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Inicio Actas Urológicas Españolas (English Edition) Muscle-derived stem cell therapy for stress urinary incontinence
Journal Information
Vol. 34. Issue 1.
Pages 15-23 (January 2010)
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Vol. 34. Issue 1.
Pages 15-23 (January 2010)
Review
Muscle-derived stem cell therapy for stress urinary incontinence
Células madre derivadas de músculo para la incontinencia urinaria de esfuerzo
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Á.R. Proaño
Corresponding author
soninonino@hotmail.com

Author for correspondence.
, A. Medrano, G. Garrido, O. Mazza
División de Urología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina
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Abstract

The knowledge of the urinary effort incontinence (UEI) has increased, giving like result an ample range of different therapeutic options available. The middle urethra and external urethral sphincter are the focus in management of UEI. Stem cells therapy for the regenerative repair of the deficient sphincter has been the leading research of incontinence. Obtaining autologous myoblasts and fibroblasts of skeletal muscle-biopsies, cultivating them and transplanting them after its differentiation, into the external urethral sphincter it warns a new concept in the treatment of the incontinence. Instead of using heterologous materials such as synthetic mesh (slings) or bulking agents (collagen, silicone, etc); we now have the potential to restore function with the use of autologous stem cells.

Keywords:
Muscle-derived stem cells
Rhabdosphincter
Urinary effort incontinence
Transurethral ultrasound
Resumen

El conocimiento de la incontinencia urinaria de esfuerzo (IUE) se ha incrementado, dando como resultado una amplia gama de diferentes opciones terapéuticas disponibles. La uretra media y el esfínter uretral externo son ahora el eje en el manejo de la IUE. La terapia con células madre para la regeneración del esfínter deficiente ha sido motivo de investigaciones novedosas. Obteniendo mioblastos y fibroblastos autólogos de biopsias musculares esqueléticas, cultivándolas e implantándolas después de su diferenciación en el esfínter uretral externo se advierte un nuevo concepto en el tratamiento de la incontinencia de esfuerzo. En lugar de utilizar materiales heterólogos, tales como mallas sintéticas (slings) o sustancias de abultamiento (colágeno, siliconas, etc.), ahora tenemos el potencial para restaurar la función con el uso de células madre autólogas.

Palabras clave:
Células madre derivadas
de músculo
Rabdoesfínter
Incontinencia urinaria de esfuerzo
Ultrasonido transuretral

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