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Moreno, A. Domínguez, C. Alpuente, A. Hernándo, J. Torres, J.A. Cabrera" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Moreno" "email" => array:1 [ 0 => "ajmorenor1@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Domínguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Alpuente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Hernándo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "J.A." "apellidos" => "Cabrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital Central de la Defensa Gómez Ulla, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Preventiva y Salud Pública, Universidad Complutense de Madrid, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características de la forma de presentación del cáncer de testículo en hospitales públicos de la Comunidad Autónoma de Madrid, España" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Testicular cancer accounts for between 1 and 1.5% of all malignancies affecting men, and constitutes the most frequent solid tumors between the age of 20 and 34,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> its incidence having increased over the last four decades (between 3 and 6% annually).<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Treatment for these tumors has evolved considerably, and a multidisciplinary approach model is considered for solid malignancies where surgery, chemotherapy (based on cisplatin) and radiotherapy play a decisive role in improving survival, from 60 to 65% in the 60s to over 95% at present.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Testicular germ cell tumors (TGCT) account for between 90 and 95% of the malignancies of the male gonads. The remaining 5% corresponds to non-germ cell testicular tumors, among which we include tumors of the sexual cords and of the gonadal stroma (Leydig cell tumor, Sertoli cell tumor, granulosa tumors [adult and juvenile], and gonadoblastomas, among others) and non-specific stromal tumors (tumors of the collector tubules and of the rete testis and non-specific stromal tumors, benign and malignant).<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Our aim was to describe the characteristics of the patients and tumors that are diagnosed and treated in public hospitals of the Madrid Health Service, Community of Madrid, Spain.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">The study population results from the hospital records of tumors within the Autonomous Community of Madrid. All patients diagnosed with testicular cancer between 1 January 1995 and 31 December 2010 were included. Testicular cancer was considered in accordance with the International Classification of Diseases for Oncology (ICD-O-3), which encodes it as C62.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> We studied both the descriptive variables of the subjects, as well as those corresponding to the tumor and the treatment received. Temporal distribution was grouped into five-year periods. Age was classified into 15-year groups, following the criteria of the National Center Data Base (NCDB)<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and age was grouped into patients under the age of 34 and patients aged 34 or older, taking the average age in the series as a cut-off point.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Histology was grouped into two categories: TGCT, the classification of which was based on that described by Mostofi and Price<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>; and “other tumors”, where the remaining histological forms are framed. For tumor extension, we used the Surveillance, Epidemiology and End Results (SEER) classification, as modified by the American Joint Committee Cancer (AJCC).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> It refers to the following stages at the time of diagnosis: stage I, localized disease with no lymph node or distant organ involvement (pT1–pT4; N0; M0); stage II, regional disease extended to regional lymph nodes, but not to distant lymph nodes or organs (pT1–pT4; N1–N3; M0); and stage III, disseminated disease extended to distant lymph nodes and/or other organs (pT1–pT4; N0–N3; M1). Treatments were grouped into “surgery”, “surgery and chemotherapy”, “surgery and radiotherapy” and “other treatments”. Data analysis was performed using the SPSS package 15.0 for Windows. The analysis of the possible associations was performed using the Chi-square test, always with a level of significance of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>0.05.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Population characteristics</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study population was comprised of 536 subjects diagnosed with testicular cancer. The temporal distribution found over the study period registered an upward trend, moving up from 6.2% in the first five-year period (33 recruited cases) to 48.3% in the last one (259 recruited cases). This increase was more dramatically observed from the third five-year period onwards (2001–05). The mean age of patients was 33.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>13.6 years; 355 cases (66% of the total) were subjects under the age of 34. The maximum rate was found in the age groups from 20 to 34 years (326 cases; 60.8% of the total), decreasing from 35 years onwards. In the age group corresponding to subjects under 34 years of age, the most frequently diagnosed histology was nonseminomatous germ cell tumor (NSGCT), with a percentage of 58.5%. Seminoma occurred in 35.6% of all the tumors within this group. On the contrary, in the age group of 34 years and over, seminoma was more common, accounting for 62% of cases. 21.1% of the cases within this group corresponded to NSGCT.