covid
Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Are profilins relevant allergens or confusion allergens?
Journal Information

Statistics

Follow this link to access the full text of the article

Editorial
Are profilins relevant allergens or confusion allergens?
C.A. Sánchez-Salguero
Pediatric Allergy Unit, Hospital Universitario Puerto Real, Cádiz, Spain
Read
2172
Times
was read the article
881
Total PDF
1291
Total HTML
Share statistics
 array:22 [
  "pii" => "S0301054614000767"
  "issn" => "03010546"
  "doi" => "10.1016/j.aller.2014.06.001"
  "estado" => "S300"
  "fechaPublicacion" => "2014-07-01"
  "aid" => "614"
  "copyright" => "SEICAP"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Allergol  Immunopathol (Madr). 2014;42:267-8"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 847
    "formatos" => array:3 [
      "EPUB" => 8
      "HTML" => 418
      "PDF" => 421
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0301054613001900"
    "issn" => "03010546"
    "doi" => "10.1016/j.aller.2013.06.005"
    "estado" => "S300"
    "fechaPublicacion" => "2014-07-01"
    "aid" => "535"
    "copyright" => "SEICAP"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Allergol  Immunopathol (Madr). 2014;42:269-74"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 565
      "formatos" => array:3 [
        "EPUB" => 5
        "HTML" => 330
        "PDF" => 230
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Double-blind food challenges in children in general paediatric practice&#58; Useful and safe&#44; but not without pitfalls"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "269"
          "paginaFinal" => "274"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;J&#46; Oole-Groen, P&#46;L&#46;P&#46; Brand"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "C&#46;J&#46;"
              "apellidos" => "Oole-Groen"
            ]
            1 => array:2 [
              "nombre" => "P&#46;L&#46;P&#46;"
              "apellidos" => "Brand"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054613001900?idApp=UINPBA00004N"
    "url" => "/03010546/0000004200000004/v1_201407030035/S0301054613001900/v1_201407030035/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "Are profilins relevant allergens or confusion allergens&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "267"
        "paginaFinal" => "268"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "C&#46;A&#46; S&#225;nchez-Salguero"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "C&#46;A&#46;"
            "apellidos" => "S&#225;nchez-Salguero"
            "email" => array:1 [
              0 => "libraygeminis&#64;hotmail&#46;com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Pediatric Allergy Unit&#44; Hospital Universitario Puerto Real&#44; C&#225;diz&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Advances in the techniques used to study allergic patients have allowed us to recognize multiple mistakes made in the past&#44; and thus to avoid prescribing patient immunotherapy treatments that are not fully valid&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the major achievements has been the molecular diagnosis of allergic diseases&#46; In effect&#44; while in the past we only had gross determinations of specific IgE to pollens&#44; we can now identify which specific protein triggers the allergic reaction in many of our patients&#46; Moreover&#44; a group of these proteins are known to cluster in panallergen families which exhibit great similarity in their three-dimensional structure&#44; causing the emergence of cross-reactions between the proteins&#46; Several panallergen families have been identified &#8211; the profilins being an example of great clinical relevance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Profilins are small proteins with a molecular weight ranging between 12 and 19<span class="elsevierStyleHsp" style=""></span>kDa&#44; and are present in all eukaryotic organisms&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> including plants&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> They participate in numerous biological processes such as cell cytoskeletal reorganization and the regulation of actin polymerization&#8211;depolymerization&#46; They likewise intervene in cell structure and mobility&#44; and play a critical role in cell division&#44; embryogenesis and cytokinesis&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Unlike plant calcium binding allergens from plants&#44; which are present in most pollens&#44; profilins are part of the storage tissues of plants &#40;fruits&#44; nuts&#44; spices&#44; latex&#41; and&#44; therefore&#44; are also responsible for cross-reactivity between pollens and foods&#44; and even between pollens and latex&#46; Of all cases of cross-reactivity in pollen-food syndrome&#44; profilin sensitization accounts for at least 20&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Profilins have highly preserved sequences&#44; with identities of between 70 and 85&#37; &#40;Ole Bet v2 and Ole e2&#41; and a prevalence of 20&#37; in most patients allergic to pollen&#46; However&#44; there are exceptions such as Chenopodium profilin &#40;Chenopodium album&#44; Che 2&#41;&#44; with a reported prevalence of 50&#37; that has caused it to be regarded as the major allergen&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Profilin was first described more than three decades ago&#44; with a molecular weight of 15<span class="elsevierStyleHsp" style=""></span>kDa&#44; joined the monomers and inhibited actin polymerization&#59; as a result&#44; these proteins are named after their property of maintaining profilamentous actin &#40;PRO-FILamentous actIN&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Profilins as allergens are found in pollens of <span class="elsevierStyleItalic">Phleum pratense</span> &#40;Phl p 12&#41;&#44; <span class="elsevierStyleItalic">Cynodon dactylon</span> &#40;Cyn d 2&#41;&#44; <span class="elsevierStyleItalic">Artemisia vulgaris</span> &#40;Art v 4&#41;&#44; <span class="elsevierStyleItalic">Zea mays</span>&#44; <span class="elsevierStyleItalic">Triticum aestiviam</span>&#44; <span class="elsevierStyleItalic">Parietaria judaica</span> &#40;Par j 3&#41;&#44; <span class="elsevierStyleItalic">Chenopodium album</span> &#40;Che a 2&#41;&#44; ambrosia elatior&#44; <span class="elsevierStyleItalic">Olea europaea</span> &#40;Ole e 2&#41;&#44; <span class="elsevierStyleItalic">Corylus avellana</span> &#40;2 Cor&#41;&#44; <span class="elsevierStyleItalic">Agnus aglutinosa</span>&#44; <span class="elsevierStyleItalic">Castanea sativa</span>&#44; palm &#40;Pho d 2&#41;&#44; <span class="elsevierStyleItalic">Mercuriales annua</span> &#40;Mer 1&#41;&#44; and also in plant foods such as apple &#40;Mal d 4&#41;&#44; peach &#40;Pru p 4&#41;&#44; melon &#40;Cuc m 2&#41;&#44; watermelon&#44; banana &#40;Mus xp 1&#41;&#44; celery &#40;Api g 4&#41;&#44; carrot &#40;Dau c 4&#41;&#44; hazelnut &#40;Cor a 2&#41;&#44; peanut &#40;Ara h 5&#41;&#44; cherry &#40;Prop av 4&#41;&#44; pear &#40;Pyr c 4&#41;&#44; pineapple &#40;Ana c 1&#41;&#44; tomato &#40;Lyc e 1&#41;&#44; soybean &#40;Gly m 3&#41;&#44; pepper &#40;Cap 2&#41; and even latex &#40;Hev b 8&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">With respect to tree pollens&#44; there is cross-reactivity in families of the order Fagales&#44; including birch&#44; hazel&#44; alder&#44; hornbeam and beech&#44; with their respective allergens Bet v 1&#44; Cor a 1&#44; Aln g 1 and Car b1&#44; for which there is a sequence identity of over 70&#37;&#46; Oleacea is of particular relevance&#44; since Ole e 1 has high sequence identity with homologous allergens&#58; 91&#37; with Fra e1&#44; and 88&#37; and 90&#37; with Lig v1 and v1 Syr&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Allergenic plant profilins are highly preserved amino acids sequences&#46; In contrast&#44; non-allergenic profilins from other eukaryotes have lesser identities of close to 30&#37;&#46; One aspect worth noting is that the sequence of the amino and carboxyl terminals of profilins in lower animals&#44; plants and fungi are highly preserved&#44; whereas among vertebrates they are highly divergent&#46; This feature is responsible for the cross-reactivity that occurs in this family of panallergens&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In northern and central Europe profilins have been identified as one of the four major allergens&#44; because patients allergic to Rosaceae cross-react with birch pollen and&#47;or grasses&#44; with the recognition of specific IgE for profilin in less than 20&#37; of the patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In Spain sensitization to date palm&#44; a common tree in the Mediterranean region&#44; ranges from 5&#46;6&#37; in Elche to 29&#46;4&#37; in Zaragoza&#44; but this type of pollen has not been found in monosensitized patients &#8211; thus suggesting cross-reactivity between pollens&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Indeed&#44; palm pollen extracts contain between 25 and 50 times the amount of the grass profilin&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">It is at this point that mention should be made of the article reviewing &#8220;Profilin sensitization in a Mediterranean population&#8221;&#46; This study aimed to describe the increased prevalence of sensitization to profilin through prick test techniques using date palm pollen &#40;Pho d 2&#41; in patients with respiratory disease living in southeast Spain&#44; identify the profilin profile&#44; and calculate the correlation between sensitization to inhaled profilin and plant allergens with respect to sensitization to plant-derived food allergens&#46; To this effect a large study population of 654 people with an age ranging from 3 to 82 years &#40;mean 24&#46;4 years&#41; was recruited&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">This dispersion in the age of the patients is one of the first discordant points of the study&#44; because we have no figures by age groups&#46; In this sense&#44; attempts to assess the pediatric population would be highly influenced by the adult population&#44; in which palm pollen sensitization would be greater if only because of the exposure time&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The aforementioned study used a large battery of allergens in the prick-test&#44; which represent most pollens of the geographical area&#44; including palm tree profiling&#44; as most similar studies already published&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;6&#44;10&#44;11</span></a> It found no statistically significant association between olive pollen and profilin&#44; or between Cupressus and profilin&#44; though an association was indeed observed with the rest of pollens&#46; This is in contrast to other authors who have evaluated and observed associations&#44; especially with olive&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#8211;14</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">It also should be mentioned that the most common foods implicated in allergic reactions are peach and nuts&#44; and a number of studies support this association&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Although it is true that this is the first study of its kind that takes place in the authors&#8217; geographical area&#44; it is not the first published&#58; in 2013 the ESPLORA published the results of a multicentre study designed to determine the profiles of sensitization in pediatric patients between 2 and 14 years of age&#44; and concluded that pediatric patients living in areas of high exposure to many allergens are polysensitized to panallergens&#46; The implementation of new diagnostic tools is therefore essential for establishing a correct diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">There are even authors who claim that the detection of IgE reactivity to a single protein marker &#40;Bet v 2&#41; would be sufficient to diagnose or rule out sensitization to profilin&#46; The detection of IgE against multiple homologous protein allergens with no cross-reactivity is clinically more informative&#44; although increases the risk of confusion or misinterpretation&#46;<span class="elsevierStyleSup">16</span></p><p id="par0085" class="elsevierStylePara elsevierViewall">In conclusion&#44; although the passing of time has led physicians to adapt to new research techniques&#44; such as molecular diagnostic procedures&#44; we are in danger of forgetting that the allergic patient is not a poly-prick test patient&#59; we should use these techniques to obtain further information and especially to avoid errors in prescribing immunotherapy&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The profile of profilins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;M&#46; Jockusch"
                            1 => "K&#46; Murk"
                            2 => "M&#46; Rothkegel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Physiol Biochem Pharmacol"
                        "fecha" => "2007"
                        "volumen" => "159"
                        "paginaInicial" => "131"
                        "paginaFinal" => "149"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A low molecular weight allergen of white birch &#40;Betula verrucosa&#41; is highly homologous to human profilin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Valenta"
                            1 => "M&#46; Duchene"
                            2 => "M&#46; Breitenbach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "1991"
                        "volumen" => "94"
                        "paginaInicial" => "368"
                        "paginaFinal" => "370"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profilins constitute a novel family of functional plant pan-allergens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Valenta"
                            1 => "M&#46; Duchene"
                            2 => "C&#46; Ebener"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1992"
                        "volumen" => "175"
                        "paginaInicial" => "377"
                        "paginaFinal" => "385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1370681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Al&#233;rgenos&#46; Tratado de Alergolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Pom&#233;s"
                            1 => "M&#46; Villalba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2007"
                        "editorial" => "Ed Ergon"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant expression&#44; purification and cross-reactivity of chenopodium profilin r Ch a 2 as a good marker for profilin sensitization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Barderas"
                            1 => "M&#46; Villalba"
                            2 => "R&#46; Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1515/BC.2004.089"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biol Chem"
                        "fecha" => "2004"
                        "volumen" => "385"
                        "paginaInicial" => "731"
                        "paginaFinal" => "737"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15449709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of profiling as a novel pollen allergen&#59; IgE autoreactivity in sensitised individuals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Valenta"
                            1 => "M&#46; Duchene"
                            2 => "K&#46; Pettenburguer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1991"
                        "volumen" => "253"
                        "paginaInicial" => "557"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1857985"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross reactivity between olive and the other species&#46; Role of Ole e 1 related proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Lombardero"
                            1 => "T&#46; Obispo"
                            2 => "B&#46; Calabozo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "paginaInicial" => "29"
                        "paginaFinal" => "34"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12492727"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pollen allergens are restricted to few protein families and show distinct patterns of species distribution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Radauer"
                            1 => "H&#46; Breiteneder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2005.09.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2006"
                        "volumen" => "117"
                        "paginaInicial" => "141"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16387597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profilinas&#58; al&#233;rgenos con relevancia cl&#237;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;M&#46; Landa-Pineda"
                            1 => "G&#46; Guidos-Fogelbach"
                            2 => "L&#46; Marchat-Marchan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Alerg Mex"
                        "fecha" => "2013"
                        "volumen" => "60"
                        "paginaInicial" => "129"
                        "paginaFinal" => "143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24274609"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Es la sensibilizaci&#243;n al polen de palmera una expresi&#243;n de la alergia a las profilinas en el &#225;rea mediterr&#225;nea&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;R&#46; Huertas"
                            1 => "J&#46;R&#46; Lavin"
                            2 => "A&#46;M&#46; garc&#237;a-Cervantes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Alergol Immunol Clin"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "175"
                        "paginaFinal" => "180"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profilin&#58; a major allergen in date palm &#40;<span class="elsevierStyleItalic">Phoenix dactylifera</span>&#41; pollen allergy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Ibarrola"
                            1 => "E&#46; Eraso"
                            2 => "M&#46;C&#46; Arilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "numero" => "Suppl&#46; 73"
                        "paginaInicial" => "283"
                        "paginaFinal" => "284"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cloning and expression on the panallergen profilin and the major allergen &#40;ole e 1&#41; from olive tree pollen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Asturias"
                            1 => "M&#46;C&#46; Arilla"
                            2 => "N&#46; G&#243;mez-Bayon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1997"
                        "volumen" => "100"
                        "paginaInicial" => "365"
                        "paginaFinal" => "372"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9314349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peach allergy in Spanish children&#58; tolerance to the pulp and molecular sensitization profile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Boyano-Mart&#237;nez"
                            1 => "M&#46; Pedrosa"
                            2 => "T&#46; Belver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ped Allergy Immunol"
                        "fecha" => "2013"
                        "volumen" => "24"
                        "paginaInicial" => "168"
                        "paginaFinal" => "172"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The major allergen of olive pollen Ole e 1 is a diagnostic marker for sensitization to Oleacea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Palomares"
                            1 => "I&#46; Swoboda"
                            2 => "M&#46; Villalba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int Arch Allergy Immunol"
                        "fecha" => "2006"
                        "volumen" => "14"
                        "paginaInicial" => "110"
                        "paginaFinal" => "118"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A multicenter study of sensitization profiles in an allergic pediatric population in an area with high allergen exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Feliu"
                            1 => "D&#46; Gonz&#225;lez de Olano"
                            2 => "E&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Investig Allergol Clin Immunol"
                        "fecha" => "2013"
                        "volumen" => "23"
                        "paginaInicial" => "337"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24260979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03010546/0000004200000004/v1_201407030035/S0301054614000767/v1_201407030035/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5552"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03010546/0000004200000004/v1_201407030035/S0301054614000767/v1_201407030035/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054614000767?idApp=UINPBA00004N"
]
Article information
ISSN: 03010546
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 0 7
2024 October 22 9 31
2024 September 28 11 39
2024 August 26 6 32
2024 July 26 4 30
2024 June 29 13 42
2024 May 22 4 26
2024 April 16 8 24
2024 March 22 7 29
2024 February 30 8 38
2024 January 21 8 29
2023 December 29 5 34
2023 November 27 6 33
2023 October 28 11 39
2023 September 18 5 23
2023 August 23 6 29
2023 July 15 9 24
2023 June 27 4 31
2023 May 54 7 61
2023 April 34 5 39
2023 March 9 3 12
2023 February 13 17 30
2023 January 15 10 25
2022 December 17 6 23
2022 November 18 12 30
2022 October 17 15 32
2022 September 27 17 44
2022 August 17 7 24
2022 July 17 7 24
2022 June 14 9 23
2022 May 20 11 31
2022 April 16 15 31
2022 March 10 6 16
2022 February 7 11 18
2022 January 16 3 19
2021 December 7 12 19
2021 November 13 16 29
2021 October 13 19 32
2021 September 15 17 32
2021 August 15 4 19
2021 July 6 9 15
2021 June 15 10 25
2021 May 9 24 33
2021 April 13 10 23
2021 March 5 11 16
2021 February 16 3 19
2021 January 7 11 18
2020 December 2 0 2
2020 November 0 4 4
2020 August 0 1 1
2020 July 0 2 2
2020 May 0 9 9
2020 April 0 3 3
2020 March 0 5 5
2020 February 0 9 9
2020 January 0 6 6
2019 December 0 1 1
2019 November 0 2 2
2019 September 0 3 3
2019 August 0 6 6
2019 July 0 12 12
2019 June 0 8 8
2019 May 0 14 14
2019 April 0 21 21
2019 March 0 2 2
2019 February 0 1 1
2019 January 0 3 3
2018 December 0 4 4
2018 February 12 0 12
2018 January 1 4 5
2017 December 5 3 8
2017 November 6 6 12
2017 October 2 6 8
2017 September 11 9 20
2017 August 8 3 11
2017 July 8 5 13
2017 June 13 14 27
2017 May 20 9 29
2017 April 9 11 20
2017 March 13 5 18
2017 February 7 8 15
2017 January 2 3 5
2016 December 12 9 21
2016 November 17 15 32
2016 October 33 4 37
2016 September 18 2 20
2016 August 19 3 22
2016 July 10 4 14
2016 June 19 7 26
2016 May 13 10 23
2016 April 13 13 26
2016 March 21 17 38
2016 February 12 21 33
2016 January 10 20 30
2015 December 12 17 29
2015 November 6 15 21
2015 October 22 18 40
2015 September 8 6 14
2015 August 18 6 24
2015 July 10 8 18
2015 May 0 2 2
2015 April 0 2 2
2015 March 1 3 4
2015 February 2 1 3
2015 January 2 2 4
2014 December 1 0 1
2014 November 2 3 5
2014 October 3 2 5
2014 September 3 3 6
2014 August 3 9 12
2014 July 11 26 37
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos