87.5%) were continent and continence recovery is detailed in <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>. Of the total number of cases, only 42 (41.58%) had a SHIM score greater or equal to 21 before surgery, with a mean IQR of 23 (22&#8211;24). Within this group, 59.52% of the patients were potent 1 year after the procedure with or without the use of PDE-5 inhibitors, using 5<span class="elsevierStyleHsp" style=""></span>mg of PDE-5 orally once a day as protocol, starting a week before the operation and during the first 6 months after it. The definitive biopsy reported a Gleason score of 7 (3<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>4) in 64.58% of the patients and the most common pathological stage was pT2c in 66.67% of the cases. The relationship between biochemical relapse and surgical margins and the D&#8217;Amico classification is shown in <a class="elsevierStyleCrossRefs" href="#fig0020">Figs. 4 and 5</a>. Most patients started oral tolerance to liquids within the first 8 postoperative hours. The mean time of drain permanence was 3.4<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>0.73 days (1&#8211;7).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Since the emergence of robotic surgery, few surgical specialties have been more influenced than urology. RALRP is currently a firmly established technique in medical practice at numerous health centers, reaching the point where it has replaced traditional open and laparoscopic techniques as the gold standard treatment for prostate cancer. The most important factors that have encouraged this development include the following: the enthusiasm displayed by surgeons for learning this new technique, the interest of patients and aggressive marketing.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Despite the absence of clear evidence of superiority of one technique over the other, it is widely accepted that among the advantages shown by RALRP we can find a decrease in operative bleeding, a lower complication rate according to the Clavien classification system and a quicker return to daily activities.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> The assessment and comparison of perioperative and follow-up parameters enable us to establish effective working methodologies aimed at improving outcomes. Patel et al. published excellent results in the largest RALRP series performed by a single surgeon. These authors reported a mean surgical time of 105<span class="elsevierStyleHsp" style=""></span>min (55&#8211;300), intraoperative bleeding of 111<span class="elsevierStyleHsp" style=""></span>cc (50&#8211;500), a mean complication rate of 4.3%, a hospital stay of 24<span class="elsevierStyleHsp" style=""></span>h in most patients and there were no reported deaths.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In our study, the mean operative time was 253.44<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>51.51<span class="elsevierStyleHsp" style=""></span>min (90&#8211;540), bleeding was 309.8<span class="elsevierStyleHsp" style=""></span>cc (25&#8211;1500), complications 12.9% and the mean hospitalization time was 3.53 days (1&#8211;11). When comparing our results with the centers of excellence in robotic surgery, we observed significant differences; however, when contrasting our series with reports from similar centers, or with reports of initial experiences in RALRP, the results were much more comparable, with a surgical time ranging from 186 to 241<span class="elsevierStyleHsp" style=""></span>min, a bleeding rate from 274 to 400 cc, a complication rate from 6.4 to 15.75% and a mean hospitalization time from 1.8 to 7 days.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,14&#8211;19</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The state of surgical margins after RP is an important independent factor that allows us to predict local recurrence of the disease, besides being an effective parameter to measure treatment effectiveness. The mean rate of positive surgical margins in most RALRP series is around 11 and 20%, it being statistically lower in the groups with stage T2 and a Gleason score &#8804;6.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#8211;19</span></a> In a multi-institutional series of 8095 patients, the rate of positive surgical margins was 15.7%, and 9.45 and 37.2% for stages pT2 and pT3 respectively.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Biochemical recurrence was of 4.9, 9.4, 13.4 and 19% at years 1, 3, 5 and 7 respectively in the study conducted by Menon et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> In our series, we observed a rate of biochemical recurrence of 12.5% with a maximum follow-up time of 44 months; however, different publications support the fact that the surgeon&#39;s experience causes positive margins to be lower as more procedures are performed.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Initial series establish continence recovery rates between 84 and 97% 12 months after the operation, this time being possibly reduced with certain modifications in the traditional surgical technique. Despite this, results are still influenced mainly by the patients&#8217; perioperative characteristics, the surgeon&#39;s experience, the surgical technique and the methodology used for information collection and presentation.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,23&#8211;25</span></a> In our series, the rate of urinary continence was 87.5%, a result which is within the parameters considered as suitable for this variable.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Age, the state of preoperative sexual potency, the comorbidity index, the preservation of NVBs, the non-thermal dissection of structures and low-energy cauterization of bleeding spots are the most important factors to regain sexual potency.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> In the present study, we obtained a potency rate of 59.52%, far below the data described by Coelho et al., whose mean rate of sexual potency at months 3, 6, 12 and over 18 months was 38.4, 61.1, 71.2 and 94%, respectively,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> largely due to the fact that the study group had a preoperative SHIM score greater than 21 in only 41.58% of the cases, despite being a relatively young group, possibly motivated by the large number of patients, 77 (76.24%), with associated systemic comorbidities (arterial hypertension, diabetes, etc.) and that preservation of both NVBs was only performed in 50% of these previously potent patients. Despite this, there are other centers that show sexual potency results in early stages similar to ours.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conclusions</span><p id="par0065" class="elsevierStylePara elsevierViewall">RALRP is a safe, reproducible procedure with good pentafecta outcomes, even during the initial experience in centers with a limited influx of patients with prostate cancer. Nonetheless, this technique represents a surgical challenge requiring its learning curve in order to optimize its implementation. Greater follow-up time and acquiring experience with a larger number of cases are definitely required to improve outcomes and to make them compatible with the centers of excellence in robotic surgery.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>"
