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Review article
De novo urologic tumors in kidney transplant patients
Tumores urológicos de novo en pacientes trasplantados renales
O. Rodríguez Fabaa,b,
Corresponding author
orodriguez@fundacio-puigvert.es

Corresponding author.
, A. Bredaa,b, L. Gausaa,b, J. Paloub, H. Villavicenciob
a Unidad de Trasplante Renal, Servicio de Urología, Fundació Puigvert, Barcelona, Spain
b Unidad de Urología Oncológica, Servicio de Urología, Fundació Puigvert, Barcelona, Spain
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and the occurrence of tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">1</span></a> Data from the U&#46;S&#46; Registry on 175&#46;732 solid organ transplants &#40;58&#46;4&#37; renal&#41; between 1987 and 2008 have shown an increase in this population of 2 times the risk of tumors compared to the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">3</span></a> These immunosuppressive therapies have been associated with tumor promotion and progression&#46; Cyclosporin A inhibits calcineurin&#44; tacrolimus interferes with TNF&#946;&#44; and azatriopinase is associated with neoplastic transformation through DNA&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although currently the leading cause of morbidity and mortality in RT is cardiovascular problems&#44; probably in the next 20 years&#44; due to increased graft survival&#44; the age of the donor and recipient&#44; as well as the second and third transplants&#44; tumors will be a leading cause of mortality in this population&#46; Besides immunosuppressants&#44; environmental factors such as obesity&#44; tobacco&#44; and chronic analgesic intake&#44; genetic factors &#40;Von Hippel-Lindau disease&#41;&#44; chronic infection by BK&#44; and acquired cystic disease have been described as risk factors for the occurrence of tumors in this population&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a> In a recent study with 123&#44;380 RT recipients&#44; the most solid-organ neoplasms were lymphoproliferative diseases &#40;1&#46;58&#37;&#41;&#44; followed by lung cancer &#40;1&#46;12&#37;&#41; and prostate cancer &#40;0&#46;82&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of urological neoplasms in such patients ranges from 0&#46;38&#37; to 5&#46;5&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Tsaur et al&#46;&#44; in a study with 1990 transplanted patients&#44; described 15 times more likely to develop renal cell cancer &#40;RCC&#41;&#44; 3 times more likely to have transitional cell bladder cancer &#40;TCBC&#41;&#44; testicular cancer &#40;TC&#41; 3 times&#44; and 2 in the case of prostate cancer &#40;PC&#41;&#44; urological tumors representing in their work 15&#37; of tumors in RT&#46; Furthermore&#44; urological tumors were the leading cause of death of neoplastic origin&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">2&#44;7</span></a> In Spain&#44; in a retrospective study of 1751 transplant patients&#44; 29 patients had urological tumors &#40;1&#46;6&#37;&#41;&#44; PC being the most frequent with 11 &#40;37&#37;&#41;&#44; followed by TCC with 5 &#40;20&#37;&#41;&#44; RCC in primitive kidney with 6 &#40;20&#46;7&#37;&#41;&#44; and RCC in transplanted kidney with 5 &#40;17&#46;2&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">8</span></a> Recently&#44; Hevia et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">9</span></a> in their series of 1365 RTs&#44; reported an incidence of 25 cases &#40;1&#46;8&#37;&#41;&#44; the most common being RCC with 11 &#40;44&#37;&#41;&#44; followed by PC with 9 &#40;36&#37;&#41;&#44; and TCBC with 5 &#40;20&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Renal cell carcinoma</span><p id="par0020" class="elsevierStylePara elsevierViewall">RCC is more common in the population undergoing hemodialysis and in the native kidneys of transplanted patients&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">10</span></a> with a prevalence that&#44; in spite of changing depending on the screening&#44; is between 0&#46;34 and 5&#46;8&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">11&#44;12</span></a> The most recognized risk factors are analgesic nephropathy and acquired cystic disease&#44; and in the case of post-RT patients&#44; immunosuppression was considered a promoter of carcinogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">13</span></a> RCC in patients with CKD has different clinicopathological features to those of the general population&#46; Neuzillet et al&#46; analyzed the differences in behavior of RCCs in 303 CKD patients and compared them to 974 cases in the general population&#46; The group of patients with CKD were diagnosed more often in an asymptomatic way &#40;87 vs&#46; 44&#37;&#41;&#44; showed smaller tumors &#40;3&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;6<span class="elsevierStyleHsp" style=""></span>cm vs&#46; 7&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;8<span class="elsevierStyleHsp" style=""></span>cm&#41;&#44; and in younger patients &#40;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years vs&#46; 62<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#41;&#46; Furthermore&#44; these tumors had a lower stage and grade&#44; with a more favorable cancer-specific mortality &#40;4&#46;3 vs&#46; 27&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">14</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Breda et al&#46; confirmed these results&#44; but also in their series&#44; in spite of the significantly better cancer-specific survival of RCCs in the CKD group&#44; when they were analyzed in the group of patients with CKD&#44; those with pretransplant RCC&#44; and it was compared to the post-RT&#44; this significant difference in survival disappeared&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">15</span></a> As for the histological subtype&#44; Hetet et al&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">16</span></a> found no differences between the different histological subtypes&#59; however&#44; recent studies have found a higher prevalence of the papillary subtype in this population&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The treatment of the RCCs that appear on the graft must be conservatively posed whenever possible according to size &#40;T1a&#41; and&#47;or location&#44; since the alternative would be transplantectomy and consequently dialysis&#46; Partial nephrectomy is the oncologically safest technique&#44; although technically more complex&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">17</span></a> In a review by Ribal et al&#46; of 15 patients with renal tumor in the graft and undergoing partial nephrectomy&#44; none had recurrence in the graft or distant spread&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">18</span></a> Radiofrequency and cryotherapy are alternatives for those more technically complex cases or in patients at high surgical risk&#46; The ultrasound screening for this population might be justified in cases with a history of chronic use of analgesics or acquired cystic disease&#59; however&#44; difficulties have been described in the case of acquired cystic disease or in native kidneys with multiple cysts or scars to differentiate by ultrasound tumor lesions of adenomas or angiomyolipomas&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">19</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Transitional cell carcinoma of the bladder</span><p id="par0035" class="elsevierStylePara elsevierViewall">Overall&#44; in the transplanted population&#44; bladder cancer&#44; both non-muscle invasive &#40;NMIBT&#41; and muscle invasive &#40;MIBT&#41; have a greater biological aggressiveness and worse prognosis&#46; The relative risk of having it is 3&#46;31 times higher than in the general population&#46; It has been postulated as one of the molecular mechanisms involved in the promotion and development of TCBC&#44; activation of the PI3K&#47;Akt&#47;mTOR pathway involved in the metabolism&#44; growth&#44; proliferation&#44; survival&#44; and angiogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">20</span></a> Furthermore&#44; mutation of PTEN&#44; present in bladder cancer&#44; has been associated with worse prognosis&#46; This mutation activates mTOR&#44; which plays a key role in translation&#44; cell growth&#44; apoptosis&#44; and angiogenesis&#46; Sirolimus &#40;SRL&#41;&#44; which is an inhibitor of mTOR&#44; could play a critical role inhibiting cell proliferation and apoptosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In RT receptors&#44; the 3 basic problems encountered in the management of TCBC are the greatest biological aggressiveness&#44; resulting in the increased incidence of NMIBT in some series&#44; the controversy that the BCG presents in transplanted patients and the greater technical difficulty of cystectomy and urinary reconstruction&#46; The most frequently diagnosed NMIBT is high-grade T1&#44; and the BCG is the optimal adjuvant therapy that decreases recurrence and progression&#46; However&#44; overall&#44; immunotherapy is not recommended in immunosuppressed patients&#44; and the series published so far comprise a limited number of patients&#46; Palou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">21</span></a> have reported the experience with BCG in high-grade NMIBT in patients receiving RT&#46; In spite of immunosuppression&#44; patients showed worse tolerance to BCG than the general population&#44; although there was recurrence in 2 of the 3 patients studied&#46; There are a total of 10 cases in the literature of patients with RT who have received BCG for NMIBT&#46; The mean time of overall follow-up was 30&#46;8 months&#44; during which a patient died of metastatic disease and another one of the complications of CKD&#46; There are no reported side effects associated with BCG<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">21&#44;22</span></a>&#59; however&#44; given the limited number of published cases&#44; no conclusions can be drawn regarding oncologic effectiveness&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The standard treatment for MIBT is radical cystectomy with lymphadenectomy&#46; In carriers of RT&#44; this surgery is technically more demanding due to the anatomical changes as a consequence of the presence of the graft&#46; When performing cystectomy&#44; we have to be particularly careful with dissection of the ureter of the graft&#44; and we have to try to preserve its vascularization as much as possible&#46; Equally&#44; in the cases where ipsilateral lymphadenectomy can be performed&#44; this must be conducted with utmost care and trying to preserve the graft and its vascularization&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">20</span></a> In these patients&#44; we may consider conducting an orthotopic diversion in the cases that keep adequate renal function &#40;&#60;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; functional urethra free of neoplasia&#44; and manual dexterity to be able to perform self-catheterization&#46; Moses et al&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">23</span></a> published their experience with 4 transplanted patients who underwent a cystectomy with urinary diversion due to MIBT&#46; In all of them&#44; the identification of the ureter of the graft was necessary using intravenous contrast&#44; and it was not possible to perform lymphadenectomy in any case on the side of the graft&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">No worsening was objectified in the renal function as a consequence of the completion of the neobladder&#46; As for oncological outcomes&#44; 2 patients had recurrence&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">23</span></a> So far&#44; 34 patients have been reported due to MIBT&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">24</span></a> In all cases&#44; regardless of the type of neobladder performed&#44; functional outcomes do not differ from the general population&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Prostate cancer</span><p id="par0055" class="elsevierStylePara elsevierViewall">The incidence and prevalence of PC in renal transplant patients is difficult to interpret because most of the records have been obtained prior to the existence of a systematic screening&#46; There are publications in which the incidence is lower than in the general population<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">25</span></a>&#59; however&#44; data from the Nordic countries show a much higher incidence of cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">26</span></a> In those series in which patients were performed a systematic screening with PSA and&#47;or DRE&#44; the incidence of prostate cancer is higher than the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">27</span></a> The prevalence is 0&#46;3&#8211;1&#46;8&#37;&#44; and it may reach 5&#46;8&#37; if screening with PSA is performed in all men&#44; recommending performing PSA and DRE in all recipients &#62;50 years&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">28</span></a> It has not been shown that PSA levels are influenced by immunosuppression or by kidney failure&#44;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">29</span></a> and most tumors &#40;84&#37;&#41; in this population are diagnosed in a localized way&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Radical prostatectomy for cases diagnosed in a localized manner can be performed perineally&#44; avoiding injury to the ureteral reimplantation and facilitating urethrovesical anastomosis without tension&#46; Hafron et al&#46; published their experience with 7 patients undergoing perineal post-RT&#44; concluding that this surgical approach for transplant patients is safe&#44; with a complication rate and oncological follow-up similar to the non-transplant population&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">30</span></a> In the case of retropubic RP&#44; we have to consider the change in the position of the separator to prevent injuring the graft&#59; equally&#44; it may be necessary to catheterize the ureter to locate the ureteroneocystostomy&#46; Probably&#44; if the perineal and retropubic RP provide the same functional and oncological results&#44;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">31</span></a> the fact of manipulating the graft and ureter less make a priori perineal RP a more feasible technique in the transplant population&#46; Similarly&#44; and given the possibility of graft failure&#44; retropubic RP hinders the performance of a 2nd transplant in the opposite iliac fossa by manipulating the anatomical space much more&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">30</span></a> increasing the technical difficulty and complications of future transplants&#46; Robotic RP has also been developed&#44; existing publications with a limited number of cases&#46; The modifications described with respect to the standard technique comprise a partial dissection of the bladder from the abdominal wall due to RT adhesions and performing lymphadenectomy on one side&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">32</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Although the natural history of PC in immunodepressed patients or patients with renal failure is little known&#44; follow-up of these patients with PSA is also recommended&#44; since kinetics is not affected&#46; External beam radiotherapy&#44; brachytherapy&#44; and androgen deprivation represent other options to consider for the treatment of PC in the transplant patient&#46; For external radiation therapy&#44; we have to consider the risk of nephritis in the graft and radiation of the bladder and ureteral reimplantation&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">30</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Testicular cancer</span><p id="par0070" class="elsevierStylePara elsevierViewall">Testicular cancer is the most common malignant tumor in the male population between 15 and 35 years and it represents 1&#37; of all malignancies in man&#46; In the population of kidney transplant recipients&#44; we found that the incidence varies across studies&#46; According to Adami et al&#46;&#44; in a study conducted in Sweden&#44; the incidence rate increased by 0&#46;7&#37; compared to the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">33</span></a> Besarani et al&#46; found no differences in incidence and prevalence in their study compared to the general population in the UK and&#44; therefore&#44; they suggest that patients are diagnosed and treated as the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">34</span></a> Tsaur et