Research letter
Immediate reaction to articaine
Division of Immunology and Allergy, Department of Chest Diseases, Eskişehir Osmangazi University, Faculty of Medicine, 26480 Eskişehir, Turkey
Read
4309
Timeswas read the article
1463
Total PDF
2846
Total HTML
Share statistics
array:23 [ "pii" => "S0301054612001085" "issn" => "03010546" "doi" => "10.1016/j.aller.2012.02.002" "estado" => "S300" "fechaPublicacion" => "2013-03-01" "aid" => "383" "copyright" => "SEICAP" "copyrightAnyo" => "2012" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Allergol Immunopathol (Madr). 2013;41:127-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1656 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 923 "PDF" => 725 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054612000675" "issn" => "03010546" "doi" => "10.1016/j.aller.2012.01.005" "estado" => "S300" "fechaPublicacion" => "2013-03-01" "aid" => "376" "copyright" => "SEICAP" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Allergol Immunopathol (Madr). 2013;41:128-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2733 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 2185 "PDF" => 537 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Research letter</span>" "titulo" => "Urticaria pigmentosa in a female patient with celiac disease: Response to a gluten-free diet" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "130" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 584 "Ancho" => 750 "Tamanyo" => 62302 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Left eyelid oedema in a woman suffering from systemic mastocytosis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Rodrigo, I. Pérez-Martínez, A.J. Lucendo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Rodrigo" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Pérez-Martínez" ] 2 => array:2 [ "nombre" => "A.J." "apellidos" => "Lucendo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054612000675?idApp=UINPBA00004N" "url" => "/03010546/0000004100000002/v2_201304200345/S0301054612000675/v2_201304200345/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054612000651" "issn" => "03010546" "doi" => "10.1016/j.aller.2012.01.004" "estado" => "S300" "fechaPublicacion" => "2013-03-01" "aid" => "375" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Allergol Immunopathol (Madr). 2013;41:121-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1982 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 1326 "PDF" => 646 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Airborne contact dermatitis to drugs" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "126" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.L. Minciullo, S. Imbesi, V. Tigano, S. Gangemi" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P.L." "apellidos" => "Minciullo" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Imbesi" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Tigano" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Gangemi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054612000651?idApp=UINPBA00004N" "url" => "/03010546/0000004100000002/v2_201304200345/S0301054612000651/v2_201304200345/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Research letter</span>" "titulo" => "Immediate reaction to articaine" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "128" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "K. Aksu, E. Kurt" "autores" => array:2 [ 0 => array:4 [ "nombre" => "K." "apellidos" => "Aksu" "email" => array:1 [ 0 => "kurtulusaksu@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Kurt" "email" => array:1 [ 0 => "dremelkurt@yahoo.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Division of Immunology and Allergy, Department of Chest Diseases, Eskişehir Osmangazi University, Faculty of Medicine, 26480 Eskişehir, Turkey" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 50-year-old woman was referred from dental clinic to be evaluated for hypersensitivity for articaine. Previously 3 years ago she had urticaria in 10–15<span class="elsevierStyleHsp" style=""></span>min after administration of a local anaesthetic agent for a dental procedure. She did not know the name of the local anaesthetic agent. For the last 6 years she had been followed with diagnoses of chronic urticaria and angioedema in dermatology department. She was treated with various antihistamines, systemic corticosteroids, montelukast, azathiopurine and cyclosporine. In her previous examinations she was allergic to house dust mite and autologous serum skin test was found to be negative. She did not report any adverse drug reactions apart from the one she had with local anaesthetic mentioned above. The patient had no family history of allergy. She was on daily levocetirizine therapy for the last 4 months.