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array:23 [ "pii" => "S030105461730099X" "issn" => "03010546" "doi" => "10.1016/j.aller.2017.05.006" "estado" => "S300" "fechaPublicacion" => "2018-05-01" "aid" => "889" "copyright" => "SEICAP" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Allergol Immunopathol (Madr). 2018;46:276-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 18 "formatos" => array:2 [ "HTML" => 10 "PDF" => 8 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054617301040" "issn" => "03010546" "doi" => "10.1016/j.aller.2017.05.010" "estado" => "S300" "fechaPublicacion" => "2018-05-01" "aid" => "894" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Allergol Immunopathol (Madr). 2018;46:281-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 10 "formatos" => array:2 [ "HTML" => 6 "PDF" => 4 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Change in gut microbiota for eczema: Implications for novel therapeutic strategies" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "290" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1516 "Ancho" => 2118 "Tamanyo" => 163198 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bacterial species involved in eczema progression. a: <span class="elsevierStyleItalic">E. coli</span> may mediate a Th1/Th2 response by affecting T cells; b: <span class="elsevierStyleItalic">C. difficile</span> may mediate a Th1/Th2 response by affecting T cells; c: <span class="elsevierStyleItalic">B. catenulatum</span> may induce IL-4 and IFN-γ production; d: <span class="elsevierStyleItalic">B. breve</span> may suppress the production of Th2 cytokine (IL-4) and IgE by inducing the secretion of regulatory (IL-10) and Th1 (IFN-γ) cytokines, and reduce allergen-induced Th2 (IL-5and IL-13) responses; e: <span class="elsevierStyleItalic">S. aureus</span> may elicit a Th17 response. Abbreviations: Th1: T helper 1; Th2: T helper 1; IL: Interleukin; IFN-γ: Interferon-γ; IgE: immunoglobulin E; Th17: T helper 17.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Y. Kang, Y. Cai, W. Pan" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Y." "apellidos" => "Kang" ] 1 => array:2 [ "nombre" => "Y." "apellidos" => "Cai" ] 2 => array:2 [ "nombre" => "W." "apellidos" => "Pan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054617301040?idApp=UINPBA00004N" "url" => "/03010546/0000004600000003/v3_201804080420/S0301054617301040/v3_201804080420/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054617300770" "issn" => "03010546" "doi" => "10.1016/j.aller.2017.04.006" "estado" => "S300" "fechaPublicacion" => "2018-05-01" "aid" => "880" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Allergol Immunopathol (Madr). 2018;46:263-75" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7 "formatos" => array:2 [ "HTML" => 4 "PDF" => 3 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "MHC class II deficiency: Report of a novel mutation and special review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "263" "paginaFinal" => "275" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1402 "Ancho" => 3312 "Tamanyo" => 120853 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The pedigree of the patient. The index patient is pointed by an arrow.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Farrokhi, M. Shabani, Z. Aryan, S. Zoghi, A. Krolo, K. Boztug, N. Rezaei" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Farrokhi" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Shabani" ] 2 => array:2 [ "nombre" => "Z." "apellidos" => "Aryan" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Zoghi" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Krolo" ] 5 => array:2 [ "nombre" => "K." "apellidos" => "Boztug" ] 6 => array:2 [ "nombre" => "N." "apellidos" => "Rezaei" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054617300770?idApp=UINPBA00004N" "url" => "/03010546/0000004600000003/v3_201804080420/S0301054617300770/v3_201804080420/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "276" "paginaFinal" => "280" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Sánchez-Borges, L. González-Aveledo, A. Capriles-Hulett, F. Caballero-Fonseca" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Sánchez-Borges" "email" => array:1 [ 0 => "sanchezbmario@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "González-Aveledo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Capriles-Hulett" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Caballero-Fonseca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Allergy and Clinical Immunology Department, Clínica El Avila, Caracas, Venezuela" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Dermatology Department, Centro Médico de Caracas, Caracas, Venezuela" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 668 "Ancho" => 900 "Tamanyo" => 89138 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Same patient as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> with crusted (Norwegian) scabies. Abundant nodules are present on penis and scrotum.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Scabies is a highly contagious skin disease of worldwide distribution caused by <span class="elsevierStyleItalic">Sarcoptes scabiei var. hominis</span>, characterised by generalised intense pruritus. Approximately 300 million cases of this ailment occur every year.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a> The infection occurs sporadically in developed countries where it is present as institutional outbreaks in hospitals, schools, nursing homes, prisons, and long-term care facilities. The recent upsurge of immigration from less developed areas into Europe, North America, and other industrialised countries carries the risk of an increase of scabies in those regions.