Neutrophil-lymphocyte ratio: a possible marker of remission in children with chronic spontaneous urticaria

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Differences between cord and capillary were compared using the Mann–Whitney U test. (*) significant, p=<0.05; (**) very significant, p=<0.001; and (***) highly significant, p=<0.0001." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Scheffer-Mendoza, S.E. Espinosa-Padilla, G. López-Herrera, F. Mujica-Guzmán, M.G. López-Padilla, L. Berrón-Ruiz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Scheffer-Mendoza" ] 1 => array:2 [ "nombre" => "S.E." "apellidos" => "Espinosa-Padilla" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "López-Herrera" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Mujica-Guzmán" ] 4 => array:2 [ "nombre" => "M.G." "apellidos" => "López-Padilla" ] 5 => array:2 [ "nombre" => "L." "apellidos" => "Berrón-Ruiz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054620300331?idApp=UINPBA00004N" "url" => "/03010546/0000004800000003/v1_202005042259/S0301054620300331/v1_202005042259/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054620300057" "issn" => "03010546" "doi" => "10.1016/j.aller.2019.10.005" "estado" => "S300" "fechaPublicacion" => "2020-05-01" "aid" => "1108" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2020;48:281-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "PDF" => 2 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Sensitisation to aeroallergens in relation to asthma and other allergic diseases in Angolan children: a cross-sectional study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "289" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Margarete Arrais, Ofélia Lulua, Francisca Quifica, José Rosado-Pinto, Jorge M.R. Gama, Miguel Brito, Luis Taborda-Barata" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Margarete" "apellidos" => "Arrais" ] 1 => array:2 [ "nombre" => "Ofélia" "apellidos" => "Lulua" ] 2 => array:2 [ "nombre" => "Francisca" "apellidos" => "Quifica" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Rosado-Pinto" ] 4 => array:2 [ "nombre" => "Jorge M.R." "apellidos" => "Gama" ] 5 => array:2 [ "nombre" => "Miguel" "apellidos" => "Brito" ] 6 => array:2 [ "nombre" => "Luis" "apellidos" => "Taborda-Barata" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054620300057?idApp=UINPBA00004N" "url" => "/03010546/0000004800000003/v1_202005042259/S0301054620300057/v1_202005042259/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Neutrophil-lymphocyte ratio: a possible marker of remission in children with chronic spontaneous urticaria" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "290" "paginaFinal" => "294" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Karaman, B. Turedi" "autores" => array:2 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Karaman" "email" => array:1 [ 0 => "saitkaraman73@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Turedi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Diyarbakır Children’s Hospital, Department of Pediatric Immunology and Allergy, Diyarbakır, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Diyarbakır Children’s Hospital, Department of Pediatric Surgery, Diyarbakır, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1429 "Ancho" => 2508 "Tamanyo" => 161371 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Procedure for inclusion of cases in the study." ] ] ] "textoCompleto" => "IntroductionChronic spontaneous urticaria (CSU) is defined as urticaria lasting for more than six weeks with either known or unknown etiology, characterized by almost daily recurring itching, wheals, and/or angioedema.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Studies in the pediatric age group show that 16.5–37% of children with CSU go into remission within the first year and 36–54% do so within the first three years.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> The disease seriously disturbs the quality of life of patients.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> Currently, there is no marker available that can predict disease prognosis. The limited studies available on this subject are mostly confined to the adult patient population.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> Few studies including adult subjects have shown that the presence of angioedema, positive autologous serum skin test result, and the presence of thyroid antibodies were indicators that chronic urticaria (CU) was unlikely to enter remission in the near future.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> Additionally, remission was shown to be more frequent among children with CSU who were under control with treatment and had low urticaria activity score.<a class="elsevierStyleCrossRef" href="#bib0030">6</a>Our aim with the present study was to investigate the relationship between the natural course of the disease and clinical and laboratory findings in children with CSU, and thus to determine the possible prognostic markers of the disease in children.Materials and methodsFifty-two patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children’s Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study. Inclusion criteria were as follows: (I) disease duration of fewer than three months when included in the study; and (II) follow-up period of at least four months. This study was conducted in accordance with the guidelines of the Ethics Committee of the University of Health Sciences, Diyarbakir Gazi Yasargil Training and Research Hospital (decision dated December 14, 2018, protocol number 2018/187, decision approval 2018/14-12).Detailed anamnesis and physical examination were performed in all patients. All patients were investigated in terms of history of atopic disease, medication use, signs of infection, signs of soft tissue and autoinflammatory diseases, and induced urticaria. If respiratory or food allergy was suspected, respiratory and skin tests were performed. Provocation tests were applied to patients who had findings suggesting physical urticaria. In order to investigate the known causes of CSU, (I) complete blood count, hepatic and renal function tests, erythrocyte sedimentation rate, (II) infection parameters (hepatitis B and C serology, urine culture, Helicobacter pylori IgG in stool and stool microscopy for parasites), (III) autoimmunity panel [antinuclear antibody (ANA), anti-thyroglobulin antibody (anti-TG), anti-thyroperoxidase (anti-TPO) antibody, free T4 and thyroid stimulating hormone (TSH)] were investigated.For the treatment of CSU, second-generation antihistamines were administered as the first level of therapy. Two weeks after treatment, antihistamine doses were increased in patients who could not control the disease with a standard dose of antihistamine. In the treatment of patients whose symptoms persisted despite high antihistamine doses for four weeks, either antihistaminic agent was modified, or antileukotrienes were added. In patients whose symptoms were not controlled after 1–4 weeks with this treatment, H2 antihistamines or omalizumab was administered.