al&#46;&#44; in their series of 1990 transplant patients&#44; described 2 cases of testicular tumor &#40;3&#37; incidence in male population&#41;&#46; One case was pT1R0 seminoma treated after orchiectomy with 2 cycles of carboplatin without observing any deterioration in the renal function of the graft&#44; and without presenting recurrence at 10 years&#46; The second case was a pT2R0 malignant trophoblastic teratoma that developed lung and brain metastases&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Penile cancer</span><p id="par0075" class="elsevierStylePara elsevierViewall">Penile cancer is a rare malignancy in the general population and in renal transplant patients&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">34</span></a> We know that it has a proven relationship with the infection of human papilloma virus &#40;HPV&#41;&#44; especially types 16 and 18&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">35</span></a> Although in the transplant population a significant increase in the incidence and risk of cervicovaginal and skin neoplasms has been described&#44;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">6</span></a> and although in the immunosuppressed population&#44; such as RT recipients&#44; they have an increased expression of lesions associated with these viruses&#44; we found no association between penile cancer and renal transplant&#46; Vajdic et al&#46; showed an increased incidence up to 10 times in the community of Australia and New Zealand attributed to HPV infection&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">36</span></a> However&#44; European studies like Besarani et al&#46; suggest that there is no increased incidence relative to the general population&#46; What all studies seem to agree on is that it is not necessary to perform any test during the follow-up of the transplant patient to discard this disease&#44; an attitude consistent with the European and American guidelines of the post-transplant patient management&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">37</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusion</span><p id="par0080" class="elsevierStylePara elsevierViewall">There is an increased incidence of urologic tumors in the renal transplant population&#46; These tumors can be approached in the same way as in the general population&#44; so because of the potential worse prognosis in relation to immunosuppression&#44; this specific population requires close follow-up to facilitate early diagnosis&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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          "identificador" => "xres437238"
          "titulo" => "Abstract"
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            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Context"
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            1 => array:2 [
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              "titulo" => "Evidence acquisition"
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              "titulo" => "Synthesis of evidence"
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              "titulo" => "Contexto"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Adquisici&#243;n de evidencia"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "S&#237;ntesis de evidencia"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
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          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Renal cell carcinoma"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Transitional cell carcinoma of the bladder"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Prostate cancer"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Testicular cancer"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Penile cancer"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conclusion"
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          "titulo" => "Conflict of interest"
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          "titulo" => "References"
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    "fechaRecibido" => "2014-05-07"
    "fechaAceptado" => "2014-05-12"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec460419"
          "palabras" => array:5 [
            0 => "Urologic tumor"
            1 => "Kidney transplantation"
            2 => "Renal cancer"
            3 => "Bladder cancer"
            4 => "Prostate cancer"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec460418"
          "palabras" => array:5 [
            0 => "Tumor urol&#243;gico"
            1 => "Trasplante renal"
            2 => "C&#225;ncer renal"
            3 => "C&#225;ncer vesical"
            4 => "C&#225;ncer de prostata"
          ]
        ]
      ]
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Context</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The ability of a transplant recipient to accept a graft depends on the ability of immunosuppressive drugs to regulate the immune system&#46; Such treatments have been associated with tumor promotion and progression&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Evidence acquisition</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A systematic literature review was carried out&#46; Electronic searches were performed in PubMed database&#46; The searching criterion was &#8220;urological tumors in kidney transplant recipients&#8221;&#46; The most important issues regarding incidence&#44; urological tumor-specific features&#44; and relevant ones about the treatment are summarized&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Synthesis of evidence</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In renal transplant&#44; 15&#37; of all tumors are urological neoplasias&#59; furthermore&#44; they are the leading neoplastic cause of death&#46; In transplant population the incidence rate of renal cell carcinoma &#40;RCC&#41;&#44; transitional cellbladder carcinoma &#40;TCBC&#41;&#44; testicular carcinoma &#40;TC&#41; and prostate cancer are increased 15&#44; 3&#44; 3 and 2 times respectively&#46; Treatments used in transplant patients are similar to those employed in the general population&#58; radical nephrectomy for the native kidney and conservative surgery for the graft are indicated for RCC&#46; Radical prostatectomy is technically feasible for localized PC&#46; Regarding transitional cell carcinoma BCG or MMC is not contraindicated&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The incidence rate of cancer has increased among transplant population&#46; These tumors can be managed following the same criteria than in general population&#46; Because in this population the prognosis is worse for the immunosuppression&#44; closer monitoring is required&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Context"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Evidence acquisition"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Synthesis of evidence"
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          3 => array:2 [
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            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Contexto</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La capacidad de un receptor para aceptar un injerto renal se debe a la regulaci&#243;n del sistema inmunol&#243;gico por los f&#225;rmacos inmunosupresores&#46; Dichos tratamientos se han relacionado con la promoci&#243;n y la progresi&#243;n tumoral&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Adquisici&#243;n de evidencia</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una revisi&#243;n sistem&#225;tica de la literatura en PubMed&#44; de los art&#237;culos referidos a &#8220;tumores urol&#243;gicos en pacientes trasplantados renales&#8221;&#46; Se resumen los aspectos m&#225;s importantes en cuanto a incidencia&#44; caracter&#237;sticas espec&#237;ficas de cada tumor urol&#243;gico y aspectos relevantes del tratamiento&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">S&#237;ntesis de evidencia</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las neoplasias urol&#243;gicas representan un 15&#37; de los tumores en el TR&#44; adem&#225;s de ser en algunas series la principal causa de muerte de origen neopl&#225;sico&#46; Dicha poblaci&#243;n tiene 15 veces m&#225;s probabilidades de presentar c&#225;ncer de c&#233;lulas renales &#40;CCR&#41;&#44; 3 veces de c&#225;ncer de c&#233;lulas transicionales de vejiga &#40;CCTV&#41;&#44; 3 veces de c&#225;ncer testicular &#40;CT&#41; y 2 de c&#225;ncer de pr&#243;stata &#40;CP&#41;&#46; Los tratamientos son similares a la poblaci&#243;n no trasplantada&#59; en caso del CCR predomina la indicaci&#243;n de nefrectom&#237;a radical en el ri&#241;&#243;n nativo y cirug&#237;a conservadora en el injerto&#46; En el CP localizado la prostatectom&#237;a radical es t&#233;cnicamente factible&#46; En el CCTV la inmunosupresi&#243;n no representa una contraindicaci&#243;n para la administraci&#243;n de BCG o MMC&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Existe un incremento en la incidencia de tumores urol&#243;gicos en la poblaci&#243;n TR&#46; Dichos tumores se pueden abordar de la misma manera que en la poblaci&#243;n general&#44; por lo que debido al potencial peor pron&#243;stico en relaci&#243;n con la inmunosupresi&#243;n se requiere en esta poblaci&#243;n espec&#237;fica un seguimiento m&#225;s estrecho&#46;</p></span>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main series of the literature describing renal transplant patients and urological tumors&#46;</p>"
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                          "etal" => true
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                            2 => "M&#46; Probst"
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                            2 => "J&#46;F&#46; Fraumeni Jr&#46;"
                            3 => "B&#46;L&#46; Kasiske"
                            4 => "A&#46;K&#46; Israni"
                            5 => "J&#46;J&#46; Snyder"
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                            5 => "D&#46; Zevin"
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                            3 => "H&#46;G&#46; Rennke"
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Article information
ISSN: 21735786
Original language: English
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Year/Month Html Pdf Total
2023 March 2 2 4
2018 February 9 2 11
2018 January 3 1 4
2017 December 7 3 10
2017 November 6 2 8
2017 October 19 3 22
2017 September 11 2 13
2017 August 9 4 13
2017 July 13 1 14
2017 June 19 6 25
2017 May 11 4 15
2017 April 9 17 26
2017 March 30 34 64
2016 July 7 1 8
2016 June 16 3 19
2016 May 21 9 30
2016 April 34 12 46
2016 March 36 12 48
2016 February 38 21 59
2016 January 33 16 49
2015 December 27 15 42
2015 November 17 9 26
2015 October 29 15 44
2015 September 27 6 33
2015 August 20 13 33
2015 July 17 6 23
2015 June 9 16 25
2015 May 24 13 37
2015 April 22 14 36
2015 March 55 25 80
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos