array:23 [ "pii" => "S0301054611002424" "issn" => "03010546" "doi" => "10.1016/j.aller.2011.04.006" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "aid" => "310" "copyright" => "SEICAP" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2012;40:210-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2831 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 2287 "PDF" => 536 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054611002527" "issn" => "03010546" "doi" => "10.1016/j.aller.2011.05.014" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "aid" => "320" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2012;40:215-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1824 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1414 "PDF" => 403 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Plasma adrenomedullin levels in children with asthma: Any relation with atopic dermatitis?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "215" "paginaFinal" => "219" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1189 "Ancho" => 1658 "Tamanyo" => 87557 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Plasma adrenomedullin levels in patients with severe asthma attack (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.043).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Kucukosmanoglu, O. Keskin, M. Karcin, M. Cekmen, A. Balat" "autores" => array:5 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Kucukosmanoglu" ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Keskin" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Karcin" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Cekmen" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Balat" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054611002527?idApp=UINPBA00004N" "url" => "/03010546/0000004000000004/v1_201304101110/S0301054611002527/v1_201304101110/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S030105461100262X" "issn" => "03010546" "doi" => "10.1016/j.aller.2011.06.006" "estado" => "S300" "fechaPublicacion" => "2012-07-01" "aid" => "330" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2012;40:204-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2370 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 1805 "PDF" => 555 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Role of laryngoscopy in children with respiratory complaints and suspected reflux" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "204" "paginaFinal" => "209" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3005 "Ancho" => 2839 "Tamanyo" => 383100 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The distribution of our patients.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Ozmen, F. Demirceken, Y. Barut, E. Dibek Misirlioglu" "autores" => array:4 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Ozmen" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Demirceken" ] 2 => array:2 [ "nombre" => "Y." "apellidos" => "Barut" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Dibek Misirlioglu" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030105461100262X?idApp=UINPBA00004N" "url" => "/03010546/0000004000000004/v1_201304101110/S030105461100262X/v1_201304101110/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Anti-inflammatory effects of curcumin in a murine model of chronic asthma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "210" "paginaFinal" => "214" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Karaman, F. Firinci, S. Cilaker, P. Uysal, K. Tugyan, O. Yilmaz, N. Uzuner, O. Karaman" "autores" => array:8 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Karaman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "F." "apellidos" => "Firinci" "email" => array:2 [ 0 => "fatih.firinci@deu.edu.tr" 1 => "fatihfirinci@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Cilaker" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Uysal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "K." "apellidos" => "Tugyan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "O." "apellidos" => "Yilmaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "N." "apellidos" => "Uzuner" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "O." "apellidos" => "Karaman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Multidisciplinary Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Pediatric Allergy and Immunology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Histology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1169 "Ancho" => 3109 "Tamanyo" => 724038 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Light microscopic findings of groups I–VI. I: asthma; II: curcumin 10; III: curcumin 20; IV: dexamethasone; V: DMSO, VI: control group. In representative histological images, lung tissues were stained with H&E (A), PAS (B) and toluidine blue (C). In Asthma (IA), DMSO (VA) and Cur10 (IIA) groups, H&E staining revealed thickened epithelium, thickened subepithelial smooth muscle (arrow with two heads) and peribronchiolar mononuclear infiltration (*). High numbers of goblet cells (arrows) were seen with PAS-staining in asthma (IB), DMSO (VB) and Cur10 (IIB) and mast cells with toluidine blue staining in asthma (IC), DMSO (VC) and Cur10 (IIC). In Cur20 group, subepithelial smooth muscle thickness decreased and a reduction in the number of goblet and mast cells were observed compared to the DMSO and cur10 groups. Cur20 suppressed goblet cell hyperplasia in lung tissue.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Asthma is one of the most common chronic respiratory diseases in industrialised countries and imposes high social and economic costs. Additionally, disease outcomes remain suboptimal despite current effective treatment modalities.