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Research letter
Occupational airborne contact dermatitis caused by usnic acid in a domestic worker
D. Pacheco
Corresponding author
pachecocas@hotmail.com

Corresponding author.
, A.R. Travassos, J. Antunes, L. Soares de Almeida, P. Filipe, T. Correia
Clínica Universitária de Dermatologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte (CHLN), Lisbon, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lichens are composite organisms consisting of the permanent association between a fungus and an alga&#46; The fungus component is called mycobiont and the algal component is called phycobiont&#59; both grow in a symbiotic relationship<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; usnic acid is one of their main components and it is found in different types of lichens&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In Portugal&#44; there are four predominant species of lichens&#58; <span class="elsevierStyleItalic">Parmelia reticulata</span>&#44; <span class="elsevierStyleItalic">P&#46; caperata</span>&#44; <span class="elsevierStyleItalic">Ramalina lusitana</span>&#44; and <span class="elsevierStyleItalic">R&#46; usnea</span>&#44; which grow mainly on olive trees&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Airborne allergic contact dermatitis &#40;AACD&#41; caused by lichens<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> may simulate photodermatitis due to its preferential location in exposed areas of the skin&#46; In rural workers&#44; AACD may appear in the context of an occupational dermatitis&#44; which is sometimes disabling&#44; or it may affect those involved in outdoor leisure activities&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Herein&#44; we described the case of a 46-year-old Caucasian woman&#44; rural domestic worker&#44; who carried oak and olive wood for fireplaces&#44; mainly between the months of October and March&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was referred to the dermatology department because of an intensely pruritic erythematous scaling dermatitis&#44; involving the face&#44; neckline&#44; and extensor surface of the hands&#44; forearms and lower limbs&#46; On the face&#44; the eyelids&#44; earlobes&#44; and retroauricular fold were affected&#46; The extensor surface of the forearms and hands showed extensive lichenification &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The dermatitis had started in the autumn&#44; and persisted throughout the winter&#44; with worsening on the uncovered areas in the beginning of the spring&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient had a history of asthmatic bronchitis and allergic rhinitis in childhood and had been followed for her respiratory allergies since 1993&#46; Her most recent laboratory investigations showed&#58; D2-<span class="elsevierStyleItalic">Dermatophagoides farinae</span> specific IgE 90&#46;10<span class="elsevierStyleHsp" style=""></span>kU&#47;L &#40;class 5&#41;&#59; D1 <span class="elsevierStyleItalic">D&#46; pteronyssinus</span> specific IgE<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>kU&#47;L &#40;class 6&#41;&#44; and total Ig E 1977<span class="elsevierStyleHsp" style=""></span>U&#47;mL &#40;ref<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>87&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient underwent patch testing with the Basic Series adopted by the GPEDC &#40;Grupo Portugu&#234;s das Dermites de Contacto&#41;&#44; and the Gloves and Clothing Series&#44; all of which were negative&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Faced with the possibility of photodermatitis&#44; the patient performed tests with the Photo Allergen Series&#44; which showed the following positivities&#58; lichen acid mix and usnic acid&#44; after UVA irradiation with 5<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Patients with lichen allergies may be photosensitive and score positively on photoepicutaneous tests&#46; The clinical relevance of this phenomenon is yet to be established&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Our patient was a rural worker who carried oak and olive wood during the cold months&#44; and who developed dermatitis of sun-exposed areas&#44; with accentuated lichenification of the dorsal hands and forearms&#44; which worsened with exposure to sunlight&#46; When faced with a rash on photo-exposed areas&#44; and outdoor activity&#44; one should always think of photosensitivity or AACD&#46; In this case&#44; the study with the Photo Allergen Series revealed positivity to lichen acid mix and usnic acid&#44; which increased after UVA irradiation&#44; thus confirming the diagnostic hypothesis of AACD&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Immediate hypersensitivity after exposure to lichens has also been described&#44; which is usually manifested through respiratory symptomatology&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; even though our patient had a history of respiratory allergies&#44; there is no evidence to support that they occurred in this setting&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Usnic acid is a lichen component which is found in species such as&#58; <span class="elsevierStyleItalic">Parmelias</span>&#44; <span class="elsevierStyleItalic">Evernia</span>&#44; <span class="elsevierStyleItalic">Usnea</span>&#44; <span class="elsevierStyleItalic">Lecanora</span>&#44; <span class="elsevierStyleItalic">Cladonia</span> or <span class="elsevierStyleItalic">Ramalina</span>&#44; and which may be photosensitising &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; These types of lichens are epiphytic&#44; i&#46;e&#46; grow on tree trunks&#44; and only a few survive in the polluted air of the cities&#44; contaminated with sulphur dioxide&#46; When lichens are fragmented by handling&#44; they release particles that can settle on the exposed skin and may cause AACD&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> an occupational dermatitis that affects rural workers who cut tree trunks&#44; or individuals with sporadic exposure during outdoor leisure activities&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> There may be concomitant reactions with the <span class="elsevierStyleItalic">Frullania</span> family due to cohabitation of both species&#46; The existence of contact dermatitis caused by allergy to the <span class="elsevierStyleItalic">Frullan</span>&#39;s sesquiterpene lactones may predispose subjects to being sensitive to lichen chemical compounds&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Lichen contact allergy is an old and often overlooked dermatitis that should be considered for subjects in contact with barked wood or wood dust&#46; It is important to know the native species from each country to have a certain aetiological factor&#46; In Portugal&#44; several studies have been published in which the main aetiological sources of this type of dermatitis&#44; both occupational and leisure-related&#44; are described&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Moreover&#44; numerous lichen components&#44; such as usnic acid and atranorin &#40;&#8220;oak moss&#8221;&#41;&#44; are used in perfumery&#46; Nowadays&#44; this is the main cause of sensitisation to this type of substances&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human subjects and animals in research</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patients&#8217; data protection</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span></span></span>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Irrad UVA 5<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>48<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Lichen acid mix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Usnic acid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#43;&#43;&nbsp;\t\t\t\t\t\t\n
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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