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Tumor characteristics</span><p id="par0025" class="elsevierStylePara elsevierViewall">TGCTs accounted for 89.7% of the total in the series: 247 patients (46%) were seminomas, 234 (43.6%) NSGCTs, and the remaining 55 (10.2%) “other tumors”. Histological distribution is shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The three histological forms were mainly diagnosed at stage I, which accounts for 74.8% (401 patients) of the total of the series. 8.2% (44 patients) were diagnosed at stage II. 16.2% (87 patients) at stage III. <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> specifies the different stages by histological group. Five patients (0.9%) were diagnosed with bilateral germ cell tumor.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Treatment characteristics</span><p id="par0035" class="elsevierStylePara elsevierViewall">A wide range of treatments has been indicated. Most tumors of the three histological groups reviewed were treated with more than one therapeutic measure, in particular surgery associated with chemotherapy (291 patients, 54.3%) or with radiotherapy (30 patients, 5.6%). 27.4% (147 patients) underwent only surgical treatment. The remaining 12.6% (68 patients) were either not treated or received other kinds of treatment consisting of different associations between surgery, radiotherapy and chemotherapy.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Chemotherapy was the most frequently used treatment in the three stages: 54.9% of stage I tumors, 70% of stage II tumors and 71% of stage III tumors. Surgery alone was used in 32.7% of stage I tumors, 13.6% of those diagnosed at stage II and 9.2% of those at stage III. Radiotherapy was indicated in 10% of stage I tumors, 9% of stage II cases and 3.4% of those at stage III. Both in the seminoma and the NSGCT groups, chemotherapy was the most frequently indicated treatment in the three stages. <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the treatments administered to the patients in the series according to stage and histology.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The association surgery and chemotherapy was the most frequently used treatment in both age groups (62% vs. 53% in subjects under 34 years of age and 34 years or over, respectively); followed by surgery alone, also in both groups (26% vs. 30%, respectively). Surgery was combined with radiotherapy in 6% of the patients under 34 years of age and in 12% of those aged 34 or older.</p><p id="par0050" class="elsevierStylePara elsevierViewall">An association (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) was demonstrated in this series between the age of presentation and the histological variety, as well as between age and the treatment received. We also demonstrated the well-known association between histology and tumor extension, with advanced stages being more common in NSGCTs, and logically between histology and the therapeutic modality administered. The existing association between tumor extension and the type of treatment administered was also expected and was hereby confirmed (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05, in all cases). No association was detected between variables such as age, tumor extension, therapeutic delay or multiplicity (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05).</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">The number of cases increased throughout the study period, as happened in the series provided by the American Cancer Society (ACS), which showed an incidence of 8090 new cases in the USA for the year 2008 and a year later showed 8400; although paradoxically, estimated a slightly lower incidence for the year 2013 (7920 new cases).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The SEER found out exactly the same results in a series from 1975 to 2010.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Llanes et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> described in 2008 an annual increase since 1991, with a significant peak in the year 2003. This finding was also observed in the series we present, with an increase in the five-year period 2001–05. These results must be consistent, since the above-mentioned series refers to a health area of 300,000 inhabitants from the Autonomous Community of Madrid. Bray et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> considered that in Spain and Slovenia this incidence had increased more dramatically (6% every year) in the last few years with respect to the rest of the countries in the European community.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The mean age is in line with that published by Scheiden et al.,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> who described a mean age of 33.7 years in their review. Cooper et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> reported a lower mean age, 26.6 years. With regard to the age groups we registered, the data also go in line with those of other authors.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Similarly, the distribution by histology coincides with the vast majority of the series reviewed,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,17</span></a> which provide a figure of 50% for seminomas and NSGCTs; however, this proportion does not coincide with what was published by the Spanish Germinal Group (GG)<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> that in 1250 patients detected a 35% of seminomas vs. a 65% of NSGCTs. This may be due, as presupposed by the authors themselves, to the fact that the early stages of seminomatous tumors were directly treated by some radiotherapy services, still unrelated to the GG.</p><p id="par0065" class="elsevierStylePara elsevierViewall">With regard to stage, our patients had localized tumor (77%) in a higher proportion than that published by Fernández-Gómez et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> (59%) or even in the data provided by the SEER (69%).<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> With regard to the proportion of patients with disseminated stage, our statistics (14%) is more similar to that provided by the SEER (12%).