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Skin tests were planned with articaine after cessation of antihistamines for 5 days and provided informed consent for allergologic workup. Positive (histamine) and negative (normal saline solution) controls were also carried out. Skin prick test was negative for articaine HCl/epinephrine HCl (Ultracaine; Sanofi aventis) (1/1). During intradermal test with articaine (1/100) in the tenth minute 30<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mm endurance and redness ensued together with globus hystericus and paraesthesia in tongue and the test was ended. The physical examination did not reveal any systemic sign of allergic reaction and the symptoms resolved completely in a few minutes without any medical intervention. This result suggested the involvement of a type I allergic reaction. Subcutaneous challenge was not performed for ethical reasons since intradermal test with articaine HCl/epinephrine HCl (1/100) was positive. Since no product containing articaine HCl without epinephrine is not available in the market, in order to exclude hypersensitivity to epinephrine, we also performed skin prick and intradermal tests with epinephrine HCl and found negative. Accordingly the patient was evaluated to be allergic to articaine. Afterwards an allergologic workup with prilocaine was planned to determine its safety for the patient. The patient presented negative prick and intradermal test with prilocaine HCl (Citanest; Astra Zeneca). Subcutenous challenge with prilocaine 0.1<span class="elsevierStyleHsp" style=""></span>ml and 1<span class="elsevierStyleHsp" style=""></span>ml was performed and came out to be negative and no adverse reactions were observed. In the following day dental procedure was performed successfully without any adverse reaction with prilocaine.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Local anaesthetics drugs are widely used since they allow performance of procedures to be safely and comfortably especially in dental and minor surgical interventions. Unfortunately adverse reactions may limit their use although allergic reactions to local anaesthetics are reported to be less than 1% in the literature.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The adverse reactions comprise of symptoms unrelated to the local anaesthetic, such as psychomotor reactions, dose-related toxic reactions and idiosyncratic or true allergic reactions in susceptible individuals. A definite diagnosis of drug hypersensitivity requires allergologic workup with the suspected drug.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Adverse reactions against local anaesthetics present as objective symptoms in 87.6% of the cases; such as urticaria, angioedema, rhinitis, dyspnoea, vomiting, chills, speech disorder, tachycardia, arrhythmia, loss of conciousness and cardiac arrest and as subjective symptoms in 12.4%; such as fear, sensation of heat, headache, vertigo, paraesthesia, nausea, tenesmus and globus hystericus.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The general thought about skin tests being not useful with amide-type local anaesthetic agents is recently been changed by some recent studies demonstrating positive skin tests in some local anaesthetic allergy cases.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a> Articaine which belongs to amide-type local anaesthetic group, is the most commonly used local anaesthetic for dental procedures. The studies carried out suggest that there is cross-reactivity among local anaesthetics of the amide group.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However tolerance to articaine may be possible because of its different chemical structure with thiophene ring, when other amide local anaesthetics are allergic, no matter it should be kept in mind that pattern of cross-reactivity may vary in different patients.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Unfortunately, we were unable to find a marketed product containing articaine without epinephrine to perform skin tests so we also performed skin prick and intradermal tests with epinephrine in order to exclude that the hypersensitivity reaction observed was due to epinephrine. The latter test being negative affirmed that the positive intradermal test implied articaine hypersensitivity. In the case presented subjective symptoms observed following intradermal articaine administration could be more exaggerated if we could have eliminated the probable effect of epinephrine in slowing down the allergic reaction.</p><p id="par0035" class="elsevierStylePara elsevierViewall">With this case we conclude that different amide-group local anaesthetics agents could be used safely after allergologic workup in hypersensitive patients. Secondly we mention that skin tests are advisable such as in the presented case skin tests may yield positive results thus a generalized allergic reaction could be prevented.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse reactions to local anesthetics: analysis of 197 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Gall" 1 => "R. Kaufmann" 2 => "C.M. Kalveram" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1996" "volumen" => "97" "paginaInicial" => "933" "paginaFinal" => "937" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8655888" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Provocation tests in drug hypersensitivity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W. Aberer" 1 => "B. Kränke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.iac.2009.04.008" "Revista" => array:6 [ "tituloSerie" => "Immunol Allergy Clin North Am" "fecha" => "2009" "volumen" => "29" "paginaInicial" => "567" "paginaFinal" => "584" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19563998" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic reaction caused by local anesthetic agents belonging to the