Editorial
EISL study (Estudio Internacional de Sibilancias en Lactantes): A global perspective of wheezing during the first year of life
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Aranda, G. Wandalsen, L. Fonzar, A.C.D. Bianca, J. Mallol, D. Solé" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C.S." "apellidos" => "Aranda" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Wandalsen" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Fonzar" ] 3 => array:2 [ "nombre" => "A.C.D." "apellidos" => "Bianca" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Mallol" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Solé" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030105461500107X?idApp=UINPBA00004N" "url" => "/03010546/0000004400000001/v1_201601070106/S030105461500107X/v1_201601070106/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "EISL study (Estudio Internacional de Sibilancias en Lactantes): A global perspective of wheezing during the first year of life" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "2" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Luis Garcia-Marcos" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Luis" "apellidos" => "Garcia-Marcos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "IMIB Bioresearch Institute, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">I would like to take the opportunity of including yet another paper from the EISL study in this issue of Allergologia et Immunopathologia (the first one in 2016) to dedicate this editorial to a multinational study which has been able to offer some new perspectives on a very frequent condition during the first year of life: recurrent wheezing.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The study started as a joint effort of several Latin-American and Spanish centres, with the latter addition of more Latin-American centres and another one in The Netherlands. Although as an anecdote it took some discussion with a reviewer on a particular paper, this was – definitely – an international study, which was carried out in three languages (Spanish, Portuguese and Dutch). The first phase, and the more numerous one, included up to 20 centres in 10 countries, with more than 30000 parents of infants surveyed. After validation in the study languages and in different settings,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> it was launched in 2005 and was extended into 2009, depending upon the centres. Two major papers were published in 2010 including the main findings on the prevalence, treatment modalities and resource consumption together with the main risk factors.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> As there were centres from very different socio-economic statuses it was possible to compare prevalence and risk factors between them. In fact the prevalence of recurrent wheezing (three or more episodes) in the first year of life was significantly higher in Latin-America as compared to Europe,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and although there were some common risk and protective factors, their impact was not the same in both parts of the world. In particular, mother education was a risk factor in Latin-America while it was not in Europe.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> After those two summarising papers, other ones – from specific centres which were not included due to a delayed start from the core group – have been published, casting new insights into this common condition in other geographical areas.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7–14</span></a> Furthermore, new centres with a more potent questionnaire (EISL phase Three) have recently offered even a clearer picture of the problem, mainly in Latin America.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,10,11,15,16</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Apart from the prevalence, treatment modes, resource consumption and risk factors, other specific issues have been addressed in the EISL publications, including the effect of latitude in the strength of the association of several risk factors on recurrent wheezing,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> the relationship between wheezing and pneumonia,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> or the influence of BMI<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> or low birth weight<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> on wheezing. Indeed other papers were focused on other allergic diseases which were secondary objectives of the EISL study, such as atopic dermatitis<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> and rhinitis;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> the latter one extended to pres-school years.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In summary, the EISL study constitutes an example of international collaboration, and – although with the limitations of any cross-sectional study – has the power of a very large sample size and variability. Allergologia et Immnopathologia welcomes any additional paper from the EISL which focuses on new aspects of wheezing in infancy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the meantime, my best wishes for 2016 to all readers!</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International Study of Wheezing in Infants (EISL): validation of written questionnaire for children aged below 3 years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "A.C. Bianca" 1 => "G.F. Wandalsen" 2 => "K. Miyagi" 3 => "L. Camargo" 4 => "D. Cezarin" 5 => "J. Mallol" 6 => "D. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 0 | 3 |
| 2024 October | 16 | 1 | 17 |
| 2024 September | 31 | 5 | 36 |
| 2024 August | 27 | 10 | 37 |
| 2024 July | 15 | 8 | 23 |
| 2024 June | 27 | 5 | 32 |
| 2024 May | 20 | 11 | 31 |
| 2024 April | 19 | 18 | 37 |
| 2024 March | 21 | 10 | 31 |
| 2024 February | 21 | 13 | 34 |
| 2024 January | 15 | 8 | 23 |
| 2023 December | 40 | 16 | 56 |
| 2023 November | 23 | 12 | 35 |
| 2023 October | 24 | 11 | 35 |
| 2023 September | 12 | 4 | 16 |
| 2023 August | 36 | 19 | 55 |
| 2023 July | 24 | 13 | 37 |
| 2023 June | 21 | 0 | 21 |
| 2023 May | 58 | 7 | 65 |
| 2023 April | 76 | 5 | 81 |
| 2023 March | 67 | 5 | 72 |
| 2023 February | 21 | 1 | 22 |
| 2023 January | 23 | 13 | 36 |
| 2022 December | 39 | 10 | 49 |
| 2022 November | 47 | 17 | 64 |
| 2022 October | 53 | 19 | 72 |
| 2022 September | 47 | 14 | 61 |
| 2022 August | 20 | 8 | 28 |
| 2022 July | 20 | 13 | 33 |
| 2022 June | 13 | 11 | 24 |
| 2022 May | 22 | 14 | 36 |
| 2022 April | 18 | 9 | 27 |
| 2022 March | 27 | 12 | 39 |
| 2022 February | 20 | 9 | 29 |
| 2022 January | 75 | 11 | 86 |
| 2021 December | 62 | 13 | 75 |
| 2021 November | 44 | 17 | 61 |
| 2021 October | 24 | 21 | 45 |
| 2021 September | 27 | 11 | 38 |
| 2021 August | 18 | 13 | 31 |
| 2021 July | 22 | 17 | 39 |
| 2021 June | 21 | 9 | 30 |
| 2021 May | 19 | 12 | 31 |
| 2021 April | 49 | 36 | 85 |
| 2021 March | 27 | 14 | 41 |
| 2021 February | 19 | 12 | 31 |
| 2021 January | 14 | 6 | 20 |
| 2020 December | 0 | 2 | 2 |
| 2020 November | 0 | 2 | 2 |
| 2020 October | 0 | 1 | 1 |
| 2020 August | 0 | 2 | 2 |
| 2020 July | 0 | 1 | 1 |
| 2020 May | 0 | 3 | 3 |
| 2020 March | 0 | 2 | 2 |
| 2020 February | 0 | 1 | 1 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 7 | 7 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 2 | 2 |
| 2019 August | 0 | 1 | 1 |
| 2019 July | 0 | 2 | 2 |
| 2019 May | 0 | 13 | 13 |
| 2018 August | 0 | 1 | 1 |
| 2018 February | 11 | 4 | 15 |
| 2018 January | 12 | 2 | 14 |
| 2017 December | 6 | 2 | 8 |
| 2017 November | 31 | 8 | 39 |
| 2017 October | 10 | 7 | 17 |
| 2017 September | 10 | 13 | 23 |
| 2017 August | 13 | 19 | 32 |
| 2017 July | 11 | 12 | 23 |
| 2017 June | 24 | 16 | 40 |
| 2017 May | 28 | 18 | 46 |
| 2017 April | 19 | 9 | 28 |
| 2017 March | 31 | 63 | 94 |
| 2017 February | 12 | 11 | 23 |
| 2017 January | 21 | 3 | 24 |
| 2016 December | 25 | 14 | 39 |
| 2016 November | 22 | 11 | 33 |
| 2016 October | 0 | 10 | 10 |
| 2016 September | 1 | 11 | 12 |
| 2016 August | 0 | 1 | 1 |
| 2016 July | 1 | 1 | 2 |
| 2016 June | 0 | 3 | 3 |
| 2016 May | 0 | 1 | 1 |
| 2016 April | 1 | 2 | 3 |
| 2016 March | 3 | 4 | 7 |
| 2016 February | 9 | 13 | 22 |
| 2016 January | 10 | 6 | 16 |
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