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array:22 [ "pii" => "S0301054619300977" "issn" => "03010546" "doi" => "10.1016/j.aller.2019.05.006" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1070" "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2020;48:73-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 11 "formatos" => array:2 [ "HTML" => 3 "PDF" => 8 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054619301193" "issn" => "03010546" "doi" => "10.1016/j.aller.2019.07.010" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1092" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2020;48:78-83" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9 "formatos" => array:2 [ "HTML" => 3 "PDF" => 6 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Frequency and clinical features of pollen-food syndrome in children" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "78" "paginaFinal" => "83" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "H. Guvenir, E. Dibek Misirlioglu, B. Buyuktiryaki, M.M. Zabun, M. Capanoglu, M. Toyran, E. Civelek, C.N. Kocabas" "autores" => array:8 [ 0 => array:2 [ "nombre" => "H." "apellidos" => "Guvenir" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Dibek Misirlioglu" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Buyuktiryaki" ] 3 => array:2 [ "nombre" => "M.M." "apellidos" => "Zabun" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Capanoglu" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Toyran" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "Civelek" ] 7 => array:2 [ "nombre" => "C.N." "apellidos" => "Kocabas" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054619301193?idApp=UINPBA00004N" "url" => "/03010546/0000004800000001/v2_202012050801/S0301054619301193/v2_202012050801/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054619301004" "issn" => "03010546" "doi" => "10.1016/j.aller.2019.06.008" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1073" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2020;48:67-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9 "formatos" => array:2 [ "HTML" => 3 "PDF" => 6 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Glycoprotein A (GARP) in children who outgrow food allergy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "67" "paginaFinal" => "72" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2730 "Ancho" => 3333 "Tamanyo" => 363999 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0045" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparison of GARP expression between children with remission of food allergy and children without medical history of food allergy (A). Comparison of GARP expression between children with and without food-specific IgE in serum (B). ROC curve visualization with cut-off estimation (C).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Katarzyna Woicka-Kolejwa, Joanna Jerzynska, Pawel Majak, Agnieszka Koniarek, Iwona Stelmach" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Katarzyna" "apellidos" => "Woicka-Kolejwa" ] 1 => array:2 [ "nombre" => "Joanna" "apellidos" => "Jerzynska" ] 2 => array:2 [ "nombre" => "Pawel" "apellidos" => "Majak" ] 3 => array:2 [ "nombre" => "Agnieszka" "apellidos" => "Koniarek" ] 4 => array:2 [ "nombre" => "Iwona" "apellidos" => "Stelmach" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054619301004?idApp=UINPBA00004N" "url" => "/03010546/0000004800000001/v2_202012050801/S0301054619301004/v2_202012050801/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Prevalence of and factors associated with underdiagnosis of pediatric asthma in Batumi, Georgia" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "73" "paginaFinal" => "77" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.E. Zejda, V. Beridze, T. Bakhtadze, S. Beridze, L. Abuladze, N. Partenadze, J. Lawson" "autores" => array:7 [ 0 => array:4 [ "nombre" => "J.E." "apellidos" => "Zejda" "email" => array:1 [ 0 => "jzejda@sum.edu.pl" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "V." "apellidos" => "Beridze" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "T." "apellidos" => "Bakhtadze" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "S." "apellidos" => "Beridze" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "L." "apellidos" => "Abuladze" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "N." "apellidos" => "Partenadze" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "J." "apellidos" => "Lawson" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Epidemiology, School of Medicine, Medical University of Silesia, Katowice, Poland" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Faculty of Natural Sciences and Health Care, Shota Rustaveli State University, Batumi, Georgia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Maternity and Child Health Center, Batumi, Georgia" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Canadian Centre for Health and Safety in Agriculture, College of Medicine, University of Saskatchewan, Saskatoon, Canada" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">International variation in the prevalence of childhood asthma is well documented by many epidemiological studies, mostly by the International Study of Asthma and Allergies in Childhood (ISAAC).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The general finding is that even if the occurrence of asthma has substantially risen over recent decades its prevalence remains relatively low in countries of Eastern Europe.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Evidence provided by epidemiological studies conducted since 2010 and based on the same protocol in Belarus, Estonia, Macedonia, and Ukraine shows that asthma is diagnosed in 1.5%–2.9% of school children and that there is some evidence that there may be underdiagnosis of asthma.