</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is known that disadvantaged populations in which overcrowding and poverty are the rule, and immunologically compromised individuals (for example, HIV-infected patients) are particularly at risk. Scabies is endemic in developing and tropical areas of the world.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a> In resource-poor urban and rural communities its prevalence may be as high as 10% of the general population and 65% of the children.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3,4</span></a> It is transmitted by close personal contact or indirectly via fomites (clothing or bed sheets).<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The morbidity of scabies is enhanced by secondary bacterial infections of the skin, especially by Group A <span class="elsevierStyleItalic">Streptococcus</span> and <span class="elsevierStyleItalic">Staphylococcus aureus</span>, which are responsible for associated clinical pictures such as cellulitis, lymphangitis, lymphadenopathy, and post-streptococcal glomerulonephritis.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recently we received in our Allergy Clinics a male patient with a severe form of scabies, with numerous popular lesions in the skin and nodular lesions in the genitalia that met the clinical criteria of Norwegian scabies. After reviewing the current literature on scabies and crusted scabies we became aware of the interesting immunological interactions between scabies mites (SM) and domestic mites (HDM) and the importance of scabies infestations for the practicing clinician, especially those working in allergology and dermatology in areas of the world with endemic scabies.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In this article a review of the immunological response to <span class="elsevierStyleItalic">S. scabiei</span>, representing a confounding factor for the diagnosis of house dust mite (HDM) hypersensitivity is presented.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Clinical features and diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Adult female mites dig tunnel-like burrows within the stratum granulosum of the epidermis and lay approximately 2–3 eggs daily. An infested subject hosts approximately 10–15 adult female mites on the entire body. The life cycle of scabies mites is 10–14 days.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The burrows are typically located on the interdigital spaces, the flexural surface of the wrists, elbows, axillae, umbilicus, belt line, nipples, buttocks, and penile shaft.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a> They appear as short, wavy, threadlike scaling lines. The presence of erythematous papules or vesicles is attributed to a type IV hypersensitivity reaction to mite, eggs, and/or excrement antigens (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), and the inflammatory response is characterised by the presence of lymphocytes, histiocytes, and polymorphonuclear leukocytes.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Clinical features that suggest the diagnosis of scabies include a polymorphic, papulovesicular, eczematous or pustular rash, intense itch (especially nocturnal and after taking hot showers), and associated secondary bacterial infections with <span class="elsevierStyleItalic">S. aureus</span> or nephritogenic <span class="elsevierStyleItalic">Streptococcus</span>. Diagnostic guidelines that have been proposed for scabies include a history of diffuse itching, lesions in at least two typical skin areas, and a household member with pruritus.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The definitive diagnosis is established by the identification of the mite, its eggs or faeces by microscopic examination of scales obtained by skin scraping.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> Since this approach may not be satisfactory in some cases, other diagnostic methods with better sensitivity and specificity have been proposed, including Videodermatoscopy, Dermatoscopy, Reflectance Confocal Microscopy, and Optical Coherence Tomography.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The differential diagnosis should take into account other pruritic skin conditions, including atopic dermatitis, contact dermatitis, papular urticaria, folliculitis, dermatitis herpetiformis, prurigo nodularis, impetigo, tinea, and bites from mosquitoes, fleas, bed bugs, and chiggers or other mites.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Crusted (Norwegian) scabies</span><p id="par0055" class="elsevierStylePara elsevierViewall">This variety of disease is a severe, highly contagious, form of scabies in which mites multiply into the millions, causing extensive skin hyperkeratotic crusting. The histopathologic study of the lesions shows a dermal infiltrate of lymphocytes and histiocytes with or without neutrophils and eosinophils, and a denser infiltration in the nodular lesions (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Crusted scabies can be treated with oral ivermectin 6<span class="elsevierStyleHsp" style=""></span>mg once per week for three weeks, plus crotamiton topical ointment (benzyl benzoate 30%). Alternative treatment, if there is no response or adverse effects occur, is with topical 1% gamma-benzene hexachloride ointment applied from the neck down once a week.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Immunological features of scabies and relevance in allergology</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Immune response to scabies</span><p id="par0065" class="elsevierStylePara elsevierViewall">Scabies mites (SM) and HDM are phylogenetically-related arthropods. Since the HDM and the human SM have similar appearance and nutrition, it is not unlikely that they or their excretions have allergens in common (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). <span class="elsevierStyleItalic">S. scabiei</span> mite produces a number of allergens homologous of HDM allergens, among them: Group 11 (paramyosin), group 14 (apolipoprotein), group 8 (glutathione S-transferase), group 3 (serine protease), and group 1 (cysteine protease).<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Importance of the immune response to scabies in allergology</span><p id="par0070" class="elsevierStylePara elsevierViewall">Scabies has two important repercussions in the routine practice of allergology:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">(1)</span><p id="par0075" class="elsevierStylePara elsevierViewall">Itch is a frequent motive of consultation in the Allergy Clinics, since there are patients who think that the itchy rash they are suffering is due to skin allergy. Scabies has to be considered in the differential diagnosis of itchy rashes by allergists practicing in endemic areas, attending low-income or overcrowded populations, immunosuppressed subjects, and institutionalised patients. Additionally, the diagnosis of scabies should be entertained in areas of developed countries with increased crowding and immigration from third world locations.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">(2)</span><p id="par0080" class="elsevierStylePara elsevierViewall">The allergenicity of <span class="elsevierStyleItalic">S. scabiei</span> leads to immune changes that can be confounders in the diagnosis of HDM allergy. In a high proportion of patients with scabies IgE antibodies to allergens from the HDM <span class="elsevierStyleItalic">Dermatophagoides pteronyssinus</span> can be demonstrated.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a> It has been demonstrated that patients with scabies show serum IgE against recombinant <span class="elsevierStyleItalic">S. scabiei</span> cysteine and serine proteases and apolipoprotein, whereas naive (unexposed) subjects show minimal IgE reactivity, and positive immediate-type skin tests performed with HDM allergen extracts are observed in patients with past or current scabies infestation, which may be due to cross-reactive antibodies to Der p 4 and Der p 20.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">14,15</span></a></p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Immune responses in crusted scabies</span><p id="par0085" class="elsevierStylePara elsevierViewall">Sera from patients with scabies contain IgE against recombinant <span class="elsevierStyleItalic">S. scabiei</span> cysteine and serine proteases and apolipoprotein, whereas naive (unexposed) subjects show minimal IgE reactivity. Patients with crusted scabies have extremely high levels of total IgE in the serum.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">16,17</span></a> Polyclonal antibodies anti-<span class="elsevierStyleItalic">S. scabiei</span> cysteine protease bind to the mite gastrointestinal tract, which suggests that <span class="elsevierStyleItalic">S. scabiei</span> cysteine proteases play a role in skin digestion and mite burrowing.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">On the other hand, sera from patients with crusted scabies show strong IgE binding to up to 21 scabies mite proteins, while sera from patients with ordinary scabies show weaker binding to a maximum of six scabies mite proteins.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">19</span></a> Furthermore, recombinant glutathione S-transferase from <span class="elsevierStyleItalic">S. scabiei</span> reacts strongly with IgE and IgG4 in sera from crusted scabies patients.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Greater serum IgE and IgG4 binding to mite apolipoprotein and eosinophilia were present in subjects with crusted scabies than in those with ordinary scabies, whereas peripheral blood mononuclear cells from subjects from both groups showed strong proliferative responses to scabies antigens, but the crusted scabies group showed a non-protective TH2 response characterised by an increased secretion of IL-5 and IL-13 and a decreased TH1 cytokine γ-interferon in response to the active cysteine protease.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Scabies represents a major confounder in the diagnosis of HDM sensitisation because scabies-infested or exposed subjects have high-titre IgE binding to Der p 4 (amylase) and Der p 20 (arginine kinase) with the anti-Der p 4 persisting in previously exposed subjects. For group 4 allergens of mites (alpha amylases found in faeces) there is evidence for high cross-reactivity from present and past scabies infestations. Der p 20 exhibits high binding to IgE and IgG from the sera of people with active scabies.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> Also group 14 (large lipid transfer protein) of scabies binds to IgE at 10-fold higher levels for scabies infested but not HDM-allergic subjects.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">21</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The use of component-resolved diagnosis (CRD) would clearly recognise the lack of Der p 1 and 2 antibodies and the high titres to Der p 4 and 20. This is likely to impact on the usefulness of HDM allergen extract testing in many countries where the prevalence of scabies infection is high.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">22</span></a> This will also be important in developing regions where changes in lifestyle are resulting in increased incidences of atopic diseases necessitating monitoring to predict health service needs. For example, in the United Kingdom the prevalence of scabies is 0.27% and therefore there will be a significant number of incorrect diagnoses in most regions.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Finally, in tropical Australia cross-reactive anti-scabies antibodies contraindicate the use of HDM extracts for allergological diagnosis in many environments where allergic diseases might be expected to increase hand-in-hand with the increased sanitation of living conditions. IgE binding to Der p 4 and 20 and the absence of binding to Der p 1 and 2 can help to identify this.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="par0115" class="elsevierStylePara elsevierViewall">In areas with high prevalence of <span class="elsevierStyleItalic">S. scabiei</span> infestation this skin disease has to be considered in allergy clinics, when evaluating patients with cutaneous itchy conditions. The presence of serum anti-<span class="elsevierStyleItalic">S. scabies</span> IgE antibodies in patients who previously developed scabies may lead to positive immediate-type skin tests to HDM allergenic extracts. This obstacle could be solved by utilising component-resolved diagnosis (molecular diagnosis).</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical disclosures</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Confidentiality of data</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Right to privacy and informed consent</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Protection of human subjects and animals in research</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1013238" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec972299" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical features and diagnosis" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Crusted (Norwegian) scabies" ] 5 => array:3 [ "identificador" => "sec0020" "titulo" => "Immunological features of scabies and relevance in allergology" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Immune response to scabies" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Importance of the immune response to scabies in allergology" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Immune responses in crusted scabies" ] ] ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Conclusions" ] 7 => array:3 [ "identificador" => "sec0045" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Confidentiality of data" ] 1 => array:2 [ "identificador" => "sec0055" "titulo" => "Right to privacy and informed consent" ] 2 => array:2 [ "identificador" => "sec0060" "titulo" => "Protection of human subjects and animals in research" ] ] ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-03-11" "fechaAceptado" => "2017-05-19" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec972299" "palabras" => array:7 [ 0 => "Allergy" 1 => "Crusted scabies" 2 => "Dermatophagoides" 3 => "Hypersensitivity" 4 => "Mites" 5 => "<span class="elsevierStyleItalic">Sarcoptes scabiei</span>" 6 => "Scabies" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to <span class="elsevierStyleItalic">Sarcoptes scabiei</span> allergens which cross-react with <span class="elsevierStyleItalic">Dermatophagoides</span> major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously. Additionally, scabies should be included routinely in the differential diagnosis of itchy rashes in patients living in those areas.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 900 "Tamanyo" => 72892 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">44-year-old male patient complained of an intensely itchy, predominantly nocturnal, rash on buttocks, scrotum, penis and thighs. After examination of skin scales crusted (Norwegian) scabies was diagnosed. In this photo, note abundant erythematous papules on buttocks and thighs.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 668 "Ancho" => 900 "Tamanyo" => 89138 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Same patient as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> with crusted (Norwegian) scabies. Abundant nodules are present on penis and scrotum.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2003 "Ancho" => 2250 "Tamanyo" => 255644 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Taxonomy of mites. 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Year/Month | Html | Total | |
---|---|---|---|
2024 October | 340 | 13 | 353 |
2024 September | 555 | 32 | 587 |
2024 August | 555 | 43 | 598 |
2024 July | 499 | 33 | 532 |
2024 June | 282 | 25 | 307 |
2024 May | 304 | 42 | 346 |
2024 April | 185 | 34 | 219 |
2024 March | 225 | 26 | 251 |
2024 February | 340 | 39 | 379 |
2024 January | 549 | 59 | 608 |
2023 December | 526 | 63 | 589 |
2023 November | 643 | 77 | 720 |
2023 October | 550 | 36 | 586 |
2023 September | 393 | 4 | 397 |
2023 August | 380 | 15 | 395 |
2023 July | 429 | 34 | 463 |
2023 June | 436 | 16 | 452 |
2023 May | 650 | 22 | 672 |
2023 April | 527 | 21 | 548 |
2023 March | 374 | 22 | 396 |
2023 February | 396 | 24 | 420 |
2023 January | 429 | 26 | 455 |
2022 December | 373 | 25 | 398 |
2022 November | 328 | 44 | 372 |
2022 October | 355 | 54 | 409 |
2022 September | 342 | 31 | 373 |
2022 August | 406 | 44 | 450 |
2022 July | 241 | 34 | 275 |
2022 June | 299 | 29 | 328 |
2022 May | 294 | 23 | 317 |
2022 April | 350 | 34 | 384 |
2022 March | 380 | 35 | 415 |
2022 February | 464 | 20 | 484 |
2022 January | 531 | 24 | 555 |
2021 December | 509 | 34 | 543 |
2021 November | 486 | 62 | 548 |
2021 October | 571 | 40 | 611 |
2021 September | 422 | 53 | 475 |
2021 August | 498 | 42 | 540 |
2021 July | 436 | 35 | 471 |
2021 June | 384 | 44 | 428 |
2021 May | 386 | 37 | 423 |
2021 April | 1172 | 121 | 1293 |
2021 March | 690 | 56 | 746 |
2021 February | 290 | 30 | 320 |
2021 January | 170 | 40 | 210 |
2020 December | 11 | 1 | 12 |
2020 July | 0 | 1 | 1 |
2019 December | 1 | 2 | 3 |
2019 May | 3 | 4 | 7 |
2018 November | 2 | 0 | 2 |
2018 August | 1 | 0 | 1 |
2018 May | 1 | 0 | 1 |
2018 April | 2 | 0 | 2 |
2018 January | 0 | 2 | 2 |