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Many parents err on the side of caution about conventional medical treatments for asthma, particularly inhaled corticosteroid treatment, therefore, adherence to current therapies is frequently poor.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> The use of complementary and alternative treatments in asthma patients is increasing as an adjunct and also as a substitute for effective and proven anti-inflammatory therapies.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> Herbal preparations have been cited as one of the most popular complementary treatment modalities used by asthmatic patients.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> There are reports that 11–40% of people with asthma use herbal remedies.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,7</span></a> Many important drugs currently used to treat asthma such as B2-agonists, anticholinergics, methylxanthines, and cromones have herbal origins.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Curcumin (diferuloylmethane), a dietary pigment responsible for the yellow colour of curry, has been shown to exhibit anti-inflammatory, anti-tumour, anti-oxidant, and anti-viral activities.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–14</span></a> Modulatory effects of curcumin on immune functions include inhibition of lymphocyte proliferation, and the production of monocyte chemotactic protein and tumour necrosis factor.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,16</span></a> Consequently, curcumin may have potential efficacy in controlling inflammatory diseases. Indeed, curcumin has been used for the treatment of various inflammatory diseases in certain countries.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,16</span></a> The possible benefits of curcumin in asthma treatment have yet to be thoroughly investigated. Therefore, in this study, our aim is to investigate the efficacy of curcumin on lung histopathology in a murine model of chronic asthma.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Experimental animals</span><p id="par0015" class="elsevierStylePara elsevierViewall">Specific pathogen-free, 6- to 8-week-old, female BALB/c mice, weighting 18–20<span class="elsevierStyleHsp" style=""></span>g, were maintained in a pathogen-free laboratory of Dokuz Eylul University. They were kept in hygienic macrolene cages in air-conditioned rooms and allowed ad libitum with food and water on a 12-h light/12-h dark cycle. All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of the Dokuz Eylul University. Thirty-five BALB/c mice were divided into six groups: I, II, III, IV, V, and control group, with each group including seven mice.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Sensitisation and inhalational exposure</span><p id="par0020" class="elsevierStylePara elsevierViewall">BALB/c mice are high responders to ovalbumin.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The mice in study groups I, II, III, IV, and V were sensitised via two intraperitoneal injections, on days 0 and 14 of the experiment, of 10<span class="elsevierStyleHsp" style=""></span>μg/0.1<span class="elsevierStyleHsp" style=""></span>mL chicken egg albumin (ovalbumin, grade V, ≥98% pure; Sigma, St. Louis, MO, USA) with alum as an adjuvant. The mice in study groups I, II, III, IV, and V were then exposed to aerosolised ovalbumin for 30<span class="elsevierStyleHsp" style=""></span>min per day on 3 days per week for 8 weeks, beginning from the 21st day of the study. The mice in control group were administered normal saline with alum intraperitoneally on 0 and 14th days of the experiment, and exposed to aerosolised saline for 30<span class="elsevierStyleHsp" style=""></span>min per day on 3 days per week for 8 weeks, beginning from the 21st day of the study.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,18</span></a> Exposures were carried out in a whole body inhalation exposure system. Temperature and relative humidity were maintained between 20–25<span class="elsevierStyleHsp" style=""></span>°C and 40–60%, respectively. A solution of 2.5% ovalbumin in normal saline was delivered by aerosolisation via compressed air to a sidestream jet nebuliser injected into a chamber. The aerosol generated by this nebuliser comprised >80% particles with a diameter of <4<span class="elsevierStyleHsp" style=""></span>μm. Particle concentration was maintained in the range of 10–20<span class="elsevierStyleHsp" style=""></span>mg/mm<span class="elsevierStyleSup">3</span>.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study drugs</span><p id="par0025" class="elsevierStylePara elsevierViewall">Mice in Group I received saline. Mice in groups II, III, IV, and V instead received curcumin at a dose of 10<span class="elsevierStyleHsp" style=""></span>mg/kg, curcumin 20<span class="elsevierStyleHsp" style=""></span>mg/kg, dexamethasone 1<span class="elsevierStyleHsp" style=""></span>mg/kg, and DMSO (solvent of the curcumin used in the study) 1<span class="elsevierStyleHsp" style=""></span>mg/kg, respectively, intraperitoneally once a day in the last 5 days of the challenge period (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>). Intraperitoneal doses of curcumin and dexamethasone were chosen from other studies conducted also with BALB/c mice.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Histopathological analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Animals were sacrificed by an overdose of ketamin 24<span class="elsevierStyleHsp" style=""></span>h after the last drug administration. Two investigators who were blinded to the treatment groups interpreted the histopathology. Tissue specimens were obtained from the mid zone of the left lung of mice. Samples were fixed in 10% formalin for light microscopic evaluation. After fixation, samples were embedded in paraffin for light microscopic evaluation and serial sections of 5-μm thickness were prepared. After choosing the first section randomly, 10 sections in each mouse were selected by skipping over 10 sections and proceeding to the staining process. For light microscopic evaluation, three different staining processes were used. The first 10 samples were stained with haematoxylin and eosin (H&E). In these samples, general tissue features were examined and the thicknesses of epithelium and subepithelial smooth muscle layers of the medium and small airways were measured. In order to evaluate the thicknesses of epithelium and subepithelial smooth muscle layers, measurements were performed from four points of each airway at levels of 3, 6, 9, and 12 o’clock. Considering that each section contained approximately two to three airways, around 20 or more airways were evaluated for each mouse.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Photomicrographs were taken by JVC TK-890-E camera (Japan), which was adapted on Olympus BH-2 RFCA model microscope (Olympus Optical, Tokyo, Japan). The histological analysis was carried out with UTHSCSA Image Tool for Windows Version 3.00 software.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The consecutive 10 sections were stained with toluidine blue and the other 10 sections with periodic acid-Schiff (PAS). Photomicrographs were taken randomly from five fields of each section which were stained with toluidine blue. For mast cell enumeration, a standard transparent counting frame representing an area of 16,400<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span> was used manually and eight fields in each photograph were examined for each mouse. Goblet cells stained with PAS were enumerated in 10 sections of each mouse. In each section, three to five randomly selected airways were photographed. Circumferences of all airways were measured and goblet cell numbers in these areas were recorded. For standardisation, goblet cell numbers in 100<span class="elsevierStyleHsp" style=""></span>μm were analysed by division of total goblet cell number to the total length of airway circumferences and multiplying the result by one hundred.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">SPSS 11 package program was used for the statistical analysis. Data were presented as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation (SD) (minimum–maximum) of seven animals in each group. The comparisons between all groups were conducted using the Kruskal–Wallis method. When differences were statistically significant, Mann–Whitney <span class="elsevierStyleItalic">U</span> test was used for group comparisons. <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 was considered statistically significant.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The light microscopic examinations revealed normal findings in the control group (Group VI) (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>). In the chronic asthma group (Group I, placebo), the numbers of mast cells and goblet cells as well as the thicknesses of epithelium, and subepithelial smooth muscle layer were significantly higher when compared to the control group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Additionally, <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> demonstrates that characteristic asthmatic changes were successfully established in mice of Group I.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">In Group II (curcumin 10<span class="elsevierStyleHsp" style=""></span>mg/kg), thickness of epithelium was significantly lower compared to Group I. The thickness of subepithelial smooth muscle and the numbers of mast cells and goblet cells were similar to Group I (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>-Cur10). When compared with dexamethasone group, the only advantage of curcumin 10<span class="elsevierStyleHsp" style=""></span>mg/kg was observed in epithelium thickness (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">When curcumin was administered at a dose of 20<span class="elsevierStyleHsp" style=""></span>mg/kg (Group III), significant improvement occurred in all histological parameters similar to dexamethasone, the gold standard treatment of asthma (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a> – instead Group III).</p><p id="par0065" class="elsevierStylePara elsevierViewall">In Group IV (dexamethasone 1<span class="elsevierStyleHsp" style=""></span>mg/kg), all histological parameters were significantly better compared to Group I (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>, Group IV). Although DMSO (the solvent of curcumin in the present study) administration resulted in a minor improvement in epithelial thickness in Group V with respect to that of Group I, it is observed that the beneficial effects of curcumin were independent of DMSO.</p><p id="par0070" class="elsevierStylePara elsevierViewall">When low and high dosages of curcumin were compared with each other; all variables except for epithelium thicknesses were found to be significantly better in Group III (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Structural changes in asthmatic airways occur as a result of an injury/repair process, on which there is an ongoing need for beneficial drugs.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Since herbal medicines are amongst the most preferred alternative treatment modalities by caregivers, we aimed to investigate the efficacy of curcumin on lung histological changes in a murine model of chronic asthma. This is, to the best of our knowledge, the first time such a study has been undertaken.