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our recent population-based survey performed in 5351 urban and rural children in the Batumi region (Georgia) showed a low prevalence of pediatric asthma in urban children –1.8% (95%CI: 1.3%–2.3%).<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Moreover the findings revealed that a diagnosis of chronic bronchitis was known and reported by parents in 5.5% of the children, and a diagnosis of spastic bronchitis in 7.3% of the children. Similar low figures regarding the occurrence of pediatric asthma were found in other countries of Eastern Europe.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> A low prevalence of reported pediatric asthma suggested that some cases of pediatric asthma in the Batumi region remained undiagnosed. The goal of the study was to estimate the level of underdiagnosis of pediatric asthma in the urban population of children in Batumi and find out if children with a newly established diagnosis of asthma differ from children with previously established and known diagnosis of asthma, in terms of environmental and host factors pertinent to the epidemiological pattern of pediatric asthma.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Study population and study design</span><p id="par0015" class="elsevierStylePara elsevierViewall">In 2018 we published the results of a population-based respiratory health survey performed in children aged 6–16 years, residing in the Batumi Region, Georgia.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The survey included 3239 urban and 2113 rural children. The present analysis was based on data from that study, obtained in urban children. Based on the survey results, two groups of children were identified: the group of children with diagnosed asthma and the group of children suspected for undiagnosed asthma. Urban children were selected due to practical considerations regarding access to clinical testing.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Definition of asthma status based on survey</span><p id="par0020" class="elsevierStylePara elsevierViewall">Diagnosed asthma was defined as the parents’ report (questionnaire) of physician-diagnosed asthma in a child. Among the survey sample of 3239 urban children, 59 had diagnosed asthma. Undiagnosed asthma was defined as asthma found in children with reported (questionnaire) asthma-like symptoms but without diagnosis of asthma at the time of the questionnaire survey. A child was suspected to have undiagnosed asthma if the questionnaire included a positive answer to one or more of the following questions: “In the last 12 months has your child had a dry cough at night apart from a cough associated with a cold or chest infection?”; “Has this child had a cough that occurred with shortness of breath or rapid breathing?”; “Does this child usually have congestion in the chest or bring up phlegm or mucus apart from colds?”; “Has this child had wheezing or whistling in the chest in the last 12 months apart from symptoms associated with a cold or chest infection?”; “In the last 12 months has your child’s chest ever sounded wheezy during or after exercise/sports?”.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Clinical testing and physician diagnosis of asthma</span><p id="par0025" class="elsevierStylePara elsevierViewall">In total, 489 out of 3239 children had asthma-like symptoms and all were invited for clinical examination performed by one pediatrician certified in allergology and experienced in the field of children’s respiratory diseases including asthma, and familiar with GINA guidelines on the diagnosis of asthma. Some children did not complete the clinical examination due to migration or lack of parental consent. In total, 437 children (89.3%) underwent clinical examination. Detailed interviews showed no convincing symptoms of asthma in 87 children, thus leaving 350 children for further examination. Spirometry showed obstructive disorder in 178 children and 107 had a reversible airflow obstruction as shown by salbutamol trial. Measurement of FeNO was performed in 178 children with the following results: <20<span class="elsevierStyleHsp" style=""></span>ppb in 18 children, 20–50<span class="elsevierStyleHsp" style=""></span>ppb in 77 children, 51–100<span class="elsevierStyleHsp" style=""></span>ppb in 50 children, and >100<span class="elsevierStyleHsp" style=""></span>ppb in 33 children. All children examined for asthma underwent skin prick testing (Allergopharma – standard prick panel for Europe). Sensitization to at least one allergen was found in 105 children with the most frequent positive test being for <span class="elsevierStyleItalic">Dermatophagoides farinae</span>/<span class="elsevierStyleItalic">Dermatophagoides pteronyssinus</span> in 86 children. Asthma symptoms, sensitization to at least one allergen (skin prick test), and reversible airway obstruction were the principal criteria used to establish the diagnosis of asthma. The choice and application of the diagnostic methods depended on the physician’s decision and was not covered by the protocol of this study. The consulting physician was requested to answer the question of whether a child had asthma (yes/no).