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array:22 [ "pii" => "S0301054611003235" "issn" => "03010546" "doi" => "10.1016/j.aller.2011.09.002" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "aid" => "339" "copyright" => "SEICAP" "copyrightAnyo" => "2011" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Allergol Immunopathol (Madr). 2012;40:1-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4604 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 3939 "PDF" => 655 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054611000851" "issn" => "03010546" "doi" => "10.1016/j.aller.2010.11.003" "estado" => "S300" "fechaPublicacion" => "2012-01-01" "aid" => "255" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2012;40:3-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2455 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 2023 "PDF" => 421 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "8" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 277 "Ancho" => 995 "Tamanyo" => 39242 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Representative western-blot analysis using whole protein biopsy explants of non-CD controls and treated-CD patients, after 24<span class="elsevierStyleHsp" style=""></span>h of basal culture (Basal), and after 3<span class="elsevierStyleHsp" style=""></span>h of gliadin challenge (100<span class="elsevierStyleHsp" style=""></span>μg/ml) with (Gli<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>Asc) and without (Gli) ascorbate supplementation (20<span class="elsevierStyleHsp" style=""></span>mM) and 21<span class="elsevierStyleHsp" style=""></span>h of basal culture. C: human recombinant IL-15 lane.</p> <p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Basal IL-15 was only detected in one CD patient. Gliadin induced IL-15 production in both non-CD controls (three out of three) and treated CD patients (seven out of eight). Ascorbate inhibited IL-15 production in all cases, even in a patient who had detectable basal levels of IL-15.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Bernardo, B. Martínez-Abad, S. Vallejo-Diez, E. Montalvillo, V. Benito, B. Anta, L. Fernández-Salazar, A. Blanco-Quirós, J.A. Garrote, E. Arranz" "autores" => array:10 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Bernardo" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Martínez-Abad" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Vallejo-Diez" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Montalvillo" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Benito" ] 5 => array:2 [ "nombre" => "B." "apellidos" => "Anta" ] 6 => array:2 [ "nombre" => "L." "apellidos" => "Fernández-Salazar" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "Blanco-Quirós" ] 8 => array:2 [ "nombre" => "J.A." "apellidos" => "Garrote" ] 9 => array:2 [ "nombre" => "E." "apellidos" => "Arranz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054611000851?idApp=UINPBA00004N" "url" => "/03010546/0000004000000001/v1_201304101101/S0301054611000851/v1_201304101101/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Vitamin C as a supplementary therapy for celiac disease?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "2" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "K. Lindfors" "autores" => array:1 [ 0 => array:4 [ "nombre" => "K." "apellidos" => "Lindfors" "email" => array:1 [ 0 => "katri.lindfors@uta.fi" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere, Finland" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] 1 => array:3 [ "autoresLista" => "K. Kaukinen" "autores" => array:1 [ 0 => array:2 [ "nombre" => "K." "apellidos" => "Kaukinen" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "School of Medicine, University of Tampere and Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Celiac disease is one of the most common food-related enteropathies in Western countries, affecting up to 1–2% of the European population.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> The disease occurs in a subgroup of genetically predisposed individuals who are positive for either human leukocyte antigen DQ2 or DQ8. The disease is triggered by consumption of dietary wheat-, rye- and barley-derived gluten and it often manifests with intestinal symptoms such as diarrhoea and malabsorbtion. The intestinal symptoms correlate with findings of small-bowel mucosal damage characterised by villous atrophy with crypt hyperplasia. Celiac disease is also hallmarked by the presence of antibodies against gluten-derived gliadin peptides as well as autoantibodies against transglutaminase 2.