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In the present study, the structural histopathological changes observed in the asthmatic group and the significant improvement in dexamethasone group revealed that the model was successfully established. Administration of curcumin in our study significantly reduced the histological characteristics of airway inflammation. The airway response is mediated by IgE-dependent mast cell degranulation and the resulting release of mediators such as histamine and leukotrienes. Curcumin is reported to block histamine release by mast cells and inhibit lipoxygenase activity, thereby possibly inhibiting formation of leukotrienes.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21–23</span></a> Curcumin has also been demonstrated to inhibit production of inflammatory cytokines such as IL-5 and IL-8 involved in the development of inflammation and also found to inhibit the activation of transcription factors like nuclear factor kappa-B (NF-kB) and activating protein 1 (AP-1). The anti-adhesion property of curcumin was recently demonstrated.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Our observation of reduced airway constriction in BALB/c mice could be attributed to these properties of curcumin. However, this remains to be determined in the future.</p><p id="par0085" class="elsevierStylePara elsevierViewall">In 2003, Ram et al. investigated the effect of curcumin on airway hyperresponsiveness in sensitised guinea pigs.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> They noted that curcumin inhibited ovalbumin-induced airway constriction and airway hyperreactivity as by a constant-volume body plethysmograph.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In 2008, Moon et al. evaluated the anti-inflammatory effect of curcumin at cytokine level in prevention of another model of ovalbumin-induced murine asthma.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> They found that pre-treatment with curcumin resulted in the absence of ovalbumin-induced increase in nitric oxide, IL-4, IL-5, IFN-γ, and IgE levels.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In addition to the abovementioned studies, we demonstrated the ability of curcumin to reverse the ovalbumin-induced histological airway changes.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Our study had some limitations. We could not measure cytokine levels and perform electron microscopic evaluation. However, using the method described by Temelkovski et al., in which a progressive inflammatory response replicating many features of human asthma is developed in the airways of mice, increases the value of our study.</p><p id="par0095" class="elsevierStylePara elsevierViewall">In conclusion, the current study shows that administration of curcumin is effective in resolving the established chronic histopathological changes of lungs in a murine model of asthma. Further studies with long-term treatments which evaluate the effects of curcumin on lung inflammation and remodelling are needed.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xres86130" "titulo" => array:5 [ 0 => "Abstract" 1 => "Background" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec74290" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Experimental animals" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Sensitisation and inhalational exposure" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Study drugs" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Histopathological analysis" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Statistical analysis" ] ] ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-02-15" "fechaAceptado" => "2011-04-01" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec74290" "palabras" => array:5 [ 0 => "Antiinflammatory" 1 => "Chronic asthma" 2 => "Curcumin" 3 => "Mouse" 4 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Curcumin, a dietary pigment responsible for the yellow colour of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Forty-two BALB/c mice were divided into six groups: I, II, III, IV, V, and control group. All groups except the controls were sensitised and challenged with ovalbumin. Group I received nebulised saline in challenge period. Mice in groups II, III, IV, and V were administered curcumin at a dose of 10<span class="elsevierStyleHsp" style=""></span>mg/kg, curcumin 20<span class="elsevierStyleHsp" style=""></span>mg/kg, dexamethasone 1<span class="elsevierStyleHsp" style=""></span>mg/kg, and dimethyl sulfoxide 1<span class="elsevierStyleHsp" style=""></span>mg/kg, respectively, intraperitoneally once a day for the final 5 days of the challenge period. Animals were sacrificed 24<span class="elsevierStyleHsp" style=""></span>h after the last drug administration and the airway samples were evaluated histologically by light microscopy.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">All histological parameters in Group III improved similar to Group IV when compared to Group I. In Group II, only thickness of epithelium was significantly lower compared with regard to Group I. All variables except epithelium thicknesses were found to be significantly better in Group III compared to Group II.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our study, we demonstrated that curcumin administration alleviates the pathological changes of chronic asthma. Curcumin might be a promising therapy for asthma in the future.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 761 "Ancho" => 2473 "Tamanyo" => 107609 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Mouse model of airway inflammation and treatment with curcumin.