<a class="elsevierStyleCrossRefs" href="#bib0035">7,8</a> Patients were invited for follow-up visits once every four weeks. Those who did not have urticarial symptoms for at least three months without use of medication were accepted as being in remission. The patient group in remission and the symptomatic patient group were compared in terms of clinical and laboratory properties.Statistical analysesIBM SPSS version 22.0 (Armonk, NY, USA) was used for all statistical analyses. The Kolmogorov–Smirnov test was used to test the normality of variables. Parametric methods were used for analysis of variables with a normal distribution, whereas non-parametric methods were used for analysis of variables that were not normally distributed. The Pearson’s chi-square and linear-by-linear association tests were used with an exact test for the comparison of categorical data. The categorical data are expressed as a percentage of the number (n) of children evaluated. The level of significance for the analyses was p < 0.05. Correlation of variables was analyzed with Spearman’s rho test.ResultsOne hundred and twenty-eight cases with CU were followed. The diagnosis of chronic inducible urticaria in 48 cases and CSU in 80 cases was confirmed. A total of 52 cases were included in the study (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), and 32 of them (61.5%) were male. Mean age at the time of diagnosis was 9.4 ± 4.4 years, and disease duration was 5.0 ± 3.1 months. Six patients (11.5%) had additional atopic disease (two patients had allergic rhinitis, two had asthma, and two had both). Twelve patients (23%) were detected to have autoimmunity. Among these patients, two patients had hashimoto thyroiditis, and one patient had type 1 diabetes mellitus disease. In the other nine patients only autoantibodies were detected. Helicobacter pylori IgG antibody was detected in six (11.5%) patients. Two of these patients developed remission with treatment. Mean erythrocyte sedimentation rate (ESR) was 15.4 ± 10.3 mm/h; mean serum total IgE antibody level was 76.8 ± 107.0 IU/L; mean absolute neutrophil count was 4.7 ± 2.0 × 103/µl; mean absolute lymphocyte count was 3.2 ± 1.5 × 103/µl; mean neutrophil/lymphocyte ratio (NLR) was 1.8 ± 1.6; mean absolute eosinophil count was 0.2 ± 0.2 × 103/µl; mean absolute basophil count was 0.03 ± 0.02 × 103/µl; and mean platelet count was 315.2 ± 90.8 × 103/µl (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Thirty-one cases with CSU were controlled by a standard dose of second-generation antihistamines, and 14 cases were controlled by increased dosage of antihistamines. Five cases with CSU were controlled by modification of second-generation antihistamines, and two cases were controlled by the addition of antileukotrienes to antihistamines.<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Twenty-four (46.2%) patients went into remission. Upon comparing the remission group and the symptomatic group in terms of demographic properties including sex, age at diagnosis, duration of urticaria and additional atopic disease, it was found that younger age at diagnosis and short duration of urticaria were good prognostic indicators. With regard to laboratory findings including autoimmunity, ESR, Helicobacter pylori IgG antibody, serum total IgE level, absolute neutrophil count, absolute lymphocyte count, NLR, absolute eosinophil count, absolute basophil count and platelet count, it was found that those with higher neutrophil count and NLR had lower remission rate (p < 0.05) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). While there was no correlation between absolute neutrophil count and disease duration (p > 0.05), a positive correlation was found between NLR and disease duration (p < 0.05).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>DiscussionIn this study, we found that younger age at diagnosis and being in the initial months of the disease were associated with good prognosis, while elevated absolute neutrophil count and neutrophil/lymphocyte ratio were associated with poor prognosis in children with CSU. A positive correlation was found between neutrophil/lymphocyte ratio and disease duration.The majority of patients with CSU have been reported to be aged between 20–59 years old.<a class="elsevierStyleCrossRef" href="#bib0045">9</a> In a study of 117 patients with CSU from the adult and pediatric age populations, Hiragun et al.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> reported that those younger than 19 years old had greater remission rates compared to older patients. Similarly, we found more frequent remission among younger patients in the present study.Most adult patients with CSU are reported to be women; however there are very few studies that investigated whether there is any difference between the sexes with regard to remission.<a class="elsevierStyleCrossRef" href="#bib0050">10</a> In their study of adult CSU patients, Gregoriou et al.<a class="elsevierStyleCrossRef" href="#bib0055">11</a> reported that female patients went into remission later than male patients. Similarly, in their study, Harris et al.<a class="elsevierStyleCrossRef" href="#bib0060">12</a> retrospectively evaluated 52 children with CU and found a remission rate of 37% among females at the end of one year, and reported that this rate was greater compared to males. On the contrary, Chansakulporn et al.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> did not find a difference between sexes regarding remission rates in their study including children with CSU. Sahiner et al.<a class="elsevierStyleCrossRef" href="#bib0070">14</a> studied the pediatric age group of patients with CU, and reported that prognosis with regard to remission was not good in females older than 10 years old. Consistent with the literature, we found no difference between sexes regarding remission rates.Epidemiological studies showed that while approximately 50% of adult patients with CSU enter remission within the first three months, 80% do so within the first year, and 11% remain symptomatic even after the 5th year.<a class="elsevierStyleCrossRef" href="#bib0075">15</a> In their study, Eser et al.<a class="elsevierStyleCrossRef" href="#bib0080">16</a> retrospectively evaluated 52 pediatric patients with CSU and found that disease duration at time of initial presentation was longer among late-remitting cases. On the other hand, Chansakulporn et al.