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At the right, the serous detachment is completely gone, as well as a clear reduction of the peripapillary diffusion and the absence of focal exudation points.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. López-Prats, D. Salom, E. Sanz-Marco, S. García-Delpech, P. Udaondo, M. Díaz-Llopis" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "López-Prats" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Salom" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Sanz-Marco" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "García-Delpech" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Udaondo" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Díaz-Llopis" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S036566911100178X" "doi" => "10.1016/j.oftal.2011.02.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S036566911100178X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579411000314?idApp=UINPBA00004N" "url" => "/21735794/0000008600000007/v1_201305091027/S2173579411000314/v1_201305091027/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173579411000302" "issn" => "21735794" "doi" => "10.1016/j.oftale.2011.02.003" "estado" => "S300" "fechaPublicacion" => "2011-07-01" "aid" => "113" "copyright" => "Sociedad Española de Oftalmología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Soc Esp Oftalmol. 2011;86:213-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1569 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1243 "PDF" => 318 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Effect of mitomycin C on corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK)" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "213" "paginaFinal" => "217" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto de la mitomicina C en el engrosamiento corneal tras queratectomía subepitelial con láser excimer (LASEK)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. De Benito-Llopis, M.A. Teus, P. Drake-Casanova" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "De Benito-Llopis" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Teus" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Drake-Casanova" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0365669111001754" "doi" => "10.1016/j.oftal.2011.02.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669111001754?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579411000302?idApp=UINPBA00004N" "url" => "/21735794/0000008600000007/v1_201305091027/S2173579411000302/v1_201305091027/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>" "titulo" => "Retinal capillary hemangioma and von Hippel-Lindau disease: Diagnostic and therapeutic implications" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "218" "paginaFinal" => "221" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Salazar, C. González-Castaño, P. Rozas, J. Castro" "autores" => array:4 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Salazar" "email" => array:1 [ 0 => "raquelsalazarmendez@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "González-Castaño" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Rozas" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Castro" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Principado de Asturias, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemangioma capilar retiniano y enfermedad de von Hippel-Lindau: implicaciones diagnósticas y terapéuticas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1062 "Ancho" => 1750 "Tamanyo" => 633424 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Optic coherence tomography: (a) initial EMQ and (b) final appearance.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The von Hippel-Lindau (VHL) disease is a hereditary disease caused by germinal mutations in the VHL tumor suppressing gene. The prevalence is estimated at 1/36,000 births and penetration is nearly complete by age 65. Approximately half of VHL cases are familial, with the other half being sporadic due to new mutations.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The clinical expressions of VHL are highly diverse, with more than 40 lesions being described in 14 different organs, including retinal capillary hemangioma (RCH), cerebellum or spinal hemangioblastoma, renal pheochromocytomas and carcinomas (the main cause of death). Even though 50% of patients exhibited only one characteristic and very few develop the complete syndrome, all must undergo a systematic detection protocol (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Frequently, RCH is the first expression and is present in 70% of patients, with its frequency increasing with age. RCH can appear in isolation or as a part of the VHL disease, where one-third are multiple and half are bilateral. In the presence of familial history, the existence of RCH is considered to be a diagnostic criteria for the syndrome (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Possible ophthalmological expressions also include other vascular hamartoma and what is known as “twin vessels”. Optic pathway alterations are rare, although one case has been described with an optic nerve tumor.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical case</span><p id="par0020" class="elsevierStylePara elsevierViewall">A male, 26, exhibited visual acuity reduction in the left eye with a 2-year evolution. The subject is a bearer of the mutation causing the VHL disease, father and brother with systemic syndrome expressions. Upon exploration, the VA of the LE is of 0.4. The LE ocular fundus exhibits orange-colored endophytic tumoration of two papilla diameters in the superior temporal arch with dilated nutrition vessels (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Optic coherence tomography (OCT) evidences a diffuse cystic edema in the posterior pole and angiography (AFG) reveals early hyperfluorescence of the lesion with delayed losses (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). A systemic study was requested which in addition revealed solid nodules in both kidneys suggesting bilateral hypernephroma (subsequently confirmed after performing radical left nephrectomy), a hypercapturing nodule in the right supra-renal gland, a likely neuroendocrine pancreatic tumor and multiple hemangioblastomas in protuberance and spinal chord, with slight medullar edema associated.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Argon laser photocoagulation was initiated in 2 sessions, during which subretinal hemorrhage occurs along the vascular arch and vitreous hemorrhage (VH). Two months later and due to the lack of absorption of the VH, it was decided to perform a 23G vitrectomy during which the treatment for the lesion was completed with endolaser. Three months after the surgery, the patient VA was of 0.6. OCT showed a good foveal profile, with resolution of the macular edema (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). AFG confirmed the closure of nutrition vessels, the lesion exhibited a cicatricial appearance (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>), and even though capture began early, there is no loss, and substituted vessels can be appreciated in the periphery of the lesion.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">RCH is an angiomatous hamartoma which histopathologically consists in a proliferation of capillary vessels that alters the normal sensory architecture of the retina. These lesions frequently exhibit endophytic growth and mainly are located in the peripheral and superior temporal area, although the juxtapapillary hemangioma has been described in 11–15% of VHL cases.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The visual loss associated to RCH could be due to several causes, including exudative (25%) or tractional (9%) phenomena, the development of epiretinal membranes and HV. It has been recently demonstrated that the retinal function of patients with VHL could be affected even in the absence of RCH. The RCH diagnostic requires completing the systemic study in search of other organ lesions which could limit survival, such as kidney carcinoma.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In general, lesions increase progressively in size and rarely regress spontaneously. Accordingly, it is recommendable to establish prophylactic treatments when they are still small. Laser photocoagulation is the most adequate method for small lesions under 3<span class="elsevierStyleHsp" style=""></span>mm in size, although a maximum size of 4.5<span class="elsevierStyleHsp" style=""></span>mm can be considered. The prognosis is generally uncertain in larger tumors. Several sessions are required and the risk of therapeutic failure is high. Large size burns are utilized, with low intensity and extended duration. It is recommended to begin by limiting the lesion and then acting on the vessels (which requires several sessions) and finally on the tumor surface, although the effects are not permanent in all cases. Cryotherapy is reserved for larger size tumors, pre-equatorial locations or when opacity prevents photocoagulation, although exudation can temporarily increase after the application thereof. Additional options include brachytherapy, reserved for selected cases, and vitrectomy indicated in cases of HV and massive tractional or exudative retinal detachment.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3–5</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">None of the authors have declared any conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xres152541" "titulo" => array:3 [ 0 => "Abstract" 1 => "Clinical case" 2 => "Discussion" ] ] 1 => array:2 [ "identificador" => "xpalclavsec140540" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres152542" "titulo" => array:3 [ 0 => "Resumen" 1 => "Caso clínico" 2 => "Discusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec140541" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical case" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of interests" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-02-02" "fechaAceptado" => "2011-03-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec140540" "palabras" => array:4 [ 0 => "Retinal capillary haemangioma" 1 => "Von Hippel-Lindau disease" 2 => "Laser photocoagulation" 3 => "Vitrectomy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec140541" "palabras" => array:4 [ 0 => "Hemangioma capilar retiniano" 1 => "Enfermedad von Hippel-Lindau" 2 => "Fotocoagulación láser" 3 => "Vitrectomía" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Clinical case</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Man carrier of the von Hippel-Lindau (VHL) gene, with long-onset loss of vision in left eye. He had a retinal capillary haemangioma (HCR) and diffuses cystic edema in posterior pole. The systemic study revealed bilateral kidney tumors. Laser photocoagulation was performed which produced a subretinal and vitreous hemorrhage that required vitrectomy.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retinal capillary haemangioma (HCR) is the earliest and most frequent manifestation of the von Hippel-Lindau disease. Its detection requires it to be treated early and to rule out other visceral lesions. Laser photocoagulation is the most recommended treatment of small-size HCR. The most frequent complications are vitreous and subretinal hemorrhages.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Caso clínico</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Varón con disminución de visión en ojo izquierdo de larga evolución. Portador del gen de VHL. Presenta hemangioma capilar retiniano (HCR) y edema quístico difuso en polo posterior. El estudio sistémico revela la existencia de masas renales bilaterales. Se inicia fotocoagulación con láser argón, produciéndose hemorragia subretiniana y hemorragia vítrea que precisó vitrectomía.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El HCR constituye la manifestación más frecuente y precoz en la enfermedad de VHL. Su detección obliga a su tratamiento precoz, así como a descartar otras lesiones viscerales. La fotocoagulación láser es el tratamiento de elección en el HCR de pequeño tamaño. Entre sus complicaciones destaca la hemorragia vítrea y subretiniana.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Partially presented as a clinical case panel at the 86 Congreso Nacional of the Sociedad Española de Oftalmología, September 22–25, 2010, Madrid, Spain.</p>" ] 1 => array:2 [ "etiqueta" => "☆☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Salazar R, et al. Hemangioma capilar retiniano y enfermedad de von Hippel-Lindau: implicaciones diagnósticas y terapéuticas. Arch Soc Esp Oftalmol. 2011;86:218–21.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 986 "Ancho" => 800 "Tamanyo" => 104665 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Retinal capillary hemangioma.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 940 "Ancho" => 1750 "Tamanyo" => 111782 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Angiography appearance of the lesion.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1062 "Ancho" => 1750 "Tamanyo" => 633424 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Optic coherence tomography: (a) initial EMQ and (b) final appearance.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 424 "Ancho" => 1750 "Tamanyo" => 107154 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evolution of the lesion (a) after the first laser session, (b) after the second session and (c) final appearance.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Assessment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Hawaii \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Newfoundland \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Cambridge \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ophthalmoscopy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Every 1–5 years from age 6 in risk cases and every 6–12 months in affected patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Annual in risk cases and every 6 months for affected patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Annual between age 5 and 60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AFG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not routine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not routine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Annual from 10 years onwards \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Physical exploration and catecholamines in 24 h urine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Every 1–5 years from age 10 in risk cases and annually in affected patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Annual \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Annual \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NMR/CAT brain and spinal chord \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NMR from age 20. Every 10 years in risk cases and every 1–5 years for affected patients or with clinical suspicion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Baseline CAT basal in 1st–2nd decade and with focality and clinical suspicion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Every 3 years between age 15 and 40, then every 5 years from age 40 to 60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Echography/abdominal CAT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Between age 15 and 20 every 1–5 years, echography and/or CAT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Abdominal echography. CAT is kidney carcinoma or pheochromocytoma is suspected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Every 3 years between age 20 and 60 (more frequently with multiple kidney cysts) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab246781.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Von Hippel-Lindau disease detection protocols.</p>" ] ] 5 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">With familial history</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">One or more of the following lesions are required:</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>RCH \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>SNC hemangioblastoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Organ lesions: kidney carcinoma, pheochromocytoma, renal/pancreatic cysts, pancreatic islet tumors, paragangliomas, epidydimis cystadenomas, endolymphatic sac tumors \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Without familial history</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RCH and/or SNC hemangioblastoma (if only one of these tumors expresses, a second organ lesion is necessary)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab246780.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Diagnostic criteria for the von Hippel-Lindau disease.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumores vasculares de la retina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. 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Koenig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Ophthalmol" "fecha" => "1974" "volumen" => "92" "paginaInicial" => "121" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4858803" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735794/0000008600000007/v1_201305091027/S2173579411000326/v1_201305091027/en/main.assets" "Apartado" => array:4 [ "identificador" => "8724" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Short communication" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735794/0000008600000007/v1_201305091027/S2173579411000326/v1_201305091027/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579411000326?idApp=UINPBA00004N" ]
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Retinal capillary hemangioma and von Hippel-Lindau disease: Diagnostic and therapeutic implications
Hemangioma capilar retiniano y enfermedad de von Hippel-Lindau: implicaciones diagnósticas y terapéuticas
R. Salazar
, C. González-Castaño, P. Rozas, J. Castro
Corresponding author
Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Principado de Asturias, Spain