amide group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Cuesta-Herranz" 1 => "M. de las Heras" 2 => "M. Fernández" 3 => "M. Lluch" 4 => "E. Figueredo" 5 => "A. Umpierrez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1997" "volumen" => "99" "paginaInicial" => "427" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9058702" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic reaction caused by articaine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. El-Qutob" 1 => "C. Morales" 2 => "A. Peláez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergol Immunopathol (Madr)" "fecha" => "2005" "volumen" => "33" "paginaInicial" => "115" "paginaFinal" => "116" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immediate allergy to mepivacaine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Estrada" 1 => "J.L. Perez-Laiz" 2 => "M. Latasa" 3 => "A. Rodríguez-Paredes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "492" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21995186" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03010546/0000004100000002/v2_201304200345/S0301054612001085/v2_201304200345/en/main.assets" "Apartado" => array:4 [ "identificador" => "5550" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Research letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03010546/0000004100000002/v2_201304200345/S0301054612001085/v2_201304200345/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054612001085?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 14 | 15 | 29 |
| 2024 September | 37 | 21 | 58 |
| 2024 August | 39 | 20 | 59 |
| 2024 July | 40 | 8 | 48 |
| 2024 June | 59 | 19 | 78 |
| 2024 May | 46 | 7 | 53 |
| 2024 April | 22 | 7 | 29 |
| 2024 March | 29 | 9 | 38 |
| 2024 February | 59 | 16 | 75 |
| 2024 January | 61 | 10 | 71 |
| 2023 December | 57 | 9 | 66 |
| 2023 November | 40 | 13 | 53 |
| 2023 October | 79 | 23 | 102 |
| 2023 September | 45 | 4 | 49 |
| 2023 August | 42 | 6 | 48 |
| 2023 July | 55 | 14 | 69 |
| 2023 June | 48 | 11 | 59 |
| 2023 May | 77 | 11 | 88 |
| 2023 April | 66 | 10 | 76 |
| 2023 March | 80 | 8 | 88 |
| 2023 February | 56 | 7 | 63 |
| 2023 January | 50 | 18 | 68 |
| 2022 December | 50 | 6 | 56 |
| 2022 November | 51 | 15 | 66 |
| 2022 October | 72 | 13 | 85 |
| 2022 September | 36 | 9 | 45 |
| 2022 August | 31 | 23 | 54 |
| 2022 July | 37 | 14 | 51 |
| 2022 June | 19 | 14 | 33 |
| 2022 May | 15 | 13 | 28 |
| 2022 April | 24 | 26 | 50 |
| 2022 March | 23 | 24 | 47 |
| 2022 February | 25 | 13 | 38 |
| 2022 January | 53 | 11 | 64 |
| 2021 December | 49 | 25 | 74 |
| 2021 November | 59 | 26 | 85 |
| 2021 October | 71 | 23 | 94 |
| 2021 September | 23 | 26 | 49 |
| 2021 August | 14 | 7 | 21 |
| 2021 July | 15 | 23 | 38 |
| 2021 June | 11 | 18 | 29 |
| 2021 May | 14 | 18 | 32 |
| 2021 April | 80 | 51 | 131 |
| 2021 March | 21 | 22 | 43 |
| 2021 February | 15 | 12 | 27 |
| 2021 January | 13 | 6 | 19 |
| 2020 December | 1 | 2 | 3 |
| 2020 November | 0 | 3 | 3 |
| 2020 October | 0 | 1 | 1 |
| 2020 September | 0 | 3 | 3 |
| 2020 August | 0 | 4 | 4 |
| 2020 July | 0 | 4 | 4 |
| 2020 June | 0 | 5 | 5 |
| 2020 May | 0 | 4 | 4 |
| 2020 April | 0 | 3 | 3 |
| 2020 March | 0 | 2 | 2 |
| 2020 February | 0 | 4 | 4 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 5 | 5 |
| 2019 November | 0 | 8 | 8 |
| 2019 October | 0 | 3 | 3 |
| 2019 September | 0 | 9 | 9 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 6 | 6 |
| 2019 June | 0 | 11 | 11 |
| 2019 May | 0 | 48 | 48 |
| 2019 April | 0 | 23 | 23 |
| 2018 March | 1 | 1 | 2 |
| 2018 February | 5 | 5 | 10 |
| 2018 January | 9 | 3 | 12 |
| 2017 December | 14 | 1 | 15 |
| 2017 November | 5 | 6 | 11 |
| 2017 October | 7 | 5 | 12 |
| 2017 September | 8 | 18 | 26 |
| 2017 August | 13 | 4 | 17 |
| 2017 July | 8 | 14 | 22 |
| 2017 June | 15 | 11 | 26 |
| 2017 May | 15 | 10 | 25 |
| 2017 April | 9 | 20 | 29 |
| 2017 March | 8 | 59 | 67 |
| 2017 February | 10 | 9 | 19 |
| 2017 January | 10 | 8 | 18 |
| 2016 December | 18 | 12 | 30 |
| 2016 November | 26 | 13 | 39 |
| 2016 October | 22 | 10 | 32 |
| 2016 September | 16 | 13 | 29 |
| 2016 August | 14 | 6 | 20 |
| 2016 July | 10 | 2 | 12 |
| 2016 June | 8 | 8 | 16 |
| 2016 May | 7 | 9 | 16 |
| 2016 April | 9 | 17 | 26 |
| 2016 March | 9 | 21 | 30 |
| 2016 February | 10 | 21 | 31 |
| 2016 January | 14 | 21 | 35 |
| 2015 December | 13 | 13 | 26 |
| 2015 November | 9 | 16 | 25 |
| 2015 October | 13 | 20 | 33 |
| 2015 September | 14 | 11 | 25 |
| 2015 August | 6 | 7 | 13 |
| 2015 July | 2 | 3 | 5 |
| 2015 June | 2 | 7 | 9 |
| 2015 May | 5 | 6 | 11 |
| 2015 April | 9 | 17 | 26 |
| 2015 March | 8 | 4 | 12 |
| 2015 February | 8 | 4 | 12 |
| 2015 January | 11 | 4 | 15 |
| 2014 December | 20 | 9 | 29 |
| 2014 November | 9 | 3 | 12 |
| 2014 October | 16 | 7 | 23 |
| 2014 September | 22 | 4 | 26 |
| 2014 August | 9 | 5 | 14 |
| 2014 July | 15 | 1 | 16 |
| 2014 June | 5 | 1 | 6 |
| 2014 May | 17 | 4 | 21 |
| 2014 April | 7 | 5 | 12 |
| 2014 March | 35 | 18 | 53 |
| 2014 February | 33 | 8 | 41 |
| 2014 January | 34 | 11 | 45 |
| 2013 December | 26 | 12 | 38 |
| 2013 November | 30 | 6 | 36 |
| 2013 October | 19 | 9 | 28 |
| 2013 September | 16 | 9 | 25 |
| 2013 August | 18 | 9 | 27 |
| 2013 July | 28 | 16 | 44 |
| 2013 June | 27 | 6 | 33 |
| 2013 May | 26 | 10 | 36 |
| 2013 April | 16 | 10 | 26 |
| 2013 March | 95 | 0 | 95 |
Show all