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> reported that disease duration was not a remission marker in their study including adult CSU patients. In line with the literature, we found that patients mostly went into remission during the initial month of the disease.Contradicting results have been found in studies investigating the relationship between autoimmunity and remission in CSU. In their study including an adult group of patients with CU, Kulthanan et al.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> reported that there was no association of remission with either positive or negative autologous serum test result. In contrast, Staubach et al.<a class="elsevierStyleCrossRef" href="#bib0090">18</a> reported that remission occurred later among adult cases with positive autologous serum skin test result. In their study of adult patients, Chanprapaph et al.<a class="elsevierStyleCrossRef" href="#bib0095">19</a> reported that thyroid peroxidase antibody was a remission marker in CSU patients with autoimmune thyroiditis. Consistent with the literature, we found that there was no relationship between autoimmunity and remission.Many studies have reported that CSU is a systemic chronic inflammatory disease.<a class="elsevierStyleCrossRef" href="#bib0100">20</a> NLR has been used as a marker of systemic inflammation in various diseases because the physiological response of circulating leukocytes in the human body to stress is an elevation in neutrophil count and a reduction in lymphocyte count.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> However, the number of patients evaluated is limited and further studies are required to confirm the role of NLR as a remission marker. Ye et al.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> reported a correlation of uncontrollable CU with C3, TNF-α, and eosinophilic cationic protein levels. Aleem et al.<a class="elsevierStyleCrossRef" href="#bib0115">23</a> reported that CRP level was correlated with CSU activity and could be used as a remission marker. Consistent with the literature, we found both neutrophil count and NLR among inflammation markers were elevated in the symptomatic patient group. Additionally, there was a positive correlation between NLR and disease duration.Various basophil-associated disorders have been reported in patients with CSU. Grattan et al.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> reported a relationship between circulating basophil levels and CU disease activity score, with reduced basophil count in patients with CU. Ye et al.<a class="elsevierStyleCrossRef" href="#bib0125">25</a> stated that reduction in basophil count could be a marker of severe CU in such patients. In their study including adult CSU patients, Berti et al.<a class="elsevierStyleCrossRef" href="#bib0130">26</a> reported that positive histamine release test result was an indicator of whether remission will occur before 12 months. In contrast to the literature, we did not find a relationship between basophil count and remission in the present study.Elevated serum total IgE levels have been shown in 93% of patients with CU. In their study including adult patients, Kessel et al.<a class="elsevierStyleCrossRef" href="#bib0135">27</a> showed that serum total IgE level was frequently elevated in cases with CU and was associated with both disease severity and duration. Unlike the literature findings, we did not find a relationship between serum total IgE level and remission.In conclusion, our results show that remission was achieved sooner when onset of CSU was at a younger age in children. We found reduced remission rates as the disease duration increased. Among inflammation markers, neutrophil count and neutrophil/lymphocyte ratio are elevated in CSU patients with poor prognosis. Neutrophil/lymphocyte ratio can be used as a remission marker in CSU.Ethical approvalApproval by the local ethics committee was granted.Funding sourceNo external funding was secured for this study.Financial disclosureThe authors have no financial relationships relevant to this article to disclose.Conflict of interestThe authors have no conflicts of interest to disclose." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1332607" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1227728" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analyses" ] ] ] 4 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Ethical approval" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Funding source" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Financial disclosure" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-18" "fechaAceptado" => "2019-11-12" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1227728" "palabras" => array:4 [ 0 => "Allergy" 1 => "Children" 2 => "Chronic" 3 => "Urticaria" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "BackgroundChronic spontaneous urticaria (CSU) is a disease that seriously disturbs the quality of life of the patient. Currently there is no prognostic marker of the disease. Our aim in this study was to determine possible prognostic markers of CSU in children. MethodAll patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children’s Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study. Clinical and laboratory findings were compared between the symptomatic patient group and the patient group that remained in remission for at least three months without use of medication. ResultsOf the 52 cases included in the study, 32 (61.5%) were male. Mean age at time of diagnosis was 9.4 ± 4.4 years. Twenty-four cases (46.2%) went into remission. Young age at the time of diagnosis and being in the initial months of the disease were found to be associated with good prognosis (p < 0.05). Among laboratory results, elevation in absolute neutrophil count and neutrophil/lymphocyte ratio (NLR) were found to be associated with poor prognosis (p < 0.05). NLR was positively correlated with disease duration (p < 0.05). ConclusionFor childhood CSU, younger age and initial months of the disease are good prognostic indicators, while only neutrophil/lymphocyte count can be used as a remission marker." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1429 "Ancho" => 2508 "Tamanyo" => 161371 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Procedure for inclusion of cases in the study." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender (male), n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 (61.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age, years<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.4 ± 4.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disease duration, month<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.0 ± 3.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Atopic disease, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Remission, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (46.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Autoimmunity, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (23) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Helicobacter pylori IgG, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sedimentation (mm/h)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.4 ± 10.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Serum total IgE level (IU/L)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.8 ± 107.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute neutrophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.7 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute lymphocyte count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 ± 1.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neutrophil-lymphocyte ratio<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.8 ± 1.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute eosinophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute basophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 ± 0.02 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Platelet count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">315.2 ± 90.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2284127.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Mean ± SD." ] ] ] "descripcion" => array:1 [ "en" => "General characteristics of 52 patients." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "p-value of less than 0.05 are bolded." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Remission group, n = 24 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Symptomatic group, n = 28 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender (male), n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (62.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (60.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.202 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age, years<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.0 ± 4.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.5 ± 4.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.046 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disease duration, months<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.5 ± 2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.4 ± 3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Atopic disease, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (8.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (14.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.473 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Autoimmunity, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (20.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7(19.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.785 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Helicobacter pylori IgG, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (17.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.475 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sedimentation (mm/h)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.9 ± 11.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.1 ± 9.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.806 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Serum total IgE level (IU/L)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72.5 ± 92.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80.2 ± 119.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.812 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute neutrophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.3 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.3 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute lymphocyte count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.3 ± 1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 ± 1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.749 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neutrophil-lymphocyte ratio<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3 ± 0.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.26 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.036 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute eosinophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.939 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absolute basophil count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 ± 0.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 ± 0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.958 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Platelet count (×103/µl)<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">329.7 ± 115.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">303.3 ± 63.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.307 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2284126.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "Mean ± SD." ] ] ] "descripcion" => array:1 [ "en" => "Comparison of remission group and symptomatic group in patients with chronic spontaneous urticaria." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2018 revision and update" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. 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S. Karamana,

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saitkaraman73@gmail.com

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, B. Turedib

a Diyarbakır Children’s Hospital, Department of Pediatric Immunology and Allergy, Diyarbakır, Turkey

b Diyarbakır Children’s Hospital, Department of Pediatric Surgery, Diyarbakır, Turkey

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    "titulo" => "Neutrophil-lymphocyte ratio&#58; a possible marker of remission in children with chronic spontaneous urticaria"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic spontaneous urticaria &#40;CSU&#41; is defined as urticaria lasting for more than six weeks with either known or unknown etiology&#44; characterized by almost daily recurring itching&#44; wheals&#44; and&#47;or angioedema&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Studies in the pediatric age group show that 16&#46;5&#8211;37&#37; of children with CSU go into remission within the first year and 36&#8211;54&#37; do so within the first three years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The disease seriously disturbs the quality of life of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Currently&#44; there is no marker available that can predict disease prognosis&#46; The limited studies available on this subject are mostly confined to the adult patient population&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Few studies including adult subjects have shown that the presence of angioedema&#44; positive autologous serum skin test result&#44; and the presence of thyroid antibodies were indicators that chronic urticaria &#40;CU&#41; was unlikely to enter remission in the near future&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Additionally&#44; remission was shown to be more frequent among children with CSU who were under control with treatment and had low urticaria activity score&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our aim with the present study was to investigate the relationship between the natural course of the disease and clinical and laboratory findings in children with CSU&#44; and thus to determine the possible prognostic markers of the disease in children&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">Fifty-two patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children&#8217;s Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study&#46; Inclusion criteria were as follows&#58; &#40;I&#41; disease duration of fewer than three months when included in the study&#59; and &#40;II&#41; follow-up period of at least four months&#46; This study was conducted in accordance with the guidelines of the Ethics Committee of the University of Health Sciences&#44; Diyarbakir Gazi Yasargil Training and Research Hospital &#40;decision dated December 14&#44; 2018&#44; protocol number 2018&#47;187&#44; decision approval 2018&#47;14-12&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Detailed anamnesis and physical examination were performed in all patients&#46; All patients were investigated in terms of history of atopic disease&#44; medication use&#44; signs of infection&#44; signs of soft tissue and autoinflammatory diseases&#44; and induced urticaria&#46; If respiratory or food allergy was suspected&#44; respiratory and skin tests were performed&#46; Provocation tests were applied to patients who had findings suggesting physical urticaria&#46; In order to investigate the known causes of CSU&#44; &#40;I&#41; complete blood count&#44; hepatic and renal function tests&#44; erythrocyte sedimentation rate&#44; &#40;II&#41; infection parameters &#40;hepatitis B and C serology&#44; urine culture&#44; Helicobacter pylori IgG in stool and stool microscopy for parasites&#41;&#44; &#40;III&#41; autoimmunity panel &#91;antinuclear antibody &#40;ANA&#41;&#44; anti-thyroglobulin antibody &#40;anti-TG&#41;&#44; anti-thyroperoxidase &#40;anti-TPO&#41; antibody&#44; free T4 and thyroid stimulating hormone &#40;TSH&#41;&#93; were investigated&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For the treatment of CSU&#44; second-generation antihistamines were administered as the first level of therapy&#46; Two weeks after treatment&#44; antihistamine doses were increased in patients who could not control the disease with a standard dose of antihistamine&#46; In the treatment of patients whose symptoms persisted despite high antihistamine doses for four weeks&#44; either antihistaminic agent was modified&#44; or antileukotrienes were added&#46; In patients whose symptoms were not controlled after 1&#8211;4 weeks with this treatment&#44; H2 antihistamines or omalizumab was administered&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> Patients were invited for follow-up visits once every four weeks&#46; Those who did not have urticarial symptoms for at least three months without use of medication were accepted as being in remission&#46; The patient group in remission and the symptomatic patient group were compared in terms of clinical and laboratory properties&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Statistical analyses</span><p id="par0030" class="elsevierStylePara elsevierViewall">IBM SPSS version 22&#46;0 &#40;Armonk&#44; NY&#44; USA&#41; was used for all statistical analyses&#46; The Kolmogorov&#8211;Smirnov test was used to test the normality of variables&#46; Parametric methods were used for analysis of variables with a normal distribution&#44; whereas non-parametric methods were used for analysis of variables that were not normally distributed&#46; The Pearson&#8217;s chi-square and linear-by-linear association tests were used with an exact test for the comparison of categorical data&#46; The categorical data are expressed as a percentage of the number &#40;n&#41; of children evaluated&#46; The level of significance for the analyses was p&#8239;&#60;&#8239;0&#46;05&#46; Correlation of variables was analyzed with Spearman&#8217;s rho test&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">One hundred and twenty-eight cases with CU were followed&#46; The diagnosis of chronic inducible urticaria in 48 cases and CSU in 80 cases was confirmed&#46; A total of 52 cases were included in the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and 32 of them &#40;61&#46;5&#37;&#41; were male&#46; Mean age at the time of diagnosis was 9&#46;4&#8239;&#177;&#8239;4&#46;4 years&#44; and disease duration was 5&#46;0&#8239;&#177;&#8239;3&#46;1 months&#46; Six patients &#40;11&#46;5&#37;&#41; had additional atopic disease &#40;two patients had allergic rhinitis&#44; two had asthma&#44; and two had both&#41;&#46; Twelve patients &#40;23&#37;&#41; were detected to have autoimmunity&#46; Among these patients&#44; two patients had hashimoto thyroiditis&#44; and one patient had type 1 diabetes mellitus disease&#46; In the other nine patients only autoantibodies were detected&#46; Helicobacter pylori IgG antibody was detected in six &#40;11&#46;5&#37;&#41; patients&#46; Two of these patients developed remission with treatment&#46; Mean erythrocyte sedimentation rate &#40;ESR&#41; was 15&#46;4&#8239;&#177;&#8239;10&#46;3&#8239;mm&#47;h&#59; mean serum total IgE antibody level was 76&#46;8&#8239;&#177;&#8239;107&#46;0&#8239;IU&#47;L&#59; mean absolute neutrophil count was 4&#46;7&#8239;&#177;&#8239;2&#46;0&#8239;&#215;&#8239;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#59; mean absolute lymphocyte count was 3&#46;2&#8239;&#177;&#8239;1&#46;5&#8239;&#215;&#8239;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#59; mean neutrophil&#47;lymphocyte ratio &#40;NLR&#41; was 1&#46;8&#8239;&#177;&#8239;1&#46;6&#59; mean absolute eosinophil count was 0&#46;2&#8239;&#177;&#8239;0&#46;2&#8239;&#215;&#8239;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#59; mean absolute basophil count was 0&#46;03&#8239;&#177;&#8239;0&#46;02&#8239;&#215;&#8239;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#59; and mean platelet count was 315&#46;2&#8239;&#177;&#8239;90&#46;8&#8239;&#215;&#8239;10<span class="elsevierStyleSup">3</span>&#47;&#181;l &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Thirty-one cases with CSU were controlled by a standard dose of second-generation antihistamines&#44; and 14 cases were controlled by increased dosage of antihistamines&#46; Five cases with CSU were controlled by modification of second-generation antihistamines&#44; and two cases were controlled by the addition of antileukotrienes to antihistamines&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Twenty-four &#40;46&#46;2&#37;&#41; patients went into remission&#46; Upon comparing the remission group and the symptomatic group in terms of demographic properties including sex&#44; age at diagnosis&#44; duration of urticaria and additional atopic disease&#44; it was found that younger age at diagnosis and short duration of urticaria were good prognostic indicators&#46; With regard to laboratory findings including autoimmunity&#44; ESR&#44; Helicobacter pylori IgG antibody&#44; serum total IgE level&#44; absolute neutrophil count&#44; absolute lymphocyte count&#44; NLR&#44; absolute eosinophil count&#44; absolute basophil count and platelet count&#44; it was found that those with higher neutrophil count and NLR had lower remission rate &#40;p&#8239;&#60;&#8239;0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; While there was no correlation between absolute neutrophil count and disease duration &#40;p&#8239;&#62;&#8239;0&#46;05&#41;&#44; a positive correlation was found between NLR and disease duration &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In this study&#44; we found that younger age at diagnosis and being in the initial months of the disease were associated with good prognosis&#44; while elevated absolute neutrophil count and neutrophil&#47;lymphocyte ratio were associated with poor prognosis in children with CSU&#46; A positive correlation was found between neutrophil&#47;lymphocyte ratio and disease duration&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The majority of patients with CSU have been reported to be aged between 20&#8211;59 years old&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In a study of 117 patients with CSU from the adult and pediatric age populations&#44; Hiragun et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> reported that those younger than 19 years old had greater remission rates compared to older patients&#46; Similarly&#44; we found more frequent remission among younger patients in the present study&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Most adult patients with CSU are reported to be women&#59; however there are very few studies that investigated whether there is any difference between the sexes with regard to remission&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In their study of adult CSU patients&#44; Gregoriou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> reported that female patients went into remission later than male patients&#46; Similarly&#44; in their study&#44; Harris et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> retrospectively evaluated 52 children with CU and found a remission rate of 37&#37; among females at the end of one year&#44; and reported that this rate was greater compared to males&#46; On the contrary&#44; Chansakulporn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> did not find a difference between sexes regarding remission rates in their study including children with CSU&#46; Sahiner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> studied the pediatric age group of patients with CU&#44; and reported that prognosis with regard to remission was not good in females older than 10 years old&#46; Consistent with the literature&#44; we found no difference between sexes regarding remission rates&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Epidemiological studies showed that while approximately 50&#37; of adult patients with CSU enter remission within the first three months&#44; 80&#37; do so within the first year&#44; and 11&#37; remain symptomatic even after the 5th year&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> In their study&#44; Eser et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> retrospectively evaluated 52 pediatric patients with CSU and found that disease duration at time of initial presentation was longer among late-remitting cases&#46; On the other hand&#44; Chansakulporn et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> reported that disease duration was not a remission marker in their study including adult CSU patients&#46; In line with the literature&#44; we found that patients mostly went into remission during the initial month of the disease&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Contradicting results have been found in studies investigating the relationship between autoimmunity and remission in CSU&#46; In their study including an adult group of patients with CU&#44; Kulthanan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> reported that there was no association of remission with either positive or negative autologous serum test result&#46; In contrast&#44; Staubach et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported that remission occurred later among adult cases with positive autologous serum skin test result&#46; In their study of adult patients&#44; Chanprapaph et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> reported that thyroid peroxidase antibody was a remission marker in CSU patients with autoimmune thyroiditis&#46; Consistent with the literature&#44; we found that there was no relationship between autoimmunity and remission&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Many studies have reported that CSU is a systemic chronic inflammatory disease&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> NLR has been used as a marker of systemic inflammation in various diseases because the physiological response of circulating leukocytes in the human body to stress is an elevation in neutrophil count and a reduction in lymphocyte count&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> However&#44; the number of patients evaluated is limited and further studies are required to confirm the role of NLR as a remission marker&#46; Ye et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> reported a correlation of uncontrollable CU with C3&#44; TNF-&#945;&#44; and eosinophilic cationic protein levels&#46; Aleem et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> reported that CRP level was correlated with CSU activity and could be used as a remission marker&#46; Consistent with the literature&#44; we found both neutrophil count and NLR among inflammation markers were elevated in the symptomatic patient group&#46; Additionally&#44; there was a positive correlation between NLR and disease duration&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Various basophil-associated disorders have been reported in patients with CSU&#46; Grattan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> reported a relationship between circulating basophil levels and CU disease activity score&#44; with reduced basophil count in patients with CU&#46; Ye et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> stated that reduction in basophil count could be a marker of severe CU in such patients&#46; In their study including adult CSU patients&#44; Berti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> reported that positive histamine release test result was an indicator of whether remission will occur before 12 months&#46; In contrast to the literature&#44; we did not find a relationship between basophil count and remission in the present study&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Elevated serum total IgE levels have been shown in 93&#37; of patients with CU&#46; In their study including adult patients&#44; Kessel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> showed that serum total IgE level was frequently elevated in cases with CU and was associated with both disease severity and duration&#46; Unlike the literature findings&#44; we did not find a relationship between serum total IgE level and remission&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In conclusion&#44; our results show that remission was achieved sooner when onset of CSU was at a younger age in children&#46; We found reduced remission rates as the disease duration increased&#46; Among inflammation markers&#44; neutrophil count and neutrophil&#47;lymphocyte ratio are elevated in CSU patients with poor prognosis&#46; Neutrophil&#47;lymphocyte ratio can be used as a remission marker in CSU&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Ethical approval</span><p id="par0090" class="elsevierStylePara elsevierViewall">Approval by the local ethics committee was granted&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding source</span><p id="par0095" class="elsevierStylePara elsevierViewall">No external funding was secured for this study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Financial disclosure</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no financial relationships relevant to this article to disclose&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to disclose&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Chronic spontaneous urticaria &#40;CSU&#41; is a disease that seriously disturbs the quality of life of the patient&#46; Currently there is no prognostic marker of the disease&#46; Our aim in this study was to determine possible prognostic markers of CSU in children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">All patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children&#8217;s Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study&#46; Clinical and laboratory findings were compared between the symptomatic patient group and the patient group that remained in remission for at least three months without use of medication&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Of the 52 cases included in the study&#44; 32 &#40;61&#46;5&#37;&#41; were male&#46; Mean age at time of diagnosis was 9&#46;4&#8239;&#177;&#8239;4&#46;4 years&#46; Twenty-four cases &#40;46&#46;2&#37;&#41; went into remission&#46; Young age at the time of diagnosis and being in the initial months of the disease were found to be associated with good prognosis &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#46; Among laboratory results&#44; elevation in absolute neutrophil count and neutrophil&#47;lymphocyte ratio &#40;NLR&#41; were found to be associated with poor prognosis &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#46; NLR was positively correlated with disease duration &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">For childhood CSU&#44; younger age and initial months of the disease are good prognostic indicators&#44; while only neutrophil&#47;lymphocyte count can be used as a remission marker&#46;</p></span>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender &#40;male&#41;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">32 &#40;61&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Age&#44; years<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;4&#8239;&#177;&#8239;4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disease duration&#44; month<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;0&#8239;&#177;&#8239;3&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atopic disease&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Remission&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;46&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Autoimmunity&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Helicobacter pylori IgG&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedimentation &#40;mm&#47;h&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;4&#8239;&#177;&#8239;10&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serum total IgE level &#40;IU&#47;L&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;8&#8239;&#177;&#8239;107&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute neutrophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;7&#8239;&#177;&#8239;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute lymphocyte count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2&#8239;&#177;&#8239;1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neutrophil-lymphocyte ratio<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;8&#8239;&#177;&#8239;1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute eosinophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#8239;&#177;&#8239;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute basophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03&#8239;&#177;&#8239;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelet count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">315&#46;2&#8239;&#177;&#8239;90&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Remission group&#44; n&#8239;&#61;&#8239;24&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender &#40;male&#41;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17 &#40;62&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15 &#40;60&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; years<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;0&#8239;&#177;&#8239;4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;5&#8239;&#177;&#8239;4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;046</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disease duration&#44; months<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5&#8239;&#177;&#8239;2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;4&#8239;&#177;&#8239;3&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atopic disease&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;14&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;473&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Autoimmunity&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;20&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#40;19&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;785&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Helicobacter pylori IgG&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;17&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;475&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sedimentation &#40;mm&#47;h&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;9&#8239;&#177;&#8239;11&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;1&#8239;&#177;&#8239;9&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serum total IgE level &#40;IU&#47;L&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;5&#8239;&#177;&#8239;92&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;2&#8239;&#177;&#8239;119&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;812&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute neutrophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;3&#8239;&#177;&#8239;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;3&#8239;&#177;&#8239;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;028</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute lymphocyte count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;3&#8239;&#177;&#8239;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2&#8239;&#177;&#8239;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;749&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neutrophil-lymphocyte ratio<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#8239;&#177;&#8239;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;26&#8239;&#177;&#8239;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;036</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute eosinophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#8239;&#177;&#8239;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#8239;&#177;&#8239;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absolute basophil count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03&#8239;&#177;&#8239;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03&#8239;&#177;&#8239;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;958&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelet count &#40;&#215;10<span class="elsevierStyleSup">3</span>&#47;&#181;l&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">329&#46;7&#8239;&#177;&#8239;115&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303&#46;3&#8239;&#177;&#8239;63&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comparison of remission group and symptomatic group in patients with chronic spontaneous urticaria&#46;</p>"
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                0 => array:2 [
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                      "titulo" => "The EAACI&#47;GA<span class="elsevierStyleSup">2</span>LEN&#47;EDF&#47;WAO Guideline for the definition&#44; classification&#44; diagnosis&#44; and management of urticaria&#58; the 2018 revision and update"
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                            0 => "T&#46; Zuberbier"
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                            2 => "R&#46; Asero"
                            3 => "A&#46;H&#46; Abdul latiff"
                            4 => "D&#46; Baker"
                            5 => "B&#46; Balmer-Weber"
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                    0 => array:2 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29336054"
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                      "titulo" => "The natural history ofchronic urticaria in childhood&#58; a prospective study"
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                            0 => "S&#46; Chansakulporn"
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                            2 => "P&#46; Sangacharoenkit"
                            3 => "P&#46; Pacharn"
                            4 => "N&#46; Visitsunthorn"
                            5 => "P&#46; Vichyanond"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.05.069"
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                      "titulo" => "Unmet clinical needs in chronic spontaneous urticaria&#46; A GA&#178;LEN task force report"
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                          "etal" => true
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                            2 => "C&#46; Bindslev-Jensen"
                            3 => "A&#46; Gim&#233;nez-Arnau"
                            4 => "P&#46;J&#46; Bousquet"
                            5 => "J&#46; Bousquet"
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                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2010.02496.x"
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                            2 => "S&#46; Mihara"
                            3 => "T&#46; Akita"
                            4 => "J&#46; Tanaka"
                            5 => "M&#46; Hide"
                          ]
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                      "doi" => "10.1111/all.12078"
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                      "titulo" => "Clinical and laboratory parameters in predicting chronic urticarial duration&#58; a prospective study of 139 patients"
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Article information

ISSN: 03010546
Original language: English

DOI:10.1016/j.aller.2019.11.007

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Year/Month	Html	Pdf	Total

2024 November	9	0	9
2024 October	50	12	62
2024 September	67	19	86
2024 August	85	21	106
2024 July	94	15	109
2024 June	72	21	93
2024 May	52	13	65
2024 April	79	13	92
2024 March	84	25	109
2024 February	110	18	128
2024 January	105	26	131
2023 December	81	35	116
2023 November	113	29	142
2023 October	81	39	120
2023 September	78	16	94
2023 August	71	17	88
2023 July	111	33	144
2023 June	101	19	120
2023 May	127	20	147
2023 April	129	19	148
2023 March	129	15	144
2023 February	105	17	122
2023 January	90	15	105
2022 December	88	29	117
2022 November	77	32	109
2022 October	103	21	124
2022 September	79	28	107
2022 August	102	20	122
2022 July	71	27	98
2022 June	61	22	83
2022 May	67	26	93
2022 April	74	12	86
2022 March	96	30	126
2022 February	74	17	91
2022 January	100	30	130
2021 December	40	30	70
2021 November	64	19	83
2021 October	73	13	86
2021 September	67	17	84
2021 August	82	6	88
2021 July	40	17	57
2021 June	43	21	64
2021 May	56	16	72
2021 April	89	31	120
2021 March	34	16	50
2021 February	32	15	47
2021 January	31	14	45
2020 December	5	2	7
2020 August	2	0	2
2020 July	0	1	1
2020 June	1	2	3
2020 May	1	2	3

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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