</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Data analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Children with previously-known diagnosis of asthma (diagnosed asthma) were compared with children with newly-diagnosed asthma (undiagnosed asthma) in terms of anthropometric status, occurrence of allergic disorders, and environmental characteristics. <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1–3</a> show the names and distributions of variables used in analyses. Statistical analysis involved description of the distributions of quantitative and qualitative variables. Between-group differences in the distribution of quantitative variables were assessed by the Kruskal-Wallis test because of a non-normal distribution based on the results of the Shapiro-Wilk test. Between-group differences in the distribution of qualitative variables were assessed by the chi<span class="elsevierStyleSup">2</span> test. Inference regarding statistical significance was based on the criterion p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Results of simple analyses were verified by logistic regression analysis with diagnosed/undiagnosed asthma as the dependent variable. The complete model was parametrized using automatic backward selection of all candidate variables tested in simple analyses except for BMI (correlation with age: r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.62; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001) and physician diagnosis of hay fever (association with physician diagnosis of any allergic disorder; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001). Statistical inference was based on the values of odds ratios (OR) and their 95% confidence intervals (95%CI) according to the criterion p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.1. Underdiagnosis-corrected prevalence of pediatric asthma was estimated according to the formula: (number of diagnosed cases<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>number of undiagnosed cases)/number of children in the total study group (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3239). The study protocol was approved by a local Ethics Committee at the Batumi Shota Rustaveli State University.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">As a result of the clinical examination, there were 107 new and previously unknown cases of asthma diagnosed among children. Based on the assumption that the true occurrence of asthma is reflected by the sum of diagnosed (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>59) and undiagnosed (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>107) asthma cases it could be estimated that in the examined population the likely prevalence of asthma in urban children is 5.1% (95%CI: 4.4%–5.9%). A comparison of that estimate with the estimate provided by the survey (1.8%; 95%CI: 1.3%–2.3%) suggests that only one third of children having asthma have been diagnosed with that disease, resulting in a 65% level of underdiagnosis of pediatric asthma.</p><p id="par0045" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows a comparison of age and body mass index between children with diagnosed and undiagnosed asthma. Children with diagnosed asthma were older, on average, than those with undiagnosed asthma. Likely resulting from this, all the differences in anthropometric measurements were statistically significant. However, the age of diagnosis among those with a previous diagnosis of asthma was statistically lower than the mean age at diagnosis of new cases of asthma (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0001). The distribution of sex did not differ in a statistically significant way between the two groups (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.1): diagnosed asthma – 32.2% of boys; undiagnosed asthma – 44.8% of boys.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Compared to the group with diagnosed asthma, the group with undiagnosed asthma had less frequent diagnosis of chronic bronchitis made by physician in the past (40.6% vs. 24.3%, respectively; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.02), but did not differ in terms of past diagnosis of spastic bronchitis (44.0% vs. 44.8%, respectively; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.9). Moreover, the occurrence of the following physician diagnoses did not differ between two groups in a statistically significant way: pneumonia, sinusitis, tonsillitis, and ear infection.</p><p id="par0055" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the occurrence of allergic disorders diagnosed by physician in the past and of symptoms of allergy reported by the parents. A statistically significantly smaller prevalence of a general diagnosis of allergic disease and hay fever as well as of nasal and eye symptoms was found in children with undiagnosed asthma than in those with diagnosed asthma. The occurrence of isolated cases of such disorders as diabetes, heart diseases, gastro-intestinal diseases and neurological disorders was similar in both groups.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Parents of children with undiagnosed, as compared with parents of children with diagnosed asthma had less frequent diagnosis of asthma (1.8% vs. 8.4%, respectively; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04) and not of chronic bronchitis (7.5% vs. 8.4%, respectively; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.8). Both groups of parents did not differ in terms of questionnaire-derived diagnoses of any allergic disorder, eczema or hay fever.</p><p id="par0065" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the occurrence of selected environmental characteristics of the two study groups. Compared with the group of children with diagnosed asthma, the group of children with undiagnosed asthma had more frequent exposure to tobacco smoke at home (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.01). In the latter group, the higher parental education, dampness in the house, coal/wood-based heating in the house and contact with pets were less frequent than in the group with diagnosed asthma, although the differences were not statistically significant (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><p id="par0070" class="elsevierStylePara elsevierViewall">Results of multivariate analysis confirmed that for diagnosed asthma explanatory variables were older age (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.48; 95%CI: 1.21–1.80; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0001), any allergic disorder in a child diagnosed by physician (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.02; 95%CI: 1.46–6.23; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002), asthma in parents (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5.38; 95%CI: 0.86–33.69; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.07), and exposure to tobacco smoke at home (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.44; 95%CI: 0.21-0.92; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.02). Presence of exposure to tobacco smoke at home was associated with an increased risk of undiagnosed asthma (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.24; 95%PU: 1.08–4.64; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.02).