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              "titulo" => "Positive surgical margin"
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              "titulo" => "Definition of complications, biochemical failure, continence and potency"
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            0 => "Robot-assisted laparoscopic radical prostatectomy"
            1 => "Pentafecta"
            2 => "Prostate cancer"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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            0 => "Prostatectomía radical laparoscópica asistida por robot"
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            2 => "Cáncer de próstata"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Radical prostatectomy (RP) is the standard treatment for cancer control in the long term. The rise of minimally invasive surgery and new technologies have yielded better results and enabled us to pursue more ambitious objectives. The main works still use the trifecta as classic presentation, but this does not cover all aspects of surgery. Pentafecta is a new and more comprehensive methodology to report outcomes after RP, including complications and surgical margin status with the three major outcomes classically reported. The purpose of this study is to report our experience with robot-assisted laparoscopic radical prostatectomy (RALRP) by applying the concept of pentafecta.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Material and Method</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Describe the experience in this institution from March 2009 to December 2012 of RALRP by pentafecta.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">We performed 101 interventions and obtained the following results: Average age 60.89<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>7.32 years (40&#8211;77), total PSA 8.5<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>5.57<span class="elsevierStyleHsp" style=""></span>ng/dl (0.2&#8211;29); D&#8217;Amico classification: Low 29 (28.71%), Medium 65 (64.36%), High 7 (6.93%); Operative time 253.44<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>51.51<span class="elsevierStyleHsp" style=""></span>min (90&#8211;540), Complications 12.9% (Clavien <span class="elsevierStyleSmallCaps">I</span>&#8211;<span class="elsevierStyleSmallCaps">II</span> 10.89% and Clavien IIIa 1.98%); Positive surgical margins 20.83%; Biochemistry recurrence 12.5% follow-up (6&#8211;44 months); and Continence 87.5% per year and Potency 59.52%.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">RALRP is a safe and reproducible procedure with excellent results in terms of pentafecta, inclusive during the initial experience at a low volumen center for prostate cancer. A longer follow-up study and experience with higher volume of patients are required to obtain better results and data to be compared with excellence centers.</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">La prostatectom&iacute;a radical (PR) es el tratamiento de elecci&oacute;n para el control del c&aacute;ncer de pr&oacute;stata a largo plazo. El auge de la cirug&iacute;a m&iacute;nimamente invasiva y las nuevas tecnolog&iacute;as ha permitido obtener mejores resultados y aspirar a objetivos m&aacute;s ambiciosos. Los principales trabajos a&uacute;n emplean la trifecta como forma cl&aacute;sica de presentaci&oacute;n, pero esta no abarca todos los aspectos relacionados con la cirug&iacute;a. La pentafecta es una nueva y amplia metodolog&iacute;a; en ella se incluyen las complicaciones y el estado de los m&aacute;rgenes quir&uacute;rgicos junto con los 3 par&aacute;metros reportados cl&aacute;sicamente. El prop&oacute;sito de este estudio es reportar nuestra experiencia en prostatectom&iacute;a radical laparosc&oacute;pica asistida por robot (PRLAR) aplicando el concepto de pentafecta.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y m&eacute;todo</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Describir la experiencia de esta instituci&oacute;n entre Marzo 2009 - Diciembre 2012 de PRLAR en funci&oacute;n de pentafecta.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Se realizaron 101 intervenciones, edad promedio: 60,89<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>7,32 a&ntilde;os (40-77), PSA total 8,5<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>5,57<span class="elsevierStyleHsp" style=""></span>ng/dl (0,2-29), clasificaci&oacute;n D¿Amico: bajo 29 (28,71%), intermedio 65 (64,36%), alto 7 (6,93%), tiempo operatorio 253,44<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>51,51<span class="elsevierStyleHsp" style=""></span>min (90-540), complicaciones 12,9% (Clavien <span class="elsevierStyleSmallCaps">I</span>-<span class="elsevierStyleSmallCaps">II</span> 10,89% y Clavien IIIa 1,98%). M&aacute;rgenes quir&uacute;rgicos positivos 20,83%, recurrencia bioqu&iacute;mica 12,5% en seguimiento (6-44 meses), continencia y potencia 87,5% y 59,52% respectivamente al a&ntilde;o.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">La PRLAR es un procedimiento seguro, reproducible, con buenos resultados en funci&oacute;n de pentafecta, inclusive durante la experiencia inicial en centros con limitada afluencia de pacientes con c&aacute;ncer de pr&oacute;stata. Se requiere m&aacute;s tiempo de seguimiento y experiencia con mayor n&uacute;mero de casos para mejorar los resultados y hacerlos comparables con los centros de excelencia.</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: G&aacute;rate J, S&aacute;nchez-Salas R, Valero R, Matheus R, Le&oacute;n A, D&aacute;vila H. Resultados de pentafecta en prostatectom&iacute;a radical rob&oacute;tica: primeros 100 casos en un hospital p&uacute;blico latinoamericano. Actas Urol Esp. 2015;39:20&#8211;25.</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Parameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Values&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean age</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (years) (range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60.89<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>7.32 (40&#8211;77)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean BMI</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (kg</span>/<span class="elsevierStyleItalic">m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span>) <span class="elsevierStyleItalic">(range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25.95<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>2.92 (18.2&#8211;35.9)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Preoperative SHIM</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805;21 points&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42 (41.58%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Clinical stage</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61 (60%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 (40%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean PSA (ng/ml) (range)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8.5 (0.2&#8211;29)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">D&#8217;Amico risk category</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Low&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29 (28.71%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Intermediate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 (64.36%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>High&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 (6.93%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean operative time</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (min) (range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">253.44<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>51.51 (90&#8211;540)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number of blood transfusions</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 (7.92%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Conversions to open surgery</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 (4.95%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Complication rate</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 (12.9%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Clavien <span class="elsevierStyleSmallCaps">I</span>&#8211;<span class="elsevierStyleSmallCaps">II</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 (10.89%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Clavien <span class="elsevierStyleSmallCaps">III</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 (1.98%)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Clavien <span class="elsevierStyleSmallCaps">IV</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Clavien <span class="elsevierStyleSmallCaps">V</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Final pathologic stage (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>pT2a/b/c&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88 (91.67)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>pT3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 (3.13)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>pT3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 (4.16)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Vanished carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 (1.04)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Positive surgical margins (%)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 (20.83)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 (18.62)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 (57.14)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean pr&eacute;state weight</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (g) (range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47.27<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>27.75 (10&#8211;186)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number of lymphadenectomies (positive for cancer)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 (0)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean hospital stay</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (d) (range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3.53<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>0.73 (1&#8211;11)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Mean permanence of the catheter</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&plusmn;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD (d) (range)</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8.04<span class="elsevierStyleHsp" style=""></span>&plusmn;<span class="elsevierStyleHsp" style=""></span>3.19 (7&#8211;21)&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Perioperative characteristics (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>101).</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
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          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:28 [
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                  "host" => array:1 [
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              "identificador" => "bib0020"
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                            0 => "V. Patel"
                            1 => "A. Sivaraman"
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                      "doi" => "10.1016/j.eururo.2011.01.032"
                      "Revista" => array:6 [
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21296482"
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            5 => array:3 [
              "identificador" => "bib0030"
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                  "contribucion" => array:1 [
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                            0 => "A. Sivaraman"
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            7 => array:3 [
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ISSN: 21735786
Original language: English
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es en pt

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