<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In the case of distribution by stages, we were more in line with the experience of Cooper et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">With regard to the use of surgery as a sole treatment, our series is in line with most of the series reviewed<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19–21</span></a> (between 20% and 27%); however, it differs with the data provided in these same studies regarding the associations between surgery and chemotherapy and surgery and radiotherapy. In those series both strategies are used with the same frequency, with percentages ranging from 37–41% and 31–39% respectively; whereas in the case of the series of the Community of Madrid, it is striking the large number of patients (54%) treated with the combined regimen of surgery and chemotherapy versus those treated with the association of surgery and radiotherapy (8%).</p><p id="par0075" class="elsevierStylePara elsevierViewall">As in most of the publications reviewed, in the series we present seminoma was especially diagnosed in older age groups (35–40 years) whereas NSGCTs occurred more frequently among younger subjects (under the age of 34).<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,22,23</span></a> The most commonly used treatment in both age groups was the combination of surgery and chemotherapy. Age, in overall terms, should not influence treatment choice which is determined by histology and stage.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In the three histological groups defined, most tumors were diagnosed at localized stages. With regard to seminoma, the percentage of diagnosed cases decreases progressively as tumor stage increases<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>; however, in the case of NSGCTs, the number of patients diagnosed at disseminated stages is twice the number of those diagnosed at a regional stage, data consistent with the series from the Spanish Germinal Group (GG),<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> where the presence of metastasis at the beginning in patients with seminoma is less common (14% in our series, 21% in the GG series) than in the case of NSGCTs (31% in our series, 48% in the GG series).</p><p id="par0085" class="elsevierStylePara elsevierViewall">The treatment most frequently used was surgery combined with chemotherapy. In some of the works consulted,<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23–26</span></a> surgery combined with radiotherapy was mainly used. This association is basically used in seminoma stages I and II, the association of surgery and chemotherapy being reserved for disseminated stages. In the series by Lakomý et al.,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> when it came to treating seminomas, a clear preference for the adjuvancy with radiotherapy was observed, whereas in nonseminomatous tumors prevailed the use of adjuvant treatment with chemotherapy. This did not happen in our series, which showed a preference for adjuvant chemotherapy for both histological groups. In the series by Aparicio et al.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> comprised of 314 seminomas in stage I, surgery alone was used in 31.8% of cases, whereas in our experience it was performed in 33% of cases. In this same series, surgery was combined with chemotherapy (carboplatin) in 68% of cases, a slightly higher figure than that of our experience which stands at 47.4%. We coincided less with Osswald et al.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> since they treated seminomas in stage I with surgery and radiotherapy in over 80% of cases, which only occurred in 17.5% of cases in our series.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In conclusion, both in the case of seminomas and NSGCTs, adjuvant chemotherapy is more frequently used as stage progresses. The study by Germá et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> also highlighted, as in the case of our experience, this trend of change in the therapeutic approach to be taken in seminomas that has been followed over the past few years: radiotherapy, due to its medium- and long-term toxicity, is being replaced by adjuvant chemotherapy, which is indicated depending on stage and on the prognostic factors according to the classification provided by the International Germ Cell Cancer Consensus Group (IGCCCG). We acknowledge the main limitation of this study, which lies on the fact that the data reflected were extracted from a record without having been possible to analyze the different risk factors of these malignancies and neither was it possible to analyze in depth the different subtypes of the indicated treatments, nor their toxicity or the final results achieved.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres413802" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objective" 2 => "Material and method" 3 => "Results" 4 => "Conclusion" ] ] 1 => array:2 [ "identificador" => "xpalclavsec389467" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres413803" "titulo" => array:5 [ 0 => "Resumen" 1 => "Objetivo" 2 => "Material y método" 3 => "Resultados" 4 => "Conclusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec389466" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Population characteristics" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Tumor characteristics" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Treatment characteristics" ] ] ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-03-24" "fechaAceptado" => "2014-03-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec389467" "palabras" => array:3 [ 0 => "Testicular cancer" 1 => "Epidemiology" 2 => "Treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec389466" "palabras" => array:3 [ 0 => "Cáncer de testículo" 1 => "Epidemiología" 2 => "Tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">To study the clinical features of the patients with germ cell tumor of testis in the Autonomous Community of Madrid, emphasizing on the different treatments used.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Material and method</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of 536 patients with testicular cancer who were obtained from the Community of Madrid cancer registry, during a follow-up period of 15 years (1991–2010). Data analysis has been performed using SPSS 15.0 for Windows. Chi-square test has been used to determine possible relationships among variables. The level of significance was <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>0.05.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">An increase in the incidence rate has been detected along study period. Mean age was 33.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>13.6 years. 89.7% of cases were germ cells tumors (46% seminoma and 43.6% nonseminomatous germ cell tumor [NSGCT]) and other histologic subtypes the remaining 10.3% of cases. 74% of patients were diagnosed with stage <span class="elsevierStyleSmallCaps">I</span> disease, 8.2% with stage <span class="elsevierStyleSmallCaps">II</span> and 16.2% with stage <span class="elsevierStyleSmallCaps">III</span>; 54.3% of patients were treated with surgery plus adjuvant chemotherapy and in 5.6% of patients the treatment was surgery plus adjuvant radiotherapy. Surgery alone was used in 27.4% of cases: in 32.7% of stage <span class="elsevierStyleSmallCaps">I</span> tumors, 13.6% of stage <span class="elsevierStyleSmallCaps">II</span> and 9.2% of stage <span class="elsevierStyleSmallCaps">III</span>. Radiotherapy was prescribed in 10% of stage <span class="elsevierStyleSmallCaps">I</span> tumors, in 9% of stage <span class="elsevierStyleSmallCaps">II</span> and in 3.4% of stage <span class="elsevierStyleSmallCaps">III</span>. For the seminomas: the surgery-chemotherapy association was used in 49.8 of cases, surgery alone in 30% and surgery plus radiotherapy in 16.6% of cases. For the NSGCT, surgery plus chemotherapy was used in 70.5% of patients, surgery alone in 23.5% and surgery-radiotherapy association in 0.8% of cases.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Testicular cancer incidence is increasing. Adjuvant chemotherapy is the treatment used most frequently in the more advanced stages of both seminomas and NSGCT. The tendency to reduce the use of radiotherapy in the treatment of seminoma was confirmed.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Estudiar las características de los sujetos que padecen tumor de células germinales de testículo en la Comunidad Autónoma de Madrid, con énfasis en los distintos tratamientos empleados.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y método</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se realiza un análisis retrospectivo de una serie de 536 pacientes con cáncer de testículo, procedentes del registro de tumores de la Comunidad de Madrid, durante un periodo de 15 años (1991-2010). El análisis de los datos se ha realizado con el paquete SPSS 15.0 para Windows. Se ha empleado la prueba chi-cuadrado para la búsqueda de posibles asociaciones. El nivel de significación ha sido de p<span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>0,05.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Se detecta un incremento en la incidencia a lo largo del periodo de estudio. La edad media fue 33,6<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>13,6 años. El 89,7% fueron tumores de células germinales (46% seminoma y 43,6% tumor no seminomatoso [TCGNS]) y el 10,3% restante otras estirpes histológicas. El 74% de los pacientes fueron diagnosticados en estadio <span class="elsevierStyleSmallCaps">I</span>, el 8,2% en estadio <span class="elsevierStyleSmallCaps">II</span> y el 16,2% en el estadio <span class="elsevierStyleSmallCaps">III</span>; 54,3% recibieron tratamiento con cirugía y quimioterapia adyuvante, y 5,6% con cirugía y radioterapia adyuvante. La cirugía sola se empleó en el 27,4% de los casos; 32,7% de los tumores en estadio <span class="elsevierStyleSmallCaps">I</span>, 13,6% de los estadio <span class="elsevierStyleSmallCaps">II</span> y 9,2% de los estadio <span class="elsevierStyleSmallCaps">III</span>. La radioterapia se indicó en el 10% de los tumores estadio <span class="elsevierStyleSmallCaps">I</span>, en el 9% de los estadio <span class="elsevierStyleSmallCaps">II</span> y en el 3,4% de los estadio <span class="elsevierStyleSmallCaps">III</span>. En el caso de los seminomas, la asociación cirugía y quimioterapia se empleó en un 49,8% de los casos, cirugía sola en un 30% y cirugía asociada a radioterapia en un 16,6%. En los TCGNS la asociación cirugía y quimioterapia se empleó en un 70,5%, cirugía sola en un 23,5% y la asociación cirugía y radioterapia en el 0,8% de los casos.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">La incidencia del cáncer de testículo está en aumento. La quimioterapia adyuvante se emplea con más frecuencia en estadios más avanzados, tanto en seminomas como TCGNS. Se confirma la tendencia a disminuir el empleo de radioterapia en el tratamiento del seminoma.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Moreno A, Domínguez A, Alpuente C, Hernándo A, Torres J, Cabrera JA. Características de la forma de presentación del cáncer de testículo en hospitales públicos de la Comunidad Autónoma de Madrid, España. Actas Urol Esp. 2015;39:2–7.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">NSGCT: non-seminomatous tumor.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tumor type \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No. of cases \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percentage \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">SEMINOMAS</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">247 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Classic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">235 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anaplastic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Spermatocytic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">NSGCT</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">234 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.65 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pure pathological types \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Embryonal carcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yolk sac tumor \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Teratomas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Choriocarcinomas \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mixed tumors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">103 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unspecified NSGCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Other tumors</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab644380.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Histological distribution.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">NSGCT: non-seminomatous tumor.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stage \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Seminomas (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">NSGCT (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Others (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleSmallCaps">I</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">211 (85.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">159 (68) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 (56.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">401 (74.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleSmallCaps">II</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (8.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 (8.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleSmallCaps">III</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (6.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 (22.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (36.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">87 (16.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">247 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">234 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">536 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab644379.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Stage and histology.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">S: surgery; CT: chemotherapy; RT: radiotherapy.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stages \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">S. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">S.<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CT. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">S.<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>RT. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Others \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Seminomas</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">I</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">69 (33%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100 (47.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37 (17.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (2.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">211 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">II</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (9.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (67%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (19%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (4.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">III</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (26.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (60%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (13.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">NSGCT</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">I</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 (30.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">108 (67.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">159 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">II</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (14.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (76.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (9.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">III</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (5.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 (76.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (3.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (13.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab644381.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Treatments indicated, stages, and histology.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Testicular cancer" "autores" => array:1 [ 0 => 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Year/Month | Html | Total | |
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2018 October | 0 | 1 | 1 |
2018 March | 0 | 3 | 3 |
2018 February | 8 | 0 | 8 |
2018 January | 7 | 0 | 7 |
2017 December | 2 | 1 | 3 |
2017 November | 13 | 1 | 14 |
2017 October | 20 | 2 | 22 |
2017 September | 10 | 2 | 12 |
2017 August | 11 | 2 | 13 |
2017 July | 12 | 2 | 14 |
2017 June | 8 | 18 | 26 |
2017 May | 10 | 2 | 12 |
2017 April | 15 | 26 | 41 |
2017 March | 8 | 35 | 43 |
2017 February | 6 | 1 | 7 |
2017 January | 5 | 5 | 10 |
2016 June | 0 | 8 | 8 |
2016 May | 0 | 3 | 3 |
2016 April | 0 | 4 | 4 |
2016 March | 0 | 10 | 10 |
2016 February | 0 | 8 | 8 |
2016 January | 0 | 9 | 9 |
2015 December | 0 | 2 | 2 |
2015 November | 0 | 1 | 1 |
2015 August | 0 | 2 | 2 |
2015 July | 1 | 1 | 2 |
2015 June | 0 | 1 | 1 |
2015 April | 0 | 2 | 2 |
2015 March | 0 | 2 | 2 |
2015 February | 0 | 1 | 1 |