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The small-bowel mucosal injury in celiac disease develops gradually from initial infiltration of intraepithelial lymphocytes to shortening of the villus structure together with enlargement of crypts, finally into overt villous atrophy and crypt hyperplasia in response to activation of the small-intestinal innate and adaptive immune responses. Gluten-derived gliadin contains high amounts of repetitive glutamine- and proline-rich sequences, this rendering them highly resistant to proteolytic degradation by human gastric, pancreatic and brush-border enzymes, even in healthy individuals.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> Thus even fairly long peptides persist, some of which have been identified as toxic, inducing early effects on the small-bowel mucosal epithelium.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> Of the innate immune components these peptides induce, interleukin (IL)-15 has been shown to play a central role in the pathogenesis of celiac disease, as it contributes to intestinal epithelial cell destruction.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> On the other hand, another subset of the gliadin peptides are immunogenic and responsible for activation of T cell-mediated adaptive immunity in the mucosal <span class="elsevierStyleItalic">lamina propria</span> coupled with release of proinflammatory cytokines such as interferon (IFN)-γ, IL-6 and tumour necrosis factor (TNF)-α.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently, the above-described pathogenic process leading to small-bowel mucosal deterioration can only be prevented by complete removal of all gluten-containing food products from the diet. Although effective and harmless, such a life-long gluten-free diet is nevertheless restrictive and burdensome. Given the lifelong necessity of dieting, occasional dietary transgressions are common even in patients with good compliance, or occasionally trace amounts of gluten contamination in gluten-free products cannot be avoided.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> For all the above reasons a diet completely devoid of gluten is probably impossible to maintain and a search for alternative treatment options or dietary supplements is thus called for.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the current issue of Allergologia et Immunopathologia, Bernardo and coworkers<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> present an interesting study addressing the question as to whether vitamin C (ascorbate) could be beneficial as a dietary supplement for celiac patients. The authors used the celiac patient small-bowel mucosal biopsy organ culture system to investigate whether vitamin C is able to prevent the gliadin-induced inflammatory response by measuring the amounts of secreted nitrites, IFN-γ, TNF-α, IFN-α, IL-17, IL-13 and IL-6, as well as the total quantity of IL-15 in the cultured biopsies. They found that co-administration of vitamin C prevented the augmented secretion of nitrites, IFN-γ, TNF-α, IFN-α and IL-6 and increased the expression of IL-15 triggered by gliadin, suggesting that vitamin C supplementation might be beneficial for celiac patients.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Vitamin C is a micronutrient whose health-promoting effects can be attributed to its biological functions as a cofactor for a number of important enzymes and as a water-soluble antioxidant. As we humans are not able to synthesize vitamin C ourselves, we depend on our diet as a source of vitamin C to maintain general health. Vitamin C is known to be able to modulate immune responses in several ways, for instance by stimulating leukocyte function.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Moreover, vitamin C enhances lymphocyte proliferation in response to infection<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and it may also play a significant role in the regulation of the inflammatory response.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> It has also been suggested to be useful for the induction of tolerance to autoantigens.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The implication of vitamin C in tolerance induction makes the findings of Bernardo et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> extremely interesting. Although to our knowledge this is the first study addressing the efficacy of vitamin C as a diet supplement for celiac patients, there are studies demonstrating the beneficial effect of oral vitamin C supplementation in other disorders. For instance, in a randomised controlled trial vitamin C administered together with vitamin E has been reported to reduce oxidative stress in patients suffering from Crohn's disease, another enteropathy distinct from celiac disease.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Although during the 4-week vitamin supplementation disease activity remained stable, one cannot draw conclusions as to any long-term clinical benefits in Crohn's disease.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Although the necessity of vitamin C for general health is well known, the study by Bernardo et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> is to our knowledge the first to address the efficacy of vitamin C as a diet supplement for celiac patients. The results of this proof-of-principle study suggest that vitamin C might reduce mucosal inflammation in celiac disease and therefore encourage further studies on the subject.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of celiac disease among children in Finland" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Mäki" 1 => "K. Mustalahti" 2 => "J. Kokkonen" 3 => "P. Kulmala" 4 => "M. Haapalahti" 5 => "T. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 23 | 2 | 25 |
2024 October | 163 | 21 | 184 |
2024 September | 159 | 30 | 189 |
2024 August | 183 | 40 | 223 |
2024 July | 165 | 16 | 181 |
2024 June | 179 | 24 | 203 |
2024 May | 156 | 19 | 175 |
2024 April | 153 | 19 | 172 |
2024 March | 198 | 17 | 215 |
2024 February | 182 | 23 | 205 |
2024 January | 178 | 27 | 205 |
2023 December | 194 | 55 | 249 |
2023 November | 382 | 555 | 937 |
2023 October | 221 | 19 | 240 |
2023 September | 134 | 4 | 138 |
2023 August | 115 | 6 | 121 |
2023 July | 125 | 26 | 151 |
2023 June | 131 | 25 | 156 |
2023 May | 137 | 5 | 142 |
2023 April | 106 | 2 | 108 |
2023 March | 129 | 7 | 136 |
2023 February | 97 | 7 | 104 |
2023 January | 82 | 13 | 95 |
2022 December | 77 | 25 | 102 |
2022 November | 82 | 5 | 87 |
2022 October | 100 | 17 | 117 |
2022 September | 83 | 17 | 100 |
2022 August | 103 | 22 | 125 |
2022 July | 61 | 16 | 77 |
2022 June | 94 | 16 | 110 |
2022 May | 86 | 10 | 96 |
2022 April | 76 | 8 | 84 |
2022 March | 96 | 8 | 104 |
2022 February | 123 | 4 | 127 |
2022 January | 147 | 9 | 156 |
2021 December | 84 | 16 | 100 |
2021 November | 75 | 7 | 82 |
2021 October | 83 | 9 | 92 |
2021 September | 69 | 13 | 82 |
2021 August | 60 | 7 | 67 |
2021 July | 59 | 11 | 70 |
2021 June | 50 | 12 | 62 |
2021 May | 63 | 12 | 75 |
2021 April | 69 | 16 | 85 |
2021 March | 47 | 13 | 60 |
2021 February | 19 | 13 | 32 |
2021 January | 25 | 8 | 33 |
2020 December | 2 | 0 | 2 |
2020 October | 0 | 1 | 1 |
2020 September | 0 | 1 | 1 |
2020 July | 0 | 1 | 1 |
2020 May | 0 | 3 | 3 |
2020 February | 0 | 1 | 1 |
2020 January | 0 | 3 | 3 |
2019 December | 0 | 1 | 1 |
2019 October | 0 | 3 | 3 |
2019 July | 0 | 4 | 4 |
2019 June | 0 | 1 | 1 |
2019 May | 0 | 21 | 21 |
2018 March | 3 | 0 | 3 |
2018 February | 28 | 6 | 34 |
2018 January | 37 | 3 | 40 |
2017 December | 30 | 6 | 36 |
2017 November | 21 | 6 | 27 |
2017 October | 20 | 6 | 26 |
2017 September | 36 | 7 | 43 |
2017 August | 36 | 5 | 41 |
2017 July | 18 | 3 | 21 |
2017 June | 34 | 26 | 60 |
2017 May | 59 | 10 | 69 |
2017 April | 51 | 36 | 87 |
2017 March | 75 | 23 | 98 |
2017 February | 33 | 5 | 38 |
2017 January | 39 | 2 | 41 |
2016 December | 32 | 9 | 41 |
2016 November | 61 | 7 | 68 |
2016 October | 65 | 5 | 70 |
2016 September | 57 | 8 | 65 |
2016 August | 56 | 9 | 65 |
2016 July | 27 | 1 | 28 |
2016 June | 53 | 11 | 64 |
2016 May | 66 | 24 | 90 |
2016 April | 49 | 14 | 63 |
2016 March | 50 | 22 | 72 |
2016 February | 54 | 21 | 75 |
2016 January | 52 | 26 | 78 |
2015 December | 51 | 9 | 60 |
2015 November | 58 | 17 | 75 |
2015 October | 82 | 19 | 101 |
2015 September | 76 | 14 | 90 |
2015 August | 75 | 9 | 84 |
2015 July | 138 | 7 | 145 |
2015 June | 40 | 5 | 45 |
2015 May | 52 | 8 | 60 |
2015 April | 106 | 11 | 117 |
2015 March | 107 | 13 | 120 |
2015 February | 33 | 16 | 49 |
2015 January | 46 | 7 | 53 |
2014 December | 52 | 5 | 57 |
2014 November | 41 | 8 | 49 |
2014 October | 42 | 3 | 45 |
2014 September | 37 | 4 | 41 |
2014 August | 23 | 6 | 29 |
2014 July | 48 | 7 | 55 |
2014 June | 87 | 0 | 87 |
2014 May | 118 | 2 | 120 |
2014 April | 113 | 3 | 116 |
2014 March | 116 | 18 | 134 |
2014 February | 402 | 18 | 420 |
2014 January | 122 | 7 | 129 |
2013 December | 35 | 13 | 48 |
2013 November | 40 | 10 | 50 |
2013 October | 42 | 7 | 49 |
2013 September | 44 | 9 | 53 |
2013 August | 55 | 11 | 66 |
2013 July | 39 | 11 | 50 |
2013 June | 21 | 1 | 22 |
2013 May | 25 | 7 | 32 |
2013 April | 17 | 8 | 25 |
2013 March | 21 | 11 | 32 |
2013 February | 10 | 6 | 16 |
2013 January | 10 | 3 | 13 |
2012 December | 7 | 3 | 10 |
2012 November | 0 | 2 | 2 |
2012 October | 2 | 2 | 4 |
2012 January | 364 | 0 | 364 |