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1169 "Ancho" => 3109 "Tamanyo" => 724038 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Light microscopic findings of groups I–VI. I: asthma; II: curcumin 10; III: curcumin 20; IV: dexamethasone; V: DMSO, VI: control group. In representative histological images, lung tissues were stained with H&E (A), PAS (B) and toluidine blue (C). In Asthma (IA), DMSO (VA) and Cur10 (IIA) groups, H&E staining revealed thickened epithelium, thickened subepithelial smooth muscle (arrow with two heads) and peribronchiolar mononuclear infiltration (*). High numbers of goblet cells (arrows) were seen with PAS-staining in asthma (IB), DMSO (VB) and Cur10 (IIB) and mast cells with toluidine blue staining in asthma (IC), DMSO (VC) and Cur10 (IIC). In Cur20 group, subepithelial smooth muscle thickness decreased and a reduction in the number of goblet and mast cells were observed compared to the DMSO and cur10 groups. Cur20 suppressed goblet cell hyperplasia in lung tissue.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Normal controlGroup VI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Chronic asthma treated with placeboGroup I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Subepithelial smooth muscle thickness (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.80<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.27<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Epithelium thickness (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39.94<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.95<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Numbers of mast cells/16,400 (μm<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.34<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Numbers of goblet cells/100 (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.74<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.01<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab165525.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Histological comparison of lungs of the chronic asthma group treated with placebo (Group I) and normal control group (Group VI), (mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD).</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Curcumin (10<span class="elsevierStyleHsp" style=""></span>mg/kg)Group II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Curcumin (20<span class="elsevierStyleHsp" style=""></span>mg/kg)Group III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Dexa (1<span class="elsevierStyleHsp" style=""></span>mg/kg)Group IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">DMSOGroup V \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Placebo (asthma)Group I \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Subepithelial smooth muscle thickness (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.50<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.50<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">¥</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.57<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.59<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">€</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.88<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.86<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.97<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.27<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.64 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Epithelium thickness (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31.16<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.99<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">¥</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36.77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.53<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39.52<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.67<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.32<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.61<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.95<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Numbers of mast cells/16,400 (μm<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.16<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.34<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">¥</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.10<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.99<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">€</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.67<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.73<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.44<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Numbers of goblet cells/100 (μm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.00<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.42<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">¥</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.21<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.93<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">€</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.03<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.33<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.01<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab165526.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 in groups versus placebo.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "¥" "nota" => "<p class="elsevierStyleNotepara"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 in groups versus dexamethasone.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "€" "nota" => "<p class="elsevierStyleNotepara"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 in groups treated with two different doses of curcumin.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Comparison between study groups (mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys" 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Anti-inflammatory effects of curcumin in a murine model of chronic asthma
M. Karaman, F. Firinci, S. Cilaker, P. Uysal, K. Tugyan, O. Yilmaz, N. Uzuner, O. Karaman
10.1016/j.aller.2011.04.006Allergol Immunopathol (Madr). 2012;40:210-4