</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The results of our study suggest that the prevalence of pediatric asthma in Batumi, Georgia corrected for underdiagnosis is 5.1% (95%CI: 4.4%–5.9%). The figure of 5.1% is almost three times as large as the estimate of 1.8% (95%CI: 1.3%–2.3%) provided by our cross-sectional survey in the source population composed of urban children.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The obtained difference can be translated to a 65% level of underdiagnosis of pediatric asthma in urban children of Batumi. A smaller difference reflecting a 50% underdiagnosis of pediatric asthma was found in Poland with other European studies showing a comparable prevalence of underdiagnosis of the disease, from 37% in a Danish study to 62% in a Dutch study.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,8,9</span></a> A high prevalence of undiagnosed asthma reaching 50% was also reported for primary care adult patients.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In our earlier communication we hypothesized that some cases of undiagnosed asthma might be included in the diagnostic category of spastic bronchitis.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Current findings do not seem to support such a view since a history of chronic bronchitis and not of spastic bronchitis was more frequent in children with diagnosed than in undiagnosed asthma. However, based on the current clinical evidence we would like to expand that view. In comparison with diagnosed asthma, children with undiagnosed asthma had less frequent history of allergic disorders and of parental asthma. In terms of environmental factors, the two groups compared did not differ in a statistically significant manner except for exposure to tobacco smoke at home, which was more frequent in the undiagnosed asthma group. The latter finding is difficult to explain, although it could convey the effect of social factors. In general, our findings seem to reflect the dominant role of host-related factors and seem to suggest that in pediatric practice in the area studied asthma is more readily diagnosed when respiratory and non-respiratory allergic symptoms are combined and are thus more convincing during diagnostic work-up. Published evidence shows that children with fewer respiratory symptoms, with less severe presentation, or without the usual allergic co-morbidities are more likely to be undiagnosed.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> In pediatric practice such a possibility cannot be neglected in light of the fact that current diagnostic guidelines are often not applied by general practitioners.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> We do not have data regarding insufficient application of pertinent diagnostic standards by pediatricians in Batumi but in our opinion it represents a real problem in primary health units.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Known non-medical factors associated with the underdiagnosis of pediatric asthma include low physical activity, high BMI, serious family problems, passive smoking, under-reporting of symptoms by parents, and poor socioeconomic status.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,13,14</span></a> Our study confirmed the association of passive smoking with underdiagnosis of asthma. However, we did not have access to data concerning the potential role of physical activity of children, family problems or socioeconomic status, except for a vaguely assessed financial standing. On the other hand, some of the described factors may have local/regional specificity due to cultural and social environments or their impact may be masked by their small between-subject variability in a study group. A study in Poland showed that among non-medical factors associated with the underdiagnosis of pediatric asthma, the age of a child plays a major role and other factors of importance include a large distance between residence and health center, and low parental attention at home.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> The meaning of age, also seen in our study, seems to reflect a flow of time in arriving at the convincing diagnosis in less overt cases, in the pediatric practice.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Our study has some limitations. The correction that we used to estimate asthma prevalence was based on the assumption that undiagnosed cases of asthma might be found among children with symptoms suggestive of an asthmatic disorder. We do not claim that we provided the perfect estimate, but it seems unlikely that undiagnosed cases frequently occur among children without chronic respiratory symptoms. Such a risk is more likely in pediatric health care than in questionnaire-driven standard interviews. Indeed, a substantial proportion, even two thirds of children with undiagnosed asthma, do not report their symptoms to a doctor.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The design of our study did not include the examination of rural children. This is why our estimate of underdiagnosis of pediatric asthma is pertinent to the population of the city of Batumi. It cannot be generalized to a rural population even if our original survey showed 2.8% of asthma in rural children, compared to 1.8% of asthma in urban children.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Another potential limitation of our study is related to the lack of clinical verification of the diagnostic accuracy of physician-diagnosed asthma, as reported by parents.</p><p id="par0095" class="elsevierStylePara elsevierViewall">The strengths of our study stem from its design. Firstly, the source data set was large and distinct by a good participation rate of 91% in the urban area.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Secondly, we used a standard questionnaire. Moreover, the selection procedure for clinical examination included children with a wide spectrum of asthma-like symptoms and resulted in a large group of children. It is also important that all children were examined by one pediatrician, who was an allergologist experienced in the field of respiratory diseases and used standard diagnostic criteria.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclusion</span><p id="par0100" class="elsevierStylePara elsevierViewall">In Batumi, Georgia 65% of urban children with asthma remain undiagnosed. The prevalence of pediatric asthma in that population, corrected for underdiagnosis, is 5.1% (95%CI: 4.4%–5.9%) instead of the estimate of 1.8% (95%CI: 1.3%–2.3%) provided by the questionnaire survey. In our study, factors associated with the diagnostic accuracy of pediatric asthma include age, the presence of non-respiratory allergic disorders in children, parental history of asthma, and exposure to tobacco smoke at home. Older age of a child with suspected asthma, co-existing allergic disorders in a child and asthma in parents seem to facilitate the diagnostic process leading to the final diagnosis of pediatric asthma. Implementation of current diagnostic guidelines in pediatric practice should improve diagnostic accuracy and should substantially contribute to more appropriate management of pediatric asthma in Batumi.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This work was supported by <span class="elsevierStyleGrantSponsor" id="gs0005">University of Silesia in Katowice, Poland</span> (intramural grant: <span class="elsevierStyleGrantNumber" refid="gs0005">KNW-1-132/K/8/O</span>).</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1427787" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1304209" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study population and study design" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Definition of asthma status based on survey" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Clinical testing and physician diagnosis of asthma" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Data analysis" ] ] ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Conclusion" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-18" "fechaAceptado" => "2019-05-22" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1304209" "palabras" => array:3 [ 0 => "Asthma" 1 => "Children" 2 => "Underdiagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objective</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A recent survey in Batumi, Georgia showed a low prevalence of asthma in children (1.8%). A potential explanation is underdiagnosis of asthma. To investigate this, we conducted a follow up to the survey with the objective of estimating the level of childhood asthma underdiagnosis and to describe factors related to it.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Subjects included 437 survey participants who had a history of asthma-like symptoms and no diagnosis of asthma. All children underwent clinical examination (spirometry, skin prick tests, FeNO measurement) to identify new cases of asthma. The distribution of host and environmental factors was compared between the group with newly identified asthma and a group of 59 children with previously known asthma (diagnosed asthma).</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Clinical investigation identified 107 cases of undiagnosed asthma. The corrected asthma prevalence estimate was 5.1% (95%CI: 4.4%–5.9%) suggesting that 65% of asthma cases were undiagnosed. Compared to children with diagnosed asthma, children with undiagnosed asthma were younger (8.2<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.6 vs. 9.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.1; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0005), had less frequent history of allergic disorders (38.3% vs. 64.4%; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001), and a lower prevalence of parental asthma (1.8% vs. 8.4%; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04). The groups did not differ in terms of environmental characteristics except for more exposure to passive smoking in the undiagnosed asthma group (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.01). Multivariate analysis confirmed results of simple analyses.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In Batumi, 65% of children with asthma remain undiagnosed. Older age of a child, coexisting allergic disorders, and parental asthma seem to facilitate diagnosis. Implementation of current diagnostic guidelines should improve diagnostic accuracy of pediatric asthma in Batumi.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0060" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnosed asthma (X<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Undiagnosed asthma (X<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P value<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.2<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age of first diagnosis of asthma (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.2<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body Mass Index (kg/m<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>)<span class="elsevierStyleSup">b</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>4.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2449432.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Result of Kruskal-Wallis test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Personal characteristics of 59 children with diagnosed asthma and 107 children with undiagnosed asthma.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0065" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allergic disorder ever diagnosed by a physician/symptom of allergy \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnosed asthma N<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>59 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Undiagnosed asthma N<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>107 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P value<a class="elsevierStyleCrossRef" href="#tblfn0010">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Allergic disease – diagnosis (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (64.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 (38.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eczema – diagnosis (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (1.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0.0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hay fever – diagnosis (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (37.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (11.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sneezing/runny nose – symptom (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 (61.0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 (40.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Itchy/watery eyes – symptom (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (40.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (23.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Recurrent itchy rash – symptom (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (20.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (14.0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2449433.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Result of chi<span class="elsevierStyleSup">2</span> test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Allergic disorders diagnosed by physician in the past in 59 children with diagnosed asthma and 107 children with undiagnosed asthma.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0070" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnosed asthma N<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>59 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Undiagnosedasthma N<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>107 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P value<a class="elsevierStyleCrossRef" href="#tblfn0015">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Good financial standing of family (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (22.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (23.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Above secondary school (both parents) (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (33.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48 (44.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dampness in the house (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (28.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (21.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coal/wood-based heating (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (27.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (21.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pets (dog/cat) at home (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (15.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (10.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Exposure to tobacco smoke at home (n, %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 (49.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74 (69.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2449434.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Result of chi<span class="elsevierStyleSup">2</span> test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Social and environmental characteristics of 59 children with diagnosed asthma and 107 children with undiagnosed asthma.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.K. 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Year/Month | Html | Total | |
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2024 November | 5 | 0 | 5 |
2024 October | 37 | 5 | 42 |
2024 September | 33 | 8 | 41 |
2024 August | 44 | 42 | 86 |
2024 July | 45 | 6 | 51 |
2024 June | 24 | 7 | 31 |
2024 May | 36 | 8 | 44 |
2024 April | 65 | 16 | 81 |
2024 March | 50 | 18 | 68 |
2024 February | 39 | 23 | 62 |
2024 January | 52 | 15 | 67 |
2023 December | 53 | 21 | 74 |
2023 November | 72 | 40 | 112 |
2023 October | 84 | 42 | 126 |
2023 September | 56 | 16 | 72 |
2023 August | 48 | 15 | 63 |
2023 July | 59 | 22 | 81 |
2023 June | 54 | 16 | 70 |
2023 May | 73 | 25 | 98 |
2023 April | 44 | 16 | 60 |
2023 March | 33 | 12 | 45 |
2023 February | 41 | 19 | 60 |
2023 January | 40 | 19 | 59 |
2022 December | 35 | 19 | 54 |
2022 November | 35 | 20 | 55 |
2022 October | 44 | 18 | 62 |
2022 September | 49 | 19 | 68 |
2022 August | 61 | 13 | 74 |
2022 July | 60 | 11 | 71 |
2022 June | 49 | 14 | 63 |
2022 May | 56 | 12 | 68 |
2022 April | 80 | 8 | 88 |
2022 March | 106 | 15 | 121 |
2022 February | 106 | 7 | 113 |
2022 January | 74 | 11 | 85 |
2021 December | 45 | 10 | 55 |
2021 November | 69 | 11 | 80 |
2021 October | 37 | 9 | 46 |
2021 September | 63 | 25 | 88 |
2021 August | 91 | 26 | 117 |
2021 July | 23 | 10 | 33 |
2021 June | 29 | 6 | 35 |
2021 May | 34 | 9 | 43 |
2021 April | 45 | 18 | 63 |
2021 March | 26 | 17 | 43 |
2021 February | 13 | 11 | 24 |
2021 January | 15 | 9 | 24 |
2020 December | 4 | 2 | 6 |
2020 July | 0 | 1 | 1 |
2020 March | 1 | 0 | 1 |
2020 February | 1 | 2 | 3 |
2020 January | 2 | 0 | 2 |
2019 October | 0 | 4 | 4 |
2019 September | 0 | 2 | 2 |